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    • 2. 发明申请
    • PEPTIDES AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS
    • 肽及其用于治疗艾滋病毒感染的用途
    • WO2004056871A3
    • 2004-10-21
    • PCT/EP0314654
    • 2003-12-19
    • IPF PHARMACEUTICALSADERMANN KNUTKIRCHHOFF FRANKMUENCH JANSCHULZ AXEL
    • ADERMANN KNUTKIRCHHOFF FRANKMUENCH JANSCHULZ AXEL
    • A61K38/57A61P31/18C07K7/08C07K14/81C12N15/15G01N33/68
    • C07K7/08
    • The invention relates to peptides with biological activity against infection having the amino acid sequence Z1-LE-X1-IP-X2-X3-X4-P-X5-X6-X7-X8-X9-X10-K-X11-X12-X13-X14-X15-Z2, wherein X1 is a lysine, alanine, or aspartic acid; X2 is a cysteine, methionine or isoleucine; X3 is a serine, cysteine, lysine or glycine; X4 is an isoleucine, alanine, phenylalanine or cysteine; X5 is a proline, D-proline or a substituted L-or D-proline; X6 is a cysteine or glutamic acid; X7 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X8 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X9 is an amino acid with an aromatic side chain; X10 is a glycine, alanine or asparagine; X11 is a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D-1,2, 3,4-tetrahydroisoquinoline-3-carboxylic acid; X12 is a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X13 is an amino acid with a hydrophobic or an aromatic side chain; X14 is an amino acid with a hydrophobic or an aromatic side chain; X15 is a phenylalanine or deletion; Z1 is NH2 or a sequence of 1 to 10 amino acid residues; Z2 is COOH or a sequence of 1 to 10 amino acid residues; and peptides which are fragments and/or covalently linked oligomers and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof, and with the provisio that (a) if X12 is alanine, glycine, glutamic acid, or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid than X13, X14 and X15 are phenylalanine, valine and phenylalanine respectively; and/or (b) if X12 is phenylalanine, than X13, X14 and X15 are valine, phenylalanine and a deletion, respectively; and (c) that there are at maximum two cysteine residues in a peptide.
    • 本发明涉及具有氨基酸序列Z1-LE-X1-IP-X2-X3-X4-P-X5-X6-X7-X8-X9-X10-K-X11-X12-X13的感染生物活性肽 -X14-X15-Z2,其中X1是赖氨酸,丙氨酸或天冬氨酸; X2是半胱氨酸,甲硫氨酸或异亮氨酸; X3是丝氨酸,半胱氨酸,赖氨酸或甘氨酸; X4是异亮氨酸,丙氨酸,苯丙氨酸或半胱氨酸; X5是脯氨酸,D-脯氨酸或取代的L-或D-脯氨酸; X6是半胱氨酸或谷氨酸; X7是具有疏水或芳族侧链或半胱氨酸的氨基酸; X8是具有疏水或芳族侧链或半胱氨酸的氨基酸; X9是具有芳香侧链的氨基酸; 甘氨酸,丙氨酸或天冬酰胺; X11是脯氨酸,天冬氨酸,八氢吲哚-2-羧酸或D-1,2,3,4-四氢异喹啉-3-羧酸; X12是苯丙氨酸,丙氨酸,甘氨酸,谷氨酸或D-1,2,3,4-四氢异喹啉-3-羧酸; X13是具有疏水或芳族侧链的氨基酸; X14是具有疏水或芳族侧链的氨基酸; X15是苯丙氨酸或缺失; Z1是NH2或1〜10个氨基酸残基的序列; Z2为COOH或1〜10个氨基酸残基的序列; 以及作为片段和/或共价连接的寡聚体和/或衍生物,特别是酰胺化,烷基化,酰化,硫酸化,聚乙二醇化,磷酸化和/或糖基化衍生物及其突变体的片段和/或共价连接的肽,并且条件是(a)如果X12是丙氨酸 ,甘氨酸,谷氨酸或D-1,2,3,4-四氢异喹啉-3-羧酸分别为苯丙氨酸,缬氨酸和苯丙氨酸; 和/或(b)如果X12是苯丙氨酸,则X13,X14和X15分别是缬氨酸,苯丙氨酸和缺失; 和(c)肽中存在最多两个半胱氨酸残基。
    • 5. 发明申请
    • PEPTIDES AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS
    • 多肽及其用于治疗HIV感染的用途
    • WO2004056871A2
    • 2004-07-08
    • PCT/EP2003/014654
    • 2003-12-19
    • IPF PHARMACEUTICALSADERMANN, KnutKIRCHHOFF, FrankMÜNCH, JanSCHULZ, Axel
    • ADERMANN, KnutKIRCHHOFF, FrankMÜNCH, JanSCHULZ, Axel
    • C07K14/81
    • C07K7/08
    • The invention relates to peptides with biological activity against infection having the amino acid sequence Z 1 -LE-X 1 -IP-X 2 -X 3 -X 4 -P-X 5 -X 6 -X 7 -X 8 -X 9 -X 10 -K-X 11 -X 12 -X 13 -X 14 -X 15 -Z 2 , wherein X 1 is a lysine, alanine, or aspartic acid; X 2 is a cysteine, methionine or isoleucine; X 3 is a serine, cysteine, lysine or glycine; X 4 is an isoleucine, alanine, phenylalanine or cysteine; X 5 is a proline, D-proline or a substituted L-or D-proline; X 6 is a cysteine or glutamic acid; X 7 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X 8 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X 9 is an amino acid with an aromatic side chain; X 10 is a glycine, alanine or asparagine; X 11 is a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D-1,2, 3,4-tetrahydroisoquinoline-3-carboxylic acid; X 12 is a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X 13 is an amino acid with a hydrophobic or an aromatic side chain; X 14 is an amino acid with a hydrophobic or an aromatic side chain; X 15 is a phenylalanine or deletion; Z 1 is NH 2 or a sequence of 1 to 10 amino acid residues; Z 2 is COOH or a sequence of 1 to 10 amino acid residues; and peptides which are fragments and/or covalently linked oligomers and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof, and with the provisio that (a) if X 12 is alanine, glycine, glutamic acid, or D-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid than X 13, X 14 and X 15 are phenylalanine, valine and phenylalanine respectively; and/or (b) if X 12 is phenylalanine, than X 13 , X 14 and X 15 are valine, phenylalanine and a deletion, respectively; and (c) that there are at maximum two cysteine residues in a peptide.
    • 本发明涉及具有针对具有氨基酸序列Z 1 -LE-X 1 -IP-X 2 -X <子> 3 -X <子> 4 -PX <子> 5 -X <子> 6 -X <子 > 7 -X <子> 8 -X <子> 9 -X <子> 10 -KX <子> 11 -X <子 > 12 -X 13 -X 14 -X 15 -Z 2 -X 2,其中X 1,X 2, 1是赖氨酸,丙氨酸或天冬氨酸; X 2是半胱氨酸,甲硫氨酸或异亮氨酸; X 3是丝氨酸,半胱氨酸,赖氨酸或甘氨酸; X 4是异亮氨酸,丙氨酸,苯丙氨酸或半胱氨酸; X 5是脯氨酸,D-脯氨酸或取代的L-或D-脯氨酸; X 6是半胱氨酸或谷氨酸; X 7是具有疏水或芳香族侧链或半胱氨酸的氨基酸; X 8是具有疏水或芳香族侧链或半胱氨酸的氨基酸; X 9是具有芳族侧链的氨基酸; X 10是甘氨酸,丙氨酸或天冬酰胺; X 11是脯氨酸,天冬氨酸,八氢吲哚基-2-羧酸或D-1,2,3,4-四氢异喹啉-3-羧酸; X 12是苯丙氨酸,丙氨酸,甘氨酸,谷氨酸或D-1,2,3,4-四氢异喹啉-3-羧酸; X133是具有疏水或芳族侧链的氨基酸; X 14是具有疏水或芳族侧链的氨基酸; X155是苯丙氨酸或缺失; Z 1是NH 2或1到10个氨基酸残基的序列; Z 2是COOH或1到10个氨基酸残基的序列; 和特别是酰胺化,烷基化,酰化,硫酸化,聚乙二醇化,磷酸化和/或糖基化衍生物及其突变体的片段和/或共价连接的寡聚物和/或衍生物,并且条件是(a)如果X
    • 6. 发明申请
    • HINTERSITZ-LEHNE MIT EINEM MITTELARMLEHNENMODUL
    • 与中等ARMS模块后座椅靠背
    • WO2009036841A1
    • 2009-03-26
    • PCT/EP2008/006385
    • 2008-08-02
    • VOLKSWAGEN AKTIENGESELLSCHAFTSCHULZ, Axel
    • SCHULZ, Axel
    • B60N2/46B60N2/68
    • B60N2/68B60N2/015B60N2/36B60N2/78B60R5/006
    • Die Erfindung betrifft eine Hintersitz-Lehne (10), für eine Hintersitzanlage (100) in einem Kraftfahrzeug, in der ein Mittelarmlehnenmodul (30) anordbar ist, wobei die Hintersitz-Lehne (10) aus einem einteiligen oder mehrteiligen, gepolsterten Drahtrahmen (10A) ausgebildet ist, der/die zwischen einem Fahrzeuginnenraum und einem Gepäckraum rohbauseitig befestigt ist/sind. Es ist vorgesehen, dass ein Mittelarmlehnenmodul (30) anordbar ist, welches ebenfalls mindestens eine rohbauseitige Befestigung aufweist, wobei das Mittelarmlehnenmodul (30) in einteiliger Ausführung des gepolsterten Drahtrahmens (10A) in einem Freiraum zwischen zwei gepolsterten Bereichen der Hintersitz-Lehne (10), den Drahtrahmen (10A) überspannend oder nicht überspannend, oder in zweiteiliger Ausführung des gepolsterten Drahtrahmens (10A) in einem Freiraum zwischen zwei gepolsterten Bereichen der Hintersitz-Lehne (10) anordbar ist.
    • 本发明涉及的后座椅靠背(10),用于在机动车辆中的后座椅系统(100),其中一个中央扶手模块(30)可被布置,与所述后座椅靠背(10)由一单件或多件式衬垫线框的(10A) 是/形成被固定的车辆隔室和行李箱/是粗糙之间侧。 可以预期的是一个中央扶手模块(30)可以被布置,其中还具有至少一个粗糙侧固定,其中所述装置扶手在后座椅靠背两个填充区域之间的自由空间中的填塞线框架(10A)的单件式实施例中模块(30)(10) ,(10A)是所述线架(10A)跨越或后部座椅靠背(10)的2个填充区域之间不跨越,或在棉线框架的两件式实施例中的空间可被设置。
    • 8. 发明申请
    • OLIGOMERIC PEPTIDES AND THEIR USE FOR THE TREATMENT OF HIV INFECTIONS
    • 低分子蛋白及其用于治疗艾滋病毒感染的用途
    • WO2005123771A2
    • 2005-12-29
    • PCT/EP2005/052833
    • 2005-06-17
    • IPF PHARMACEUTICALS GMBHADERMANN, KnutKIRCHHOFF, FrankMÜNCH, JanSCHULZ, Axel
    • ADERMANN, KnutKIRCHHOFF, FrankMÜNCH, JanSCHULZ, Axel
    • C07K14/81
    • A61K38/16C07K14/8121
    • The invention relates to oligomeric peptides with biological activity against HIV infection having the amino acid sequence (Z 1 -LE - X 1 - IP - X 2 - X 3 -X 4 -P-X5-X 6 -X 7 -X 8 - X 9 -X 10 -K-X 11 -X 12 -X 13 -X 14 -X 15 -Z 2 ) n , wherein n indicates the number of monomeric peptide chains, whereby n is 2, 3 or 4; X 1 is a lysine, alanine, or aspartic acid; X 2 is a cysteine, methionine or isoleucine; X 3 is a serine, cysteine, lysine or glycine; X 4 is an isoleucine, alanine, phenylalanine or cysteine; X5 is a proline, D-proline or a substituted L-or D-proline; X 6 is a cysteine or glutamic acid; X 7 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X 8 is an amino acid with a hydrophobic or an aromatic side chain or cysteine; X g is an amino acid with an aromatic side chain; X1o is a glycine, alanine or asparagine; X11 is a proline, aspartic acid, octahydroindolyl-2-carboxylic acid or D­1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid; X 12 is a phenylalanine, alanine, glycine, glutamic acid or D-1,2,3,4­tetrahydroisoquinoline-3-carboxylic acid; X 13 is an amino acid with a hydrophobic or an aromatic side chain; X 14 is an amino acid with a hydrophobic or an aromatic side chain; X15 is a phenylalanine or deletion; Z 1 is NH 2 or a sequence of 1 to 10 amino acid residues; Z 2 is COOH or a sequence of 1 to 10 amino acid residues; and oligomeric peptides which are fragments thereof and/or derivatives, especially amidated, alkylated, acylated, sulfated, pegylated, phosphorylated and/or glycosylated derivatives, and mutants thereof; and with the proviso that (a) if X 12 is alanine, glycine, glutamic acid, or D-1,2,3,4­tetrahydroisoquinoline-3-carboxylic acid than X13, X14 and X 15 are phenylalanine, valine and phenylalanine respectively; and/or (b) if X 12 is phenylalanine, than X13, X14 and X 15 are valine, phenylalanine and a deletion, respectively; and (c) there are at maximum three cysteine residues in a peptide; and (d) the oligomeric peptide has not the sequence (LEAIPCSIPPEFLFGKPFVF) 2 (VIR-576); and (e) the monomeric peptide chains are not linked by peptide bonds between the N- terminus of one peptide chain to the C-terminus of another peptide chain.
    • 本发明涉及具有抗HIV感染的生物学活性的低聚肽,其具有氨基酸序列(Z1-X1→X4→P-X5-X6-X7-X8- X9-X10-K-X11-X12-X13-X14-X15-Z2)n,其中n表示单体肽链的数目,其中n为2,3或4; X1是赖氨酸,丙氨酸或天冬氨酸; X2是半胱氨酸,甲硫氨酸或异亮氨酸; X3是丝氨酸,半胱氨酸,赖氨酸或甘氨酸; X4是异亮氨酸,丙氨酸,苯丙氨酸或半胱氨酸; X5是脯氨酸,D-脯氨酸或取代的L-或D-脯氨酸; X6是半胱氨酸或谷氨酸; X7是具有疏水或芳族侧链或半胱氨酸的氨基酸; X8是具有疏水或芳族侧链或半胱氨酸的氨基酸; Xg是具有芳香侧链的氨基酸; X1o是甘氨酸,丙氨酸或天冬酰胺; X11是脯氨酸,天冬氨酸,八氢吲哚-2-羧酸或D1,2,3,4-四氢异喹啉-3-羧酸; X12是苯丙氨酸,丙氨酸,甘氨酸,谷氨酸或D-1,2,3,4四氢异喹啉-3-羧酸; X13是具有疏水或芳族侧链的氨基酸; X14是具有疏水或芳族侧链的氨基酸; X15是苯丙氨酸或缺失; Z1是NH2或1〜10个氨基酸残基的序列; Z2为COOH或1〜10个氨基酸残基的序列; 和作为其片段和/或衍生物,特别是酰胺化的烷基化,酰化,硫酸化,聚乙二醇化,磷酸化和/或糖基化衍生物的寡聚肽及其突变体; (a)如果X12是丙氨酸,则比X13,X14和X15分别是苯丙氨酸,缬氨酸和苯丙氨酸,甘氨酸,谷氨酸或D-1,2,3,4四氢异喹啉-3-羧酸; 和/或(b)如果X12是苯丙氨酸,则X13,X14和X15分别是缬氨酸,苯丙氨酸和缺失; 和(c)肽中最多有三个半胱氨酸残基; 和(d)寡聚肽不具有序列(LEAIPCSIPPEFLFGKPFVF)2(VIR-576); 和(e)单链肽链不通过一个肽链的N-末端与另一个肽链的C-末端之间的肽键连接。