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1. 发明申请

WO2022204330A1 METHODS KITS AND COMPOSITIONS FOR CHARACTERIZING AN ANTI-INFLAMMATORY RESPONSE OF A PRODUCT 审中-公开
公开(公告)号：WO2022204330A1
公开(公告)日：2022-09-29
申请号：PCT/US2022/021614
申请日：2022-03-23
申请人： ORGANOGENESIS, INC.
发明人： MOWRY, Katie, C. , KIMMERLING, Kelly, A. , BURNETTE, Miranda, D. , KAMMER, Mary, Rose
IPC分类号： A23L33/18 , A61K38/45 , C12N9/12
摘要： Disclosed are methods for methods for quantitating and standardizing an anti-inflammatory response of a product and methods for determining the likelihood that a product would produce an anti-inflammatory effect in a subject when administered to the subject. Accordingly, disclosed herein are methods, compositions and kits for characterizing and evaluating the anti-inflammatory effect of products, particularly therapeutic biological products.

2. 发明申请

WO2007070850A3 SKIN CARE COMPOSITIONS AND TREATMENTS 审中-公开
标题翻译：护肤组合物和治疗
公开(公告)号：WO2007070850A3
公开(公告)日：2007-11-08
申请号：PCT/US2006062090
申请日：2006-12-14
申请人： ORGANOGENESIS INC , NIXON ANDREW J
发明人： NIXON ANDREW J
IPC分类号： C12N5/08 , A61K38/21
CPC分类号： A61K8/985 , A61K9/0014 , A61K35/33 , A61K35/36 , A61Q19/08
摘要： The invention is directed compositions containing growth agents synthesized from cultured cells from skin. Skin cells such as keratinocytes and dermal fibroblasts are cultured in vitro in cell medium and in the course of culture the cultured cells synthesize and secrete agents into the cell medium. The medium containing agents are collected and incorporated into pharmaceutical or cosmetic preparations to treat an individual. The preparation is applied and has a rejuvenating effect on the cells and tissue.
摘要翻译：本发明涉及含有由皮肤培养细胞合成的生长剂的组合物。在细胞培养基中体外培养皮肤细胞如角质形成细胞和真皮成纤维细胞，并在培养过程中培养的细胞合成并分泌试剂到细胞培养基中。收集含有介质的试剂并将其掺入药物或化妆品制剂中以治疗个体。该制剂被应用并且对细胞和组织具有恢复活力的作用。

3. 发明申请

WO03060061A9 CHAMBER WITH ADJUSTABLE VOLUME FOR CELL CULTURE AND ORGAN ASSIST 审中-公开
标题翻译：具有适用于细胞培养和组织辅助的体积的室
公开(公告)号：WO03060061A9
公开(公告)日：2004-03-25
申请号：PCT/US0240984
申请日：2002-12-19
申请人： ORGANOGENESIS INC
发明人： DIMILLA PAUL A , COSMAN MAURY D , HALYCH RACHEL , ROMITO LISA , GEMMETI CHRIS , ODLUM KEVIN
IPC分类号： C12M3/00 , A61L31/00 , C12M3/04 , C12N5/06 , C12N5/08
CPC分类号： C12M29/10 , C12M41/44
摘要： The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates sandwiching a compressible gasket and a substantially incompressible stop can be adjusted using a gasket that forms a fluid-tight seal between the plates at a plurality of levels of compression. The invention enables the culture of cells between substantially parallel and rigid plates in which a relatively large volume can be used to seed the cells and the holdup volume reduced for perfusion without opening or otherwise disassembling the system to compromise its liquidtightness and sterility. The new closed, modular and scalable cell-culturing chamber can be thus perfused and used to culture cells (e.g., hepatocytes) with high levels of cell function in organ (e.g.,liver) assist systems, for production of cells, for production of cell-derived products, such as proteins or viruses, or for systems to treat biological liquids to remove toxins, such as ammonia, add cell-synthesized products, or both.
摘要翻译：本发明提供了用于培养细胞的模块化室，其中可以调节室的体积而不损害室的密封或不可靠性。本发明基于这样的原理，即可以使用在多个压缩水平下在板之间形成流体密封的垫圈来调节形成在夹住可压缩垫圈的两个板和基本上不可压缩的止挡件之间的腔室的体积。本发明使得能够在基本上平行的和刚性的板之间培养细胞，其中可以使用相对较大体积的细胞来种植细胞，并且减少用于灌注的保留体积，而不打开或以其他方式分解系统以损害其液体密度和不育性。因此可以将新的封闭的，模块化和可扩展的细胞培养室灌注并用于培养器官（例如肝）辅助系统中具有高水平细胞功能的细胞（例如肝细胞），用于细胞的产生，用于细胞生产或衍生的产品，如蛋白质或病毒，或用于处理生物液体以除去毒素（如氨），添加细胞合成产物或两者的系统。

4. 发明申请

WO2003060061A1 CHAMBER WITH ADJUSTABLE VOLUME FOR CELL CULTURE AND ORGAN ASSIST 审中-公开
标题翻译：具有适用于细胞培养和组织辅助的体积的室
公开(公告)号：WO2003060061A1
公开(公告)日：2003-07-24
申请号：PCT/US2002/040984
申请日：2002-12-19
申请人： ORGANOGENESIS INC.
发明人： DIMILLA, Paul, A. , COSMAN, Maury, D. , HALYCH, Rachel , ROMITO, Lisa , GEMMETI, Chris , ODLUM, Kevin
IPC分类号： C12M3/04
CPC分类号： C12M29/10 , C12M41/44
摘要： The invention features modular chambers for culturing cells in which the volume of a chamber can be adjusted without compromising the seal or sterility of the chamber. The invention is based on the principle that the volume of a chamber formed between two plates sandwiching a compressible gasket and a substantially incompressible stop can be adjusted using a gasket that forms a fluid-tight seal between the plates at a plurality of levels of compression. The invention enables the culture of cells between substantially parallel and rigid plates in which a relatively large volume can be used to seed the cells and the holdup volume reduced for perfusion without opening or otherwise disassembling the system to compromise its liquidtightness and sterility. The new closed, modular and scalable cell-culturing chamber can be thus perfused and used to culture cells ( e.g., hepatocytes) with high levels of cell function in organ ( e.g., liver) assist systems, for production of cells, for production of cell-derived products, such as proteins or viruses, or for systems to treat biological liquids to remove toxins, such as ammonia, add cell-synthesized products, or both.
摘要翻译：本发明提供了用于培养细胞的模块化室，其中可以调节室的体积而不损害室的密封或不可靠性。本发明基于这样的原理，即可以使用在多个压缩水平下在板之间形成流体密封的垫圈来调节形成在夹住可压缩垫圈的两个板和基本上不可压缩的止挡件之间的腔室的体积。本发明使得能够在基本上平行的和刚性的板之间培养细胞，其中可以使用相对较大体积的细胞来种植细胞，并且减少用于灌注的保留体积，而不打开或以其他方式分解系统以损害其液体密度和不育。因此可以将新的封闭的，模块化和可扩展的细胞培养室灌注并用于培养器官（例如肝）辅助系统中具有高水平细胞功能的细胞（例如肝细胞），用于细胞的产生，用于生产细胞或衍生的产品，如蛋白质或病毒，或用于处理生物液体以除去毒素（如氨），添加细胞合成产物或两者的系统。

5. 发明申请

WO2003059195A3 SYSTEM AND METHOD FOR FORMING BIOENGINEERED TUBULAR GRAFT PROSTHESES 审中-公开
公开(公告)号：WO2003059195A3
公开(公告)日：2003-07-24
申请号：PCT/US2002/041284
申请日：2002-12-19
申请人： ORGANOGENESIS INC.
发明人： COSMAN, Maury, D. , BILLIAR, Kristen , MERCER, Ryan , Miller, Bruce
IPC分类号： B32B31/00
摘要： An apparatus for forming a tube construct from a planar sheet matrix includes a stand supporting two opposing mounts (52) and spanning between the opposing mounts (52) are a mandrel (24), a porous rod, (55) and a spring-loaded roller (60) held in parallel arrangement; a guide (70) for aligning and engaging the mandrel (24) on the mounts (52); and means for imparting a tangential force on the planar sheet matrix to prevent wrinkling. The porous rod (55) has a lumen running its length and has pores that communicate between the lumen of the porous rod (55) through to the surface of the rod for water to uniformly pass through. The spring-loaded roller (60) runs along the length of the porous rod (55) creating a line of contact between the roller (60) and the mandrel (24).

6. 发明申请

WO1997045071A1 STRENGTH ENHANCEMENT OF COLLAGEN CONSTRUCTS 审中-公开
标题翻译：胶原蛋白结构强化增强
公开(公告)号：WO1997045071A1
公开(公告)日：1997-12-04
申请号：PCT/US1997008995
申请日：1997-05-28
申请人： ORGANOGENESIS INC.
发明人： ORGANOGENESIS INC. , CAVALLARO, John, F.
IPC分类号： A61F02/02
CPC分类号： A61L27/24 , A61F2/0063 , A61F2/08 , A61F2310/00365
摘要： A method for improving the tensile strength of wet collagen threads or collagen thread constructs for implantation to replace or repair tissue or organs wherein the strength of the threads is improved by plasticizing the threads with a plasticizing agent, imparting a tensile load to the collagen thread to strain the collagen thread; allowing the strain in the thread to decrease by stress-relaxation or by creep conditioning methods and, finally, removing the plasticizing agent. Prosthetic devices comprising collagen threads with improved strength characteristics are intended to repair load bearing tissues such as ligaments and tendons.
摘要翻译：一种用于改善用于植入以替代或修复组织或器官的湿胶原线或胶原线构造物的拉伸强度的方法，其中通过用增塑剂塑化线来改善丝的强度，从而将胶原线施加拉伸载荷应变胶原线; 允许螺纹中的应变通过应力松弛或蠕变调节方法降低，最后移除增塑剂。包括具有改善的强度特征的胶原线的假体装置旨在修复承载组织，例如韧带和腱。

7. 发明申请

WO1996031157A1 PERACETIC ACID CROSSLINKED NON-ANTIGENIC ICL GRAFTS 审中-公开
标题翻译： PERACTIC ACID CROSSLINKED NAN-ANGGICIC ICL GRAFTS
公开(公告)号：WO1996031157A1
公开(公告)日：1996-10-10
申请号：PCT/US1996003336
申请日：1996-03-12
申请人： ORGANOGENESIS, INC. , CARR, Robert, M., Jr. , TERMIN, Paul, L. , CONDON, Kimberlie, D. , YOUNG, Janet, Hardin
发明人： ORGANOGENESIS, INC.
IPC分类号： A61B17/00
CPC分类号： A61L27/3691 , A61F2/0077 , A61L2/18 , A61L27/24 , A61L27/3604 , A61L27/3687 , A61L27/58
摘要： This invention is directed to prosthesis, which, when implanted into a mammalian patient, serves as a functioning replacement for a body part, or tissue structure, and will undergo controlled biodegradation occurring concomitantly with bioremodeling by the patient's living cells. The prosthesis is treated so that it is rendered non-antigenic so as not to elicit a significant humoral immune response. The prosthesis of this invention, in its various embodiments, thus has dual properties. First, it functions as a substitute body part, and second, it functions as bioremodeling template for the ingrowth of host cells.
摘要翻译：本发明涉及假体，其在植入哺乳动物患者时用作身体部位或组织结构的功能性替代物，并将经受受控的生物降解，伴随患者活细胞的生物模型发生。治疗假体使其变得非抗原性，以便不引起显着的体液免疫应答。因此，在其各种实施方案中，本发明的假体具有双重性质。首先，它用作替代体部分，其次，它用作宿主细胞向内生长的生物模型。

8. 发明申请

WO1994010940A1 IN VITRO CORNEA EQUIVALENT MODEL 审中-公开
标题翻译：在体外CORNEA等效模型
公开(公告)号：WO1994010940A1
公开(公告)日：1994-05-26
申请号：PCT/US1993010727
申请日：1993-11-15
申请人： ORGANOGENESIS, INC. , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人： ORGANOGENESIS, INC. , THE PRESIDENT AND FELLOWS OF HARVARD COLLEGE , PARENTEAU, Nancy, L. , MASON, Valerie, S. , OLSEN, Bjorn, R.
IPC分类号： A61F02/14
CPC分类号： A61L27/3891 , A61F2/142 , A61K35/12 , A61L27/24 , A61L27/38 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3839 , A61L27/3895 , A61L2430/16 , C12N5/0062 , C12N5/0621 , C12N5/0697 , C12N2500/25 , C12N2501/39 , C12N2501/395 , C12N2502/085 , C12N2502/094 , C12N2502/1323 , C12N2510/04 , C12N2533/54
摘要： This invention is directed to an organ equivalent of the cornea part of the eye made using tissue culturing systems. The method of constructing the cornea equivalent results in a structure analogous to the eye cornea in vivo. The cornea equivalent is an in vitro model of the eye, which can be used for transplantation or implantation in vivo or for screening compounds in vitro.
摘要翻译：本发明涉及使用组织培养系统制造的眼睛的角膜部分的器官当量。构建角膜等价物的方法产生类似于眼内角膜的结构。角膜等效物是眼的体外模型，其可用于体内移植或植入或用于体外筛选化合物。

9. 发明申请

WO2023004359A2 PORCINE COLLAGEN COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：WO2023004359A2
公开(公告)日：2023-01-26
申请号：PCT/US2022/073957
申请日：2022-07-20
申请人： ORGANOGENESIS INC.
发明人： BILBO, Patrick , FARIA, Katherine , MOWRY, Bonnie Kathleen , RAUT, Vivek
IPC分类号： A61L26/00 , A61L15/32 , A61L17/08 , A61K38/39
摘要： The present disclosure provides compositions and methods related to wound management. The compositions include a micronized extracellular matrix and in some instances one or more antimicrobial agents. In some embodiments, the extracellular matrix is comprised of a porcine purified collagen wound matrix (CWM) and polyhexamethylene biguanide (PHMB). The composition is formulated as a powder and may be applied to a wound as a powder, or hydrated and applied to a wounds as a paste or a slurry.

10. 发明申请

WO2007048099A3 ANTIMICROBIAL COLLAGENOUS CONSTRUCTS 审中-公开
标题翻译：抗菌胶原蛋白
公开(公告)号：WO2007048099A3
公开(公告)日：2010-09-02
申请号：PCT/US2006060055
申请日：2006-10-18
申请人： ORGANOGENESIS INC , ABRAHAM GINGER A , NIXON ANDREW J
发明人： ABRAHAM GINGER A , NIXON ANDREW J
IPC分类号： A61F2/00
CPC分类号： A61L27/3629 , A61L27/18 , A61L27/24 , A61L27/3683 , A61L27/54 , A61L2300/104 , A61L2300/404 , A61L2300/604 , C08L71/02
摘要： Bioengineered collagen constructs with antimicrobial properties are provided. The bioengineered collagen constructs comprise a sheet-like layer of purified collagenous tissue matrix derived from a tissue source, such as the tunica submucosa of small intestine or a processed intestinal collagen layer derived from the tunica submucosa of small intestine, treated with an antimicrobial agent. The constructs arc biocompatible. The present invention has a variety of applications, including wound dressing and surgical repair devices. Methods for treating a damaged or diseased soft tissue are provided. Methods for treating a wound in need of care and treatment are also disclosed.
摘要翻译：提供具有抗菌性能的生物工程胶原构建体。生物工程胶原构建体包含衍生自组织来源的纯化胶原组织基质的片状层，例如小肠粘膜下层或由抗微生物剂处理的来自小肠粘膜下层的加工肠胶原层。构建体具有生物相容性。本发明具有各种应用，包括伤口敷料和手术修复装置。提供了治疗损伤或患病软组织的方法。还公开了治疗需要护理和治疗的伤口的方法。

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