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1. 发明申请

WO2017172475A1 REAL-TIME ADJUSTMENT OF APPLICATION-SPECIFIC OPERATING PARAMETERS FOR BACKWARDS COMPATIBILITY 审中-公开
标题翻译：实时调整用于反向兼容性的应用特定操作参数
公开(公告)号：WO2017172475A1
公开(公告)日：2017-10-05
申请号：PCT/US2017/023774
申请日：2017-03-23
申请人： SONY INTERACTIVE ENTERTAINMENT INC. , CERNY, Mark Evan , SIMPSON, David
发明人： CERNY, Mark Evan , SIMPSON, David
IPC分类号： G06F1/08 , G06F9/44 , G06F9/45 , G06T15/50 , G09G5/397
摘要： Performance of a new system may be optimized to run a legacy application written for a legacy system. Performance information for the legacy application is recorded or derived while running the legacy application on the new system. Performance characteristics for the legacy application running on the new system are determined by analyzing the performance information. The performance characteristics include one or more key performance metrics and other performance information. The key performance metrics must be met when the legacy application is run on the new system. The other performance information is useful for adjusting one or more operating parameters of the new system when running the legacy application on the new system. The one or more operating parameters are adjusted so that the one or more key performance metrics are met.
摘要翻译：新系统的性能可以被优化以运行为遗留系统编写的遗留应用程序。在新系统上运行遗留应用程序时记录或派生遗留应用程序的性能信息。在新系统上运行的遗留应用程序的性能特征是通过分析性能信息来确定的。性能特征包括一个或多个关键性能指标和其他性能信息。当遗留应用程序在新系统上运行时，必须满足关键性能指标。其他性能信息对于在新系统上运行遗留应用程序时调整新系统的一个或多个操作参数很有用。一个或多个操作参数被调整以便满足一个或多个关键性能指标。

2. 发明申请

WO2012006072A9 AIR IMPEDANCE ELECTROSPINNING FOR CONTROLLED POROSITY 审中-公开
公开(公告)号：WO2012006072A9
公开(公告)日：2012-01-12
申请号：PCT/US2011/042144
申请日：2011-06-28
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , BOWLIN, Gary, L. , MCCLURE, Michael, J. , SIMPSON, David, G. , YANG, Hu
发明人： BOWLIN, Gary, L. , MCCLURE, Michael, J. , SIMPSON, David, G. , YANG, Hu
IPC分类号： D04H3/16 , A61L27/56 , D01D5/00 , A61L27/38 , A61F2/02
摘要： Electrospun materials are fabricated using air-flow impedance technology, which results in the production of scaffolds in which some regions are dense with low porosity and others regions are less dense and more porous. The dense regions provide structural support for the scaffold while the porous regions permit entry of cells and other materials into the scaffold, e.g. when used for tissue engineering.

3. 发明申请

WO2011032139A2 ELECTROSPUN NERVE GUIDES FOR NERVE REGENERATION DESIGNED TO MODULATE NERVE ARCHITECTURE 审中-公开
标题翻译： ELECTROSPUN神经导向神经再生旨在调节神经结构
公开(公告)号：WO2011032139A2
公开(公告)日：2011-03-17
申请号：PCT/US2010/048744
申请日：2010-09-14
申请人： VIRGINIA COMMONWEALTH UNIVERSITY , SIMPSON, David , BOWLIN, Gary , COLELLO, Raymond , CHOW, Woon , JHN, Balendu, Shekhar
发明人： SIMPSON, David , BOWLIN, Gary , COLELLO, Raymond , CHOW, Woon , JHN, Balendu, Shekhar
IPC分类号： A61F2/02 , A61F2/04 , A61L27/54 , B29C33/02 , A61L27/14
CPC分类号： A61L27/18 , A61B17/1128 , A61F2/02 , A61L2430/32 , C08L67/04
摘要： Nerve guides which are formed from three dimensional (3D) arrays of highly aligned electrospun fibers are provided. The electrospun fibers are oriented parallel to the long axis of the guide, and gaps and elongated spaces between the stacked fiber arrays provide channels for directed axonal growth, ϊn some embodiments, the nerve guides also comprise high precision gradients of beneficial substances such as growth factors, which aid m nerve regeneration and growth along the guide.
摘要翻译：提供由高度对准的电纺纤维的三维（3D）阵列形成的神经导管。电纺丝纤维取向平行于导向器的长轴，并且堆叠的纤维阵列之间的间隙和细长空间提供用于定向轴突生长的通道。在一些实施方式中，神经导向器还包括有益物质的高精度梯度，例如生长因子，这有助于神经再生和生长沿着指南。

4. 发明申请

WO2010108114A3 POLYUNSATURATED FATTY ACID SYNTHASE NUCLEIC ACID MOLECULES AND POLYPEPTIDES, COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF 审中-公开
公开(公告)号：WO2010108114A3
公开(公告)日：2010-09-23
申请号：PCT/US2010/028009
申请日：2010-03-19
申请人： MARTEK BIOSCIENCES CORPORATION , APT, Kirk, E. , RICHTER, Leslie , SIMPSON, David , ZIRKLE, Ross
发明人： APT, Kirk, E. , RICHTER, Leslie , SIMPSON, David , ZIRKLE, Ross
IPC分类号： C07H21/04
摘要： The present invention is directed to isolated nucleic acid molecules and polypeptides of thraustochytrid polyunsaturated fatty acid (PUFA) synthases involved in the production of PUFAs, including PUFAs enriched in docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), or a combination thereof. The present invention is directed to vectors and host cells comprising the nucleic acid molecules, polypeptides encoded by the nucleic acid molecules, compositions comprising the nucleic acid molecules or polypeptides, and methods of making and uses thereof.

5. 发明申请

WO2009149181A2 METHODS AND COMPOSITIONS FOR MANIPULATING ELECTROPROCESSED SCAFFOLD MATERIAL PROPERTIES USING CROSS-LINKING AND FIBER TERTIARY STRUCTURE 审中-公开
标题翻译：使用交叉连接和光纤临时结构来处理电化学材料的方法和组合物
公开(公告)号：WO2009149181A2
公开(公告)日：2009-12-10
申请号：PCT/US2009/046125
申请日：2009-06-03
申请人： ORGANOGENESIS, INC. , SIMPSON, David, G. , BOWLIN, Gary, L. , MAHAJAN, Raul , AYRES, Chantal , BOWMAN, James, R. , NEWTOM, Daniel
发明人： SIMPSON, David, G. , BOWLIN, Gary, L. , MAHAJAN, Raul , AYRES, Chantal , BOWMAN, James, R. , NEWTOM, Daniel
IPC分类号： A61L27/24 , A61L27/50
CPC分类号： A61L27/24 , A61L27/50 , D01D5/0038
摘要： The present invention is directed to methods and compositions for manipulating electroprocessed scaffold material properties using cross-linking and fiber tertiary structure. The methods and compositions can be combined with methods and compositions directed to formation and use of electroprocessed materials, such as collagen and fibrin.
摘要翻译：本发明涉及使用交联和纤维三级结构操作电加工脚手架材料性质的方法和组合物。方法和组合物可以与针对电处理材料如胶原和纤维蛋白的形成和使用的方法和组合物组合。

6. 发明申请

WO2009105814A1 A SINGLE PHOTON EMISSION SYSTEM 审中-公开
标题翻译：单光子发射系统
公开(公告)号：WO2009105814A1
公开(公告)日：2009-09-03
申请号：PCT/AU2009/000214
申请日：2009-02-25
申请人： THE UNIVERSITY OF MELBOURNE , TRPKOVSKI, Steven , SIMPSON, David Allan , AMPEM-LASSEN, Eric , GIBSON, Brant Cameron
发明人： TRPKOVSKI, Steven , SIMPSON, David Allan , AMPEM-LASSEN, Eric , GIBSON, Brant Cameron
IPC分类号： G02F1/39 , H04B10/12
CPC分类号： H04B10/70
摘要： The present disclosure provides a method of forming a single photon emission system and a single photon emission system. The method comprises providing a single photon source arranged for single photon emission at a predetermined wavelength in response to a suitable excitation. The single photon source comprises a particle for generating the single photons. The method also comprises providing an optical pump source arranged to provide the suitable excitation in the form of suitable photons. In addition, the method comprises adjusting a pathway of the photons provided by the optical pump source and a position of the single photon source relative to each other so that the single photon source is located at a predetermined location relative to the pathway of the photons provided by the optical pump source and in use single photons are emitted by the single photon source. Providing the single photon source comprises identifying the particle for generating the single photons at a location that is remote from the predetermined location.
摘要翻译：本公开提供了形成单个光子发射系统和单个光子发射系统的方法。该方法包括提供响应于合适的激发而被布置为以预定波长的单光子发射的单个光子源。单个光子源包括用于产生单个光子的粒子。该方法还包括提供光泵浦源，其布置成以合适的光子的形式提供合适的激发。此外，该方法包括调整由光泵浦源提供的光子的路径和单个光子源相对于彼此的位置，使得单个光子源相对于所提供的光子的路径位于预定位置通过光泵浦源并且在使用中，单个光子由单个光子源发射。提供单个光子源包括识别用于在远离预定位置的位置处生成单个光子的粒子。

7. 发明申请

WO2007060402A1 PHARMACEUTICAL COMPOSITIONS 审中-公开
标题翻译：药物组合物
公开(公告)号：WO2007060402A1
公开(公告)日：2007-05-31
申请号：PCT/GB2006/004320
申请日：2006-11-21
申请人： ASTRAZENECA AB , ASTRAZENECA UK LIMITED , SIMPSON, David, Bradley, Brook , CAHILL, Julie, Kay , RICHER, Sebastien , CUMBERBATCH, Daren, James , HOLT, David John , SWAIN, Elizabeth, Anne
发明人： SIMPSON, David, Bradley, Brook , CAHILL, Julie, Kay , RICHER, Sebastien , CUMBERBATCH, Daren, James , HOLT, David John , SWAIN, Elizabeth, Anne
IPC分类号： A61K9/20 , A61K31/517
CPC分类号： A61K9/205 , A61K9/2009 , A61K9/2018 , A61K9/286 , A61K31/517
摘要： Pharmaceutical compositions comprising AZD2171 or a pharmaceutically acceptable salt thereof, including pharmaceutical compositions comprising AZD2171 or a pharmaceutically acceptable salt and a plastic filler with a high surface area, excluding lactose.
摘要翻译：包含AZD2171或其药学上可接受的盐的药物组合物，包括包含AZD2171或其药学上可接受的盐的药物组合物和具有高表面积的塑料填料，不包括乳糖。

8. 发明申请

WO2006123097A3 IMPROVED EXPRESSION ELEMENTS 审中-公开
标题翻译：改进的表达元素
公开(公告)号：WO2006123097A3
公开(公告)日：2007-01-11
申请号：PCT/GB2006001656
申请日：2006-05-09
申请人： SEROLOGICALS INVEST COMPANY IN , SIMPSON DAVID JOHN , WILLIAMS STEVEN GERAINT , IRVINE ALISTAIR SIMPSON
发明人： SIMPSON DAVID JOHN , WILLIAMS STEVEN GERAINT , IRVINE ALISTAIR SIMPSON
IPC分类号： C12N15/85
CPC分类号： C12N15/63 , C07K14/47 , C12N15/85 , C12N2830/46
摘要： The invention relates to genetic elements capable of improving the levels of expression of operably-linked transcription units. In particular, said genetic elements are derived from the 5' untranslated regions of ribosomal protein genes and may comprise a CpG island. Also provided are vectors and host cells comprising said genetic elements and methods of use to obtain high levels of recombinant gene expression.
摘要翻译：本发明涉及能够改善可操作连接的转录单位表达水平的遗传元件。特别地，所述遗传元件衍生自核糖体蛋白基因的5'非翻译区，并且可以包含CpG岛。还提供了包含所述遗传元件的载体和宿主细胞和用于获得高水平重组基因表达的方法。

9. 发明申请

WO2004032713A2 SEALANTS FOR SKIN AND OTHER TISSUES 审中-公开
标题翻译：皮肤和其他组织的密封剂
公开(公告)号：WO2004032713A2
公开(公告)日：2004-04-22
申请号：PCT/US0331637
申请日：2003-10-06
申请人： NANOMATRIX INC , UNIV VIRGINIA COMMONWEALTH , BOWLIN GARY L , SIMPSON DAVID G , WNEK GARY E , STEVENS PETER J , CADD GARY , COHEN I KELMAN , CARR MARCUS JR
发明人： BOWLIN GARY L , SIMPSON DAVID G , WNEK GARY E , STEVENS PETER J , CADD GARY , COHEN I KELMAN , CARR MARCUS JR
IPC分类号： A61B20060101 , A61F2/02 , A61F2/10 , A61B
CPC分类号： A61L24/102 , A61F2/105 , A61F2013/00314 , A61F2013/00472 , A61K38/363 , A61K38/39 , A61L24/106 , C07K14/78 , Y10T428/298 , A61K2300/00
摘要： The present invention relates to sealants for skin and other tissues. The sealants include an electroprocessed material. The sealants may contain more than one electroprocessed materials and may contain additional substances. The invention further relates to methods of making and using such sealants.
摘要翻译：本发明涉及用于皮肤和其他组织的密封剂。密封剂包括电处理材料。密封剂可能含有多于一种电处理材料，并可能含有其他物质。本发明还涉及制造和使用这种密封剂的方法。

10. 发明申请

WO2003086290A3 ELECTROPROCESSING OF MATERIALS USEFUL IN DRUG DELIVERY AND CELL ENCAPSULATION 审中-公开
公开(公告)号：WO2003086290A3
公开(公告)日：2003-10-23
申请号：PCT/US2003/010806
申请日：2003-04-07
申请人： VIRGINIA COMMONWEALTH UNIVERSITY INTELLECTUAL PROPERTY FOUNDATION , WNEK, Gary, E. , SIMPSON, David, G. , BOWLIN, Gary, L. , YAO, Li , KENAWY, El-Refaie , LAYMAN, John, M. , SANDERS, Elliot, H. , FENN, John
发明人： WNEK, Gary, E. , SIMPSON, David, G. , BOWLIN, Gary, L. , YAO, Li , KENAWY, El-Refaie , LAYMAN, John, M. , SANDERS, Elliot, H. , FENN, John
IPC分类号： C12N11/02
摘要： The invention is directed to novel compositions comprising an electroprocessed material and a substance, their formation and use. The electroprocessed material can, for example, be one or more natural materials, one or more synthetic materials, or a combination thereof. The substance can be one or more therapeutic or cosmetic substances or other compounds, molecules, cells, vesicles. The compositions can be used in substance delivery, including drug delivery within an organism by, for example, releasing substances or containing cells that release substances. The compositions can be used for other purposes, such as prostheses or similar implants.

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