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1. 发明申请

WO2007046825A2 OPTOELECTRONIC DETECTION SYSTEM 审中-公开
标题翻译：光电检测系统
公开(公告)号：WO2007046825A2
公开(公告)日：2007-04-26
申请号：PCT/US2005/043343
申请日：2005-11-30
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , SCHWOEBEL, Eric, D. , HARPER, James, D. , PETROVICK, Martha, S. , NARGI, Frances, E. , RIDER, Todd, H. , HOGAN, Kristine, E. , MATHEWS, Richard, H. , LACIRIGNOLA, Joseph , HENNESSY, Mark , VIAN, Trina, R. , JOSEPH, Rose, M. , UTTARO, Raymond , SHAUN, Berry , HOLLIS, Mark, A. , JOHNSON, Bernadette
发明人： SCHWOEBEL, Eric, D. , HARPER, James, D. , PETROVICK, Martha, S. , NARGI, Frances, E. , RIDER, Todd, H. , HOGAN, Kristine, E. , MATHEWS, Richard, H. , LACIRIGNOLA, Joseph , HENNESSY, Mark , VIAN, Trina, R. , JOSEPH, Rose, M. , UTTARO, Raymond , SHAUN, Berry , HOLLIS, Mark, A. , JOHNSON, Bernadette
IPC分类号： C12Q1/68
CPC分类号： G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要： The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译：本文所述的发明提供了用于检测可溶性抗原的方法。特别是，这些方法提供了可溶性蛋白质和化学品的检测。另外，本发明提供了检测样品中的核酸序列的方法。还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的目标颗粒，其中待检测的目标颗粒被一种或多种抗体结合。还提供了一种用于检测多个样本中的目标粒子的光电子传感器装置。

2. 发明申请

WO2003066003A2 ANTI-PATHOGEN TREATEMENTS 审中-公开
标题翻译：抗病毒治疗
公开(公告)号：WO2003066003A2
公开(公告)日：2003-08-14
申请号：PCT/US2003/003978
申请日：2003-02-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RIDER, Todd, H.
发明人： RIDER, Todd, H.
IPC分类号： A61K
CPC分类号： A61K47/48246 , A61K38/16 , A61K38/17 , A61K38/1709 , A61K38/4873 , A61K47/64 , G01N33/5091 , G01N33/56983 , Y02A50/481
摘要： Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effectormediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.
摘要翻译：描述了含有至少一个病原体检测结构域和至少一个效应子结构域的嵌合分子及其用于预防或治疗细胞或生物体中的病原体感染的方法。嵌合分子的病原体检测结构域和效应子结构域是自然界中通常不被结合在一起的结构域。本文还描述了具有至少一种病原体相互作用的分子结构和至少一种有效预测分子结构的试剂，所述试剂是在细胞中非天然存在的试剂。本文所述的预防和治疗方法对于广谱的病原体是有效的，并且表现出很少的或没有毒性的副作用。还提供了用于检测病原体，病原体成分或由病原体产生或诱导的产物的检测。

3. 发明申请

WO2007046825A9 OPTOELECTRONIC DETECTION SYSTEM 审中-公开
标题翻译：光电检测系统
公开(公告)号：WO2007046825A9
公开(公告)日：2007-06-21
申请号：PCT/US2005043343
申请日：2005-11-30
申请人： MASSACHUSETTS INST TECHNOLOGY , SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
发明人： SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
IPC分类号： C12Q1/68
CPC分类号： G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要： The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译：本文描述的本发明提供了用于检测可溶性抗原的方法。特别地，该方法提供了可溶性蛋白质和化学物质的检测。此外，本发明提供了检测样品中核酸序列的方法。还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的靶颗粒，其中待检测的靶颗粒被一种或多种抗体结合。还提供了一种用于检测多个样品中的目标颗粒的光电传感器装置。

4. 发明申请

WO2003066003A3 ANTI-PATHOGEN TREATEMENTS 审中-公开
公开(公告)号：WO2003066003A3
公开(公告)日：2003-08-14
申请号：PCT/US2003/003978
申请日：2003-02-07
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , RIDER, Todd, H.
发明人： RIDER, Todd, H.
IPC分类号： A61K39/395
摘要： Chimeric molecules that contain at least one pathogen-detection domain and at least one effector domain, and their methods of use in preventing or treating a pathogen infection in a cell or organism are described. The pathogen-detection domain and effector domain of the chimeric molecules are domains not typically found in nature to be associated together. Agents are also described herein having at least one pathogen-interacting molecular structure and at least one effectormediating molecular structure, the agent being one that is non-naturally-occurring in a cell. The methods of prevention and treatment described herein are effective for a broad spectrum of pathogens and exhibit little or no toxic side-effects. Assays for the detection of a pathogen, pathogen component, or product produced or induced by a pathogen, are also provided.

5. 发明申请

WO2007046825A3 OPTOELECTRONIC DETECTION SYSTEM 审中-公开
标题翻译：光电检测系统
公开(公告)号：WO2007046825A3
公开(公告)日：2007-07-26
申请号：PCT/US2005043343
申请日：2005-11-30
申请人： MASSACHUSETTS INST TECHNOLOGY , SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
发明人： SCHWOEBEL ERIC D , HARPER JAMES D , PETROVICK MARTHA S , NARGI FRANCES E , RIDER TODD H , HOGAN KRISTINE E , MATHEWS RICHARD H , LACIRIGNOLA JOSEPH , HENNESSY MARK , VIAN TRINA R , JOSEPH ROSE M , UTTARO RAYMOND , SHAUN BERRY , HOLLIS MARK A , JOHNSON BERNADETTE
IPC分类号： C12Q1/68
CPC分类号： G01N33/5304 , C12M1/3461 , C12M1/3476 , C12Q1/6825 , G01N21/6428 , G01N21/6454 , G01N33/582 , C12Q2565/619 , C12Q2563/131
摘要： The invention described herein provides methods for the detection of soluble antigens. In particular, the methods provide for the detection of soluble proteins and chemicals. In addition, the invention provides methods of detecting a nucleic acid sequence in a sample. Also described is an emittor cell comprising an Fc receptor and an emittor molecule for the detection of a target particle in a sample wherein the target particle to be detected is bound by one or more antibodies. Also provided is an optoelectronic sensor device for detecting a target particle in a plurality of samples.
摘要翻译：本文所述的发明提供了用于检测可溶性抗原的方法。特别是，这些方法提供了可溶性蛋白质和化学品的检测。另外，本发明提供了检测样品中的核酸序列的方法。还描述了包含Fc受体和发射体分子的发射体细胞，用于检测样品中的目标颗粒，其中待检测的目标颗粒被一种或多种抗体结合。还提供了一种用于检测多个样本中的目标粒子的光电子传感器装置。

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