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1. 发明申请

WO2006040128B1 PVA HYDROGEL 审中-公开
公开(公告)号：WO2006040128B1
公开(公告)日：2006-06-01
申请号：PCT/EP2005010931
申请日：2005-10-11
申请人： ZIMMER GMBH , MURATOGLU ORTHUN K , SPIEGELBERG STEPHEN H , RUBERTI JEFFREY W , ABT NIELS A
发明人： MURATOGLU ORTHUN K , SPIEGELBERG STEPHEN H , RUBERTI JEFFREY W , ABT NIELS A
IPC分类号： C08J3/28 , C08L29/04
CPC分类号： C08J3/28 , C08J2329/04 , Y10S524/916
摘要： The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.
摘要翻译：本发明提供了制备具有有利物理性能的共价交联乙烯基聚合物水凝胶的方法，以及通过这些方法制备的共价交联乙烯基聚合物水凝胶组合物，以及包含这种共价交联乙烯基聚合物水凝胶组合物的制品。所产生的水凝胶的物理性质可以通过改变控制参数来调节，例如物理缔合的比例，聚合物的浓度和施加的辐射量。这种共价交联的乙烯基聚合物水凝胶可根据加工条件制成半透明的，优选透明的或不透明的。所制备的乙烯基聚合物水凝胶的物理性质的稳定性可以通过控制共价交联的量来增强。

2. 发明申请

WO2005017000A1 SYSTEMS AND METHODS FOR CONTROLLING AND FORMING POLYMER GELS 审中-公开
标题翻译：用于控制和形成聚合物凝胶的系统和方法
公开(公告)号：WO2005017000A1
公开(公告)日：2005-02-24
申请号：PCT/US2004/003135
申请日：2004-02-04
申请人： CAMBRIDGE POLYMER GROUP , RUBERTI, Jeffrey, W. , BRAITHWAITE, Gavin, J., C.
发明人： RUBERTI, Jeffrey, W. , BRAITHWAITE, Gavin, J., C.
IPC分类号： C08J3/075
CPC分类号： C08J3/075 , A61L15/60 , A61L27/52 , C08J2329/04 , C08J2331/04 , C08J2339/06
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hyrodgel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including components that form the vinyl polymer hydrogel and a dispenser.
摘要翻译：在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。根据优选实施方案，制备乙烯基聚合物凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。另一方面，本发明提供了用于修复椎间盘或关节连接的试剂盒，其包括形成乙烯基聚合物水凝胶的组分和分配器。

3. 发明申请

WO2002074195A2 SYSTEM AND METHODS FOR REDUCING INTERFACIAL POROSITY IN CEMENTS 审中-公开
标题翻译：用于减少化学物质界面孔隙度的系统和方法
公开(公告)号：WO2002074195A2
公开(公告)日：2002-09-26
申请号：PCT/US2002/008466
申请日：2002-03-19
申请人： CAMBRIDGE POLYMER GROUP INC. , SPIEGELBERG, Stephen, H. , RUBERTI, jEFFREY, w. , BRAITHWAITE, Gavin, G., C.
发明人： SPIEGELBERG, Stephen, H. , RUBERTI, jEFFREY, w. , BRAITHWAITE, Gavin, G., C.
IPC分类号： A61F
CPC分类号： A61B17/8802 , A61B2017/8844 , A61F2/30767 , A61F2/30771 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/389 , A61F2/4607 , A61F2002/30011 , A61F2002/30041 , A61F2002/30112 , A61F2002/30136 , A61F2002/30138 , A61F2002/30172 , A61F2002/30828 , A61F2002/30838 , A61F2002/30848 , A61F2002/30879 , A61F2002/30892 , A61F2002/3611 , A61F2002/3625 , A61F2002/4623 , A61F2002/4631 , A61F2002/4632 , A61F2002/4651 , A61F2002/4654 , A61F2002/4662 , A61F2002/4668 , A61F2002/4672 , A61F2002/4681 , A61F2002/469 , A61F2002/4697 , A61F2230/0004 , A61F2230/0017 , A61F2230/0052 , A61F2250/0023 , A61F2310/00011 , A61F2310/00952 , A61N7/00
摘要： The present invention provides a system and a method for reducing pores, or air pockets, that form at the interface between the material used to attach or adhere the surface of a component, such as a prosthesis, to a site. A preferred embodiment of the invention includes an actuator that controls a coupler which transmits energy to a prosthesis being inserted into a material to reduce porosity at an interface between the prosthesis and the material. The system of the present invention can include an oscillating hand-held device that vibrates the stem component of an orthopedic prosthesis at a particular frequency and amplitude. The device is typically held by the hand of the surgeon, who guides the vibrating prosthesis into the cement-filled medullary cavity.
摘要翻译：本发明提供一种用于减少在用于将诸如假体的部件的表面附接或粘附到部位的材料之间的界面处形成的孔或气囊的系统和方法。本发明的优选实施例包括致动器，该致动器控制耦合器，该耦合器将能量传递到被插入到材料中的假体，以减少假体和材料之间的界面处的孔隙率。本发明的系统可以包括以特定频率和振幅振动矫形假体的茎部分的振动手持装置。该装置通常由外科医生的手握住，外科医生将该振动假体引导到填充有水泥的髓腔中。

4. 发明申请

WO2005080477A3 SYSTEMS AND METHODS FOR CONTROLLING AND FORMING POLYMER GELS 审中-公开
标题翻译：用于控制和形成聚合物凝胶的系统和方法
公开(公告)号：WO2005080477A3
公开(公告)日：2005-11-10
申请号：PCT/US2005004773
申请日：2005-02-04
申请人： CAMBRIDGE POLYMER GROUP INC , RUBERTI JEFFREY W , BRAITHWAITE GAVIN J C
发明人： RUBERTI JEFFREY W , BRAITHWAITE GAVIN J C
IPC分类号： A61L15/60 , A61L27/16 , A61L27/26 , A61L27/52 , C08J3/075 , C08F283/01
CPC分类号： A61L27/26 , A61L27/16 , A61L27/52 , C08J3/075 , C08J2329/04 , C08L29/04 , C08L71/02
摘要： In preferred embodiments, the present invention provides methods of controllably making a vinyl polymer hydrogel having desired physical properties without chemical cross links or radiation. The gelation process is modulated by controlling, for example, the temperature of a resultant vinyl polymer mixture having a gellant or using active ingredients provided in an inactive gellant complex. In accordance with a preferred embodiment, the method of manufacturing a vinyl polymer hydrogel includes the steps of providing a vinyl polymer solution comprising a vinyl polymer dissolved in a first solvent; heating the vinyl polymer solution to a temperature elevated above the melting point of the physical associations of the vinyl polymer, mixing the vinyl polymer solution with a gellant, wherein the resulting mixture has a higher Flory interaction parameter than the vinyl polymer solution; inducing gelation of the mixture of vinyl polymer solution and gellant; and controlling the gelation rate to form a viscoelastic solution, wherein workability is maintained for a predetermined period, thereby making a vinyl polymer hydrogel having the desired physical property. In further preferred embodiments, the present invention provides physically crosslinked hydrogels produced by controlled gelation of viscoelastic solution wherein workability is maintained for a predetermined period. In another aspect, the present invention provides kits for use in repairing intervertebral disks or articulated joints including a dispenser and single use containers housing components that form the vinyl polymer hydrogel.
摘要翻译：在优选的实施方案中，本发明提供了可控地制备具有所需物理性质而没有化学交联或辐射的乙烯基聚合物水凝胶的方法。通过控制例如具有胶凝剂的所得乙烯基聚合物混合物的温度或使用在非活性胶凝剂络合物中提供的活性成分来调节凝胶化过程。根据优选实施方案，制备乙烯基聚合物水凝胶的方法包括以下步骤：提供包含溶解在第一溶剂中的乙烯基聚合物的乙烯基聚合物溶液; 将乙烯基聚合物溶液加热到高于乙烯基聚合物的物理缔合的熔点的温度，将乙烯基聚合物溶液与胶凝剂混合，其中所得混合物具有比乙烯基聚合物溶液更高的Flory相互作用参数; 引起乙烯基聚合物溶液和胶凝剂混合物的凝胶化; 并控制凝胶化速率以形成粘弹性溶液，其中可加工性保持预定时间，从而制备具有所需物理性能的乙烯基聚合物水凝胶。在进一步优选的实施方案中，本发明提供通过粘弹性溶液的受控凝胶化产生的物理交联水凝胶，其中可操作性保持预定时间。在另一方面，本发明提供了用于修复椎间盘或关节连接的套件，其包括分配器和容纳形成乙烯基聚合物水凝胶的部件的单用容器。

5. 发明申请

WO2004050134A3 LAYERED ALIGNED POLYMER STRUCTURES AND METHODS OF MAKING SAME 审中-公开
标题翻译：层状排列的聚合物结构体及其制备方法
公开(公告)号：WO2004050134A3
公开(公告)日：2004-12-09
申请号：PCT/US0338087
申请日：2003-11-26
申请人： CAMBRIDGE POLYMER GROUP , BRAITHWAITE GAVIN J C , RUBERTI JEFFREY W
发明人： BRAITHWAITE GAVIN J C , RUBERTI JEFFREY W
IPC分类号： A61L27/24 , A61L27/38 , A61L27/50 , B29C41/04 , B29C41/22 , B29C41/36 , B29C41/52 , B29C47/00 , B29C67/00 , B29C67/24 , C08L89/06 , D01D5/38 , D01F4/00
CPC分类号： A61L27/3813 , A61L27/24 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3804 , A61L27/3808 , A61L27/3843 , A61L27/50 , A61L2400/18 , B29C41/045 , B29C41/22 , B29C41/36 , B29C41/52 , B29C47/0004 , B29C47/0014 , B29C67/0003 , B29C67/24 , B29C2037/90 , B29K2089/00 , B29K2995/005 , C08L89/06 , D01D5/18 , D01D5/38 , D01F4/00
摘要： This invention includes a method of producing a nanostructured artificial template comprising one or more thin, oriented layers of polymer material. The material is preferably produced by the method of introducing a shearing flow in a predominantly monomeric solution of the self-assembling polymer sub-units to the free surface of a substrate and inducing polymerization or growth of the monomer while in this shearing flow. The rate of flow of the material from the delivery system and the relative velocity between the deposition surface and the material as it is delivered to the surface are controlled to properly orient the material at the desired thickness. These rates can be adjusted to vary the properties of the film in a controlled manner. The nanostructured artificial template is useful for inducing the production of a templated extracellular matrix by a population of cells. The invention further includes a method of remodeling collagen constructs by alternating application of proteases and collagen monomers while the construct is stressed.
摘要翻译：本发明包括生产纳米结构人造模板的方法，所述纳米结构人造模板包含一个或多个聚合物材料的薄取向层。该材料优选通过在自组装聚合物亚单元的主要单体溶液中向基材的自由表面引入剪切流并在该剪切流中引发单体的聚合或生长的方法来生产。控制来自输送系统的材料的流动速率以及沉积表面与材料被输送到表面之间的相对速度，以便将材料适当地定向在期望的厚度。可以调节这些速率以便以受控的方式改变膜的性质。纳米结构人造模板可用于诱导细胞群体产生模板化细胞外基质。本发明进一步包括通过交替施用蛋白酶和胶原单体来重建胶原构建体的方法，同时构建体被加压。

6. 发明申请

WO02074195A3 SYSTEM AND METHODS FOR REDUCING INTERFACIAL POROSITY IN CEMENTS 审中-公开
标题翻译：用于减少化学物质界面孔隙度的系统和方法
公开(公告)号：WO02074195A3
公开(公告)日：2003-07-24
申请号：PCT/US0208466
申请日：2002-03-19
申请人： CAMBRIDGE POLYMER GROUP INC , SPIEGELBERG STEPHEN H , RUBERTI JEFFREY W , BRAITHWAITE GAVIN J C
发明人： SPIEGELBERG STEPHEN H , RUBERTI JEFFREY W , BRAITHWAITE GAVIN J C
IPC分类号： A61F2/00 , A61F2/30 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/38 , A61F2/46 , A61N7/00
CPC分类号： A61B17/8802 , A61B2017/8844 , A61F2/30767 , A61F2/30771 , A61F2/32 , A61F2/34 , A61F2/36 , A61F2/3662 , A61F2/389 , A61F2/4607 , A61F2002/30011 , A61F2002/30041 , A61F2002/30112 , A61F2002/30136 , A61F2002/30138 , A61F2002/30172 , A61F2002/30828 , A61F2002/30838 , A61F2002/30848 , A61F2002/30879 , A61F2002/30892 , A61F2002/3611 , A61F2002/3625 , A61F2002/4623 , A61F2002/4631 , A61F2002/4632 , A61F2002/4651 , A61F2002/4654 , A61F2002/4662 , A61F2002/4668 , A61F2002/4672 , A61F2002/4681 , A61F2002/469 , A61F2002/4697 , A61F2230/0004 , A61F2230/0017 , A61F2230/0052 , A61F2250/0023 , A61F2310/00011 , A61F2310/00952 , A61N7/00
摘要： The present invention provides a system and a method for reducing pores, or air pockets, that form at the interface between the material used to attach or adhere the surface of a component, such as a prosthesis, to a site. A preferred embodiment of the invention includes an actuator that controls a coupler which transmits energy to a prosthesis being inserted into a material to reduce porosity at an interface between the prosthesis and the material. The system of the present invention can include an oscillating hand-held device that vibrates the stem component of an orthopedic prosthesis at a particular frequency and amplitude. The device is typically held by the hand of the surgeon, who guides the vibrating prosthesis into the cement-filled medullary cavity.
摘要翻译：本发明提供一种用于减少在用于将诸如假体的部件的表面附接或粘附到部位的材料之间的界面处形成的孔或气囊的系统和方法。本发明的优选实施例包括致动器，该致动器控制耦合器，该耦合器将能量传递到被插入到材料中的假体，以减少假体和材料之间的界面处的孔隙率。本发明的系统可以包括以特定频率和振幅振动矫形假体的茎部分的振动手持装置。该装置通常由外科医生的手握住，外科医生将该振动假体引导到填充有水泥的髓腔中。

7. 发明申请

WO2012078769A1 MICROVASCULAR ANASTOMOTIC COUPLER AND METHODS OF USING THE SAME 审中-公开
标题翻译：微血管分析仪及其使用方法
公开(公告)号：WO2012078769A1
公开(公告)日：2012-06-14
申请号：PCT/US2011/063759
申请日：2011-12-07
申请人： NORTHEASTERN UNIVERSITY , RUBERTI, Jeffrey, W. , SCHECTER, David , COTE, Nicholas , MYERS, Ryan , PATEL, Jessica , OUELLETTE, Matthew , GUO, Lifei
发明人： RUBERTI, Jeffrey, W. , SCHECTER, David , COTE, Nicholas , MYERS, Ryan , PATEL, Jessica , OUELLETTE, Matthew , GUO, Lifei
IPC分类号： A61B17/11
CPC分类号： A61B17/11 , A61B2017/00004 , A61B2017/1107 , A61B2017/1132 , A61F2/064 , A61F2/07 , A61F2/915 , A61F2/962 , A61F2210/0004 , B29C70/688
摘要： Disclosed herein are devices and methods for fast and simple generation of an anastomosis. In certain embodiments, the devices and methods involve the deployment of self- expanding stents without the use of a catheter. The devices and methods disclosed herein further utilize a sheath that allows an operator to deploy the stent without the use of an inter-lumen device.
摘要翻译：本文公开了用于快速和简单地产生吻合的装置和方法。在某些实施方案中，所述装置和方法涉及在不使用导管的情况下部署自扩张支架。本文公开的装置和方法进一步利用允许操作者在不使用管腔内装置的情况下部署支架的护套。

8. 发明申请

WO2010124010A1 MICROPARTICLE ORGANIZATION 审中-公开
标题翻译：微生物组织
公开(公告)号：WO2010124010A1
公开(公告)日：2010-10-28
申请号：PCT/US2010/031922
申请日：2010-04-21
申请人： NORTHEASTERN UNIVERSITY , RUBERTI, Jeffrey, W. , SAEIDI, Nima
发明人： RUBERTI, Jeffrey, W. , SAEIDI, Nima
IPC分类号： C07K14/00 , B82B3/00
CPC分类号： C01B31/0253 , B82B3/00 , B82Y30/00 , B82Y40/00 , C01B32/168 , C01B2202/02 , C01B2202/06 , C07K14/75
摘要： Methods and compositions are described for organizing nanoparticles or microparticles into nanostructures or microstructures using collagen as a template.
摘要翻译：描述了使用胶原作为模板将纳米颗粒或微粒组织成纳米结构或微结构的方法和组合物。

9. 发明申请

WO2009126958A1 COLLAGEN FIBRILLAR CONSTRUCTION 审中-公开
标题翻译：胶原纤维结构
公开(公告)号：WO2009126958A1
公开(公告)日：2009-10-15
申请号：PCT/US2009/040364
申请日：2009-04-13
申请人： NORTHEASTERN UNIVERSITY , SAEIDI, Nima , RUBERTI, Jeffrey, W.
发明人： SAEIDI, Nima , RUBERTI, Jeffrey, W.
IPC分类号： C08H1/06 , C08L89/06
CPC分类号： C07K14/78 , C08H1/06 , C08L89/06
摘要： Methods and compositions are described for organizing collagen into fibrillar networks, e.g, short and long-range organization. Collagen produced by the disclosed methods can be used for tissue engineering.
摘要翻译：描述了用于将胶原蛋白组织成纤维网络的方法和组合物，例如短距离和远程组织。通过公开的方法生产的胶原蛋白可用于组织工程。

10. 发明申请

WO2007038601A9 NANOLOOM FOR CONTROLLING POLYMER ASSEMBLY 审中-公开
标题翻译：用于控制聚合物组件的纳米胶
公开(公告)号：WO2007038601A9
公开(公告)日：2007-10-04
申请号：PCT/US2006037681
申请日：2006-09-27
申请人： UNIV NORTHEASTERN , RUBERTI JEFFREY W , KOWALSKI GREGORY J , BURKEY DANIEL
发明人： RUBERTI JEFFREY W , KOWALSKI GREGORY J , BURKEY DANIEL
IPC分类号： B05C7/06
CPC分类号： A61L33/00 , B82Y30/00 , C08L89/06
摘要： Systems, devices, and methods are provided for assembling polymer-forming molecular components such that highly-structured arrays of polymer strands, such as collagen fibrils, are formed without the need for cells. A polymer nanoloom is designed to control the self-assembly of monomers into fibrils and related tissue constructs including ligament, tendon, cartilage, and bone. A nanoloom system comprises a polymer printhead, a temperature controller, and a movable substrate for polymer printing. A polymer printhead contains one or more nanoreactors that can control the assembly of collagen fibrils or other polymers on a nanoscale. Methods are provided for temperature-driven, enzyme-driven, and cholesteric assembly of collagen or other polymers into two- or three-dimensional tissue constructs.
摘要翻译：提供了用于组装聚合物形成分子组分的系统，装置和方法，使得形成高度结构化的聚合物链的阵列，例如胶原纤维，而不需要细胞。聚合物纳米结构设计用于控制单体自身装配成原纤维和相关组织构造，包括韧带，腱，软骨和骨。纳米液体系统包括聚合物打印头，温度控制器和用于聚合物印刷的可移动基底。聚合物打印头包含一个或多个可以控制胶原原纤维或其它聚合物在纳米级上的装配的纳米反应器。提供了将温度驱动，酶驱动和胶原蛋白或其它聚合物胆固醇装配成二维或三维组织构建体的方法。

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