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1. 发明申请

WO2007130753B1 MEDICAL IMPLANTS WITH RESERVOIR(S) 审中-公开
标题翻译：带有储存器的医用植物
公开(公告)号：WO2007130753B1
公开(公告)日：2008-05-08
申请号：PCT/US2007064755
申请日：2007-03-23
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , SCIFERT JEFFREY L
发明人： MCKAY WILLIAM F , SCIFERT JEFFREY L
IPC分类号： A61L24/02 , A61L24/10 , A61L27/24 , A61L27/46
CPC分类号： A61L27/24 , A61F2/02 , A61K9/0019 , A61K9/0024 , A61K9/1652 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/02 , A61L24/10 , A61L24/102 , A61L27/02 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/604 , A61L2400/06 , A61L2430/02 , A61L2430/38
摘要： Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body is disruptable upon wetting with a biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material, and wherein the body defines one or more reservoirs for receiving amounts of the biocompatible liquid.
摘要翻译：描述了一种医学上有用的制品，其包括一种包括一种或多种可植入物质的三维体，其中身体在与生物相容性液体润湿之后可破坏以形成适形可植入材料，例如油灰，糊状物或更易流动的浸湿植入材料，以及其中所述主体限定用于接收生物相容性液体量的一个或多个储存器。

2. 发明申请

WO2006118801A3 MULTI-PURPOSE MEDICAL IMPLANT DEVICES 审中-公开
标题翻译：多用途医疗植入装置
公开(公告)号：WO2006118801A3
公开(公告)日：2007-07-12
申请号：PCT/US2006014809
申请日：2006-04-19
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , SCIFERT JEFFREY L
发明人： MCKAY WILLIAM F , SCIFERT JEFFREY L
IPC分类号： A61L27/44
CPC分类号： A61L27/50 , A61L27/46 , C08L89/06
摘要： Described are medical devices for supporting or inducing bone growth including an implant body defining one or more separation-assist lines that facilitate separation of the body into two or more substantially pre-defined pieces. The implant body can be used and implanted as a whole or may be separated into multiple pieces, some or all of which can be used at one or multiple implant sites in a patient. Separation-assist lines in implant bodies can serve a dual role in imparting increased and controlled flexibility to the overall body when used as a whole at an implant site. Also described are methods of making and using, and kits including, such medical devices.
摘要翻译：描述了用于支撑或诱导骨生长的医疗装置，其包括限定一个或多个分离辅助线的植入物主体，所述分离辅助线有利于将体分离成两个或更多个基本上预定义的片段。植入物主体可以整体地使用和植入，或者可以分成多个部分，其中一些或全部可以在患者的一个或多个植入部位使用。植入物体中的分离辅助线可以在植入部位整体使用时赋予整体增加和控制的柔韧性双重作用。还描述了制造和使用的方法，以及包括这种医疗装置的试剂盒。

3. 发明申请

WO2007130753A3 MEDICAL IMPLANTS WITH RESERVOIR(S) 审中-公开
标题翻译：医学植入物储层（S）
公开(公告)号：WO2007130753A3
公开(公告)日：2008-02-14
申请号：PCT/US2007064755
申请日：2007-03-23
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F , SCIFERT JEFFREY L
发明人： MCKAY WILLIAM F , SCIFERT JEFFREY L
IPC分类号： A61L24/02 , A61L24/10 , A61L27/24 , A61L27/46
CPC分类号： A61L27/24 , A61F2/02 , A61K9/0019 , A61K9/0024 , A61K9/1652 , A61L24/0015 , A61L24/0036 , A61L24/0042 , A61L24/0084 , A61L24/02 , A61L24/10 , A61L24/102 , A61L27/02 , A61L27/46 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/112 , A61L2300/252 , A61L2300/412 , A61L2300/414 , A61L2300/45 , A61L2300/604 , A61L2400/06 , A61L2430/02 , A61L2430/38
摘要： Described is a medically useful article comprising a three-dimensional body including one or more implantable substances, wherein the body is disruptable upon wetting with a biocompatible liquid to form a conformable implantable material such as a putty, paste or more flowable wetted implant material, and wherein the body defines one or more reservoirs for receiving amounts of the biocompatible liquid.
摘要翻译：描述了一种包括三维主体的医学上有用的制品，所述三维主体包括一种或多种可植入物质，其中所述主体在用生物相容性液体润湿以形成适合的可植入材料例如腻子，糊剂或更易流动的湿润植入物材料时是可破坏的，其中所述主体限定用于接收一定量的所述生物相容性液体的一个或多个储存器。

4. 发明申请

WO2011094316A3 HIGHLY COMPRESSION RESISTANT MATRIX WITH POROUS SKELETON 审中-公开
标题翻译：高耐压矩阵与多孔的SKELETON
公开(公告)号：WO2011094316A3
公开(公告)日：2011-12-29
申请号：PCT/US2011022582
申请日：2011-01-26
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61L27/40 , A61F2/28 , A61L27/10 , A61L27/12 , A61L27/14 , A61L27/24 , A61L27/42 , A61L27/54 , A61L27/56
CPC分类号： A61F2/4644 , A61F2002/4648 , A61K9/0024 , A61K9/19 , A61K9/70 , A61K9/7007 , A61L27/425 , A61L27/56
摘要： A highly compression resistant matrix is provided for implantation at or near a target tissue site beneath the skin. The matrix comprises a polymer and a ceramic skeleton. The compression resistance provides retention of a volume that facilitates bone regeneration.
摘要翻译：提供高抗压基质用于植入在皮肤下方的靶组织部位处或附近。该基质包括聚合物和陶瓷骨架。抗压性提供了保持促进骨再生的体积。

5. 发明申请

WO2011094735A3 SURGICAL RETRACTOR INSTRUMENT SYSTEMS AND METHODS OF USING THE SAME 审中-公开
标题翻译：手术回缩器仪器系统及其使用方法
公开(公告)号：WO2011094735A3
公开(公告)日：2011-12-08
申请号：PCT/US2011023318
申请日：2011-02-01
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61B17/02 , A61B19/00 , G01L5/00
CPC分类号： A61B17/0206 , A61B2017/00017 , A61B2017/00115 , A61B2017/00128 , A61B2017/00398 , A61B2017/00539 , A61B2017/00544 , A61B2017/0212 , A61B2090/064 , A61B2090/065
摘要： A retractor system for percutaneous surgery in a patient includes first and second retractor portions positionable opposite one another in an incision of the patient. The system also includes at least one actuating member operable to provide an oscillating motion to at least one of the first and second retractor portions. The actuating member is in communication with a controller and is responsive to the controller to move and adjust at least one of the first and second retractor portions between a first position and a second position. The system also includes at least one pressure sensor and display and at least one timing circuit with display. In another form, a method is directed to retracting tissue for percutaneous access to a surgical site in a patient using the pressure sensors and display as will as the timing circuit and display to assure that the amount of pressure applied and the duration does not exceed pre-determined values.
摘要翻译：用于患者经皮手术的牵开器系统包括可在患者切口中彼此相对定位的第一和第二牵开器部分。该系统还包括至少一个致动构件，其可操作以向第一牵拉器部分和第二牵拉器部分中的至少一个提供摆动运动。致动构件与控制器连通并且响应于控制器在第一位置和第二位置之间移动和调节第一牵拉器部分和第二牵拉器部分中的至少一个。该系统还包括至少一个压力传感器和显示器以及至少一个具有显示器的定时电路。在另一种形式中，一种方法涉及使用压力传感器缩回用于经皮进入患者手术部位的组织，并且如同计时电路和显示器那样显示，以确保施加的压力量和持续时间不超过预先设定的时间 - 确定的值。

6. 发明申请

WO2011094626A3 NON-INVASIVE DEVICES AND METHODS TO DIAGNOSE PAIN GENERATORS 审中-公开
标题翻译：非侵入性装置和诊断疼痛发生器的方法
公开(公告)号：WO2011094626A3
公开(公告)日：2011-10-27
申请号：PCT/US2011023045
申请日：2011-01-28
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61B5/00 , G01N29/24
CPC分类号： A61B8/00 , A61B5/06 , A61B5/441 , A61B5/4514 , A61B5/4528 , A61B5/4824 , A61B6/12 , A61B8/4245 , A61B8/4254
摘要： Devices and methods are provided that diagnose one or more pain generators at or near the spine in a patient suffering from pain. In one embodiment, a device is provided that includes: an external transducer probe having a proximal end, a distal end and a body therebetween wherein the probe is configured to be placed in contact with the skin of a patient near a pain generator or suspected pain generator; an energy source that supplies the probe with energy; and a conduit for engaging the energy source and the proximal end of the probe. The energy is transferred from the energy source to the distal end of the probe through the skin of the patient and has an intensity to deliver and produce a pain signal when at least the distal end of the probe is near the pain generator or suspected pain generator.
摘要翻译：提供了诊断患有疼痛的患者的脊柱处或附近的一个或多个疼痛发生器的装置和方法。在一个实施例中，提供了一种装置，其包括：外部换能器探头，其具有近端，远端以及其间的主体，其中，所述探头被配置为与疼痛发生器附近的患者皮肤接触或怀疑疼痛发电机; 为探针提供能量的能源; 以及用于接合能量源和探针的近端的导管。当探针的至少远端靠近疼痛发生器或疑似疼痛发生器时，能量从能量源传递到探针的远端并穿过患者的皮肤，并具有传递和产生疼痛信号的强度。

7. 发明申请

WO2010021823A4 OSTEOGENIC COMPOSITIONS CONTAINING A COLORING AGENT 审中-公开
标题翻译：含有着色剂的成骨组合物
公开(公告)号：WO2010021823A4
公开(公告)日：2010-06-03
申请号：PCT/US2009052360
申请日：2009-07-31
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61L27/50 , A61F2/00 , A61L27/22 , A61L27/24 , A61L27/26
CPC分类号： A61K38/1875 , A61L27/24 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/56 , A61L2300/414 , A61L2300/442 , A61L2300/45 , A61L2300/604 , A61L2430/02
摘要： An osteogenic composition is provided for implantation at or near a target tissue site beneath the skin, the osteogenic composition comprising a growth factor and a coloring agent, wherein the coloring agent imparts color to the growth factor to allow the user to see the growth factor at or near the target tissue site. In some embodiments, a method is provided for accelerating bone repair, the method comprising mixing bone morphogenic protein-2 and a coloring agent to form a mixture; applying the mixture to a surface of a porous collagen matrix, wherein the coloring agent allows the user to see bone morphogenic protein-2 distribution on or in the porous collagen matrix; and implanting the porous collagen matrix at or near a target tissue site in need of bone repair.
摘要翻译：提供成骨组合物用于植入皮肤下方的目标组织部位处或附近，所述成骨组合物包含生长因子和着色剂，其中着色剂赋予生长因子颜色以允许使用者在或靠近目标组织部位。在一些实施方案中，提供了用于加速骨修复的方法，所述方法包括混合骨形态发生蛋白-2和着色剂以形成混合物; 将混合物施加到多孔胶原基质的表面，其中着色剂允许使用者看到多孔胶原基质上或其中的骨形态发生蛋白-2分布; 以及将多孔胶原基质植入需要骨修复的靶组织部位处或附近。

8. 发明申请

WO2009129149A3 DRUG DEPOTS HAVING DIFFERENT RELEASE PROFILES FOR REDUCING, PREVENTING OR TREATING PAIN AND INFLAMMATION 审中-公开
标题翻译：具有用于减少，预防或治疗疼痛和炎症的不同释放特征的药物组合物
公开(公告)号：WO2009129149A3
公开(公告)日：2009-12-10
申请号：PCT/US2009040240
申请日：2009-04-10
申请人： WARSAW ORTHOPEDIC INC , MCKAY WILLIAM F
发明人： MCKAY WILLIAM F
IPC分类号： A61K9/20 , A61K31/485 , A61K47/34 , A61P29/00
CPC分类号： A61K9/7007 , A61K9/0002 , A61K9/0024 , A61K31/135 , A61K31/192 , A61K31/366 , A61K31/4168 , A61K31/485 , A61K31/573 , A61K31/58 , A61K31/655
摘要： Effective treatments of pain and/or inflammation are provided. Through the administration of an effective amount of at least analgesic and/or at least one anti-inflammatory agent at or near a target site, one can reduce, prevent or treat inflammation and pain.
摘要翻译：提供有效的疼痛和/或炎症治疗。通过在目标部位或其附近施用有效量的至少止痛剂和/或至少一种抗炎剂，可以减少，预防或治疗炎症和疼痛。

9. 发明申请

WO2009129437A2 METHODS AND COMPOSITIONS FOR TREATING POST-OPERATIVE PAIN COMPRISING CLONIDINE 审中-公开
标题翻译：用于治疗术后疼痛的方法和组合
公开(公告)号：WO2009129437A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040910
申请日：2009-04-17
申请人： WARSAW ORTHOPEDIC INC , MEDTRONIC INC , KING VANJA MARGARETA , HOBOT CHRISTOPHER M , MCKAY WILLIAM F , WOHABREBBI AMIRA , MCDONALD PHILLIP EDWARD , CARTER TROY
发明人： KING VANJA MARGARETA , HOBOT CHRISTOPHER M , MCKAY WILLIAM F , WOHABREBBI AMIRA , MCDONALD PHILLIP EDWARD , CARTER TROY
IPC分类号： A61K9/00 , A61K31/4162
CPC分类号： A61L31/16 , A61K9/0024 , A61K9/204 , A61K31/4162 , A61K31/4168 , A61K47/34 , A61L31/06 , A61L2300/204 , A61L2300/402 , A61L2300/604
摘要： The present invention is directed to an implantable drug depot useful for reducing, preventing or treating post-operative pain in a patient in need of such treatment, the implantable drug depot comprising a therapeutically effective amount of clonidine or pharmaceutically acceptable salt thereof and a polymer; wherein the depot is implantable at a site beneath the skin to reduce, prevent or treat post-operative pain, and the depot is capable of releasing (i) about 5% to about 45% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a first period of up to 48 hours and (ii) about 55% to about 95% of the clonidine or pharmaceutically acceptable salt thereof relative to a total amount of the clonidine or pharmaceutically acceptable salt thereof loaded in the drug depot over a subsequent period of at least 3 days.
摘要翻译：本发明涉及可用于减少，预防或治疗需要这种治疗的患者的手术后疼痛的可植入药物贮存库，所述可植入药物储库包含治疗有效量的可乐定或其药学上可接受的盐和聚合物; 其中所述贮存库可植入皮肤下面的部位以减少，预防或治疗手术后疼痛，并且所述贮库能够释放（i）约5％至约45％的可乐定或其药学上可接受的盐相对于在最多48小时的第一时间内装载在药物贮库中的可乐定或其药学上可接受的盐的总量和（ii）可乐定或其药学上可接受的盐的约55％至约95％相对于至少3天的随后期间，将可乐定或其药学上可接受的盐装载在药物贮库中。

10. 发明申请

WO2009129210A2 COMPOSITIONS AND METHODS FOR TREATING POST-OPERATIVE PAIN USING CLONIDINE AND BUPIVACAINE 审中-公开
标题翻译：用于治疗术后疼痛的组合物和方法
公开(公告)号：WO2009129210A2
公开(公告)日：2009-10-22
申请号：PCT/US2009040453
申请日：2009-04-14
申请人： MEDTRONIC INC , WARSAW ORTHOPEDIC INC , WOHABREBBI AMIRA , KING VANJA MARGARETA , MCKAY WILLIAM F
发明人： WOHABREBBI AMIRA , KING VANJA MARGARETA , MCKAY WILLIAM F
IPC分类号： A61K9/16 , A61K9/20
CPC分类号： A61K9/0024 , A61K9/204 , A61K31/4168 , A61K31/445 , A61K45/06
摘要： Effective treatments of pain that accompanies post-operative surgeries are provided. Through the administration of an effective amount of a combination of bupivacaine and clonidine at or near a target site, one can alleviate or prevent pain. This administration of bupivacaine and clonidine or pharmaceutically acceptable salts thereof is particularly useful following surgery.
摘要翻译：提供了伴随手术后手术的有效治疗疼痛。通过在目标部位或其附近施用有效量的布比卡因和可乐定的组合，可以减轻或预防疼痛。布比卡因和可乐定或其药学上可接受的盐的施用在手术后是特别有用的。

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