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1. 发明申请

WO2011116004A2 CRANIAL SUTURE SNAKE ALGORITHM 审中-公开
标题翻译： CRANIAL SUTURE SNAKE算法
公开(公告)号：WO2011116004A2
公开(公告)日：2011-09-22
申请号：PCT/US2011/028539
申请日：2011-03-15
申请人： GEORGIA TECH RESEARCH CORPORATION , HERMANN, Christopher, Douglas , BOYAN, Barbara, Dale , SCHWARTZ, Zvi
发明人： HERMANN, Christopher, Douglas , BOYAN, Barbara, Dale , SCHWARTZ, Zvi
IPC分类号： G06T7/40
CPC分类号： G06T7/0083 , G06T7/12 , G06T7/136 , G06T7/149 , G06T2207/10081 , G06T2207/20116 , G06T2207/30008
摘要： The invention is directed toward methods for assisting in interpreting medical images, especially useful for segmenting images produced by computed tomography or micro-computed tomography. In one embodiment, the invention is directed to method comprising initially identifying the images of the bones from a medical image, estimating a preliminary boundary of the bones, and subsequently segmenting the bones using a snake algorithm initialized by the preliminary boundary of the bones. The results can then be used to establish morphometric measurements from the medical images based on the segmented bone boundaries. In one embodiment of the present invention, the snake algorithm used is a continuous parametric Fourier series representation to fit and optimize the preliminary boundary of the bones to a more accurate representation of the segmented bone boundary from the data included in the image.
摘要翻译：本发明涉及用于辅助解释医学图像的方法，特别对于分割由计算机断层摄影或微型计算机断层摄影产生的图像尤其有用。在一个实施例中，本发明涉及一种方法，其包括首先从医学图像识别骨骼的图像，估计骨骼的初步边界，并且随后使用由骨骼的初步边界初始化的蛇算法来分割骨骼。然后可以将结果用于基于分割的骨边界从医学图像建立形态测量。在本发明的一个实施例中，所使用的蛇算法是连续的参数傅立叶级数表示，以适应和优化骨骼的初步边界，以从包括在图像中的数据更精确地表示分割的骨边界。

2. 发明申请

WO2006042132A3 MICROENCAPSULATION OF CELLS IN HYDROGELS USING ELECTROSTATIC POTENTIALS 审中-公开
标题翻译：使用静电潜力的水凝胶中细胞的微观结构
公开(公告)号：WO2006042132A3
公开(公告)日：2007-08-16
申请号：PCT/US2005036202
申请日：2005-10-07
申请人： GEORGIA TECH RES INST , BOYAN BARBARA DALE , KINNEY RAMSEY CHRISTIAN , SCHWARTZ ZVI
发明人： BOYAN BARBARA DALE , KINNEY RAMSEY CHRISTIAN , SCHWARTZ ZVI
IPC分类号： C12N11/00 , C12N5/077 , C12N11/04 , C12Q1/02
CPC分类号： C12N5/0655 , A61K2035/126 , C12N5/0012 , C12N2533/74
摘要： Compositions and methods for producing encapsulated cells having an average diameter of less than about 200 µm are provided . Methods for using the disclosed encapsulated cells are also provided
摘要翻译：提供了生产平均直径小于约200μm的包封细胞的组合物和方法。还提供了使用所公开的封装细胞的方法

3. 发明申请

WO2012126005A3 POLYMER HYDROGELS FOR IN VIVO APPLICATIONS AND METHODS FOR USING AND PREPARING SAME 审中-公开
标题翻译：用于体内应用的聚合物水凝胶和使用和制备它们的方法
公开(公告)号：WO2012126005A3
公开(公告)日：2014-04-24
申请号：PCT/US2012029686
申请日：2012-03-19
申请人： GEORGIA TECH RES INST , MURTHY NIREN , HERMANN CHRISTOPHER , WILSON DAVID SCOTT , NING XINGHAI , BOYAN BARBARA D , SCHWARTZ ZVI , GULDBERG ROBERT , DIAB TAMIM
发明人： MURTHY NIREN , HERMANN CHRISTOPHER , WILSON DAVID SCOTT , NING XINGHAI , BOYAN BARBARA D , SCHWARTZ ZVI , GULDBERG ROBERT , DIAB TAMIM
IPC分类号： A61K9/14
CPC分类号： A61K47/32 , A61K9/06 , A61K38/1709 , A61L27/52 , A61L2430/02 , C07K14/51
摘要： Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.
摘要翻译：描述了通过叠氮化物和炔烃之间的环加成反应产生的聚合物水凝胶的组合物和方法，其在不经催化剂的情况下快速进行，以在不到90秒内产生聚合物水凝胶。聚合物水凝胶可用于在水溶液中局部递送治疗剂的体内应用。证明了在小鼠模型中治疗性递送蛋白质的实例。

4. 发明申请

WO2012071527A2 PROTEIN DELIVERY FROM STEM CELL MICROCARRIERS 审中-公开
标题翻译：蛋白质从干细胞微载体递送
公开(公告)号：WO2012071527A2
公开(公告)日：2012-05-31
申请号：PCT/US2011062068
申请日：2011-11-23
申请人： GEORGIA TECH RES INST , BOYAN BARBARA DALE , SCHWARTZ ZVI , LEE CHRISTOPHER S D , LESLIE SHIRAE KERISHA , KINNEY RAMSEY C
发明人： BOYAN BARBARA DALE , SCHWARTZ ZVI , LEE CHRISTOPHER S D , LESLIE SHIRAE KERISHA , KINNEY RAMSEY C
IPC分类号： A61K38/18 , C12N5/073
CPC分类号： A61K35/28 , A61K9/5036 , A61K2035/128 , C12N5/0655 , C12N5/0667 , C12N2500/25 , C12N2500/32 , C12N2500/34 , C12N2500/38 , C12N2501/15 , C12N2501/155 , C12N2501/39 , C12N2533/74
摘要： Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.
摘要翻译：公开了用于将细胞和其他生物活性物质递送至有需要的受试者中的患病或受损组织的微珠载体的方法和组合物。

5. 发明申请

WO2010054125A1 FORMULATIONS AND USES OF 24R, 25-DIHYDROXYVITAMIN D3 AS AN ANTI-APOPTOTIC 审中-公开
标题翻译： 24R，25-二羟基维生素D3作为抗病毒药物的制剂和用途
公开(公告)号：WO2010054125A1
公开(公告)日：2010-05-14
申请号：PCT/US2009/063455
申请日：2009-11-05
申请人： GEORGIA TECH RESEARCH CORPORATION , DENISON, Tracy Adam , BOYAN, Barbara D. , SCHWARTZ, Zvi , HURST-KENNEDY, Jennifer
发明人： DENISON, Tracy Adam , BOYAN, Barbara D. , SCHWARTZ, Zvi , HURST-KENNEDY, Jennifer
IPC分类号： A61K31/592 , A61K31/593 , A61K31/59 , A61K45/00
CPC分类号： A61K31/593 , A61K9/0019 , A61K31/685 , A61K31/728 , A61K35/24 , A61K45/06 , A61K2300/00
摘要： The various embodiments of the present disclosure relate generally to formulations and uses of Vitamin D and derivatives thereof for the treatment of osteoarthritis. More particularly, the various embodiments of the present disclosure relate to formulations and uses for 24R, 25-dihydroxyvitamin D 3 as an anti-apoptotic. One aspect of the present invention involves a method of treating osteoarthritis that comprises administering an effective amount of a composition comprising Vitamin D, such as vitamin D 3 , or a derivative thereof to a subject for treatment of osteoarthritis.
摘要翻译：本公开的各种实施方案一般涉及维生素D及其衍生物用于治疗骨关节炎的制剂和用途。更具体地，本公开的各种实施方案涉及24R，25-二羟基维生素D3作为抗凋亡剂的制剂和用途。本发明的一个方面涉及治疗骨关节炎的方法，其包括将有效量的维生素D如维生素D3或其衍生物的组合物给予治疗骨关节炎。

6. 发明申请

WO2012071527A3 PROTEIN DELIVERY FROM STEM CELL MICROCARRIERS 审中-公开
公开(公告)号：WO2012071527A3
公开(公告)日：2012-05-31
申请号：PCT/US2011/062068
申请日：2011-11-23
申请人： GEORGIA TECH RESEARCH CORPORATION , BOYAN, Barbara, Dale , SCHWARTZ, Zvi , LEE, Christopher, S.D , LESLIE, Shirae, Kerisha , KINNEY, Ramsey, C.
发明人： BOYAN, Barbara, Dale , SCHWARTZ, Zvi , LEE, Christopher, S.D , LESLIE, Shirae, Kerisha , KINNEY, Ramsey, C.
IPC分类号： C12N5/077 , C12N5/071
摘要： Disclosed are methods and compositions of microbead carriers for delivery of cells and other biologically active substances to diseased or damaged tissue in a subject in need thereof.

7. 发明申请

WO2011116004A3 CRANIAL SUTURE SNAKE ALGORITHM 审中-公开
标题翻译： CRANIAL SUTURE SNAKE算法
公开(公告)号：WO2011116004A3
公开(公告)日：2013-02-28
申请号：PCT/US2011028539
申请日：2011-03-15
申请人： GEORGIA TECH RES INST , HERMANN CHRISTOPHER DOUGLAS , BOYAN BARBARA DALE , SCHWARTZ ZVI
发明人： HERMANN CHRISTOPHER DOUGLAS , BOYAN BARBARA DALE , SCHWARTZ ZVI
IPC分类号： G06K9/34
CPC分类号： G06T7/0083 , G06T7/12 , G06T7/136 , G06T7/149 , G06T2207/10081 , G06T2207/20116 , G06T2207/30008
摘要： The invention is directed toward methods for assisting in interpreting medical images, especially useful for segmenting images produced by computed tomography or micro-computed tomography. In one embodiment, the invention is directed to method comprising initially identifying the images of the bones from a medical image, estimating a preliminary boundary of the bones, and subsequently segmenting the bones using a snake algorithm initialized by the preliminary boundary of the bones. The results can then be used to establish morphometric measurements from the medical images based on the segmented bone boundaries. In one embodiment of the present invention, the snake algorithm used is a continuous parametric Fourier series representation to fit and optimize the preliminary boundary of the bones to a more accurate representation of the segmented bone boundary from the data included in the image.
摘要翻译：本发明涉及用于辅助解释医学图像的方法，特别对于分割由计算机断层摄影或微型计算机断层摄影产生的图像尤其有用。在一个实施例中，本发明涉及一种方法，其包括首先从医学图像识别骨骼的图像，估计骨骼的初步边界，并且随后使用由骨骼的初步边界初始化的蛇算法来分割骨骼。然后可以将结果用于基于分割的骨边界从医学图像建立形态测量。在本发明的一个实施例中，所使用的蛇算法是连续的参数傅立叶级数表示，以适应和优化骨骼的初步边界，以从包括在图像中的数据更精确地表示分割的骨边界。

8. 发明申请

WO2012126005A2 POLYMER HYDROGELS FOR IN VIVO APPLICATIONS AND METHODS FOR USING AND PREPARING SAME 审中-公开
标题翻译：用于体内应用的聚合物水凝胶和使用和制备它们的方法
公开(公告)号：WO2012126005A2
公开(公告)日：2012-09-20
申请号：PCT/US2012/029686
申请日：2012-03-19
申请人： GEORGIA TECH RESEARCH CORPORATION , MURTHY, Niren , HERMANN, Christopher , WILSON, David Scott , NING, Xinghai , BOYAN, Barbara D. , SCHWARTZ, Zvi , GULDBERG, Robert , DIAB, Tamim
发明人： MURTHY, Niren , HERMANN, Christopher , WILSON, David Scott , NING, Xinghai , BOYAN, Barbara D. , SCHWARTZ, Zvi , GULDBERG, Robert , DIAB, Tamim
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , A61K9/06 , A61K38/1709 , A61L27/52 , A61L2430/02 , C07K14/51
摘要： Compositions and methods are described for a polymer hydrogel created by a cycloaddition reaction between an azide and an alkyne that proceeds rapidly without catalyst to produce the polymer hydrogel in less than ninety seconds. The polymer hydrogel can be used in in vivo applications for the localized delivery of therapeutic agent in aqueous solutions. An example of therapeutic delivery of a protein in a mouse model is demonstrated.
摘要翻译：描述了通过叠氮化物和炔烃之间的环加成反应产生的聚合物水凝胶的组合物和方法，其在不经催化剂的情况下快速进行，以在不到90秒内产生聚合物水凝胶。聚合物水凝胶可用于在水溶液中局部递送治疗剂的体内应用。证明了在小鼠模型中治疗性递送蛋白质的实例。

9. 发明申请

WO2011103307A1 COMPOSITIONS AND METHODS FOR MODIFYING IN VIVO CALCIFICATION OF HYDROGELS 审中-公开
标题翻译：用于修改血压计的血小板计算的组合物和方法
公开(公告)号：WO2011103307A1
公开(公告)日：2011-08-25
申请号：PCT/US2011/025268
申请日：2011-02-17
申请人： GEORGIA TECH RESEARCH CORPORATION , SCHWARTZ, Zvi , LEE, Christopher S.D. , MOYER, Hunter R. , BOYAN, Barbara
发明人： SCHWARTZ, Zvi , LEE, Christopher S.D. , MOYER, Hunter R. , BOYAN, Barbara
IPC分类号： C08L5/04
CPC分类号： A61L27/20 , A61L27/38 , A61L27/52 , A61L2300/40 , A61L2400/02 , A61L2430/02 , C08B37/0084 , C08J3/075 , C08J3/246 , C08L5/04
摘要： Provided herein according to some embodiments of the invention are methods of inhibiting or preventing calcification of hydrogels. Such methods may include combining the hydrogel with a buffer solution having a pH lower than 7.4; forming hydrogel by crosslinking alginate in a solution comprising a bisphosphonate compound; and/or forming hydrogel by crosslinking polyanionic polymer with a polyvalent cation that is not Ca2+. Compositions that may be used in such methods are also provided herein. Also provided herein according to some embodiments of the invention are methods of bone regeneration and/or formation that include administering hydrogel that does not encapsulate biological material that affects calcification and/or bone formation to an area of a subjects body that is in need of bone formation and/or regeneration.
摘要翻译：根据本发明的一些实施方案，本文提供了抑制或预防水凝胶钙化的方法。这样的方法可以包括将水凝胶与pH低于7.4的缓冲溶液组合; 通过在包含双膦酸盐化合物的溶液中交联藻酸盐形成水凝胶; 和/或通过用不是Ca 2+的多价阳离子交联聚阴离子聚合物形成水凝胶。也可以在这些方法中使用的组合物。根据本发明的一些实施方案，本文还提供了骨再生和/或形成的方法，其包括将不包封影响钙化和/或骨形成的生物材料的水凝胶施用于需要骨的受试者身体的区域形成和/或再生。

10. 发明申请

WO2011094604A1 SURFACE MODIFICATION OF IMPLANT DEVICES 审中-公开
标题翻译：植入装置的表面修改
公开(公告)号：WO2011094604A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/023011
申请日：2011-01-28
申请人： GEORGIA TECH RESEARCH CORPORATION , IBACACHE, Rolando, Arturo, Gittens , SANDHAGE, Kenneth, H. , TANNENBAUM, Rina , SCHWARTZ, Zvi , BOYAN, Barbara
发明人： IBACACHE, Rolando, Arturo, Gittens , SANDHAGE, Kenneth, H. , TANNENBAUM, Rina , SCHWARTZ, Zvi , BOYAN, Barbara
IPC分类号： A61F2/02
CPC分类号： A61F2/30771 , A61C8/0012 , A61C8/0013 , A61F2002/3084 , A61L27/06 , A61L2400/12 , A61L2400/18 , Y10T428/24355
摘要： Provided according to embodiments of the invention are methods of manufacturing implant devices. In methods described herein, implant devices are exposed to a reactive gas that includes a reactive species, and optionally, an inert gas, at elevated temperatures, for a duration sufficient to generate a high density of nanoscale structures on the exposed surface of the device. Also provided are implant devices formed by a method described herein.
摘要翻译：根据本发明的实施例提供的是制造植入装置的方法。在本文所述的方法中，将植入装置暴露于反应性气体，所述反应性气体包括反应性物质和任选的惰性气体，在升高的温度下持续足够的时间以在装置的暴露表面上产生高密度的纳米尺度结构。还提供了通过本文所述的方法形成的植入装置。

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