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1. 发明申请

WO2005025586B1 CYTOKINE MODULATORS AND RELATED METHOD OF USE 审中-公开
标题翻译：细胞因子调节剂及其相关使用方法
公开(公告)号：WO2005025586B1
公开(公告)日：2005-05-06
申请号：PCT/IB2004051742
申请日：2004-09-10
申请人： ACCESS BUSINESS GROUP INT LLC , RANDOLPH RUSSELL K , ROH-SCHMIDT HAERI
发明人： RANDOLPH RUSSELL K , ROH-SCHMIDT HAERI
IPC分类号： A61K31/05 , A61K31/122 , A61K36/07 , A61K36/185 , A61K36/28 , A61K36/30 , A61K36/324 , A61K36/45 , A61K36/53 , A61K36/61 , A61K36/63 , A61K36/738 , A61K36/74 , A61K36/82 , A61K36/87 , A61K36/906 , A61P37/00 , A61K35/78
CPC分类号： A61K36/87 , A61K31/05 , A61K31/122 , A61K36/07 , A61K36/185 , A61K36/28 , A61K36/30 , A61K36/324 , A61K36/45 , A61K36/53 , A61K36/61 , A61K36/63 , A61K36/738 , A61K36/74 , A61K36/82 , A61K36/906 , Y10S514/885 , A61K2300/00
摘要： A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin. Based on the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and/or inflammatory response, and subsequently treat, diseases and/or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis, osteoporosis and Alzheimer's disease.
摘要翻译：用于调节细胞因子以调节炎症或免疫调节反应的组合物。组合物可以包括玫瑰果，蓝莓，黑莓，接骨木，蔓越莓，迷迭香，丁香，发烧，荨麻根，朝鲜蓟，芦苇蘑菇，橄榄提取物，绿茶提取物，葡萄籽提取物，白藜芦醇，Aframomum melegueta，boswellia serrata中的至少一种提取物，富马酸，异丙酚，生育三烯酚，月见草油，INM-176，琉璃苣油，磷虾油，至少一种类型的叶黄素（例如虾青素），生咖啡提取物和阿魏酸。具体地说，本发明的组合物可以包括：玫瑰果和黑莓，蓝莓，接骨木和任选的磷虾油中的至少一种; 或玫瑰果，白藜芦醇和Aframomum melegueta和虾青素中的至少一种。基于组合物的细胞因子调节和细胞因子反应抑制，其可用于调节免疫调节和/或炎症反应，并且随后治疗与炎症反应相关的疾病和/或异常状况，例如心血管疾病，关节炎，骨质疏松症和阿尔茨海默病。

2. 发明申请

WO2004014298B1 COMPOSITION AND METHOD FOR LOWERING CHOLESTEROL 审中-公开
标题翻译：用于降低胆固醇的组合物和方法
公开(公告)号：WO2004014298B1
公开(公告)日：2004-08-26
申请号：PCT/US0323885
申请日：2003-07-31
申请人： ACCESS BUSINESS GROUP INT LLC , BROVELLI ERNESTO A , VALLEJOS JULIO ANDRES , ROH-SCHMIDT HAERI
发明人： BROVELLI ERNESTO A , VALLEJOS JULIO ANDRES , ROH-SCHMIDT HAERI
IPC分类号： A23L2/38 , A23F3/14 , A23L1/30 , A61K20060101 , A61K36/18 , A61K36/54 , A61P3/06 , A61P9/10 , A61K35/78
CPC分类号： A61K36/54 , A23F3/14 , A23L33/105
摘要： The present invention relates to a composition comprising Persea american var. drymifolia for lowering cholesterol levels.
摘要翻译：本发明涉及包含Persea american var。 drymifolia用于降低胆固醇水平。

3. 发明申请

WO2003063806A1 TOPICAL ANTI-INFLAMMATORY COMPOSITIONS AND METHODS OF REDUCING INFLAMMATION 审中-公开
标题翻译：局部抗炎组合物和减少炎症的方法
公开(公告)号：WO2003063806A1
公开(公告)日：2003-08-07
申请号：PCT/US2003/002767
申请日：2003-01-30
申请人： ALTICOR INC. , MAYNE, James, R. , ROH-SCHMIDT, Haeri
发明人： MAYNE, James, R. , ROH-SCHMIDT, Haeri
IPC分类号： A61K7/00
CPC分类号： A61Q19/00 , A61K8/63 , A61K8/97 , A61K36/484 , A61K36/55 , A61K2800/75 , A61K2300/00
摘要： Topical anti-inflammatory compositions are described that include effective amounts of a linseed extract and a licorice extract. In addition, methods of reducing inflammation are described, which include applying topically to a site of inflammation an effective amount of a composition comprising a linseed extract and a licorice extract.
摘要翻译：描述了局部抗炎组合物，其包括有效量的亚麻子提取物和甘草提取物。此外，描述了减少炎症的方法，其包括将局部施用于炎症部位的有效量的包含亚麻子提取物和甘草提取物的组合物。

4. 发明申请

WO2008051594A3 ANTI-RESORPTIVE AND BONE BUILDING DIETARY SUPPLEMENTS AND METHODS OF USE 审中-公开
标题翻译：抗消化和骨建筑饮食补充剂和使用方法
公开(公告)号：WO2008051594A3
公开(公告)日：2008-10-09
申请号：PCT/US2007022619
申请日：2007-10-24
申请人： KREMPIN DAVID W , MURRAY MARY A , LIN YUMEI , GELLENBECK KEVIN W , DA COSTA SILVIA R , WILKINS LEON M , ROH-SCHMIDT HAERI , RANA JATINDER , REBHUN JOHN F , FAST DAVID J
发明人： KREMPIN DAVID W , MURRAY MARY A , LIN YUMEI , GELLENBECK KEVIN W , DA COSTA SILVIA R , WILKINS LEON M , ROH-SCHMIDT HAERI , RANA JATINDER , REBHUN JOHN F , FAST DAVID J
IPC分类号： A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/87 , A61P19/00 , A61P19/10
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，降低或预防骨吸收，增加骨强度，改善骨结构和改善骨结构的膳食补充剂组合物和方法，其包含第一组合物，其包含槲皮素，地黄。，熟地黄sp。根，西伯利亚人参，槐花，甘草和伊普黄酮，其中第一种组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 和第二组合物，其包含石榴提取物与西伯利亚人参，银杏，绿茶，槐花，熟地，葡萄籽，冬，和依普黄酮中的至少一种的组合，其中第二组合物的组合抑制 RANK-L的表达。

5. 发明申请

WO2005027716A3 PROGRAM FOR REGULATING HEALTH CONDITIONS 审中-公开
标题翻译：规范健康条件的计划
公开(公告)号：WO2005027716A3
公开(公告)日：2006-06-22
申请号：PCT/US2004029629
申请日：2004-09-10
申请人： ACCESS BUSINESS GROUP INT LLC , INTERLEUKIN GENETICS INC , KREMPIN DAVID W , KORNMAN KENNETH S , RANDOLPH RUSSELL K , ROH-SCHMIDT HAERI
发明人： KREMPIN DAVID W , KORNMAN KENNETH S , RANDOLPH RUSSELL K , ROH-SCHMIDT HAERI
IPC分类号： C12Q1/68 , A61B20060101 , B01D57/02 , G01N33/00 , G06F19/00
CPC分类号： G06Q50/24 , G16H10/20 , G16H50/70 , Y02A90/22 , Y02A90/26
摘要： A program for regulating a health condition. The program includes one or more assessments including a genetic test, biomarker test, and lifestyle assessment; a personalized intervention; and a follow up test for monitoring a subject's health condition.
摘要翻译：调节健康状况的方案。该计划包括一项或多项评估，包括基因测试，生物标志物测试和生活方式评估; 个性化干预; 以及用于监测受试者健康状况的随访测试。

6. 发明申请

WO2005047548A1 METHODS AND KITS FOR REDUCING CELLULAR DAMAGE, INHIBITING FREE RADICAL PRODUCTION, AND SCAVENGING FREE RADICALS IN MAMMALS 审中-公开
标题翻译：用于减少细胞损伤，抑制自由放射生产的方法和工具，以及在哺乳动物中自由放射自由基
公开(公告)号：WO2005047548A1
公开(公告)日：2005-05-26
申请号：PCT/US2004/037362
申请日：2004-11-10
申请人： ACCESS BUSINESS GROUP INTERNATIONAL LLC , AMC CANCER RESEARCH , EVANS, Gregory, S. , GROCHOSKI, Gregory , RANDOLPH, Keith , CONNOR, Lynne, Marie , SCIMECA, John, V. , GELLENBECK, Kevin, W. , MAYNE, James, R. , ROH-SCHMIDT, Haeri , SLAGA, Thomas, J. , HANAUSEK-WALASZEK, Margaret , WALASZEK, Zbigniew
发明人： EVANS, Gregory, S. , GROCHOSKI, Gregory , RANDOLPH, Keith , CONNOR, Lynne, Marie , SCIMECA, John, V. , GELLENBECK, Kevin, W. , MAYNE, James, R. , ROH-SCHMIDT, Haeri , SLAGA, Thomas, J. , HANAUSEK-WALASZEK, Margaret , WALASZEK, Zbigniew
IPC分类号： C12Q1/68
CPC分类号： A61K45/06 , A61K31/015 , A61K31/22 , A61K31/355 , A61K31/375 , A61K36/35 , A61K36/736 , A61K36/82 , A61K36/87 , A61K2300/00
摘要： Methods of reducing cellular damage are described that include (a) administering to the mammal an oral dosage form comprising a therapeutically effective amount of a first antioxidant, and (b) administering to the mammal a topical dosage form comprising a therapeutically effective amount of a second antioxidant, wherein at least one of the first antioxidant and the second antioxidant comprises acerola concentrate. Methods of inhibiting free radical production, methods of scavenging free radicals, and kits for reducing cellular damage are also described.
摘要翻译：描述了减少细胞损伤的方法，其包括（a）向哺乳动物施用包含治疗有效量的第一抗氧化剂的口服剂型，和（b）向哺乳动物施用包含治疗有效量的第二抗体的局部剂型抗氧化剂，其中所述第一抗氧化剂和所述第二抗氧化剂中的至少一种包含精粉。还描述了抑制自由基产生的方法，清除自由基的方法和用于减少细胞损伤的试剂盒。

7. 发明申请

WO2008051586A3 ANTI-RESORPTIVE AND BONE BUILDING DIETARY SUPPLEMENTS AND METHODS OF USE 审中-公开
标题翻译：抗消化和骨建筑饮食补充剂和使用方法
公开(公告)号：WO2008051586A3
公开(公告)日：2008-09-25
申请号：PCT/US2007022593
申请日：2007-10-24
申请人： KREMPIN DAVID W , MURRAY MARY A , LIN YUMEI , GELLENBECK KEVIN W , DA COSTA SILVIA R , WILKINS LEON M , ROH-SCHMIDT HAERI , RANA JATINDER , REBHUN JOHN F , FAST DAVID J
发明人： KREMPIN DAVID W , MURRAY MARY A , LIN YUMEI , GELLENBECK KEVIN W , DA COSTA SILVIA R , WILKINS LEON M , ROH-SCHMIDT HAERI , RANA JATINDER , REBHUN JOHN F , FAST DAVID J
IPC分类号： A61K31/352 , A61K36/185 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/87 , A61P19/00 , A61P19/10
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth and, decreasing or preventing bone resorption comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases BMP-2 gene expression, promoter activity, or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophorajaponica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长并降低或预防骨吸收的膳食补充剂组合物和方法，其包含第一组合物，其包含槲皮素，地黄属，熟地根，西伯利亚人参，日本槐，甘草和伊普黄酮，其中第一种组合物的组合增加BMP-2基因表达，启动子活性或蛋白质表达; 以及第二组合物，其包含石榴提取物与西伯利亚人参，银杏，绿茶，槐花，地黄，葡萄籽，冬，和伊普黄酮中的至少一种的组合，其中第二组合物的组合抑制表达 RANK-L。

8. 发明申请

WO2008051594A2 ANTI-RESORPTIVE AND BONE BUILDING DIETARY SUPPLEMENTS AND METHODS OF USE 审中-公开
标题翻译：抗生素和骨骼建筑膳食补充剂和使用方法
公开(公告)号：WO2008051594A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022619
申请日：2007-10-24
申请人： KREMPIN, David, W. , MURRAY, Mary, A. , LIN, Yumei , GELLENBECK, Kevin, W. , DA COSTA, Silvia, R. , WILKINS, Leon, M. , ROH-SCHMIDT, Haeri , RANA, Jatinder , REBHUN, John, F. , FAST, David, J.
发明人： KREMPIN, David, W. , MURRAY, Mary, A. , LIN, Yumei , GELLENBECK, Kevin, W. , DA COSTA, Silvia, R. , WILKINS, Leon, M. , ROH-SCHMIDT, Haeri , RANA, Jatinder , REBHUN, John, F. , FAST, David, J.
IPC分类号： A61K31/352 , A61K36/185 , A61K36/484 , A61K36/258 , A61K36/87 , A61K36/489 , A61P19/00 , A61P19/10
CPC分类号： A61K36/87 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/185 , A61K36/254 , A61K36/258 , A61K36/484 , A61K36/489 , A61K36/804 , A61K2300/00
摘要： Disclosed herein are dietary supplement compositions and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Rehmannia sp., Rehmannia sp. root, Siberian ginseng, Sophora japonica, licorice, and ipriflavone, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression; and a second composition comprising an extract of pomegranate in combination with at least one of Siberian ginseng, Ginkgo biloba, green tea, Sophora japonica, Rehmannia sp., grape seed, Dong Quai, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
摘要翻译：本文公开了用于增加或刺激骨生长，减少或预防骨吸收，增加骨强度，改善骨结构和改善骨架构的膳食补充剂组合物和方法，其包含第一组合物，其包含以下组合：槲皮素，地黄sp 地精根，西伯利亚人参，苦参，甘草和异黄酮，其中第一组合物的组合增加骨形态发生蛋白-2基因，启动子或蛋白质表达; 以及第二组合物，其包含与西伯利亚人参，银杏，绿茶，苦参，地黄，葡萄籽，东奎和异丙酚中的至少一种组合的石榴提取物，其中第二组合物的组合抑制 RANK-L的表达。

9. 发明申请

WO2007024901A1 CYTOKINE MODULATORS AND RELATED METHODS OF USE 审中-公开
标题翻译：细胞因子调节剂及其相关使用方法
公开(公告)号：WO2007024901A1
公开(公告)日：2007-03-01
申请号：PCT/US2006/032847
申请日：2006-08-23
申请人： ACCESS BUSINESS GROUP INTERNATIONAL LLC , RANDOLPH, Russell, K. , ROH-SCHMIDT, Haeri
发明人： RANDOLPH, Russell, K. , ROH-SCHMIDT, Haeri
IPC分类号： A61K36/73 , A61K36/906 , A61K36/738 , A61P29/00
CPC分类号： A61K36/45 , A61K36/73 , A61K36/738 , A61K36/906 , A61K2300/00
摘要： A composition for modulating cytokines to regulate an inflammatory or immunomodulatory response. The composition can include at least one of rosehips, blueberry, blackberry, elderberry, cranberry, rosemary, clove, feverfew, nettle root, artichoke, reishi mushroom, olive extract, green tea extract, grape seed extract, resveratrol, viniferin, Aframomum melegueta, boswellia serrata extract, boswellia forte, ipriflavone, tocotrienols, evening primrose oil, INM-176, borage oil, krill oil, at least one type of xanthophyll (e.g., astaxanthin), green coffee extract and ferulic acid. Specifically, a composition of the invention can include: rosehips and at least one of blackberry, blueberry, elderberry, and optionally krill oil; or rosehips, resveratrol and at least one of Aframomum melegueta and astaxanthin. Based on the cytokine modulation and cytokine response inhibition of the composition, it can be used to regulate an immunomodulatory and/or inflammatory response, and subsequently treat diseases and/or abnormal conditions associated with inflammatory response, for example, cardiovascular conditions, arthritis, osteoporosis and Alzheimer's disease.
摘要翻译：用于调节细胞因子以调节炎症或免疫调节反应的组合物。组合物可以包括玫瑰果，蓝莓，黑莓，接骨木，蔓越莓，迷迭香，丁香，发烧，荨麻根，朝鲜蓟，芦苇蘑菇，橄榄提取物，绿茶提取物，葡萄籽提取物，白藜芦醇，荧光素，红曲霉，波斯维西亚锯齿提取物，富马酸，异黄酮，生育三烯酚，月见草油，INM-176，琉璃苣油，磷虾油，至少一种类型的叶黄素（例如虾青素），生咖啡提取物和阿魏酸。具体地说，本发明的组合物可以包括：玫瑰果和黑莓，蓝莓，接骨木和任选的磷虾油中的至少一种; 或玫瑰果，白藜芦醇和Aframomum melegueta和虾青素中的至少一种。基于组合物的细胞因子调节和细胞因子反应抑制，其可用于调节免疫调节和/或炎症反应，并且随后治疗与炎症反应相关的疾病和/或异常状况，例如心血管疾病，关节炎，骨质疏松症和阿尔茨海默病。

10. 发明申请

WO2009123821A2 DIETARY SUPPLEMENT AND RELATED METHOD 审中-公开
标题翻译：膳食补充和相关方法
公开(公告)号：WO2009123821A2
公开(公告)日：2009-10-08
申请号：PCT/US2009/036147
申请日：2009-03-05
申请人： ACCESS BUSINESS GROUP INTERNATIONAL LLC , HUANG, Ruo, G. , MISSLER, Stephen, R. , LEMAY, Marc, J., P. , KAHLER, Edward, S. , PUSATERI, Donald, J. , ROH-SCHMIDT, Haeri , RAMAKRISHNAN, Shyam
发明人： HUANG, Ruo, G. , MISSLER, Stephen, R. , LEMAY, Marc, J., P. , KAHLER, Edward, S. , PUSATERI, Donald, J. , ROH-SCHMIDT, Haeri , RAMAKRISHNAN, Shyam
IPC分类号： A61K36/00
CPC分类号： A61K36/53 , A23L19/01 , A23L33/105 , A23L33/15 , A23L33/16 , A23V2002/00 , A61K31/4188 , A61K31/7048 , A61K31/714 , A61K33/00 , A61K33/04 , A61K33/06 , A61K33/18 , A61K33/24 , A61K33/30 , A61K33/32 , A61K33/34 , A61K33/42 , A61K36/185 , A61K36/752 , A61K36/8965 , A61K45/06 , A61K2300/00 , A23V2250/21162 , A23V2250/70 , A23V2250/156 , A23V2250/213
摘要： A composition including a unique combination of fruits, vegetables, herbs, and optionally vitamins, minerals and specialty ingredients. The composition can include a fruit ingredient, a vegetable ingredient and an herbal ingredient, wherein the fruit ingredient is at least one of pomegranate and citrus bioflavonoids, wherein the vegetable ingredient is at least one of asparagus, lutein, lycopene and watercress, and wherein the herbal ingredient is at least one of basil, oregano and rosemary. The composition can be administered to subjects to correct a dietary deficiency of phytochemicals and other nutrients, improve plasma concentrations of antioxidant nutrients,, and increase the activity of genetic mechanisms for DNA repair and stability.
摘要翻译：包括水果，蔬菜，草药和任选的维生素，矿物质和特种成分的独特组合的组合物。所述组合物可以包括水果成分，植物成分和草药成分，其中所述水果成分是石榴和柑橘类生物类黄酮中的至少一种，其中所述植物成分是芦笋，叶黄素，番茄红素和水田芥中的至少一种，并且其中草药成分至少是罗勒，牛至和迷迭香中的一种。可以将组合物施用于受试者以校正植物化学物质和其他营养物的膳食缺乏症，改善抗氧化营养物质的血浆浓度，并增加DNA修复和稳定性的遗传机制的活性。

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