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1. 发明申请

WO2011089396A2 PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE. 审中-公开
标题翻译： PYRUVAMIDE化合物作为DITE MITE 1 PEPTIDASE ALLERGEN及其使用的抑制剂。
公开(公告)号：WO2011089396A2
公开(公告)日：2011-07-28
申请号：PCT/GB2011/000079
申请日：2011-01-21
申请人： ST GEORGE'S HOSPITAL MEDICAL SCHOOL , THE UNIVERSITY OF MANCHESTER , ROBINSON, Clive , ZHANG, Jihui , GARROD, David, Ronald , PERRIOR, Trevor, Robert , NEWTON, Gary, Karl , JENKINS, Kerry , BEEVERS, Rebekah, Elisabeth , KIMBERLEY, Meriel, Ruth , STEWART, Mark, Richard
发明人： ROBINSON, Clive , ZHANG, Jihui , GARROD, David, Ronald , PERRIOR, Trevor, Robert , NEWTON, Gary, Karl , JENKINS, Kerry , BEEVERS, Rebekah, Elisabeth , KIMBERLEY, Meriel, Ruth , STEWART, Mark, Richard
IPC分类号： C07K5/06 , C07K5/08 , A61P37/08 , A61P37/06
CPC分类号： C07K5/0202 , A01N37/46 , A01N43/16 , A01N43/30 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/48 , A01N43/60 , A01N43/72 , A01N43/84 , A61K38/00 , A61K38/06 , A61K38/07 , A61K45/06 , C07K5/06008 , C07K5/06034 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as "PVA compounds"), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及式（X）的某些丙酮酰胺化合物（为了方便起见，统称为“PVA化合物”），其特别是抑制尘螨组 1肽酶变应原（例如，Der p 1，Der f 1，Eur m 1）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制尘螨组1肽酶变应原和治疗由尘螨1组肽酶变应原; 通过抑制尘螨组1肽酶变应原而得到改善; 哮喘; 鼻炎; 过敏性结膜炎特应性皮炎; 由尘螨触发的过敏状况; 由尘螨组1肽酶变应原触发的过敏状况; 和犬特应性

2. 发明申请

WO2011089396A3 PYRUVAMIDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN 审中-公开
标题翻译： PYRUVAMIDE化合物作为DITE MITE GROUP 1 PEPTIDASE ALLERGEN的抑制剂
公开(公告)号：WO2011089396A3
公开(公告)日：2012-04-26
申请号：PCT/GB2011000079
申请日：2011-01-21
申请人： ST GEORGE S HOSPITAL MEDICAL SCHOOL , UNIV MANCHESTER , ROBINSON CLIVE , ZHANG JIHUI , GARROD DAVID RONALD , PERRIOR TREVOR ROBERT , NEWTON GARY KARL , JENKINS KERRY , BEEVERS REBEKAH ELISABETH , KIMBERLEY MERIEL RUTH , STEWART MARK RICHARD
发明人： ROBINSON CLIVE , ZHANG JIHUI , GARROD DAVID RONALD , PERRIOR TREVOR ROBERT , NEWTON GARY KARL , JENKINS KERRY , BEEVERS REBEKAH ELISABETH , KIMBERLEY MERIEL RUTH , STEWART MARK RICHARD
IPC分类号： C07K5/06 , A01N43/00 , A61K38/06 , A61P37/08 , C07K5/08
CPC分类号： C07K5/0202 , A01N37/46 , A01N43/16 , A01N43/30 , A01N43/36 , A01N43/38 , A01N43/40 , A01N43/42 , A01N43/48 , A01N43/60 , A01N43/72 , A01N43/84 , A61K38/00 , A61K38/06 , A61K38/07 , A61K45/06 , C07K5/06008 , C07K5/06034 , C07K5/06078 , C07K5/06139 , C07K5/06191 , C07K5/0804 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0821 , C07K5/0827
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain pyruvamide compounds of the formula (X) (for convenience, collectively referred to herein as "PVA compounds"), which, inter alia, inhibit a dust mite Group 1 peptidase allergen (e.g., Der p 1, Der f 1, Eur m 1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及式（X）的某些丙酮酰胺化合物（为了方便起见，统称为“PVA化合物”），其特别是抑制尘螨组 1肽酶变应原（例如，Der p 1，Der f 1，Eur m 1）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制尘螨组1肽酶变应原和治疗由尘螨组1肽酶变应原; 通过抑制尘螨组1肽酶变应原而得到改善; 哮喘; 鼻炎; 过敏性结膜炎特应性皮炎; 由尘螨触发的过敏状况; 由尘螨组1肽酶变应原触发的过敏状况; 和犬特应性

3. 发明申请

WO2012004554A1 ALDEHYDE COMPOUNDS AS INHIBITORS OF DUST MITE GROUP 1 PEPTIDASE ALLERGEN AND THEIR USE 审中-公开
标题翻译：作为杀菌剂组合物的杀虫剂化合物1杀菌剂过敏原及其使用
公开(公告)号：WO2012004554A1
公开(公告)日：2012-01-12
申请号：PCT/GB2011/001011
申请日：2011-07-04
申请人： ST GEORGE'S HOSPITAL MEDICAL SCHOOL , THE UNIVERSITY OF MANCHESTER , ROBINSON, Clive , ZHANG, Jihui , GARROD, David Ronald , PERRIOR, Trevor Robert , NEWTON, Gary Karl , JENKINS, Kerry , STEWART, Mark Richard , KIMBERLEY, Meriel Ruth
发明人： ROBINSON, Clive , ZHANG, Jihui , GARROD, David Ronald , PERRIOR, Trevor Robert , NEWTON, Gary Karl , JENKINS, Kerry , STEWART, Mark Richard , KIMBERLEY, Meriel Ruth
IPC分类号： C07K5/06 , A61K38/05 , A61P33/14
CPC分类号： C07K5/06191 , A61K38/00 , C07K5/06034 , C07K5/06078
摘要： The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aldehyde compounds of the following formula (A) (for convenience, collectively referred to herein as "ALD compounds"), which, inter alia , inhibit a dust mite Group 1 peptidase allergen ( e.g. , Der p 1, Der f 1, Eur m 1 ). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo , to inhibit a dust mite Group 1 peptidase allergen, and in the treatment of diseases and disorders that are mediated by a dust mite Group 1 peptidase allergen; that are ameliorated by the inhibition of a dust mite Group 1 peptidase allergen; asthma; rhinitis; allergic conjunctivitis; atopic dermatitis; an allergic condition which is triggered by dust mites; an allergic condition which is triggered by a dust mite Group 1 peptidase allergen; and canine atopy.
摘要翻译：本发明一般涉及治疗化合物领域，更具体地涉及以下式（A）的某些醛化合物（为了方便起见，统称为“ALD化合物”），其特别地抑制尘螨第1组肽酶变应原（例如，Der p 1，Der f 1，Eur m 1）。本发明还涉及包含这些化合物的药物组合物，以及这些化合物和组合物在体外和体内的用途，以抑制尘螨组1肽酶变应原和治疗由尘螨1组肽酶变应原; 通过抑制尘螨组1肽酶变应原而得到改善; 哮喘; 鼻炎; 过敏性结膜炎特应性皮炎; 由尘螨触发的过敏状况; 由尘螨组1肽酶变应原触发的过敏状况; 和犬特应性

4. 发明申请

WO2004023603A1 EARTH CONNECTION 审中-公开
标题翻译：接地连接
公开(公告)号：WO2004023603A1
公开(公告)日：2004-03-18
申请号：PCT/GB2003/003857
申请日：2003-09-08
申请人： HCL FASTENERS LTD. , BYRON INTERNATIONAL LTD. , ROBINSON, Clive
发明人： ROBINSON, Clive
IPC分类号： H01R4/64
CPC分类号： H01R4/64 , F16L3/12 , H01R4/643
摘要： The present invention provides a clip (18) for establishing a connection between an earth bond cable (12) and extraneous metalwork (16) or other conductive object. The clip (18) comprising a flexible strap (20) having two ends, a first mating connector (22) secured at the first end of the strap (20) and a second mating connector (24) secured at the second end of the strap (20). The two connectors mate with each other to form the clip (18) into a closed loop and secure the strap (20) around the conductive object (16). The clip (18) has at least one opening extending through the clip (18), preferably through the strap (20); an electrically conductive earth bond cable (12) is fed through the opening and the clip (18) is then secured to the conductive object (16) by inter-engaging the mating connectors (22, 24) so as to clamp the earth bond cable (14) between the clip (18) and the conductive object (16).
摘要翻译：本发明提供了一种用于建立接地电缆（12）和外部金属制品（16）或其它导电物体之间的连接的夹子（18）。夹子（18）包括具有两端的柔性带（20），固定在带（20）的第一端的第一配合连接器（22）和固定在带的第二端的第二配合连接器（24）（20）。两个连接器彼此配合以将夹子（18）形成为闭合的环并将带（20）固定在导电物体（16）周围。夹子（18）具有穿过夹子（18）延伸的至少一个开口，优选地通过带子（20）; 导电接地电缆（12）通过开口进给，夹子（18）然后通过相互配合的配合连接器（22,24）固定到导电物体（16）上，以便将接地电缆（18）和导电物体（16）之间的间隙（14）。

5. 发明申请

WO9929339A3 PREVENTION AND/OR TREATMENT OF ALLERGIC CONDITIONS 审中-公开
标题翻译：预防和/或治疗过敏性病症
公开(公告)号：WO9929339A3
公开(公告)日：1999-08-12
申请号：PCT/GB9803721
申请日：1998-12-11
申请人： UNIV MANCHESTER , ST GEORGES HOSP MEDICAL SCHOOL , GARROD DAVID RONALD , ROBINSON CLIVE
发明人： GARROD DAVID RONALD , ROBINSON CLIVE
IPC分类号： A61K45/00 , A61K31/137 , A61K31/336 , A61K31/381 , A61K38/55 , A61K45/06 , A61P11/02 , A61P11/06 , A61P17/00 , A61P27/14 , A61P29/02 , A61P37/08 , A61P43/00
CPC分类号： A61K38/55
摘要： The present invention relates to the use of an inhibitor of cysteine proteinase activity in conjunction with an inhibitor of any serine proteinase activity other than trypsin for the manufacture of a medicament for the prevention or treatment of a condition in which an allergen traverses an epithelial barrier such as asthma. Also included in the invention are formulations and kits containing serine and cysteine proteinase inhibitors and their use in the prevention or treatment of conditions in which an allergen traverses an epithelial barrier.
摘要翻译：本发明涉及半胱氨酸蛋白酶活性抑制剂与胰蛋白酶以外的任何丝氨酸蛋白酶活性抑制剂一起用于制备用于预防或治疗过敏原穿过上皮屏障的病症的药物的用途，作为哮喘。本发明还包括含有丝氨酸和半胱氨酸蛋白酶抑制剂的制剂和试剂盒及其在预防或治疗变应原穿过上皮屏障的病症中的用途。

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