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1. 发明申请

WO2009120513A3 MALLEABLE MULTI-COMPONENT IMPLANTS AND MATERIALS THEREFOR 审中-公开
标题翻译：可能的多组分植入物及其材料
公开(公告)号：WO2009120513A3
公开(公告)日：2010-06-17
申请号：PCT/US2009036988
申请日：2009-03-12
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAKM F , SCIFERT JEFFREY L , REMSEN KATHY L , VICKERS SCOTT M , DIDIER BILLY , GILLISSEN MIRIAN
发明人： MCKAY WILLIAKM F , SCIFERT JEFFREY L , REMSEN KATHY L , VICKERS SCOTT M , DIDIER BILLY , GILLISSEN MIRIAN
IPC分类号： A61L27/26 , A61L27/44 , A61L27/54
CPC分类号： A61K38/1875 , A61K9/0024 , A61L27/26 , A61L27/54 , A61L2300/414 , A61L2430/02 , C08L5/04 , C08L89/06
摘要： Described are implantable, malleable medical materials comprising mineral particles, insoluble collagen fibers, and a gel-forming polysaccharide component and/or another added gel-former. The malleable medical materials can be used treat bone or other tissue defects in patients, including in conjunction with biologically active factors such as osteogenic proteins. Also described are methods and materials that can be used to prepare the malleable medical materials.
摘要翻译：描述了包括矿物颗粒，不溶性胶原纤维和形成凝胶的多糖组分和/或另外添加的凝胶形成剂的可植入的可延展的医用材料。可延展的医疗材料可用于治疗患者的骨骼或其他组织缺陷，包括结合生物活性因子如成骨蛋白。还描述了可用于制备可延展的医疗材料的方法和材料。

2. 发明申请

WO2009120513A2 MALLEABLE MULTI-COMPONENT IMPLANTS AND MATERIALS THEREFOR 审中-公开
标题翻译：可能的多组分植入物及其材料
公开(公告)号：WO2009120513A2
公开(公告)日：2009-10-01
申请号：PCT/US2009/036988
申请日：2009-03-12
申请人： WARSAW ORTHOPEDIC, INC. , MCKAY, Williakm, F. , SCIFERT, Jeffrey, L. , REMSEN, Kathy, L. , VICKERS, Scott, M. , DIDIER, Billy , GILLISSEN, Mirian
发明人： MCKAY, Williakm, F. , SCIFERT, Jeffrey, L. , REMSEN, Kathy, L. , VICKERS, Scott, M. , DIDIER, Billy , GILLISSEN, Mirian
IPC分类号： A61L27/26 , A61L27/54
CPC分类号： A61K38/1875 , A61K9/0024 , A61L27/26 , A61L27/54 , A61L2300/414 , A61L2430/02 , C08L5/04 , C08L89/06
摘要： Described are implantable, malleable medical materials comprising mineral particles, insoluble collagen fibers, and a gel-forming polysaccharide component and/or another added gel-former. The malleable medical materials can be used treat bone or other tissue defects in patients, including in conjunction with biologically active factors such as osteogenic proteins. Also described are methods and materials that can be used to prepare the malleable medical materials.
摘要翻译：描述了包括矿物颗粒，不溶性胶原纤维和形成凝胶的多糖组分和/或另外添加的凝胶形成剂的可植入的可延展的医用材料。可延展的医疗材料可用于治疗患者的骨骼或其他组织缺陷，包括结合生物活性因子如成骨蛋白。还描述了可用于制备可延展的医疗材料的方法和材料。

3. 发明申请

WO2011017091A1 SI SUBSTITUTED CALCIUM PHOSPHATE CEMENT FOR DRUG DELIVERY 审中-公开
标题翻译： SI替代磷酸氢钙水泥用于药物递送
公开(公告)号：WO2011017091A1
公开(公告)日：2011-02-10
申请号：PCT/US2010/043362
申请日：2010-07-27
申请人： WARSAW ORTHOPEDIC, INC. , AMSDEN, Brian , GARCIA, Monica, Y. , GRANT, Ian, D. , SCIFERT, Jeffrey, L. , SMITH, Timothy, J.N.
发明人： AMSDEN, Brian , GARCIA, Monica, Y. , GRANT, Ian, D. , SCIFERT, Jeffrey, L. , SMITH, Timothy, J.N.
IPC分类号： A61L24/00 , A61L24/04 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58
CPC分类号： A61L24/0063 , A61L24/0015 , A61L24/0042 , A61L24/046 , A61L24/08 , A61L27/18 , A61L27/20 , A61L27/46 , A61L27/54 , A61L27/58 , A61L2300/402 , A61L2300/404 , A61L2300/414 , A61L2300/602 , C08L71/02 , C08L5/02
摘要： This invention relates to biomineral-based cements incorporating biopolymer carriers for the site specific introduction of natural or synthetic compounds that influence bone repair and/or patient recovery. The invention further relates to methods for producing such biphasic calcium phosphate cements for drug delivery.
摘要翻译：本发明涉及结合生物聚合物载体的生物矿物基水泥，用于特异性引入影响骨修复和/或患者恢复的天然或合成化合物的位点。本发明还涉及用于制备用于药物递送的这种双相磷酸钙粘结剂的方法。

4. 发明申请

WO2008021795A3 FLOWABLE CARRIER MATRIX 审中-公开
标题翻译：流动载体矩阵
公开(公告)号：WO2008021795A3
公开(公告)日：2008-05-08
申请号：PCT/US2007075303
申请日：2007-08-07
申请人： WARSAW ORTHOPEDIC INC , BEALS NEIL B , SCIFERT JEFFREY L PH D , BODEN SCOTT D
发明人： BEALS NEIL B , SCIFERT JEFFREY L PH D , BODEN SCOTT D
IPC分类号： A61K9/00 , A61K38/00 , A61K47/02 , A61K47/42 , A61K47/46
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or educed-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenetic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译：通过首先将胶原海绵片切割成多个相对较小的片，可以以微创方式将载体基质递送至患者体内的目标位置。这些部件的大小使其在潮湿时能够流过套管和/或导出直径的注射器尖端。将这些碎片放入注射器中，并用形态发生溶液润湿，并且任选地与填充材料混合，该填充材料的尺寸与通过套管的尺寸相似。彻底混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注射到患者体内。

5. 发明申请

WO2008021795A2 FLOWABLE CARRIER MATRIX 审中-公开
标题翻译：流动载体矩阵
公开(公告)号：WO2008021795A2
公开(公告)日：2008-02-21
申请号：PCT/US2007/075303
申请日：2007-08-07
申请人： WARSAW ORTHOPEDIC, INC , BEALS, Neil, B. , SCIFERT, Jeffrey, L. PH, D. , BODEN, Scott, D.
发明人： BEALS, Neil, B. , SCIFERT, Jeffrey, L. PH, D. , BODEN, Scott, D.
IPC分类号： A61K47/02 , A61K47/42 , A61K47/46 , A61K38/00
CPC分类号： A61K9/0024 , A61K9/0085 , A61K38/177 , A61K38/1774 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1858 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/30 , A61K47/42 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/414
摘要： A carrier matrix may be delivered to a target position within a patient in a minimally invasive manner by first cutting a collagen sponge sheet into a plurality of relatively small pieces. These pieces are sized so that, when wet, they are capable of flowing through a cannula and/or educed-diameter syringe tip. The pieces are placed into a syringe and wetted, say with a morphogenic solution, and optionally mixed with a bulking material, which is similarly sized to fit through the cannula. The thoroughly mixed and wetted product forms a viscous aggregate which may then be injected into the patient at the target site.
摘要翻译：通过首先将胶原海绵片切割成多个相对小的片，可以以微创方式将载体基质递送到患者体内的目标位置。这些件的尺寸设计成使得当它们变湿时，它们能够流过插管和/或直径注射器针尖。将片放置在注射器中并用形态发生溶液润湿，并且可选地与填充材料混合，膨胀材料的尺寸类似于穿过套管。充分混合和润湿的产品形成粘性聚集体，然后可以在目标部位将其注入患者体内。

6. 发明申请

WO2007133941A2 THERAPEUTIC AGENT CARRIER AND METHOD OF TREATING BONE FRACTURES 审中-公开
标题翻译：治疗药物载体和治疗骨折的方法
公开(公告)号：WO2007133941A2
公开(公告)日：2007-11-22
申请号：PCT/US2007067981
申请日：2007-05-02
申请人： WARSAW ORTHOPEDIC INC , MAROTTA JAMES S , BODEN SCOTT D , SCIFERT JEFFREY L PH D
发明人： MAROTTA JAMES S , BODEN SCOTT D , SCIFERT JEFFREY L PH D
CPC分类号： A61B17/15 , A61B17/06166 , A61B17/68 , A61B17/72 , A61B50/30 , A61B2017/00464 , A61B2017/564 , A61B2050/005 , A61B2050/006 , A61B2090/061 , A61F2/0095 , A61F2/28 , A61F2002/2817 , A61F2002/2825 , A61F2002/30062 , A61F2002/30115 , A61F2002/30116 , A61F2002/30131 , A61F2002/30138 , A61F2002/30159 , A61F2002/30235 , A61F2002/30237 , A61F2002/30238 , A61F2002/30551 , A61F2002/30593 , A61F2002/30616 , A61F2002/30617 , A61F2002/30677 , A61F2002/30714 , A61F2002/30822 , A61F2002/30827 , A61F2002/30828 , A61F2002/30831 , A61F2002/3096 , A61F2002/4658 , A61F2210/0004 , A61F2230/0006 , A61F2230/0013 , A61F2230/0017 , A61F2230/0028 , A61F2230/0069 , A61F2250/0089 , A61F2250/0097 , A61F2310/00179 , A61F2310/00365 , A61L27/54 , A61L2300/222 , A61L2300/252 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/414 , A61L2300/432 , A61L2300/802
摘要： A therapeutic agent carrier for treating a defect in a bone is disclosed and can include a body that can be configured to approximate a portion of the bone. Further, the therapeutic agent carrier can include a plurality of grooves formed along the body. Each groove can correspond to an incremental length of the body. The therapeutic agent carrier can also include a plurality of dosage stamps along the body and each of the plurality of dosage stamps is adjacent to a corresponding to groove.
摘要翻译：公开了一种用于治疗骨缺损的治疗剂载体，并且可以包括可构造为近似骨的一部分的主体。此外，治疗剂载体可以包括沿着身体形成的多个凹槽。每个凹槽可以对应于身体的增量长度。治疗剂载体还可以包括沿着身体的多个剂量标记，并且多个剂量标记中的每一个与对应的凹槽相邻。

7. 发明申请

WO2006118801A3 MULTI-PURPOSE MEDICAL IMPLANT DEVICES 审中-公开
标题翻译：多用途医疗植入装置
公开(公告)号：WO2006118801A3
公开(公告)日：2007-07-12
申请号：PCT/US2006014809
申请日：2006-04-19
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , SCIFERT JEFFREY L
发明人： MCKAY WILLIAM F , SCIFERT JEFFREY L
IPC分类号： A61L27/44
CPC分类号： A61L27/50 , A61L27/46 , C08L89/06
摘要： Described are medical devices for supporting or inducing bone growth including an implant body defining one or more separation-assist lines that facilitate separation of the body into two or more substantially pre-defined pieces. The implant body can be used and implanted as a whole or may be separated into multiple pieces, some or all of which can be used at one or multiple implant sites in a patient. Separation-assist lines in implant bodies can serve a dual role in imparting increased and controlled flexibility to the overall body when used as a whole at an implant site. Also described are methods of making and using, and kits including, such medical devices.
摘要翻译：描述了用于支撑或诱导骨生长的医疗装置，其包括限定一个或多个分离辅助线的植入物主体，所述分离辅助线有利于将体分离成两个或更多个基本上预定义的片段。植入物主体可以整体地使用和植入，或者可以分成多个部分，其中一些或全部可以在患者的一个或多个植入部位使用。植入物体中的分离辅助线可以在植入部位整体使用时赋予整体增加和控制的柔韧性双重作用。还描述了制造和使用的方法，以及包括这种医疗装置的试剂盒。

8. 发明申请

WO2011011786A4 IMPLANTABLE SCREW AND SYSTEM FOR SOCKET PRESERVATION 审中-公开
公开(公告)号：WO2011011786A4
公开(公告)日：2011-08-18
申请号：PCT/US2010043250
申请日：2010-07-26
申请人： WARSAW ORTHOPEDIC INC , SPAGNOLI DANIEL B , MOBLEY TODD A , SCIFERT JEFFREY L
发明人： SPAGNOLI DANIEL B , MOBLEY TODD A , SCIFERT JEFFREY L
IPC分类号： A61C13/107 , A61C8/00 , A61C13/02 , A61L27/06 , A61L27/54
CPC分类号： A61C8/008 , A61C8/0024 , A61C8/0075 , A61C2008/0084
摘要： An implantable screw for preserving the integrity of an oral socket and for maintaining space during bone grafting procedures is provided, where the screw has a healing abutment head having a region adapted to support soft tissue, a threaded shaft and a tip adapted to penetrate bone tissue. The temporary implantable screws provided may be used in conjunction with bone graft materials and are removable for placement of an oral implant.

9. 发明申请

WO2011009030A3 SYSTEM AND METHODS OF PRESERVING AN ORAL SOCKET 审中-公开
标题翻译：保留口服窝口的系统和方法
公开(公告)号：WO2011009030A3
公开(公告)日：2011-05-19
申请号：PCT/US2010042236
申请日：2010-07-16
申请人： WARSAW ORTHOPEDIC INC , SPAGNOLI DANIEL , MOBLEY TODD A , SCIFERT JEFFREY L
发明人： SPAGNOLI DANIEL , MOBLEY TODD A , SCIFERT JEFFREY L
IPC分类号： A61C8/00 , A61C13/02 , A61C13/107 , A61C13/225 , A61L27/54
CPC分类号： A61C8/008 , A61C8/0006 , A61C8/0012 , A61C8/0022 , A61C8/0024 , A61C8/0075 , A61C2008/0084 , A61L31/148 , A61L31/16 , A61L2430/12
摘要： An implantable screw for preserving the integrity of an oral socket is provided, where the screw has a healing abutment head having a region adapted to support soft tissue, a threaded shaft and a tip adapted to penetrate bone tissue. The implantable screw provided may be used for regenerating the tissue of an oral socket and may be used in conjunction with bone graft materials. The implantable screws are removable for placement of an oral implant.
摘要翻译：提供了一种用于保持口腔的完整性的可植入螺钉，其中螺钉具有愈合的邻接头部，其具有适于支撑软组织的区域，螺纹轴和适于穿透骨组织的尖端。所提供的可植入螺钉可以用于再生口腔的组织，并且可以与骨移植材料结合使用。可植入的螺钉是可拆卸的，用于放置口腔植入物。

10. 发明申请

WO2007130753A3 MEDICAL IMPLANTS WITH RESERVOIR(S) 审中-公开
标题翻译：医学植入物储层（S）
公开(公告)号：WO2007130753A3
公开(公告)日：2008-02-14
申请号：PCT/US2007064755
申请日：2007-03-23
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , SCIFERT JEFFREY L
发明人： MCKAY WILLIAM F , SCIFERT JEFFREY L
IPC分类号： A61L24/02 , A61L24/10 , A61L27/24 , A61L27/46
CPC分类号： A61L27/24 , A61F2/02 , A61K9/0019 , A61K9/0024 , A61K9/1652 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/02 , A61L24/10 , A61L24/102 , A61L27/02 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/604 , A61L2400/06 , A61L2430/02 , A61L2430/38
摘要： Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body is disruptable upon wetting with a biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material, and wherein the body defines one or more reservoirs for receiving amounts of the biocompatible liquid.
摘要翻译：描述了一种包括三维主体的医学上有用的制品，所述三维主体包括一种或多种可植入物质，其中所述主体在用生物相容性液体润湿以形成适合的可植入材料例如腻子，糊剂或更易流动的湿润植入物材料时是可破坏的，其中所述主体限定用于接收一定量的所述生物相容性液体的一个或多个储存器。

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