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1. 发明申请

WO2012038943A1 MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：WO2012038943A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054228
申请日：2011-09-26
申请人： RANBAXY LABORATORIES LIMITED , KHERA, Manoj Kumar , SATTIGERI, Jitendra , YADAV, Neeraj Kumar , RAUF, Abdul Rehman Abdul , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
发明人： KHERA, Manoj Kumar , SATTIGERI, Jitendra , YADAV, Neeraj Kumar , RAUF, Abdul Rehman Abdul , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
IPC分类号： C07C309/60 , C07C321/28 , C07C333/08 , A61K31/192 , A61K31/325 , A61P11/00 , A61P19/02 , A61P35/00
CPC分类号： C07C317/46 , C07C323/52 , C07C323/60
摘要： The present invention relates to certain sulfone acetic acid derivatives of formula I as MMP inhibitor and processes for its syntheses. The invention also relates to pharmacological compositions containing the compounds of the present invention and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple scleorisis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of a matrix metalloproteinase using the compounds.
摘要翻译：本发明涉及作为MMP抑制剂的某些式I的砜乙酸衍生物及其合成方法。本发明还涉及含有本发明化合物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，银屑病，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化症，牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移以及其他以使用该化合物过度表达和过度激活基质金属蛋白酶为特征的炎症性疾病。

2. 发明申请

WO2010013222A1 PYRROLE CARBOXYLIC ACID DERIVATIVES AS ANTIBACTERIAL AGENTS 审中-公开
标题翻译：吡咯羧酸衍生物作为抗菌剂
公开(公告)号：WO2010013222A1
公开(公告)日：2010-02-04
申请号：PCT/IB2009053331
申请日：2009-07-30
申请人： RANBAXY LAB LTD , SHARMA LALIMA , SATTIGERI JITENDRA A , KUMAR NARESH , YADAV AJAY , MOMIN RIJWAN , AHMED SHAHADAT , CLIFFE IAN A , BHATNAGAR PRADIP KUMAR , KULKARNI RAKESH DINKAR , GHOSH SANJAY , RAJ V SAMUEL , UPADHYAY DILIP J
发明人： SHARMA LALIMA , SATTIGERI JITENDRA A , KUMAR NARESH , YADAV AJAY , MOMIN RIJWAN , AHMED SHAHADAT , CLIFFE IAN A , BHATNAGAR PRADIP KUMAR , GHOSH SANJAY , RAJ V SAMUEL , UPADHYAY DILIP J
IPC分类号： C07D401/14 , A61K31/403 , A61K31/431 , A61K31/454 , A61K31/506 , A61P31/04 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14
CPC分类号： C07D417/14 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14
摘要： The present invention provides DNA Gyrase and/or Topo IV inhibitors of formula I, which can be used as antibacterial agents. Compounds disclosed herein can be used for treating or preventing conditions caused by or contributed by gram positive, gram negative and anaerobic bacteria, more particularly against, for example, Staphylococci, Streptococci, Enterococci, Haemophilus, Pseudomonus spp., Acenetobacter spp., M?raxalla spp., Chlamydia spp., Mycoplasma spp., Legionella spp., Mycobacterium spp., Helicobacter, Clostridium spp., Bacteroides spp., Cot?ne bacterium, Bacillus spp., Enterobactericeae (E.coli, Klebsiella spp., Proteus spp.,etc. ) or any combination thereof Also provided, are processes for preparing compounds disclosed herein, pharmaceutical compositions containing compounds disclosed herein, and methods of treating bacterial infections.
摘要翻译：本发明提供了可用作抗菌剂的式I的DNA促旋酶和/或Topo IV抑制剂。本文公开的化合物可用于治疗或预防由革兰氏阳性，革兰氏阴性和厌氧细菌引起或贡献的病症，特别是针对例如葡萄球菌，链球菌，肠球菌，嗜血杆菌，假单胞菌属，醋酸杆菌属，拉氏酵母属，衣原体属，支原体属，军团菌属，分枝杆菌属，幽门螺杆菌属，梭菌属，拟杆菌属，梭菌属，芽孢杆菌属，肠杆菌属（E.coli，Klebsiella spp。，Proteus 物种等）或其任何组合。还提供了制备本文公开的化合物的方法，含有本文公开的化合物的药物组合物，以及治疗细菌感染的方法。

3. 发明申请

WO2007054790A1 PROCESS FOR PREPARATION OF (3R, 5R)-7-[2-(4-FLUOROPHENYL)-5-ISOPROPYL-3-PHENYL-4-[(4-HYDROXY METHYL PHENYL AMINO) CARBONYL]-PYRROL-1-YL]-3,5-DIHYDROXY-HEPTANOIC ACID HEMI CALCIUM SALT 审中-公开
标题翻译：（3R，5R）-7- [2-（4-氟苯基）-5-异丙基-3-苯基] -4 - [（4-羟基甲基苯胺基）羰基] - 吡咯-1-基] - 3,5-二羟基 - 庚二酸钠钙盐
公开(公告)号：WO2007054790A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/003153
申请日：2006-11-08
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, Anant , SETHI, Sachin , KISHORE, Kaushal
发明人： SATTIGERI, Jitendra, Anant , SETHI, Sachin , KISHORE, Kaushal
IPC分类号： C07D207/34
CPC分类号： C07D207/34 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/554 , A61K31/70 , A61K45/06 , C07D405/06 , A61K2300/00
摘要： The present invention relates to processes for the preparation of (3R, 5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-[(4-hydroxy methyl phenyl amino) carbonyl]-pyrrol-1-yl]-3,5-dihydroxy-heptanoic acid hemi calcium salt.
摘要翻译：本发明涉及制备（3R，5R）-7- [2-（4-氟苯基）-5-异丙基-3-苯基-4 - [（4-羟基甲基苯基氨基）羰基] - 吡咯 -1-基] -3,5-二羟基 - 庚酸半钙盐。

4. 发明申请

WO2007054789A1 PHARMACEUTICAL COMBINATION COMPRISING ATORVASTATIN DERIVATIVES 审中-公开
标题翻译：包含ATORVASTATIN衍生物的药物组合
公开(公告)号：WO2007054789A1
公开(公告)日：2007-05-18
申请号：PCT/IB2006/003152
申请日：2006-11-08
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra A. , BANSAL, Vinay S.
发明人： SATTIGERI, Jitendra A. , BANSAL, Vinay S.
IPC分类号： A61K31/4025 , A61K31/40
CPC分类号： C07D207/34 , A61K31/397 , A61K31/40 , A61K31/4025 , A61K31/44 , A61K31/4439 , A61K31/445 , A61K31/47 , A61K31/554 , A61K31/70 , A61K45/06 , C07D405/06 , A61K2300/00
摘要： This invention relates to a combination product or medicament comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixture thereof. Also provided herein are the pharmaceutical compositions comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixture thereof and optionally together with at least one pharmaceutically acceptable carrier, and methods for the treatment or prophylaxis of cardiovascular diseases, Alzheimer's disease, obesity, diabetes or inflammatory diseases comprising administering to a mammal in need thereof therapeutically effective amounts of combination pharmaceutical composition comprising at least one novel substituted pyrrole derivative and one or more dyslipidemic agents, antiobesity agents, antihyperglycaemic agents, anti-inflammatory agents or mixtures thereof.
摘要翻译：本发明涉及包含至少一种新的取代的吡咯衍生物和一种或多种血脂异常剂，抗肥胖剂，抗高血糖药，抗炎剂或其混合物的组合产品或药物。本文还提供了包含至少一种新的取代的吡咯衍生物和一种或多种血脂变剂，抗肥胖剂，抗高血糖药，抗炎剂或其混合物以及任选地与至少一种药学上可接受的载体的药物组合物，以及用于治疗或预防心血管疾病，阿尔茨海默氏病，肥胖症，糖尿病或炎性疾病，包括向有需要的哺乳动物施用治疗有效量的组合药物组合物，其包含至少一种新的取代的吡咯衍生物和一种或多种血脂异常剂，抗肥胖剂，抗高血糖药药剂，抗炎剂或其混合物。

5. 发明申请

WO2007029086A3 DERIVATIVES OF 3-AZABICYCLO[3.1.0]HEXANE AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS 审中-公开
标题翻译： 3-亚氨基半胱氨酸[3.1.0] HEXANE作为DIPEPTIDYL PEPTIDASE-IV抑制剂的衍生物
公开(公告)号：WO2007029086A3
公开(公告)日：2007-05-18
申请号：PCT/IB2006002419
申请日：2006-09-01
申请人： RANBAXY LAB LTD , SATTIGERI JITENDRA A , ANDAPPAN MURUGAIAH M S , KISHORE KAUSHAL , SETHI SACHIN , KANDALKAR SACHIN RAMESH , PAL CHANCHAL KUMAR , MAHAJAN DIPAK C , AHMED SHAHADAT , PARKALE SANTHOSH SADASHIV , SRINIVASAN T , SHARMA LALIMA , BANSAL VINAY S , CHUGH ANITA , DAVIS JOSEPH ALEXANAND
发明人： SATTIGERI JITENDRA A , ANDAPPAN MURUGAIAH M S , KISHORE KAUSHAL , SETHI SACHIN , KANDALKAR SACHIN RAMESH , PAL CHANCHAL KUMAR , MAHAJAN DIPAK C , AHMED SHAHADAT , PARKALE SANTHOSH SADASHIV , SRINIVASAN T , SHARMA LALIMA , BANSAL VINAY S , CHUGH ANITA , DAVIS JOSEPH ALEXANAND
IPC分类号： C07D209/52 , A61K31/439 , A61P3/00 , A61P5/00 , C07D403/12
CPC分类号： C07D403/12 , C07D209/52 , C07D401/14 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention relates to 3-azabicyclo[3.1.0] hexane derivatives of formula (I) as \ dipeptidyl peptidase-IV inhibitors and the processes for the synthesis of the said compounds. This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating diabetes, especially type 2 diabetes, as well as prediabetes, diabetic dyslipidemia, metabolic acidosis, ketosis, satiety disorders, and obesity. These inhibitors can also be used to treat conditions manifested by a variety of metabolic, neurological, anti-inflammatory, and autoimmune disorders like inflammatory disease, multiple sclerosis, rheumatoid arthritis; viral, cancer and gastrointestinal disorders. The compounds of this invention can also be used for treatment . of infertility arising due to polycystic ovary syndrome.
摘要翻译：本发明涉及作为\二肽基肽酶-IV抑制剂的式（I）的3-氮杂双环[3.1.0]己烷衍生物和合成所述化合物的方法。本发明还涉及含有本发明化合物的药物组合物，以及治疗糖尿病，特别是2型糖尿病以及糖尿病前期，糖尿病性血脂异常，代谢性酸中毒，酮症，饱腹感和肥胖症的方法。这些抑制剂也可用于治疗由各种代谢，神经，抗炎和自身免疫性疾病如炎症性疾病，多发性硬化症，类风湿性关节炎，病毒，癌症和胃肠道疾病。本发明的化合物也可用于治疗。由多囊卵巢综合症引起的不育症。

6. 发明申请

WO2004106299A3 SUBSTITUTED PYRROLE DERIVATIVES AND THEIR USE AS HMG-CO INHIBITORS 审中-公开
公开(公告)号：WO2004106299A3
公开(公告)日：2004-12-09
申请号：PCT/IB2004/001761
申请日：2004-05-28
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , SATTIGERI, Jitendra , KUMAR, Yatendra , ARYAN, Ram, Chander , RAMANATHAN, Vikram, Krishna , CHUGH, Anita
发明人： SALMAN, Mohammad , SATTIGERI, Jitendra , KUMAR, Yatendra , ARYAN, Ram, Chander , RAMANATHAN, Vikram, Krishna , CHUGH, Anita
IPC分类号： C07D405/06
摘要： The present invention relates to substituted pyrrole derivatives of formula I, which can be used as 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors. Compounds disclosed herein can function as cholesterol lowering agents and can be used for the treatment of cholesterol-related diseases and related symptoms. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and methods of treating cholesterol-related diseases and related symptoms. Its pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, metabolites, polymorphs, tautomers, racemates, pure enantiomers, diastereoisomers or N-oxides wherein Formula (II).

7. 发明申请

WO2003008391A1 AZOLE COMPOUNDS AS ANTI-FUNGAL AGENTS 审中-公开
标题翻译：化合物作为抗真菌剂
公开(公告)号：WO2003008391A1
公开(公告)日：2003-01-30
申请号：PCT/IB2002/002662
申请日：2002-07-08
申请人： RANBAXY LABORATORIES LIMITED , SALMAN, Mohammad , KATOCH, Rita , VERMA, Ashwani, Kumar , SATTIGERI, Jitendra , RATTAN, Ashok
发明人： SALMAN, Mohammad , KATOCH, Rita , VERMA, Ashwani, Kumar , SATTIGERI, Jitendra , RATTAN, Ashok
IPC分类号： C07D249/12
CPC分类号： C07D231/12 , C07D233/56 , C07D249/08 , C07D249/12
摘要： The present invention relates to the derivatives of specially substituted azole compounds which have improved antifungal activity as compared with presently available agents in this class and the processes for the preparation thereof. This invention also relates to pharmaceutical preparations containing the compounds of the present invention and their use in treating and/or preventing the fungal infections in mammals, preferably humans.
摘要翻译：本发明涉及特定取代的唑类化合物的衍生物，其与本类目前可得的试剂相比具有改善的抗真菌活性及其制备方法。本发明还涉及含有本发明化合物的药物制剂及其用于治疗和/或预防哺乳动物，优选人类的真菌感染的用途。

8. 发明申请

WO2012038944A1 MATRIX METALLOPROTEINASE INHIBITORS 审中-公开
标题翻译：基质金属蛋白酶抑制剂
公开(公告)号：WO2012038944A1
公开(公告)日：2012-03-29
申请号：PCT/IB2011/054229
申请日：2011-09-26
申请人： RANBAXY LABORATORIES LIMITED , KHERA, Manoj Kumar , PALLE, Venkata P. , SATTIGERI, Viswajanani , SATTIGERI, Jitendra , SONI, Ajay , RAUF, Abdul Rehman Abdul , SIVAKUMAR, R. , REDDY, Ranadheer R. , MUSIB, Arpita , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
发明人： KHERA, Manoj Kumar , PALLE, Venkata P. , SATTIGERI, Viswajanani , SATTIGERI, Jitendra , SONI, Ajay , RAUF, Abdul Rehman Abdul , SIVAKUMAR, R. , REDDY, Ranadheer R. , MUSIB, Arpita , CLIFFE, Ian A. , BHATNAGAR, Pradip Kumar , RAY, Abhijit , SRIVASTAVA, Punit , DASTIDAR, Sunanda Ghosh
IPC分类号： C07D209/48 , C07D253/04 , C07D401/12 , C07C271/28 , A61K31/27 , A61K31/4035 , A61K31/53 , A61P11/00 , A61P19/02 , A61P35/00
CPC分类号： C07D253/04 , C07C271/28 , C07D209/48 , C07D401/12
摘要： The present invention relates to methyl sulfonamides and N-formamides derivatives of formula (I) and to processes for their syntheses. The invention also relates to pharmacological compositions containing these derivatives and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatie arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation which leads to restenosis and ischemic heart failure, stroke, renal disease, tumor metastasis, and other inflammatory disorders characterized by over expression and over activation of an matrix metalloproteinase using the compounds.
摘要翻译：本发明涉及式（I）的甲基磺酰胺和N-甲酰胺衍生物及其合成方法。本发明还涉及含有这些衍生物的药物组合物和治疗哮喘，类风湿性关节炎，COPD，鼻炎，骨关节炎，银屑病关节炎，牛皮癣，肺纤维化，肺部炎症，急性呼吸窘迫综合征，牙周炎，多发性硬化，牙龈炎，动脉粥样硬化，干眼症，新生内膜增生，其导致再狭窄和缺血性心力衰竭，中风，肾脏疾病，肿瘤转移和其他以使用该化合物过度表达和过度活化基质金属蛋白酶为特征的炎症性疾病。

9. 发明申请

WO2008035315A3 INHIBITORS OF PHOSPHODIESTERASE TYPE-IV 审中-公开
标题翻译：磷酸酯酶类型IV的抑制剂
公开(公告)号：WO2008035315A3
公开(公告)日：2008-12-04
申请号：PCT/IB2007053854
申请日：2007-09-22
申请人： RANBAXY LAB LTD , RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , RAY ABHIJIT , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA
发明人： RUDRA SONALI , GUPTA NIDHI , BAREGAMA LALIT KUMAR , AGARWAL RITU , KHAIRNAR VINAYAK VASANTRAO , CHAKLADAR SASWATI , RAMAIAH MANDADAPU RAGHU , MUTHUKAMAL NAGARAJAN , BALACHANDRAN SARLA , RAMNANI SARIKA , PALLE VENKATA P , DASTIDAR SUNANDA G , RAY ABHIJIT , VIJAYKRISHNAN LALITHA , SATTIGERI JITENDRA
IPC分类号： C07D261/04 , A61K31/41 , A61P29/00 , C07D261/20 , C07D498/10
CPC分类号： C07D498/10 , C07D261/04 , C07D261/20
摘要： The present invention relates to catechol derivatives of formula (I), which can be used as inhibitors of phosphodiesterase (PDPI) type 4 or type 7, Compounds disclosed herein can be useful in the treatment of CNS disorders, inflammatory diseases such as, AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases especially in humans. Processes for the preparation of disclosed compounds are provided, as well as pharmaceutical compositions containing the disclosed compounds, and their use as phosphodiesterase (PDE) type 4 or type 7 inhibitors.
摘要翻译：本发明涉及式（I）的儿茶酚衍生物，其可用作4型或7型磷酸二酯酶（PDPI）的抑制剂。本文公开的化合物可用于治疗CNS疾病，炎性疾病如AIDS，哮喘，关节炎，支气管炎，慢性阻塞性肺疾病（COPD），牛皮癣，过敏性鼻炎，休克，特应性皮炎，克罗恩病，成人呼吸窘迫综合征（ARDS），嗜酸性肉芽肿，过敏性结膜炎，骨关节炎，溃疡性结肠炎等炎症性疾病在人类提供了制备所公开化合物的方法，以及含有所公开化合物的药物组合物及其作为4型或7型抑制剂的磷酸二酯酶（PDE）的用途。

10. 发明申请

WO2006117743A1 SUBSTITUTED AROMATIC COMPOUNDS AS ANTIDIABETIC AGENTS 审中-公开
标题翻译：取代的芳族化合物作为抗菌剂
公开(公告)号：WO2006117743A1
公开(公告)日：2006-11-09
申请号：PCT/IB2006/051346
申请日：2006-04-28
申请人： RANBAXY LABORATORIES LIMITED , SATTIGERI, Jitendra, A. , KUNDU, Mrinalkanti , SHARMA, Lalima , GUPTA, Priya , KANDALKAR, Sachin, Ramesh , THANGATHIRUPATHY, Srinivasan
发明人： SATTIGERI, Jitendra, A. , KUNDU, Mrinalkanti , SHARMA, Lalima , GUPTA, Priya , KANDALKAR, Sachin, Ramesh , THANGATHIRUPATHY, Srinivasan
IPC分类号： C07D213/30 , C07D263/58 , C07D277/82 , C07D213/74 , C07D265/36 , C07D239/90 , C07D279/16 , A61K31/41 , A61K31/435 , A61K31/495 , A61K31/535 , A61P3/10
CPC分类号： C07D213/30 , C07D213/74 , C07D239/90 , C07D263/58 , C07D265/36 , C07D277/82 , C07D279/16
摘要： The present invention relates to substituted aromatic compounds, which have PPAR modulating activity, and hence can be used as anti-diabetic agents. Compounds described herein can be used as peroxisome proliferation activated receptor (PPAR) modulators. Such compounds can also be used as therapeutic agents for treating diseases and conditions mediated through any of the isoforms of PPAR, diabetes and diabetes-associated complications, diseases or conditions in which insulin resistance is the central pathophysiological mechanism and diseases or conditions such as Type II diabetes, dyslipidaemia, hypertension, coronary heart disease, cardiovascular disease, atherosclerosis, nephrosclerosis, polycystic ovarian syndrome, eating disorders, diabetes nephropathy, glomerulonephritis, glomerularsclerosis, nephrotic syndrome, psoriasis or obesity. Processes for the preparation of the described compounds, pharmaceutical compositions containing such compounds, and methods for treating diabetes mellitus and diseases and conditions mediated through insulin resistance are also provided.
摘要翻译：本发明涉及具有PPAR调节活性的取代芳族化合物，因此可用作抗糖尿病药。本文所述的化合物可用作过氧化物酶体增殖激活受体（PPAR）调节剂。这些化合物也可用作治疗通过PPAR，糖尿病和糖尿病相关并发症的任何一种介导的疾病和病症的治疗剂，其中胰岛素抵抗是中枢病理生理学机制和疾病或病症如II型糖尿病，血脂异常，高血压，冠心病，心血管疾病，动脉粥样硬化，肾硬化，多囊卵巢综合征，进食障碍，糖尿病肾病，肾小球性肾炎，肾小球硬化症，肾病综合征，银屑病或肥胖症。还提供了制备所述化合物的方法，含有这些化合物的药物组合物，以及治疗糖尿病的方法以及通过胰岛素抵抗介导的疾病和病症。

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