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1. 发明申请

WO02088363A3 REGULATION OF NOVEL HUMAN PROLYL 4-HYDROXYLASES 审中-公开
标题翻译：新型人造四羟甲基磷灰石的调控
公开(公告)号：WO02088363A3
公开(公告)日：2003-07-31
申请号：PCT/EP0204734
申请日：2002-04-30
申请人： BAYER AG , RAMAKRISHNAN SHYAM , FLAMME INGO , OEHME FELIX , ELLINGHAUS PETER
发明人： RAMAKRISHNAN SHYAM , FLAMME INGO , OEHME FELIX , ELLINGHAUS PETER
IPC分类号： A61K38/00 , A61K48/00 , C12N9/02 , C12N15/53 , C12Q1/26 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/0071 , A61K38/00 , A61K48/00 , C12Q1/26 , G01N2500/20
摘要： Reagents that regulate human prolyl 4-hydroxylase and reagents which bind to human prolyl 4-hydroxylase gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cardiovascular disorders, cancer, inflammatory diseases, fibrotic disorders, and CNS disorders.
摘要翻译：调节人脯氨酰4-羟化酶的试剂和与人脯氨酰4-羟化酶基因产物结合的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，包括但不限于心血管疾病，癌症，炎症性疾病，纤维化疾病，和CNS疾病。

2. 发明申请

WO0188126A8 REGULATION OF HUMAN alpha1&Agr; ADRENERGIC RECEPTOR-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类α1和Agr的调控 ADRENERGIC RECEPTOR-like G蛋白偶联受体
公开(公告)号：WO0188126A8
公开(公告)日：2003-06-12
申请号：PCT/EP0105383
申请日：2001-05-11
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K31/7088 , A61K39/00 , A61K39/395 , A61P9/10 , A61P11/06 , A61P19/10 , A61P25/18 , A61P25/28 , A61P31/18 , A61P35/00 , C07K14/705 , C07K14/72 , C12N15/12 , C12N15/26 , C12N15/62 , C12Q1/68 , G01N33/68
CPC分类号： C07K14/723 , A61K39/00 , C07K14/70571
摘要： Reagents which regulate human alpha1aadrenergic receptor-like GPCR and reagents which bind to human alpha1a adrenergic receptor-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, obesity cancers, anorexia, bulimia, asthma, Parkinson's diseases, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
摘要翻译：调节人α1肾上腺素能受体样GPCR的试剂和与人α1a肾上腺素受体样GPCR基因产物结合的试剂可以在预防，改善或纠正功能障碍或疾病中起作用，包括但不限于细菌，真菌等感染，原生动物和病毒感染，特别是由艾滋病毒病毒，疼痛，肥胖症，厌食，贪食症，哮喘，帕金森病，急性心力衰竭，低血压，高血压，尿潴留，骨质疏松症，心绞痛，心肌梗死，溃疡，哮喘引起的那些感染，过敏，多发性硬化，良性前列腺肥大，以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，几种智力迟钝和运动障碍，如亨廷顿病和图雷特综合征。

3. 发明申请

WO0206453A3 REGULATION OF HUMAN DESC1-LIKE SERINE PROTEASE 审中-公开
标题翻译：人类DESC1样丝氨酸蛋白酶的调节
公开(公告)号：WO0206453A3
公开(公告)日：2002-12-05
申请号：PCT/EP0107859
申请日：2001-07-09
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： G01N33/50 , A61K35/74 , A61K36/06 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P9/00 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P25/00 , A61P25/02 , A61P25/16 , A61P25/28 , A61P35/00 , A61P43/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N9/64 , C12N15/09 , C12N15/57 , C12Q1/02 , C12Q1/37 , C12Q1/68 , G01N33/15 , G01N33/53 , G01N33/566 , A61K31/7088
CPC分类号： C12N9/6424 , A61K38/00 , C07K2319/00
摘要： Reagents which regulate human DESC1-like serine protease and reagents which bind to human DESC1-like serine protease gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to cancer, chronic obstructive pulmonary disease (COPD), cardiovascular, and peripheral or central nervous system disease.
摘要翻译：调节人类DESC1样丝氨酸蛋白酶的试剂和与人类DESC1样丝氨酸蛋白酶基因产物结合的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，所述功能障碍或疾病包括但不限于癌症，慢性阻塞性肺病（COPD ），心血管疾病和外周或中枢神经系统疾病。

4. 发明申请

WO0185959A3 REGULATION OF HUMAN LYSOSTAPHIN-LIKE PROTEASE 审中-公开
标题翻译：人类赖氨酸样蛋白的调控
公开(公告)号：WO0185959A3
公开(公告)日：2002-06-20
申请号：PCT/EP0105347
申请日：2001-05-10
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , A61K48/00 , A61P9/00 , A61P25/00 , A61P29/00 , A61P31/00 , A61P35/00 , C12N9/64 , C12N15/57 , A61K31/70 , A61K38/48 , A61K39/395 , C12N1/21 , C12N5/10 , C12N15/62 , C12Q1/37 , C12Q1/68
CPC分类号： C12N9/6491 , A61K38/00 , A61K48/00 , C07K2319/00
摘要： Reagents which regulate human lysostaphin-like protease activity and reagents which bind to human lysostaphin-like protease gene products can be used to regulate extracellular matrix degradation. Such regulation is particularly useful for treating metastasis of malignant cells, tumor angiogenesis, inflammation, cardiovascular disease, including hypertension, aneurysmal dilatation, and atherosclerosis, neurodegenerative diseases, and pathogenic infections.
摘要翻译：调节人类溶葡萄球菌样蛋白酶活性的试剂和结合人类溶葡萄球菌素样蛋白酶基因产物的试剂可用于调节细胞外基质降解。这种调节对于治疗恶性细胞的转移，肿瘤血管生成，炎症，心血管疾病，包括高血压，动脉瘤扩张和动脉粥样硬化，神经变性疾病和致病性感染特别有用。

5. 发明申请

WO0200704A3 REGULATION OF HUMAN PHOSPHOLIPASE C-LIKE ENZYME 审中-公开
标题翻译：人类磷脂酶C样酶的调节
公开(公告)号：WO0200704A3
公开(公告)日：2002-06-13
申请号：PCT/EP0107360
申请日：2001-06-28
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , C12N9/16 , C12N15/12 , A61K31/7088 , A61K38/46 , A61K39/395 , C12N9/00 , C12N9/20 , C12N15/11 , C12N15/62 , C12Q1/44 , C12Q1/68 , G01N33/577
CPC分类号： C12N9/16 , A61K38/00 , A61K2039/505 , C07K2319/00
摘要： Reagents which regulate human phospholipase C-like enzyme and reagents which bind to human phospholipase C-like enzyme gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, cancer, CNS diseases, and chronic obstructive pulmonary disease.
摘要翻译：调节人类磷脂酶C样酶的试剂和结合人类磷脂酶C样酶基因产物的试剂可以在预防，改善或纠正功能障碍或疾病，包括但不限于癌症，CNS疾病和慢性疾病阻塞性肺病。

6. 发明申请

WO0192503A3 REGULATION OF HUMAN CALCIUM-INDEPENDENT ALPHA-LATRO-TOXIN-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类钙依赖性阿尔法 - 类似激素的G蛋白偶联受体的调控
公开(公告)号：WO0192503A3
公开(公告)日：2002-06-13
申请号：PCT/EP0106088
申请日：2001-05-29
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： C07K14/705 , A61K38/00 , C07K16/28 , C12N9/00 , C12N9/04 , C12N15/11 , C12N15/63 , G01N33/566 , G01N33/94
CPC分类号： C07K14/705 , C07K2319/00 , C12N2799/021 , C12N2799/026
摘要： Reagents which regulate human calcium-independent alpha-latrotoxin-like G protein-coupled receptor (CIRL) and reagents which bind to human CIRL gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases associated with aberrant exocytosis in both the endocrine system and the nervous system.
摘要翻译：调节人类钙依赖性非依赖性的α-内毒素样G蛋白偶联受体（CIRL）的试剂和与人类CIRL基因产物结合的试剂可以在预防，改善或纠正与异常胞吐作用相关的功能障碍或疾病方面发挥作用内分泌系统和神经系统。

7. 发明申请

WO0194385A8 HUMAN HM74-LIKE G PROTEIN COUPLED RECEPTOR 审中-公开
标题翻译：人类HM74样G蛋白偶联受体
公开(公告)号：WO0194385A8
公开(公告)日：2002-06-06
申请号：PCT/EP0106380
申请日：2001-06-05
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： C07K14/705 , C12N15/12 , C07K16/28 , C12N15/62 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/705
摘要： Reagents which regulate human HM74-like G protein coupled receptor can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, CNS diseases such as Parkinson's disease, cardiovascular diseases such as acute heart failure, hypotension, hypertension, angina pectoris, and myocardial infarction, urinary retention, osteoporosis, obesity, ulcers, asthma, inflammation, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
摘要翻译：调节人HM74样G蛋白偶联受体的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，包括但不限于感染如细菌，真菌，原生动物和病毒感染，特别是由HIV引起的感染病毒，疼痛，癌症，厌食症，贪食症，哮喘，CNS疾病如帕金森病，心血管疾病如急性心力衰竭，低血压，高血压，心绞痛和心肌梗塞，尿潴留，骨质疏松症，肥胖症，溃疡，哮喘，炎症，过敏症，多发性硬化症，良性前列腺肥大，以及精神病和神经疾病，包括焦虑症，精神分裂症，躁狂抑郁症，deli妄，痴呆，若干智力障碍和运动障碍，如亨廷顿病和图雷特综合征。

8. 发明申请

WO0200891A3 HUMAN NAPSIN-LIKE ASPARTYL PROTEASE 审中-公开
标题翻译：人类NAPSIN-like ASPARTYL PROTEASE
公开(公告)号：WO0200891A3
公开(公告)日：2002-04-11
申请号：PCT/EP0107000
申请日：2001-06-21
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K38/00 , C12N9/64 , C12N15/57 , A61K38/48 , C12N15/62 , C12Q1/68 , G01N33/50
CPC分类号： C12N9/6478 , A61K38/00 , C07K2319/00
摘要： Reagents which regulate human napsin-like aspartyl protease activity and reagents which bind to human napsin-like aspartyl protease gene products can be used to treat cancer and osteoporosis.
摘要翻译：可以使用调节人类Napsin样天冬氨酰蛋白酶活性的试剂和与人类Napsin样天冬氨酰蛋白酶基因产物结合的试剂来治疗癌症和骨质疏松症。

9. 发明申请

WO0168701A3 REGULATION OF HUMAN SEVEN TRANSMEMBRANE - LIKE G PROTEIN - COUPLED RECEPTOR (7TM-GPCR) 审中-公开
标题翻译：人类转运蛋白的调控 - 如G蛋白 - 偶联受体（7TM-GPCR）
公开(公告)号：WO0168701A3
公开(公告)日：2002-03-21
申请号：PCT/EP0102978
申请日：2001-03-15
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： C07K14/705 , C07K14/72
CPC分类号： C07K14/705
摘要： Reagents which regulate human seven transmembrane-like G protein-coupled receptor (7TM-GPCR) protein and reagents which bind to human 7TM-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, infections such as bacterial, fungal, protozoan, and viral infections, particularly those caused by HIV viruses, pain, cancers, anorexia, bulimia, asthma, Parkinson's diseases, acute heart failure, hypotension, hypertension, urinary retention, osteoporosis, angina pectoris, myocardial infarction, ulcers, asthma, allergies, multiple sclerosis, benign prostatic hypertrophy, and psychotic and neurological disorders, including anxiety, schizophrenia, manic depression, delirium, dementia, several mental retardation, and dyskinesias, such as Huntington's disease and Tourett's syndrome.
摘要翻译：调节人类七跨膜样G蛋白偶联受体（7TM-GPCR）蛋白的试剂和与人7TM-GPCR基因产物结合的试剂可以在预防，改善或纠正功能障碍或疾病中发挥作用，包括但不限于特别是由HIV病毒，疼痛，癌症，厌食症，贪食症，哮喘，帕金森病，急性心力衰竭，低血压，高血压，尿潴留，骨质疏松症，心绞痛等引起的感染，如细菌，真菌，原生动物和病毒感染，心肌梗塞，溃疡，哮喘，过敏，多发性硬化，良性前列腺肥大，以及精神病和神经障碍，包括焦虑，精神分裂症，躁狂抑郁，del妄，痴呆，几种智力低下和运动障碍，如亨廷顿氏病和图雷特综合征。

10. 发明申请

WO0168700A3 REGULATION OF HUMAN SUBSTANCE P-LIKE G PROTEIN-COUPLED RECEPTOR 审中-公开
标题翻译：人类物质P型G蛋白偶联受体的调控
公开(公告)号：WO0168700A3
公开(公告)日：2002-03-21
申请号：PCT/EP0102861
申请日：2001-03-14
申请人： BAYER AG , RAMAKRISHNAN SHYAM
发明人： RAMAKRISHNAN SHYAM
IPC分类号： A61K49/00 , A61P25/00 , A61P37/00 , C07K14/705 , C12N15/12 , A61K38/17 , C12N5/10 , C12N15/11 , C12N15/66 , C12Q1/68
CPC分类号： A61K49/0004 , C07K14/70571
摘要： Reagents which regulate human substance P G protein-coupled receptor (SP-GPCR) protein and reagents which bind to human SP-GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, urinary incontinence, inflammatory diseases (e.g., arthritis, psoriasis, asthma and inflammatory bowel disease), anxiety, depression or dysthymic disorders, cluster headache, colitis, psychosis, pain, allergies such as eczema and rhinitis, chronic obstructive airways disease, hypersensitivity disorders such as poison ivy, vasospastic diseases such as angina, migraine and Reynaud's disease, fibrosing and collagen diseases such as scleroderma and eosinophilic fascioliasis, reflex sympathetic dystrophy such as shoulder/hand syndrome, addiction disorders such as alcoholism, stress related somatic disorders, peripheral neuropathy, neuralgia, neuropathological disorders such as Alzheimer's disease, AIDS related dementia, diabetic neuropathy and multiple sclerosis, disorders related to immune enhancement or suppression such as systemic lupus erythematosus, and rheumatic diseases such as fibrositis.
摘要翻译：调节人类物质PG蛋白偶联受体（SP-GPCR）蛋白质的试剂和与人类SP-GPCR基因产物结合的试剂可以在预防，改善或矫正功能障碍或疾病中发挥作用，包括但不限于尿失禁，炎性疾病（例如关节炎，银屑病，哮喘和炎性肠病），焦虑症，抑郁症或神经性神经障碍，丛集性头痛，结肠炎，精神病，疼痛，过敏如湿疹和鼻炎，慢性阻塞性气道疾病，过敏性疾病如毒素常春藤，血管痉挛性疾病如心绞痛，偏头痛和雷诺病，纤维化和胶原病如硬皮病和嗜酸粒细胞性纤维性疾病，反射性交感神经营养不良症如肩/手综合症，成瘾症如酒精中毒，应激相关的躯体疾病，周围神经病变，神经痛，神经病理学疾病如阿尔茨海默病，AIDS相关性痴呆，糖尿病神经病变 y和多发性硬化，与免疫增强或抑制相关的疾病如系统性红斑狼疮，以及风湿性疾病如纤维性疾病。

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