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1. 发明申请

WO2009122323A1 METHOD OF PREPARING A SWALLOWABLE CAPSULE COMPRISING A SENSOR 审中-公开
标题翻译：制备包含传感器的易碎胶囊的方法
公开(公告)号：WO2009122323A1
公开(公告)日：2009-10-08
申请号：PCT/IB2009/051215
申请日：2009-03-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , DIJKSMAN, Johan, F. , PIERIK, Anke , RENSEN, Judith, M. , SHIMIZU, Jeff , VAN DER MADE, Petrus, L., A. , PARDOEL, Michel, G. , DE JONGH, Frits, T. , KLEIBEUKER, Johan, G.
发明人： DIJKSMAN, Johan, F. , PIERIK, Anke , RENSEN, Judith, M. , SHIMIZU, Jeff , VAN DER MADE, Petrus, L., A. , PARDOEL, Michel, G. , DE JONGH, Frits, T. , KLEIBEUKER, Johan, G.
IPC分类号： A61B5/00 , A61B5/07
CPC分类号： A61B5/073 , A61B5/14539 , A61B5/1495 , A61B2560/0223
摘要： The inventions relates to a kit comprising a swallowable capsule (1, 45) with a potentiometric sensor (3), such as a pH sensor, with an unfilled electrolyte cell (31). The kit further includes a separate container (46) containing a liquid electrolyte. The kit can, e.g., be packed in a blister package. After unpacking the capsule the electrolyte cell (31) is filled with the electrolyte.
摘要翻译：本发明涉及一种试剂盒，其包括具有电位传感器（3）的可吞咽胶囊（1,45），例如具有未填充电解质电池（31）的pH传感器。该试剂盒还包括含有液体电解质的单独的容器（46）。试剂盒可以例如包装在泡罩包装中。在拆开胶囊之后，电解质电池（31）充满电解质。

2. 发明申请

WO2011018753A1 DRUG DELIVERY DEVICE WITH COMPRESSIBLE DRUG RESERVOIR 审中-公开
标题翻译：具有可压缩药物储存的药物递送装置
公开(公告)号：WO2011018753A1
公开(公告)日：2011-02-17
申请号：PCT/IB2010/053610
申请日：2010-08-10
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZOU, Hans , SHIMIZU, Jeff , DIJKSMAN, Johan Frederik
发明人： ZOU, Hans , SHIMIZU, Jeff , DIJKSMAN, Johan Frederik
IPC分类号： A61M31/00
CPC分类号： A61M5/1452 , A61M31/002
摘要： A drug delivery device (50) is provided comprising a drug reservoir(10) and a piston (11). The drug reservoir (10) is provided for comprising a drug and comprises a flexible wall (22) and a dispensing hole (15) for dispensing the drug into an environment of the drug delivery device (50). The piston (11) is provide for pressing against the flexible wall (22) to compress the drug reservoir (10) for pushing an amount of the drug through the dispensing hole (15). An adhesion interface (51) between a surface of the piston (11) and the flexible wall (22) prevents sliding between the surface of the piston (11) and the flexible wall (22).
摘要翻译：提供了药物输送装置（50），其包括药物储存器（10）和活塞（11）。药物储存器（10）被设置成包括药物并且包括柔性壁（22）和用于将药物分配到药物输送装置（50）的环境中的分配孔（15）。活塞（11）用于压靠柔性壁（22）以压缩药物储存器（10），用于推动一定量的药物通过分配孔（15）。在活塞（11）的表面和柔性壁（22）之间的粘合界面（51）防止活塞（11）的表面和柔性壁（22）之间的滑动。

3. 发明申请

WO2009156919A1 ELECTRONIC PILL COMPRISING A PLURALITY OF MEDICINE RESERVOIRS 审中-公开
标题翻译：包含多种药物储存的电子药丸
公开(公告)号：WO2009156919A1
公开(公告)日：2009-12-30
申请号：PCT/IB2009/052604
申请日：2009-06-18
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZOU, Hans , SHIMIZU, Jeff , ALBU, Lucian, R. , DIJKSMAN, Johan, F.
发明人： ZOU, Hans , SHIMIZU, Jeff , ALBU, Lucian, R. , DIJKSMAN, Johan, F.
IPC分类号： A61M31/00 , A61J7/04
CPC分类号： A61M31/002
摘要： Electronic pill (1, 11, 21) comprising a plurality of medicine reservoirs (2, 12, 22), each of the reservoirs comprising a discharge opening (3, 13, 23) covered by a removable cover (6, 16, 26). The pill comprises at least one actuator responsive to control circuitry for removing the cover from the discharge opening (3, 13, 23). The actuator can for example be a spring loaded piston (4) breaking a foil cover when dispensing the medicament. 5 Alternatively, the cover can be a rotatable disk (16) or cylinder (26) with an opening (17, 27) which can be brought in line with the discharge opening of a reservoir under the action of the actuator.
摘要翻译：包括多个药物储存器（2,12,22）的电子药丸（1,11,21），每个储存器包括由可移除的盖（6,16,26）覆盖的排出口（3,13,33）。所述药丸包括响应于控制电路的至少一个致动器，用于从所述排放开口（3,13,33）移除所述盖。致动器可以例如是在分配药物时破坏箔盖的弹簧加载的活塞（4）。或者，盖可以是具有开口（17,27）的可旋转盘（16）或圆筒（26），该开口可在致动器的作用下与储存器的排出口一致。

4. 发明申请

WO2009104110A1 ADMINISTRATION OF DRUGS TO A PATIENT 审中-公开
标题翻译：药物对患者的管理
公开(公告)号：WO2009104110A1
公开(公告)日：2009-08-27
申请号：PCT/IB2009/050553
申请日：2009-02-11
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , SHIMIZU, Jeff
发明人： SHIMIZU, Jeff
IPC分类号： A61B5/00 , A61B5/07 , A61M31/00
CPC分类号： A61M31/002 , A61B5/073 , A61B5/14539 , A61B5/42 , A61B5/4839 , A61M2205/3523 , A61M2205/50 , A61M2210/1053 , A61M2210/1057 , A61M2210/106
摘要： The invention relates to a method and an electronic pill (20) for the administration of at least one drug (3) to a patient, wherein the delivery profile of the drug is determined according to at least one individual parameter of the patient. The individual parameter may particularly relate to the genotype (GEN) or phenotype of the patient and for example comprise the distribution of proteins in the gastrointestinal tract (GIT). Optionally, the individual parameter may be adjusted based on measurements by the electronic pill or external devices during its passage through the gastrointestinal tract.
摘要翻译：本发明涉及一种用于向患者施用至少一种药物（3）的方法和电子药丸（20），其中药物的递送特征根据患者的至少一个个体参数确定。个体参数可以特别涉及患者的基因型（GEN）或表型，并且例如包括蛋白质在胃肠道（GIT）中的分布。可选地，可以基于电子药丸或外部装置在通过胃肠道期间的测量来调整个体参数。

5. 发明申请

WO2009031088A1 METHOD AND APPARATUS FOR CHEMICAL ANALYSIS OF FLUIDS 审中-公开
标题翻译：流体化学分析方法与装置
公开(公告)号：WO2009031088A1
公开(公告)日：2009-03-12
申请号：PCT/IB2008/053503
申请日：2008-08-29
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ALBU, Lucian, R. , ZOU, Hans , SHIMIZU, Jeff
发明人： ALBU, Lucian, R. , ZOU, Hans , SHIMIZU, Jeff
IPC分类号： G01N27/02 , G01N27/416
CPC分类号： G01N27/27
摘要： An apparatus and method for electrochemical fluid analysis comprises a chamber (1202) having a depth dimension for accommodating a volume of a fluid under test, first and second electrodes (A1) disposed within the chamber and extending along the depth dimension in spaced relation with each other, and a soluble solid, such as an annealed polymer, e.g. EUDRAGIT occupying a lateral gap between the first and second electrodes. The rate of dissolution as monitored by electrochemical impedance spectroscopy (EIS) of the soluble solid within the fluid depends on the chemical concentration of a corresponding analyte present in solution in the fluid. In one embodiment a silicon-based integrated circuit device defining an upper margin includes an array of electrodes disposed along said upper margin to permit direct exposure of the electrode array to the fluid under test. The device is constructed using CMOS technology.
摘要翻译：用于电化学流体分析的装置和方法包括具有用于容纳待测流体体积的深度尺寸的腔室（1202），设置在腔室内的第一和第二电极（A1），并且沿着与每个腔室间隔开的深度尺寸延伸另一种和可溶性固体，例如退火的聚合物，例如 EUDRAGIT占据第一和第二电极之间的横向间隙。通过流体中可溶性固体的电化学阻抗谱（EIS）监测的溶解速率取决于流体中溶液中存在的相应分析物的化学浓度。在一个实施例中，限定上边缘的硅基集成电路器件包括沿着所述上边缘设置的电极阵列，以允许电极阵列直接暴露于待测流体。该器件采用CMOS技术构建。

6. 发明申请

WO2008135930A1 SENSOR SYSTEM BASED ON COMPOUND WITH SOLUBILITY DEPENDING ON ANALYTE CONCENTRATION 审中-公开
标题翻译：基于分析仪浓度敏感性的化合物传感器系统
公开(公告)号：WO2008135930A1
公开(公告)日：2008-11-13
申请号：PCT/IB2008/051709
申请日：2008-05-02
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , ZOU, Hans , ALBU, Lucian Remus , SHIMIZU, Jeff
发明人： ZOU, Hans , ALBU, Lucian Remus , SHIMIZU, Jeff
IPC分类号： G01N33/50 , G01N33/84 , G01N33/543 , G01N27/414
CPC分类号： G01N27/4145
摘要： A biochemical sensing device for measuring an analyte level, e.g., for in vivo applications. An exemplary device includes an electrode (12), a power supply (18) connected to the electrode, and a compound/polymer coating (14) on the electrode. The compound/polymer is soluble in a solution, and its rate of solubility is dependent on an analyte-related property of the solution, e.g., the solution pH. The biochemical sensing device can further include an electrical switch (16) in the connection between the power supply and the electrode. The biochemical sensing device can further include a data processor (22) connected to the power supply (18), and a data memory component (24) connected to the data processor. A process for measuring analyte-related property of a solution is also provided. The process includes providing an electrode coated with a compound/polymer, wherein the compound/polymer has an analyte- dependent solubility profile, exposing the compound/polymer coated electrode to the solution, measuring the conductance at the electrode as a function of time, and correlating the rate of conductance to the solubility of the compound/polymer to determine the pH of the solution.
摘要翻译：用于测量分析物水平的生物化学感测装置，例如用于体内应用。示例性装置包括电极（12），连接到电极的电源（18）和电极上的化合物/聚合物涂层（14）。化合物/聚合物可溶于溶液，其溶解度取决于溶液的分析物相关性质，例如溶液pH。生物化学感测装置还可以包括在电源和电极之间的连接中的电开关（16）。生物化学感测装置还可以包括连接到电源（18）的数据处理器（22）和连接到数据处理器的数据存储器组件（24）。还提供了用于测量溶液的分析物相关性质的方法。该方法包括提供涂覆有化合物/聚合物的电极，其中所述化合物/聚合物具有分析物依赖性溶解度分布，将化合物/聚合物涂覆的电极暴露于溶液，测量作为时间的函数的电极电导，以及将电导率与化合物/聚合物的溶解度相关联以确定溶液的pH。

7. 发明申请

WO2008062335A1 MEDICAMENT DELIVERY DEVICE, CAPSULE AND IN VIVO MEDICINE DELIVERY OR DIAGNOSTIC SYSTEM 审中-公开
标题翻译：药物输送装置，胶囊和体内药物递送或诊断系统
公开(公告)号：WO2008062335A1
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054491
申请日：2007-11-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , DIJKSMAN, Johan Frederik , DE JONGH, Frits Tobi , PARDOEL, Michel Gerardus , PIERIK, Anke , RENSEN, Judith Margreet , SHIMIZU, Jeff , ZOU, Hans , ALBU, Remus , IORDANOV, Ventzeslav , BOEVE, Hans Marc Bert
发明人： DIJKSMAN, Johan Frederik , DE JONGH, Frits Tobi , PARDOEL, Michel Gerardus , PIERIK, Anke , RENSEN, Judith Margreet , SHIMIZU, Jeff , ZOU, Hans , ALBU, Remus , IORDANOV, Ventzeslav , BOEVE, Hans Marc Bert
IPC分类号： A61M5/145 , A61M5/148
CPC分类号： A61M5/14593 , A61B1/041 , A61B5/01 , A61B5/073 , A61B5/14539 , A61B5/4839 , A61M5/14276 , A61M31/002 , A61M2005/14204 , A61M2205/3561
摘要： A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.
摘要翻译：一种药物输送装置，其包括驱动机构和具有储存器（2）的壳体（1），其至少部分地填充有物质，并且至少在一侧上用柔性壁（21）密封。驱动机构适于将活塞（23）压靠在柔性壁（21）上，从而通过储存器（2）中的开口（25）将物质从储存器（2）释放。这提供了一种安全可靠的药物输送装置。

8. 发明申请

WO2008062333A3 INGESTIBLE ELECTRONIC CAPSULE AND IN VIVO DRUG DELIVERY OR DIAGNOSTIC SYSTEM 审中-公开
公开(公告)号：WO2008062333A3
公开(公告)日：2008-05-29
申请号：PCT/IB2007/054481
申请日：2007-11-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , DIJKSMAN, Johan Frederik , DE JONGH, Frits Tobi , PARDOEL, Michael Gerardus , MALAURIE, Claude Jean-Marie , DROINET, Yvan O.J.G. , PIERIK, Anke , RENSEN, Judith Margreet , SHIMIZU, Jeff , ZOU, Hans , ALBU, Remus
发明人： DIJKSMAN, Johan Frederik , DE JONGH, Frits Tobi , PARDOEL, Michael Gerardus , MALAURIE, Claude Jean-Marie , DROINET, Yvan O.J.G. , PIERIK, Anke , RENSEN, Judith Margreet , SHIMIZU, Jeff , ZOU, Hans , ALBU, Remus
IPC分类号： A61B5/07
摘要： An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4,5,7,8,9,11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).

9. 发明申请

WO2008038199A1 MEDICAMENT DELIVERY APPARATUS 审中-公开
标题翻译：药物递送装置
公开(公告)号：WO2008038199A1
公开(公告)日：2008-04-03
申请号：PCT/IB2007/053826
申请日：2007-09-20
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , DIJKSMAN, Johan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , SHIMIZU, Jeff , ZOU, Hans , PARDOEL, Michel , DE JONGH, Frits Tobi
发明人： DIJKSMAN, Johan Frederik , PIERIK, Anke , RENSEN, Judith Margreet , SHIMIZU, Jeff , ZOU, Hans , PARDOEL, Michel , DE JONGH, Frits Tobi
IPC分类号： A61B5/00 , A61M31/00
CPC分类号： A61M31/002 , A61B5/073 , A61B5/4839 , A61M31/00
摘要： An electronic capsule (100) is provided. The capsule (100) has a discrete drive element (300) comprising: a housing (109), electronics for making the electronic capsule (100) operable, a pumping mechanism (115) for dosing and displacing a substance, a power source (105) for powering the electronic capsule (100) and enabling the electronics and the pumping mechanism (115) to operate, and a locking mechanism (130); and a discrete payload element (200) comprising: a housing (109), a reservoir (210) for storing the substance, one or more openings (250) in the housing (109) for releasing the substance from the reservoir (210) and a locking mechanism (230) for engaging the drive element locking mechanism (130). Engagement of the drive element locking mechanism (130) with the payload element locking mechanism (230) secures the drive element (300) to the payload element (200), thereby making the electronic capsule (100) operable and specific.
摘要翻译：提供电子胶囊（100）。所述胶囊（100）具有离散的驱动元件（300），包括：壳体（109），用于使所述电子胶囊（100）可操作的电子设备，用于计量和移位物质的泵送机构（115），电源），用于对所述电子胶囊（100）供电并使得所述电子设备和所述泵送机构（115）能够操作;以及锁定机构（130）。和离散有效载荷元件（200），包括：壳体（109），用于存储物质的储存器（210），用于将物质从储存器（210）释放的壳体（109）中的一个或多个开口（250）用于接合驱动元件锁定机构（130）的锁定机构（230）。驱动元件锁定机构（130）与有效载荷元件锁定机构（230）的接合将驱动元件（300）固定到有效载荷元件（200），从而使电子胶囊（100）可操作和特定。

10. 发明申请

WO2012129497A2 SWALLOWABLE MEDICATION CAPSULE 审中-公开
标题翻译：吞咽胶囊
公开(公告)号：WO2012129497A2
公开(公告)日：2012-09-27
申请号：PCT/US2012/030332
申请日：2012-03-23
申请人： MEDIMETRICS PERSONALIZED DRUG DELIVERY B.V. , ZOU, Hans , SHIMIZU, Jeff
发明人： ZOU, Hans , SHIMIZU, Jeff
IPC分类号： A61K9/48 , A61K9/50 , A61K47/48 , A61K47/30
CPC分类号： A61M31/00 , A61K9/4808 , A61M31/002
摘要： The invention relates to a swallowable medication capsule capable 200 of dispensing fluid medicine stored in a medication compartment 211 through a valveless exit hole 207. A vent hole 206 enables ventilation of an actuator cavity 212 which houses an actuator used for displacing a surface 205 which separates the medication cavity 211 and the actuator cavity 212. By locating the vent and exit holes close to each other so that contact with contracting parts of the gastrointestinal tract and the exterior surface 221 is not able to prohibit a pressure passageway between the vent and exit holes, creation of a pressure difference of pressures in the medication and actuator cavity is prohibited.
摘要翻译：本发明涉及一种能够通过无阀出口孔207分配存储在药物室211中的流体药物的可吞咽药物胶囊。通气孔206能够使致动器腔212通风，致动器腔212容纳用于移动表面205的致动器，药腔211和致动器空腔212.通过使通气孔和出口孔彼此靠近，使得与胃肠道的收缩部分和外表面221的接触不能禁止通气孔和出口孔之间的压力通道，禁止在药物和致动器腔中形成压力差。

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