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    • 8. 发明申请
    • AROMATIC AMIDES ABSORBING THE U.V.
    • 芳香胺吸收紫外线
    • WO8704923A2
    • 1987-08-27
    • PCT/FR8700039
    • 1987-02-13
    • ROBERT DOMINIQUEJUNG LOUIS
    • ROBERT DOMINIQUEJUNG LOUIS
    • C07C323/59A61K8/00A61K8/36A61K8/368A61K8/38A61K8/40A61K8/41A61K8/42A61K8/44A61K8/46A61K8/49A61K8/64A61K8/65A61K8/97A61K31/165A61K31/245A61Q17/04C07C67/00C07C233/00C07C233/12C07C255/34C07C313/00C07D233/54C07D233/64C07D235/08C07D235/14C07D235/18
    • A61Q17/04A61K8/447A61K8/4946C07D233/54
    • Derivatives of amino-benzoic acids, hydroxy-benzoic acids, cinnamic acids, urocanic acids and benzimidazols have been synthetized. The photoprotector power of each class of compounds has been tested. It is the result of four different isolated or conjugate mechanisms. Mechanism 1: absorption of ultraviolet radiations between 360 nm and 260 nm (UVB and/or UVA). Mechanism 2: prolonged absorption of ultraviolet radiations between 360 nm and 260 nm by preferential fixation and in a prolonged way at the epiderm of the human skin of the compound and this by introducing into their chemical structure sulphured or not, peptidic, amino-acid groups. Mechanism 3: induction of the melanogenesis, natural protection system of the skin. Mechanism 4: selection of a compound which is either liposoluble or hydrosoluble according to the galenic form (solution, emulsion, spray). The present invention claims the chemical structure of new compounds, their synthesis, photoprotective activity and the utilization of all the disclosed compounds in order to avoid photodermatosis consecutive to the administration of medicaments, to the use of cosmetics and/or perfumes by man.
    • 已经合成了氨基 - 苯甲酸,羟基 - 苯甲酸,肉桂酸,尿刊酸和苯并咪唑的衍生物。 已对各类化合物的光电保护功率进行了测试。 这是四种不同的孤立或共轭机制的结果。 机制1:在360nm和260nm之间吸收紫外线辐射(UVB和/或UVA)。 机制2:通过优先固定和在化合物的人皮肤的表皮上以延长的方式延长了360nm和260nm之间的紫外线辐射的吸收,并且通过将其引入其硫化或不硫化的氨基酸基团的化学结构 。 机制3:诱导黑素生成,皮肤自然保护系统。 机理4:根据盖仑型形式(溶液,乳液,喷雾)选择脂溶性或水溶性化合物。 本发明要求新化合物的化学结构,它们的合成,光保护活性和所有公开的化合物的利用,以避免药物施用连续的光致皮肤病,人的化妆品和/或香水的使用。