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1. 发明申请

WO2003012405A3 ASPECTS OF BASIC OCT ENGINE TECHNOLOGIES FOR HIGH SPEED OPTICAL COHERENCE TOMOGRAPHY AND LIGHT SOURCE AND OTHER IMPROVEMENTS IN OCT 审中-公开
公开(公告)号：WO2003012405A3
公开(公告)日：2003-02-13
申请号：PCT/US2002/024880
申请日：2002-08-05
申请人： ROLLINS, Andrew, M. , IZATT, Joseph, A. , WESTPHAL, Volker , YAZDANFAR, Siavash
发明人： ROLLINS, Andrew, M. , IZATT, Joseph, A. , WESTPHAL, Volker , YAZDANFAR, Siavash
IPC分类号： G01N21/17
摘要： An optical coherence tomography (OCT) system including an interferometer (108;110;110') provides illuminating light along a first optical path (104;120;204;204') to a sample(102) and an optical delay line (D) and collects light from the sample (102) along a second optical path (106,106a; 128a, 128b,128c, 206;206') remitted at several scattering angles to a detector (P). In one embodiment, illuminating light is directed along a number of incident light paths (154a,154b,154c) through a focusing lens (158) to a sample (102). The light paths (154a,154b,154c) and focusing lens (158) are related to the sample (102) and to both the incident light source (101) and the detector (P). In another embodiment, a focusing system (252,262) directs light to a location in the sample (102). A transmission grating (256) or acousto-optic modulator (256'directs light from the sample (102) at an angle representative of the wavelengthof the incident light on the transmission grating (256) or acousto-optic modulator (256').

2. 发明申请

WO2003012405A2 ASPECTS OF BASIC OCT ENTINE TECHNOLOGIES FOR HIGH SPEED OPTICAL COHERENCE TOMOGRAPHY AND LIGHT SOURCE AND OTHER IMPROVEMENTS IN OPTICAL COHERENCE TOMOGRAPHYEAL 审中-公开
标题翻译：基础OCT系统技术在高速光学相干光学和光源技术中的应用及光学相干光子学中的其他改进
公开(公告)号：WO2003012405A2
公开(公告)日：2003-02-13
申请号：PCT/US2002/024880
申请日：2002-08-05
申请人： ROLLINS, Andrew, M. , IZATT, Joseph, A. , WESTPHAL, Volker , YAZDANFAR, Siavash
发明人： ROLLINS, Andrew, M. , IZATT, Joseph, A. , WESTPHAL, Volker , YAZDANFAR, Siavash
IPC分类号： G01N21/17
CPC分类号： G01N21/4795 , A61B5/0066 , G01B11/2441
摘要： An optical coherence tomography (OCT) system including an interferometer (108;110;110') provides illuminating light along a first optical path (104;120;204;204') to a sample(102) and an optical delay line (D) and collects light from the sample (102) along a second optical path (106,106a; 128a, 128b,128c, 206;206') remitted at several scattering angles to a detector (P). In one embodiment, illuminating light is directed along a number of incident light paths (154a,154b,154c) through a focusing lens (158) to a sample (102). The light paths (154a,154b,154c) and focusing lens (158) are related to the sample (102) and to both the incident light source (101) and the detector (P). In another embodiment, a focusing system (252,262) directs light to a location in the sample (102). A transmission grating (256) or acousto-optic modulator (256'directs light from the sample (102) at an angle representative of the wavelengthof the incident light on the transmission grating (256) or acousto-optic modulator (256').
摘要翻译：包括干涉仪（108; 110; 110'）的光学相干断层摄影（OCT）系统将沿着第一光路（104; 120; 204; 204'）的照明光提供给样本（102）和光学延迟线并且沿着以几个散射角度被送达到检测器（P）的第二光路（106,106a; 128a，128b，128c，206; 206'）从样品（102）收集光。在一个实施例中，照明光沿着多个入射光路（154a，154b，154c）通过聚焦透镜（158）引导到样品（102）。光路（154a，154b，154c）和聚焦透镜（158）与样品（102）和入射光源（101）和检测器（P）两者相关。在另一个实施例中，聚焦系统（252,262）将光引导到样品（102）中的位置。透射光栅（256）或声光调制器（256'）以表示透射光栅（256）或声光调制器（256'）上的入射光的波长的角度定向来自样品（102）的光。

3. 发明申请

WO2002071042A2 FREQUENCY-ENCODED PARALLEL OCT AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：频率编码的并行OCT和相关系统和方法
公开(公告)号：WO2002071042A2
公开(公告)日：2002-09-12
申请号：PCT/US2002/002532
申请日：2002-01-29
申请人： IZATT, Joseph, A. , ROLLINS, Andrew, M.
发明人： IZATT, Joseph, A. , ROLLINS, Andrew, M.
IPC分类号： G01N21/47
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02007 , G01B9/0201 , G01B9/02028 , G01B9/02091 , G01B2290/35 , G01B2290/40 , G01N21/4795
摘要： Methods and apparatus for performing optical coherence-domain reflectometry (OCDR) and optical coherence tomography (OCT) include techniques for increasing the number of depths of a sample that can be scanned simultaneously; these techniques relax or eliminate pathlength scanning requirements of the delay line. Depth encoding and differentiating/separating of depth-related data is accomplished using several frequency-encoding approaches, such as multiple-pathlength delay line that imposes a different frequency shift one each different pathlength or delay by employing a rotating reflective cylinder, stretching a fiber optic member, tilting a mirror to impose a linear phase ramp on the spectrum of the light wave, operating an accousto-optic beam deflector. Use of Mach-Zehnder interferometers and cascades of Mach-Zehnder interferometers with respective path lengths between its two arms to obtain frequency encoding for OCDR and OCT.
摘要翻译：用于执行光学相干域反射测量（OCDR）和光学相干断层扫描（OCT）的方法和装置包括用于增加可同时扫描的样品的深度数量的技术; 这些技术放松或消除延迟线的光程长度扫描要求。深度编码和深度相关数据的微分/分离使用几种频率编码方法来实现，诸如通过采用旋转反射圆柱体来施加每个不同的光程长度或延迟的不同频移的多路径长度延迟线，成员，倾斜镜子以在光波的光谱上施加线性相位斜坡，操作声光束偏转器。使用Mach-Zehnder干涉仪和Mach-Zehnder干涉仪级联，其两个臂之间具有相应的路径长度，以获得OCDR和OCT的频率编码。

4. 发明申请

WO2003011764A3 REAL-TIME IMAGING SYSTEM AND METHOD 审中-公开
公开(公告)号：WO2003011764A3
公开(公告)日：2003-02-13
申请号：PCT/US2002/024721
申请日：2002-08-05
申请人： WESTPHAL, Volker , ROLLINS, Andrew, M , UNG-ARUNYAWEE, Rujchai , IZATT, Joseph, A
发明人： WESTPHAL, Volker , ROLLINS, Andrew, M , UNG-ARUNYAWEE, Rujchai , IZATT, Joseph, A
IPC分类号： A61B5/00
摘要： Software techniques that are used for real-time imaging in OCT (Optical coherence tomography), particularly for correcting geometric and angular image distortions. In addition, a methodology for quantitative image correction in OCT images includes procedures for correction of non-telocentric scan patterns, as well as a novel approach for refraction correction in layered media based on Fermat's principle.

5. 发明申请

WO03011764A2 REAL-TIME IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：实时成像系统和方法
公开(公告)号：WO03011764A2
公开(公告)日：2003-02-13
申请号：PCT/US0224721
申请日：2002-08-05
申请人： WESTPHAL VOLKER , ROLLINS ANDREW M , UNG-ARUNYAWEE RUJCHAI , IZATT JOSEPH A
发明人： WESTPHAL VOLKER , ROLLINS ANDREW M , UNG-ARUNYAWEE RUJCHAI , IZATT JOSEPH A
IPC分类号： A61B3/10 , A61B3/107 , A61B3/12 , A61B5/00 , A61B5/103 , G01B9/02 , G01N21/47 , C01N
CPC分类号： A61B5/6852 , A61B3/1005 , A61B3/102 , A61B3/107 , A61B3/12 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/441 , A61B5/7257 , A61B5/726 , G01B9/02002 , G01B9/02045 , G01B9/02069 , G01B9/02083 , G01B9/02087 , G01B9/02091 , G01B2290/65 , G01N21/4795
摘要： Software techniques that are used for real-time imaging in OCT (Optical coherence tomography), particularly for correcting geometric and angular image distortions. In addition, a methodology for quantitative image correction in OCT images includes procedures for correction of non-telocentric scan patterns, as well as a novel approach for refraction correction in layered media based on Fermat's principle.
摘要翻译：用于OCT（光学相干层析成像）实时成像的软件技术，特别是用于校正几何和角度图像失真的软件技术。此外，OCT图像中的定量图像校正方法包括校正非端粒中心扫描图案的程序，以及基于费马原理的分层介质中折射校正的新方法。

6. 发明申请

WO02071042A3 FREQUENCY-ENCODED PARALLEL OCT AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：频率编码的并行OCT及相关系统和方法
公开(公告)号：WO02071042A3
公开(公告)日：2002-11-07
申请号：PCT/US0202532
申请日：2002-01-29
申请人： IZATT JOSEPH A , ROLLINS ANDREW M
发明人： IZATT JOSEPH A , ROLLINS ANDREW M
IPC分类号： A61B5/00 , G01B9/02 , G01N21/47 , G01B11/24
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02007 , G01B9/0201 , G01B9/02028 , G01B9/02091 , G01B2290/35 , G01B2290/40 , G01N21/4795
摘要： Methods and apparatus for performing optical coherence-domain reflectometry (OCDR) and optical coherence tomography (OCT) include techniques for increasing the number of depths of a sample that can be scanned simultaneously; these techniques relax or eliminate pathlength scanning requirements of the delay line. Depth encoding and differentiating/separating of depth-related data is accomplished using several frequency-encoding approaches, such as multiple-pathlength delay line that imposes a different frequency shift one each different pathlength or delay by employing a rotating reflective cylinder, stretching a fiber optic member, tilting a mirror to impose a linear phase ramp on the spectrum of the light wave, operating an accousto-optic beam deflector. Use of Mach-Zehnder interferometers and cascades of Mach-Zehnder interferometers with respective path lengths between its two arms to obtain frequency encoding for OCDR and OCT.
摘要翻译：用于执行光学相干域反射（OCDR）和光学相干断层扫描（OCT）的方法和设备包括用于增加可以同时扫描的样本的深度数量的技术; 这些技术放宽或消除延迟线的路径长度扫描要求。深度相关数据的深度编码和区分/分离是使用几种频率编码方法完成的，例如通过采用旋转反射柱体对每个不同路径长度或延迟施加不同频移的多路径长度延迟线，拉伸光纤成员，倾斜一面镜子，对光波谱施加一个线性相位斜坡，操作一个声光束偏转器。使用Mach-Zehnder干涉仪和Mach-Zehnder干涉仪的级联，其两臂之间的路径长度分别为OCDR和OCT获得频率编码。

7. 发明申请

WO02075242A2 METHOD AND APPARATUS FOR POLARIZATION-SENSITIVE OPTICAL COHERENCE TOMOGRAPHY 审中-公开
标题翻译：用于偏振敏感光学相干测量的方法和装置
公开(公告)号：WO02075242A2
公开(公告)日：2002-09-26
申请号：PCT/US0202065
申请日：2002-01-22
申请人： ROTH JONATHAN E , IZATT JOSEPH A , ROLLINS ANDREW M
发明人： ROTH JONATHAN E , IZATT JOSEPH A , ROLLINS ANDREW M
IPC分类号： A61B5/00 , G01B9/02 , G01B9/04 , G01N21/47
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02011 , G01B9/02072 , G01B9/02091 , G01B9/04 , G01B2290/70 , G01N21/4795 , Y10T29/49716
摘要： A method and apparatus for extracting the vector optical properties of biological samples with micron-scale resolution in three dimensions, using polarization-sensitive optical coherence tomography (PS-OCT). The method measures net retardance, net fast axis, and reflexivity. Polarization sensing is accomplished by illuminating the sample with at least three separate polarization states, using consecutive acquisitions of the same pixel, A-scan, or B-scan. The method can be implemented using non-polarization-maintaining fiber and a single detector. This PS-OCT method reported measures fast axis explicitly. In a calibration test of the system, net retardance was measured with an average error of 7.5 DEG (standard deviation 2.2 DEG ) over the retardance range 0 DEG to 180 DEG , and fast axis with average error of 4.8 DEG over the range 0 DEG to 180 DEG .
摘要翻译：一种使用偏振光敏光学相干断层扫描（PS-OCT）三维提取微尺度分辨率的生物样品的矢量光学性质的方法和装置。该方法测量净延迟，净快轴和反射率。通过使用相同像素，A扫描或B扫描的连续采集，以至少三个单独的极化状态照射样本来实现极化感测。该方法可以使用非偏振保持光纤和单个检测器来实现。这种PS-OCT方法报道了快轴测量。在系统的校准测试中，在0°至180°的延迟范围内，平均误差为7.5°（标准偏差2.2°），平均误差为4.8°，在0°至 180度。

8. 发明申请

WO03011764A9 REAL-TIME IMAGING SYSTEM AND METHOD 审中-公开
标题翻译：实时成像系统及方法
公开(公告)号：WO03011764A9
公开(公告)日：2004-04-01
申请号：PCT/US0224721
申请日：2002-08-05
申请人： WESTPHAL VOLKER , ROLLINS ANDREW M , UNG-ARUNYAWEE RUJCHAI , IZATT JOSEPH A
发明人： WESTPHAL VOLKER , ROLLINS ANDREW M , UNG-ARUNYAWEE RUJCHAI , IZATT JOSEPH A
IPC分类号： A61B3/10 , A61B3/107 , A61B3/12 , A61B5/00 , A61B5/103 , G01B9/02 , G01N21/47
CPC分类号： A61B5/6852 , A61B3/1005 , A61B3/102 , A61B3/107 , A61B3/12 , A61B5/0059 , A61B5/0064 , A61B5/0066 , A61B5/441 , A61B5/7257 , A61B5/726 , G01B9/02002 , G01B9/02045 , G01B9/02069 , G01B9/02083 , G01B9/02087 , G01B9/02091 , G01B2290/65 , G01N21/4795
摘要： Software techniques that are used for real-time imaging in OCT (Optical coherence tomography), particularly for correcting geometric and angular image distortions. In addition, a methodology for quantitative image correction in OCT images includes procedures for correction of non-telocentric scan patterns, as well as a novel approach for refraction correction in layered media based on Fermat's principle.
摘要翻译：用于OCT（光学相干断层扫描）中的实时成像的软件技术，特别是用于校正几何和角度图像失真。此外，OCT图像中定量图像校正的方法包括校正非中心扫描图案的方法，以及基于费马原理的分层介质中的折射校正的新颖方法。

9. 发明申请

WO2012061697A1 DEVICE AND METHOD FOR DETERMINING THE PRESENCE OF MIDDLE EAR FLUID 审中-公开
标题翻译：用于确定中耳流体存在的装置和方法
公开(公告)号：WO2012061697A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059311
申请日：2011-11-04
申请人： THE CLEVELAND CLINIC FOUNDATION , SETH, Rahul , FORD, Matthew, R. , ROLLINS, Andrew, M. , KRAKOVITZ, Paul, R.
发明人： SETH, Rahul , FORD, Matthew, R. , ROLLINS, Andrew, M. , KRAKOVITZ, Paul, R.
IPC分类号： A61B1/267
CPC分类号： A61B1/227 , A61B1/063 , A61B1/0638 , A61B1/0684 , A61B5/0075 , A61B5/0084 , A61B5/12 , A61B5/6817
摘要： A device for determining the presence of abnormal fluid in a middle ear of a subject includes an elongated probe, a first light source housed within the elongated probe, and a second light source housed within the elongated probe. The elongated probe includes a distal end for inspection of an ear. The First light source is configured to convey an optical beam through a tympanic membrane associated with the middle ear of the subject, without puncturing the tympanic membrane. The second light source is configured to convey light through the distal end of the elongated probe and illuminate the tympanic membrane.
摘要翻译：用于确定受试者中耳中异常流体的存在的装置包括细长探针，容纳在细长探针内的第一光源和容纳在细长探针内的第二光源。细长的探针包括用于检查耳朵的远端。第一光源构造成将光束传送通过与受试者的中耳相关联的鼓膜，而不刺穿鼓膜。第二光源构造成将光通过细长探针的远端传送并照亮鼓膜。

10. 发明申请

WO02071042B1 FREQUENCY-ENCODED PARALLEL OCT AND ASSOCIATED SYSTEMS AND METHODS 审中-公开
标题翻译：频率编码的并行OCT和相关系统和方法
公开(公告)号：WO02071042B1
公开(公告)日：2003-07-24
申请号：PCT/US0202532
申请日：2002-01-29
申请人： IZATT JOSEPH A , ROLLINS ANDREW M
发明人： IZATT JOSEPH A , ROLLINS ANDREW M
IPC分类号： A61B5/00 , G01B9/02 , G01N21/47 , G01B11/24
CPC分类号： A61B5/0066 , A61B5/0073 , G01B9/02002 , G01B9/02007 , G01B9/0201 , G01B9/02028 , G01B9/02091 , G01B2290/35 , G01B2290/40 , G01N21/4795
摘要： Methods and apparatus for performing optical coherence-domain reflectometry (OCDR) and optical coherence tomography (OCT) include techniques for increasing the number of depths of a sample that can be scanned simultaneously; these techniques relax or eliminate pathlength scanning requirements of the delay line. Depth encoding and differentiating/separating of depth-related data is accomplished using several frequency-encoding approaches, such as multiple-pathlength delay line that imposes a different frequency shift one each different pathlength or delay by employing a rotating reflective cylinder, stretching a fiber optic member, tilting a mirror to impose a linear phase ramp on the spectrum of the light wave, operating an accousto-optic beam deflector. Use of Mach-Zehnder interferometers and cascades of Mach-Zehnder interferometers with respective path lengths between its two arms to obtain frequency encoding for OCDR and OCT.
摘要翻译：用于执行光学相干域反射测量（OCDR）和光学相干断层扫描（OCT）的方法和装置包括用于增加可同时扫描的样品的深度数量的技术; 这些技术放松或消除延迟线的光程长度扫描要求。深度编码和深度相关数据的微分/分离使用几种频率编码方法来实现，诸如通过采用旋转反射圆柱体来施加每个不同的光程长度或延迟的不同频移的多路径长度延迟线，成员，倾斜镜子以在光波的光谱上施加线性相位斜坡，操作声光束偏转器。使用Mach-Zehnder干涉仪和Mach-Zehnder干涉仪级联，其两个臂之间具有相应的路径长度，以获得OCDR和OCT的频率编码。

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