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1. 发明申请

WO2021252502A1 METHODS AND SYSTEMS FOR DETERMINING AN OBJECT MAP 审中-公开
公开(公告)号：WO2021252502A1
公开(公告)日：2021-12-16
申请号：PCT/US2021/036420
申请日：2021-06-08
申请人： RODRIGUEZ-DIAZ, Eladio , SINGH, Satish
发明人： RODRIGUEZ-DIAZ, Eladio , SINGH, Satish
IPC分类号： G06T1/40 , G06T7/00 , G06T7/11 , G06T2207/10016 , G06T2207/10068 , G06T2207/20081 , G06T2207/20084 , G06T2207/30032 , G06T2207/30096 , G06T7/0012
摘要： The present disclosure relates to techniques for the treatment of patient tissue. The techniques may include resection or removal of such tissue. Error reduction in the identification and presentation of specific tissue types may be realized through these techniques. An image may be received that provides a visual representation of the tissue. Pixels of the image may be segmented to form a boundary. Portions of the image may be classified for resection and resection of the tissue may be performed.

2. 发明申请

WO2010070625A1 SYSTEM AND METHOD FOR GENERATING A SIGNAL WITH A RANDOM LOW PEAK TO AVERAGE POWER RATIO WAVEFORM FOR AN ORTHOGONAL FREQUENCY DIVISION MULTIPLEXING SYSTEM 审中-公开
标题翻译：用于产生具有随机低峰值的信号的平均功率比波形的系统和方法用于正交频分多路复用系统
公开(公告)号：WO2010070625A1
公开(公告)日：2010-06-24
申请号：PCT/IB2009/055860
申请日：2009-12-19
申请人： NXP B.V. , SINGH, Satish , AHIRWAR, Vijay
发明人： SINGH, Satish , AHIRWAR, Vijay
IPC分类号： H04L27/26
CPC分类号： H04L5/0007 , H04L27/2621
摘要： A method for generating a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system involves processing a complex vector to generate a processed complex vector and performing an inverse fast Fourier transform on the processed complex vector to generate a signal with a random low peak to average power ratio waveform for an orthogonal frequency division multiplexing system.
摘要翻译：用于产生具有用于正交频分复用系统的随机低峰值与平均功率比波形的信号的方法涉及处理复矢量以生成经处理的复矢量并对所处理的复矢量执行快速傅立叶逆变换以产生信号具有用于正交频分复用系统的随机低峰值与平均功率比波形。

3. 发明申请

WO2009002580A3 METHOD FOR BACTERIAL LYSIS 审中-公开
标题翻译：细菌检测方法
公开(公告)号：WO2009002580A3
公开(公告)日：2009-04-09
申请号：PCT/US2008059158
申请日：2008-04-02
申请人： BOSTON MEDICAL CT CORP , KLAPPERICH CATHERINE , KAUFMAN JESSICA , KULINSKI MARIA DOMINIKA , ALTMAN DAVID , SINGH SATISH
发明人： KLAPPERICH CATHERINE , KAUFMAN JESSICA , KULINSKI MARIA DOMINIKA , ALTMAN DAVID , SINGH SATISH
IPC分类号： B01L3/00 , C01B31/02 , C12N1/06 , G01N1/28
CPC分类号： B01L3/502707 , B01L2200/10 , B01L2300/0681 , B82Y30/00 , B82Y40/00 , C01B32/15 , C01B2202/34 , C01B2202/36 , C12N1/066 , C12Q1/6806 , C12Q2565/629 , C12Q2531/113
摘要： The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microf luidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with carbon particles, for example carbon nanotubes.The microfluidic devices and methods of the present invention are useful for cell lysis of cells within a biological sample, such as a untreated biological sample comprising microorganisms, such as but not limited to gram positive and gram negative bacteria. In some embodiments, the microfluidic devices of the present invention can also optionally comprise other modules enabling further processing of the biological sample, for example isolation, purification and detection of biomolecules released from the lysed cells, such as but not limited to nucleic acids or proteins or peptides from the lysed cells, providing a complete Lab- on- a- Chip analysis system for biomolecules released from difficult to lyse microorganisms in a single step or process. The microfluidic devices of the present invention can also be adapted and are useful to methods to enrich for microorganisms in a biological sample, for example enrich for a desired type of bacteria within a biological sample. The microfluidic devices and methods of the present invention can be adapted to perform highly efficient lysis of microorganisms within a biological sample for diagnostic tests, for example for diagnosis of infectious agents and pathogens, such as bacteria, viruses or parasites.
摘要翻译：本发明涉及用于细胞裂解的微流体装置，例如细菌和微生物。特别地，本发明涉及微流控装置和这种微流体装置的制造方法，其包括具有填充有嵌入有碳颗粒的聚合物整体的至少一个通道的基底，例如碳纳米管。本发明的微流体装置和方法本发明可用于生物样品中的细胞的细胞裂解，例如包含微生物的未处理的生物样品，例如但不限于革兰氏阳性细菌和革兰氏阴性细菌。在一些实施方案中，本发明的微流体装置还可以任选地包含能够进一步处理生物样品的其它模块，例如从裂解的细胞释放的生物分子的分离，纯化和检测，例如但不限于核酸或蛋白质或来自裂解细胞的肽，为在单个步骤或过程中从难以裂解的微生物释放的生物分子提供完整的Lab-a-Chip分析系统。本发明的微流体装置也可以适用于富集生物样品中微生物的方法，例如富集生物样品中所需类型的细菌。本发明的微流体装置和方法可以适用于对生物样品中的微生物进行高效裂解，用于诊断测试，例如用于诊断感染因子和病原体，例如细菌，病毒或寄生虫。

4. 发明申请

WO2009002580A9 METHOD FOR BACTERIAL LYSIS 审中-公开
标题翻译：细菌裂解方法
公开(公告)号：WO2009002580A9
公开(公告)日：2008-12-31
申请号：PCT/US2008/059158
申请日：2008-04-02
申请人： BOSTON MEDICAL CENTER CORPORATION , KLAPPERICH, Catherine , KAUFMAN, Jessica , KULINSKI, Maria, Dominika , ALTMAN, David , SINGH, Satish
发明人： KLAPPERICH, Catherine , KAUFMAN, Jessica , KULINSKI, Maria, Dominika , ALTMAN, David , SINGH, Satish
IPC分类号： B01L3/00 , C01B31/02 , C12N1/06 , G01N1/28
摘要： The present invention is directed to a microfluidic device for lysis of cells, such as bacteria and microorganisms. In particular, the present invention relates to microf luidic devices and methods of manufacture of such microfluidic devices comprising a substrate with at least one channel packed with a polymer monolith embedded with carbon particles, for example carbon nanotubes.The microfluidic devices and methods of the present invention are useful for cell lysis of cells within a biological sample, such as a untreated biological sample comprising microorganisms, such as but not limited to gram positive and gram negative bacteria. In some embodiments, the microfluidic devices of the present invention can also optionally comprise other modules enabling further processing of the biological sample, for example isolation, purification and detection of biomolecules released from the lysed cells, such as but not limited to nucleic acids or proteins or peptides from the lysed cells, providing a complete Lab- on- a- Chip analysis system for biomolecules released from difficult to lyse microorganisms in a single step or process. The microfluidic devices of the present invention can also be adapted and are useful to methods to enrich for microorganisms in a biological sample, for example enrich for a desired type of bacteria within a biological sample. The microfluidic devices and methods of the present invention can be adapted to perform highly efficient lysis of microorganisms within a biological sample for diagnostic tests, for example for diagnosis of infectious agents and pathogens, such as bacteria, viruses or parasites.
摘要翻译：本发明涉及用于裂解细胞如细菌和微生物的微流体装置。具体而言，本发明涉及微流体装置和这种微流体装置的制造方法，该微流体装置包括具有至少一个填充有嵌入有碳颗粒的聚合物整料的通道的基底，例如碳纳米管。本发明的微流体装置和方法本发明可用于生物样品（例如包含微生物的未经处理的生物样品，例如但不限于革兰氏阳性和革兰氏阴性细菌）内细胞的细胞裂解。在一些实施方案中，本发明的微流体装置还可以任选地包含能够进一步处理生物样品的其它模块，例如分离，纯化和检测从裂解的细胞释放的生物分子，例如但不限于核酸或蛋白质或来自裂解细胞的肽，提供完整的Lab-on-Chip分析系统，用于在单个步骤或过程中从难以裂解的微生物中释放的生物分子。本发明的微流体装置也可适用于并且可用于丰富生物样品中的微生物的方法，例如富集生物样品内的期望类型的细菌。本发明的微流体装置和方法可以适用于对生物样品中的微生物进行高效裂解以进行诊断测试，例如用于诊断感染物和病原体，如细菌，病毒或寄生虫。

5. 发明申请

WO2006096490A3 ANTI-MAdCAM ANTIBODY COMPOSITIONS 审中-公开
公开(公告)号：WO2006096490A3
公开(公告)日：2006-09-14
申请号：PCT/US2006/007554
申请日：2006-03-02
申请人： PHARMACIA & UPJOHN COMPANY LLC , ALLAN, Corey, Mathew , DAS, Tapan, Kanti , GANSER, Scott, Steven , NEMA, Sandeep , SINGH, Satish, Kumar , ZENG, David, Li
发明人： ALLAN, Corey, Mathew , DAS, Tapan, Kanti , GANSER, Scott, Steven , NEMA, Sandeep , SINGH, Satish, Kumar , ZENG, David, Li
IPC分类号： C07K16/28 , A61K39/395
摘要： The present invention relates to anti-MAdCAM antibody compositions comprising a chelating agent, and methods of treating inflammatory disease in a subject.

6. 发明申请

WO2006096488A2 PLATFORM ANTIBODY COMPOSITIONS 审中-公开
标题翻译：平台抗体组合物
公开(公告)号：WO2006096488A2
公开(公告)日：2006-09-14
申请号：PCT/US2006/007551
申请日：2006-03-02
申请人： PHARMACIA & UPJOHN COMPANY LLC , DAS, Tapan, Kanti , KING, Kevin , NEMA, Sandeep , SINGH, Satish, Kumar , STEINMEYER, David, Ethan , ZENG, David, Li
发明人： DAS, Tapan, Kanti , KING, Kevin , NEMA, Sandeep , SINGH, Satish, Kumar , STEINMEYER, David, Ethan , ZENG, David, Li
IPC分类号： A61K39/395 , A61K31/198 , C07K16/28 , C07K16/24
CPC分类号： C07K16/243 , A61K39/3955 , A61K39/39591 , A61K2039/505 , C07K2317/21 , A61K2300/00
摘要： The present invention provides novel compositions of human IgG 2 antibodies comprising a chelating agent. The present invention also provides novel antibody compositions that exhibit improved chemical and/or physical stability. Also provided are methods of treating diseases and conditions with compositions of human IgG 2 antibodies, including inflammatory diseases and neoplasia disorders.
摘要翻译：本发明提供包含螯合剂的人IgG 2抗体的新型组合物。本发明还提供了表现出改善的化学和/或物理稳定性的新型抗体组合物。还提供了用包含炎症性疾病和瘤形成障碍的人IgG 2抗体组合物治疗疾病和病症的方法。

7. 发明申请

WO2003090734A1 TOLTERODINE SALTS 审中-公开
标题翻译：妥洛司坦盐
公开(公告)号：WO2003090734A1
公开(公告)日：2003-11-06
申请号：PCT/SE2003/000634
申请日：2003-04-22
申请人： PHARMACIA & UPJOHN COMPANY , HAWLEY, Michael , SINGH, Satish, Kumar , MOROZOWICH, Walter , WARCHOL, Mark, P.
发明人： HAWLEY, Michael , SINGH, Satish, Kumar , MOROZOWICH, Walter , WARCHOL, Mark, P.
IPC分类号： A61K31/137
CPC分类号： A61K31/205 , C07C215/54
摘要： The present invention concerns novel pharmaceutically active compounds, pharmaceutical compositions containing the same, the compounds for use as medicaments, and use of the compounds for the manufacture of specific medicaments. The present invention also concerns a method of treatment involving administration of the compounds. Specifically, the compounds are pharmaceutically acceptable salts of tolterodine or hydroxytolterodine, wherein the salt is of an acid selected from the group consisting of aliphatic mono- and dicarboxylic acids comprising from 7 to 24 carbon atoms, alkanedisulfonic acids comprising from 2 to 4 carbon atoms, naphthoic acid derivatives comprising from 11 to 27 carbon atoms, maleic acid and fumaric acid.
摘要翻译：本发明涉及新型药物活性化合物，含有它们的药物组合物，用作药物的化合物以及该化合物用于制备特定药物的用途。本发明还涉及涉及给药化合物的治疗方法。具体地说，这些化合物是托特罗定或羟基炔诺酮的药学上可接受的盐，其中该盐是选自包含7-24个碳原子的脂族单羧酸和二羧酸，包含2至4个碳原子的链烷二磺酸，包含11至27个碳原子的萘甲酸衍生物，马来酸和富马酸。

8. 发明申请

WO2010064132A1 MUTANTS OF STAPHYLOKINASE CARRYING AMINO AND CARBOXY-TERMINAL EXTENSIONS FOR POLYETHYLENE GLYCOL CONJUGATION 审中-公开
标题翻译：携带亚氨基的印刷胶原酶和聚乙二醇凝胶的羧基末端延伸的突变体
公开(公告)号：WO2010064132A1
公开(公告)日：2010-06-10
申请号：PCT/IB2009/007645
申请日：2009-12-04
申请人： COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH , SINGH, Satish , DIKSHIT, Kanak, Lata
发明人： SINGH, Satish , DIKSHIT, Kanak, Lata
IPC分类号： C12N9/48 , C07K14/31 , C12N1/21 , A61K38/48
CPC分类号： C12N9/52 , A61K38/00 , A61K38/4886 , A61K47/48215 , A61K47/60 , C12N9/48 , C12Y304/24029
摘要： The present invention relate to a system having electrical equipments integrated on a structure. The system comprising at least one electrical equipment located at a spaced apart relationship and mounted on at least one structure. The present invention also relate to a method for isolation of electrical equipments. The method comprises opening and closing the contact by engaging or disengaging one or more terminals of the electrical equipments correspondingly with the supply line or the distribution line by a mechanism for isolation. The said mechanism is a handle or a moving mechanism which is associated with a movement in vertical direction or horizontal direction or with a movement that provide isolation.
摘要翻译：本发明涉及一种具有集成在结构上的电气设备的系统。所述系统包括位于间隔开的关系并且安装在至少一个结构上的至少一个电气设备。本发明还涉及一种隔离电气设备的方法。该方法包括通过用于隔离的机构将电气设备的一个或多个端子与供应管线或配电线相对应地接合或分离来打开和关闭触点。所述机构是手柄或移动机构，其与垂直方向或水平方向上的运动或提供隔离的运动相关联。

9. 发明申请

WO2006096491A9 ANTI-CTLA-4 ANTIBODY COMPOSITIONS 审中-公开
标题翻译：抗CTLA-4抗体组合物
公开(公告)号：WO2006096491A9
公开(公告)日：2008-05-29
申请号：PCT/US2006007555
申请日：2006-03-02
申请人： PHARMACIA & UPJOHN CO LLC , ABATE JUSTIN DONALD , DAS TAPAN KANTI , ELLIOTT CARRIE MARIE , MUTHURANIA KEVIN WAMITI , NEMA SANDEEP , SINGH SATISH KUMAR
发明人： ABATE JUSTIN DONALD , DAS TAPAN KANTI , ELLIOTT CARRIE MARIE , MUTHURANIA KEVIN WAMITI , NEMA SANDEEP , SINGH SATISH KUMAR
IPC分类号： A61K39/395 , A61K47/18 , A61P35/00 , C07K16/28
CPC分类号： C07K16/243 , A61K39/3955 , A61K39/39591 , A61K2039/505 , C07K2317/21 , A61K2300/00
摘要： The present invention provides for novel compositions of anti-CTLA-4 antibodies comprising a chelating agent. Also provided are method of treating diseases and conditions with novel compositions of CTLA-4 antibodies, including various neoplasia conditions.
摘要翻译：本发明提供了包含螯合剂的抗CTLA-4抗体的新组合物。还提供了用CTLA-4抗体的新组合物治疗疾病和病症的方法，包括各种肿瘤病症。

10. 发明申请

WO2008011056A2 DEVICE WITH INTEGRATED MULTI-FIBER OPTICAL PROBE AND METHODS OF USE 审中-公开
标题翻译：具有综合多光纤探测器的设备及其使用方法
公开(公告)号：WO2008011056A2
公开(公告)日：2008-01-24
申请号：PCT/US2007/016267
申请日：2007-07-18
申请人： TRUSTEES OF BOSTON UNIVERSITY, ET AL. , BIGIO, Irving , SINGH, Satish
发明人： BIGIO, Irving , SINGH, Satish
CPC分类号： A61B5/415 , A61B5/0075 , A61B5/0084 , A61B5/418 , A61B5/7267 , A61B10/06 , A61B2017/00057
摘要： Biopsy instruments are integrated with a multi-fiber optical probe adapted to perform diagnostic measurements. In addition to being able to analyze, treat or remove tissue, such integrated devices characterize tissue by measuring the amount of scattering and absorption of light transmitted into the tissue. Each fiberoptic probe has an illuminating fiber that provides a broadband light source for transmission into tissue, and a collecting fiber that collects the light scattered by the tissue and transmits the collected light to a spectrometer. One embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a multi-fiber optical probe which is conveyed through a hollow central channel. Another embodiment is an endoscope-mediated tool with a jaw-type biopsy forceps and a plurality of multi-fiber optical probes. Yet another embodiment is an endoscopic polypectomy-type snare catheter with a multi- fiber optical probe located at the tip.
摘要翻译：活检仪器与适用于执行诊断测量的多光纤光探头集成。除了能够分析，处理或去除组织之外，这种集成装置通过测量透射到组织中的光的散射和吸收量来表征组织。每个光纤探针具有照明光纤，其提供用于传输到组织中的宽带光源，以及收集光纤，其收集由组织散射的光并将所收集的光传输到光谱仪。一个实施例是内窥镜介导的工具，其具有夹钳式活检钳和多纤维光学探针，其通过中空中心通道输送。另一个实施例是具有颚式活检钳和多个多纤维光学探针的内窥镜介导的工具。另一个实施例是一种内窥镜息肉切除术型圈套导管，其具有位于尖端处的多光纤光学探针。

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