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    • 3. 发明申请
    • GENETIC POLYMORPHISMS SENSITIVELY PREDICTING ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY
    • 遗传多态性敏感预测不良药物反应(ADR)和药物效能
    • WO2004018708A3
    • 2004-08-26
    • PCT/EP0308298
    • 2003-07-28
    • BAYER HEALTHCARE AGSCHWERS STEPHANKALLABIS HARALDREIFENBERGER ELKESTROPP UDOSCHMITZ GERD
    • SCHWERS STEPHANKALLABIS HARALDREIFENBERGER ELKESTROPP UDOSCHMITZ GERD
    • C12Q1/68
    • C12Q1/6883C12Q2600/156
    • The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising: SEQ ID 1-21 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence.
    • 本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒,包括确定人类受试者在他汀类药物治疗后是否有患上药物反应风险的抗体或人类受试者是高反应者还是低反应者 他汀类药物或代谢物。 本发明提供了进一步的诊断方法和试剂盒,包括确定人受试者是否处于心血管疾病风险的抗体。 本发明进一步涉及编码表型相关(PA)基因多肽的分离的多核苷酸,其用于鉴定治疗剂并可用于制备治疗心血管疾病或影响药物反应的药物的方法 所述多核苷酸选自如SEQ ID 1-21所示的组,其具有等位基因变异,如包含在功能性周围的序列部分中所示,如PA基因多肽的全长cDNA并具有或不具有PA基因启动子序列。
    • 4. 发明申请
    • GENETIC POLYMORPHISMS SENSITIVELY PREDICTING ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY
    • 遗传多态性对预后不良反应(ADR)和药物有效性的敏感性预测
    • WO2004018708A2
    • 2004-03-04
    • PCT/EP2003/008298
    • 2003-07-28
    • BAYER HEALTHCARE AGSCHWERS, StephanKALLABIS, HaraldREIFENBERGER, ElkeSTROPP, UdoSCHMITZ, Gerd
    • SCHWERS, StephanKALLABIS, HaraldREIFENBERGER, ElkeSTROPP, UdoSCHMITZ, Gerd
    • C12Q1/68
    • C12Q1/6883C12Q2600/156
    • The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising: SEQ ID 1-21 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence.
    • 本发明提供了诊断方法和试剂盒,包括寡核苷酸和/或多核苷酸或衍生物,还包括确定人受试者在他汀类药物治疗后是否有风险发生药物不良反应的抗体,或者人受试者是否 他汀类药物的高或低反应者或良好或不好的代谢者。 本发明提供了进一步的诊断方法和试剂盒,其包括确定人受试者是否有心血管疾病风险的抗体。 本发明还提供了多态性序列和其他基因。本发明进一步涉及编码表型相关(PA)基因多肽的分离的多核苷酸,其用于鉴定治疗剂并用于制备治疗心血管疾病或影响药物应答的药物的方法 ,所述多核苷酸选自包含具有等位基因变异的SEQ ID1-121,所述等位基因变异包含在功能性包含的序列部分中,如PA基因多肽的全长cDNA和有或没有PA基因启动子序列。