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1. 发明申请

WO2004018708A3 GENETIC POLYMORPHISMS SENSITIVELY PREDICTING ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY 审中-公开
标题翻译：遗传多态性敏感预测不良药物反应（ADR）和药物效能
公开(公告)号：WO2004018708A3
公开(公告)日：2004-08-26
申请号：PCT/EP0308298
申请日：2003-07-28
申请人： BAYER HEALTHCARE AG , SCHWERS STEPHAN , KALLABIS HARALD , REIFENBERGER ELKE , STROPP UDO , SCHMITZ GERD
发明人： SCHWERS STEPHAN , KALLABIS HARALD , REIFENBERGER ELKE , STROPP UDO , SCHMITZ GERD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.The present invention further relates to isolated polynucleotides encoding a phenotype associated (PA) gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease or influence drug response, the polynucleotide is selected from the group comprising: SEQ ID 1-21 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for PA gene polypeptide and with or without the PA gene promoter sequence.
摘要翻译：本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否有患上药物反应风险的抗体或人类受试者是高反应者还是低反应者他汀类药物或代谢物。本发明提供了进一步的诊断方法和试剂盒，包括确定人受试者是否处于心血管疾病风险的抗体。本发明进一步涉及编码表型相关（PA）基因多肽的分离的多核苷酸，其用于鉴定治疗剂并可用于制备治疗心血管疾病或影响药物反应的药物的方法所述多核苷酸选自如SEQ ID 1-21所示的组，其具有等位基因变异，如包含在功能性周围的序列部分中所示，如PA基因多肽的全长cDNA并具有或不具有PA基因启动子序列。

2. 发明申请

WO2004069867A3 GENETIC POLYMORPHISMS AS PREDICTIVE DIAGNOSTICS FOR ADVERSE DRUG REACTIONS (ADR) AND DRUG EFFICACY 审中-公开
标题翻译：作为不良药物反应（ADR）和药物效力的预测诊断的遗传多态性
公开(公告)号：WO2004069867A3
公开(公告)日：2005-03-24
申请号：PCT/EP2004000884
申请日：2004-01-31
申请人： BAYER HEALTHCARE AG , STROPP UDO , SCHWERS STEPHAN , KALLABIS HARALD , SCHMITZ GERD
发明人： STROPP UDO , SCHWERS STEPHAN , KALLABIS HARALD , SCHMITZ GERD
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/715 , C07K14/81 , C12Q1/68
CPC分类号： C07K14/4702 , A61K38/00 , C07K14/7156 , C07K14/8132 , C12Q1/6876 , C12Q2600/156
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy or whether the human subject is a high or low responder or a good a or bad metabolizer of statins. The invention provides further diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. Still further the invention provides polymorphic sequences and other genes.
摘要翻译：本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否有患上药物反应风险的抗体或人类受试者是高反应者还是低反应者他汀类药物或代谢物。本发明提供了进一步的诊断方法和试剂盒，包括确定人受试者是否处于心血管疾病风险的抗体。本发明还提供了多态序列和其他基因。

3. 发明申请

WO2007071382A3 METHOD FOR THE PREDICTION OF ADVERSE DRUG RESPONSES TO STATINS 审中-公开
标题翻译：预防不良药物应对统计的方法
公开(公告)号：WO2007071382A3
公开(公告)日：2007-10-11
申请号：PCT/EP2006012265
申请日：2006-12-19
申请人： BAYER HEALTHCARE AG , SCHWERS STEPHAN , STROPP UDO , KALLABIS HARALD , SCHUPPERT ANDREAS , BURGHAUS ROLF , VON TOERNE CHRISTIAN , SCHMITZ GERD
发明人： SCHWERS STEPHAN , STROPP UDO , KALLABIS HARALD , SCHUPPERT ANDREAS , BURGHAUS ROLF , VON TOERNE CHRISTIAN , SCHMITZ GERD
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/42 , C12Q1/50 , C12Q2600/106 , C12Q2600/156 , C12Q2600/172 , G01N33/92
摘要： The invention provides diagnostic methods and kits including oligo and/or polynucleotides or derivatives, including as well antibodies determining whether a human subject is at risk of getting adverse drug reaction after statin therapy. Still further the invention provides polymorphic sequences and other genes. The present invention further relates to isolated polynucleotides encoding a SADR gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat statin induced adverse drug reactions (SADR), the polynucleotide is selected from the group comprising: SEQ ID 1-35 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for SADR gene polypeptide and with or without the SADR gene promoter sequence.
摘要翻译：本发明提供了包括寡核苷酸和/或多核苷酸或衍生物的诊断方法和试剂盒，包括确定人类受试者在他汀类药物治疗后是否存在药物反应不利的风险的抗体。本发明还提供了多态序列和其他基因。本发明还涉及编码SADR基因多肽的分离的多核苷酸，其用于鉴定治疗剂并可用于制备治疗他汀类药物诱导的不良药物反应（SADR）的药物的方法中，所述多核苷酸选自SEQ ID No.1 -35具有等位基因变异，如包含在功能性周围的序列部分中所示，如SADR基因多肽的全长cDNA并具有或不具有SADR基因启动子序列。

4. 发明申请

WO03059946A2 GENETIC POLYMORPHISMS PREDICTING CARDIOVASCULAR DISEASE AND MEDICATION EFFICACY 审中-公开
标题翻译：遗传多态性预测心血管疾病和药物效能
公开(公告)号：WO03059946A2
公开(公告)日：2003-07-24
申请号：PCT/EP0300161
申请日：2003-01-10
申请人： BAYER AG , STROPP UDO , SCHWERS STEPHAN , KALLABIS HARALD , SCHMITZ GERD
发明人： STROPP UDO , SCHWERS STEPHAN , KALLABIS HARALD , SCHMITZ GERD
IPC分类号： A61K38/00 , A61K38/17 , C07K14/47 , C07K14/49 , C07K14/52 , C07K14/535 , C07K14/775 , C07K14/81 , C12Q1/68
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/4702 , C07K14/49 , C07K14/52 , C07K14/535 , C07K14/775 , C07K14/8132 , C12Q2600/156
摘要： The present invention relates to isolated polynucleotides encoding a cardiovascular associated CA gene polypeptide useful in methods to identify therapeutic agents and useful for preparation of a medicament to treat cardiovascular disease, the polynucleotide is selected from the group comprising:SEQ ID 1, 2, 3, 4, 5, 6 with allelic variation as indicated in the sequences section contained in a functional surrounding like full length cDNA for CA gene polypeptide and with or without the CA gene promoter sequence.The invention also provides diagnostic methods and kits including antibodies determining whether a human subject is at risk for a cardiovascular disease. The invention provides further polymorphic sequences and other genes.
摘要翻译：本发明涉及编码心血管相关CA基因多肽的分离的多核苷酸，其用于鉴定治疗剂并可用于制备治疗心血管疾病的药物的方法中，所述多核苷酸选自SEQ ID No.1,2,3， 4,5,6等位基因变异，如包含在功能性周围的序列部分中所示，如CA基因多肽的全长cDNA和具有或不具有CA基因启动子序列。本发明还提供诊断方法和试剂盒，其包括确定是否人类受试者面临心血管疾病的风险。本发明提供了更多的多态序列和其他基因。

5. 发明申请

WO2011006909A3 MARKER SEQUENCES FOR ADIPOSITY 审中-公开
标题翻译：标记序列肥胖及其用途
公开(公告)号：WO2011006909A3
公开(公告)日：2011-03-31
申请号：PCT/EP2010060090
申请日：2010-07-13
申请人： PROTAGEN AG , UNIVERSITAETSKLINIKUM REGENSBURG , SCHMITZ GERD , HANSEN JENS , BAESSLER ANDREA , FISCHER MARCUS , LUEKING ANGELIKA , KOWALD AXEL , MUELLNER STEFAN
发明人： SCHMITZ GERD , HANSEN JENS , BAESSLER ANDREA , FISCHER MARCUS , LUEKING ANGELIKA , KOWALD AXEL , MUELLNER STEFAN
IPC分类号： C12Q1/68 , G01N33/68
CPC分类号： C12Q1/6883 , C12Q2600/158 , G01N33/6893 , G01N2800/044 , G01N2800/50 , G01N2800/52 , G01N2800/60
摘要： The invention relates to novel marker sequences for adiposity (synonym: obesity (also: corpulence, excess overweight)) and the diagnostic use thereof and to a method for screening potential substances for adiposity using said marker sequences. The invention further relates to a diagnostic device containing such marker sequences for adiposity, especially a protein biochip and the use thereof.
摘要翻译：本发明涉及新的标记序列为肥胖（同义词：肥胖，英格兰肥胖（也:.肥胖症，严重肥胖，肥胖）），和它们的诊断应用，其中包括用于通过这些标记序列来筛选肥胖的潜在药物的方法。此外，本发明涉及含有用于治疗肥胖，例如标记序列的诊断装置，且特别是蛋白芯片及其用途。

6. 发明申请

WO0165257A3 METHOD FOR THE ANALYSIS OF EXOGENIC AND ENDOGENIC CELL ACTIVATION 审中-公开
标题翻译：法分析外源性和内源性细胞活化
公开(公告)号：WO0165257A3
公开(公告)日：2002-03-28
申请号：PCT/DE0100817
申请日：2001-03-05
申请人： SCHMITZ GERD , GOETZ ALEXANDRA
发明人： SCHMITZ GERD , GOETZ ALEXANDRA
IPC分类号： G01N33/542 , G01N33/566 , G01N33/569 , A61K31/00 , A61K38/00 , A61K39/00
CPC分类号： G01N33/566 , G01N33/542 , G01N33/56972 , G01N2400/50
摘要： The invention relates to a method for the analysis of exogenic and endogenic cell activation, comprising the measurement of the aggregation of receptors in a CD14-inclusive receptor cluster. The above is preferably achieved, by the measurement of the energy transfer between the individual receptors, whereby a measurement by means of fluorescence resonance energy transfer (FRET) is preferred. The invention further relates to a method for the diagnosis of systemic inflammations, such as sepsis, arteritis, or auto-immune disease states, or an arteriosclerotic or inflammatory disease of the coronary arteries (CAD such as angina pectoris, coronary infarct or coronary scleroses), or of the cerebral arteries (such as stroke), or a pre-cursor to one of these disease states, which is based on a measurement of the aggregation of receptors in a CD14-inclusive receptor cluster and, furthermore, the use of compounds which inhibit the clustering of CD14 for treatment of the above disease states.
摘要翻译：本发明涉及一种方法，用于分析外源性和内源性细胞的活化，包括在包含受体簇一个CD14受体组装的测量。优选地，这是通过测量所述个体的受体，由此通过荧光共振能量转移的装置（FRET）的测定是优选的之间的能量转移来完成。本发明还涉及一种方法，用于诊断全身性炎症例如脓毒症，动脉炎或自身免疫性疾病，或动脉硬化或冠状动脉（CAD，如心绞痛，心肌梗塞或Coronarsclerosen）或脑动脉（如中风）的炎性疾病或的前体的这些疾病，这是基于组装受体在CD14受体，包括簇，以及使用该防止CD14的聚类对这些疾病的治疗的化合物的测量值。

7. 发明申请

WO0170810A3 ATP BINDING CASSETTE TRANSPORTER 1 (ABC1) GENE POLYMORPHISMS AND USES THEREOF FOR THE DIAGNOSIS AND TREATMENT OF LIPID DISORDERS, CARDIOVASCULAR DISEASES AND INFLAMMATORY DISEASES 审中-公开
标题翻译： ATP BINDING CASSETTE TRANSPORTER 1（ABC1）基因多态性及其用于诊断和治疗脂肪障碍，心血管疾病和炎症性疾病的用途
公开(公告)号：WO0170810A3
公开(公告)日：2002-01-03
申请号：PCT/EP0102545
申请日：2001-03-07
申请人： BAYER AG , SCHMITZ GERD , BODZIOCH MAREK
发明人： SCHMITZ GERD , BODZIOCH MAREK
IPC分类号： A61K48/00 , C07K14/705 , C12N15/12 , C07K16/28 , C12N5/10 , C12N9/00 , C12N15/11 , C12Q1/68 , G01N33/53
CPC分类号： C07K14/705 , A61K48/00
摘要： The present invention provides four common polymorphisms in the gene encoding the ATP-binding cassette transporter-1 (ABC1), which are associated with decreased ApoA-I mediated efflux of cholesterol, the first step of reverse cholesterol transport. The provided data can be taken as evidence that common polymorphisms in ABC1 directly affect cellular lipid homeostasis, which is a key factor in the atherogenetic process. The frequencies of three of the common ABC1 variants are significantly increased in a population of men having low HDL-C levels and established CHD relative to CHD-free control subjects. The use of the provided ABC1 polymorphisms for the diagnosis and treatment of lipid disorders, cardiovascular diseases, and inflammatory diseases like psoriasis and lupus erythematodes is claimed.
摘要翻译：本发明在编码ATP结合盒转运蛋白-1（ABC1）的基因中提供四种常见的多态性，其与降低的ApoA-I介导的胆固醇流出相关，是逆向胆固醇转运的第一步。提供的数据可以作为ABC1中常见多态性直接影响细胞脂质体内平衡的证据，这是致动脉粥样化过程的关键因素。在HDL-C水平低的男性人群中，三种常见的ABC1变异体的频率显着增加，并且相对于无冠心病对照受试者而言确立CHD。要求使用所提供的ABC1多态性来诊断和治疗脂质疾病，心血管疾病和诸如牛皮癣和红斑狼疮的炎性疾病。

8. 发明申请

WO0018912A3 ATP BINDING CASSETTE GENES AND PROTEINS FOR DIAGNOSIS AND TREATMENT OF LIPID DISORDERS AND INFLAMMATORY DISEASES 审中-公开
标题翻译： ATP结合性卡斯特基因和蛋白质用于诊断和治疗脂质紊乱和炎性疾病
公开(公告)号：WO0018912A3
公开(公告)日：2000-08-17
申请号：PCT/EP9906991
申请日：1999-09-21
申请人： BAYER AG , SCHMITZ GERD , KLUCKEN JOCHEN
发明人： SCHMITZ GERD , KLUCKEN JOCHEN
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61K48/00 , A61P3/06 , A61P9/10 , A61P29/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/02 , C12Q1/68 , A61K38/17 , C07K16/28
CPC分类号： C07K14/705 , A61K38/00
摘要： Modulation of the activity of transmembrane proteins belonging to the ATP binding cassette (ABC) transporter protein family which are etiologically involved in cholesterol driven atherogenic processes and inflammatory diseases like psoriasis, lupus erythematodes and others provides therapeutic means to treat such diseases. Furthermore, detection of herein identified ABC transporter proteins of their respective biochemical activities involved in such atherogenic and inflammatory processes provides diagnostic means for clinical application of diagnosis and monitoring of dyslipidemias, atherosclerosis or inflammatory diseases like psoriasis and lupus erythematodes.
摘要翻译：属于ATP结合盒（ABC）转运蛋白家族的跨膜蛋白的活性的调节是病因学上涉及胆固醇驱动的致动脉粥样化过程和炎性疾病如牛皮癣，红斑狼疮等的治疗手段，用于治疗这些疾病。此外，本文鉴定的涉及这些致动脉粥样化和炎症过程的各自生物化学活性的本文鉴定的ABC转运蛋白为临床应用诊断和监测血脂异常，动脉粥样硬化或炎性疾病如牛皮癣和红斑狼疮提供了诊断手段。

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