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1. 发明申请

WO1992007330A1 TELECOMMUNICATIONS DEVICE AND RELATED METHOD 审中-公开
标题翻译：电信设备及相关方法
公开(公告)号：WO1992007330A1
公开(公告)日：1992-04-30
申请号：PCT/US1991007703
申请日：1991-10-16
申请人： RICHARD, Daniel, D.
IPC分类号： G06F15/30
CPC分类号： G06F17/289 , G06F17/2872 , G06Q40/02 , H04N1/00127 , H04N1/00204
摘要： A telecommunications system includes a method for at least partially automatically converting monetary amounts in a document from one currency to a second currency. In addition, the telecommunications system includes a method for at least partially automatically translating a document being input in one natural language at a transmitting machine such as a facsimile or telecopier to a second natural language to be displayed, printed or otherwise communicated at a receiving end of a telecommunications link. A document containing the monetary amounts or translated portions is transmitted from a transmitting machine (40) and displayed, printed or otherwise communicated at a receiving end (36) of a telecommunication link. The monetary conversion and/or language translation may occur at any point in the telecommunications system, particularly at a transmitting facsimile device, a receiving facsimile device or a central facility operatively connected to a telecommunication network (26). The monetary conversion is preferably accomplished fully automatically, with decoders being used for determining identities of input and output currencies.
摘要翻译：电信系统包括用于至少部分地将文档中的货币金额从一种货币转换为第二种货币的方法。此外，电信系统包括一种用于至少部分地自动将在诸如传真机或电视传真机之类的发送机器输入的自然语言的文档翻译成要在接收端显示，打印或以其他方式传送的第二自然语言的方法的电信链路。包含货币量或翻译部分的文件从发送机（40）发送并在电信链路的接收端（36）处显示，打印或以其他方式通信。货币转换和/或语言翻译可以发生在电信系统中的任何一点，特别是在可操作地连接到电信网络（26）的发送传真设备，接收传真设备或中央设备上。货币兑换优选完全自动完成，解码器用于确定输入和输出货币的身份。

2. 发明申请

WO2007016245A3 REPROGRAMMING OF ADULT OR NEONIC STEM CELLS AND METHODS OF USE 审中-公开
标题翻译：成人或新生儿干细胞的分化及使用方法
公开(公告)号：WO2007016245A3
公开(公告)日：2007-11-22
申请号：PCT/US2006029193
申请日：2006-07-28
申请人： VIVICELLS INTERNATIONAL LLC , FITZSIMMONS FREDERICK J , RICHARD DANIEL D
发明人： FITZSIMMONS FREDERICK J , RICHARD DANIEL D
IPC分类号： C12N5/00 , A01N63/00 , C12N5/074
CPC分类号： C12N5/16 , A61K35/545 , C12N5/0696 , C12N2506/00
摘要： The present invention relates to methods of reprogramming adult stem cells or stem cells obtained from umbilical or placental cord blood or more preferably, the placeta or umbilical cord tissue itself or the amniotic fluid or amnion. The resulting stem cells and methods of using these stem cells represent additional aspects of the present invention. Stem cells according to the present invention, especially neonic stem cells (those obtained/reprogrammed from neonate stem cells), represent great potential in duplicating embryonic stem cell research without utilizing embryonic stems cells which have raised ethical and moral issues. The stem cells of the present invention which are reprogrammed are obtained from adults or from neonates without causing injury or death to a fetus in the case of embryonic stem cells and are non-controversial. In this sense, the present invention avoids many of the legal, ethical or moral considerations which have complicated the use of embryonic stem cells.
摘要翻译：本发明涉及重新编程从脐带或胎盘脐带血获得的成体干细胞或干细胞的方法，或更优选地，placeta或脐带组织本身或羊水或羊膜。所得干细胞和使用这些干细胞的方法代表本发明的另外方面。根据本发明的干细胞，特别是新生干细胞（从新生儿干细胞获得/重新编程的细胞），在不利用引起伦理和道德问题的胚胎干细胞的情况下，重复胚胎干细胞研究的巨大潜力。重新编程的本发明的干细胞从成人或新生儿获得，在胚胎干细胞的情况下不会对胎儿造成伤害或死亡，并且是无争议的。在这个意义上，本发明避免了复杂使用胚胎干细胞的许多法律，伦理或道义上的考虑。

3. 发明申请

WO2003075789A3 DUAL BLOOD DONATION PLUS METHOD 审中-公开
公开(公告)号：WO2003075789A3
公开(公告)日：2003-09-18
申请号：PCT/US2003/006317
申请日：2003-03-03
申请人： RICHARD, Daniel, D.
发明人： RICHARD, Daniel, D.
IPC分类号： A01N1/02
摘要： The invention provides methods enabling: (1) a blood donor to utilize the buffy coat of a blood sample to provide for autologous and/or allogeneic transplantation of certain components within the buffy coat; (2) segregation of a blood sample into component parts, including at least two samples, wherein a first sample is directed to autologous treatment of the blood donor or donor family member (an allogeneic treatment), and the other sample is directed to allogeneic treatment of diseases or organ creation for the general population (non-family members). Blood samples may be cryopreserved before use in the instant invention. In addition, the cryopreserved cells may be given to a researcher as a source of non-controversial biological material (stem cells or other cells). Of course, the present methods also encourage individuals to store their own cells for use in the near future of with future technical advances and to preserve today for tomorrow's technology sm . In one embodiment of the invention, blood samples are: (1) separated into components of the buffy coat and in particular, stem and/or progenitor cells; (2) genetically analyzed to assess genetic predisposition to disease in a donor family history; and (3) are dedicated to use by a donor family member in the event the family member succumbs to a disease state consistent with the genetic analysis.

4. 发明申请

WO2003075789A2 DUAL BLOOD DONATION PLUS METHOD 审中-公开
标题翻译：双血液加注方法
公开(公告)号：WO2003075789A2
公开(公告)日：2003-09-18
申请号：PCT/US2003/006317
申请日：2003-03-03
申请人： RICHARD, Daniel, D.
发明人： RICHARD, Daniel, D.
IPC分类号： A61F
CPC分类号： A01N1/02 , C12N5/0647
摘要： The invention provides methods enabling: (1) a blood donor to utilize the buffy coat of a blood sample to provide for autologous and/or allogeneic transplantation of certain components within the buffy coat; (2) segregation of a blood sample into component parts, including at least two samples, wherein a first sample is directed to autologous treatment of the blood donor or donor family member (an allogeneic treatment), and the other sample is directed to allogeneic treatment of diseases or organ creation for the general population (non-family members). Blood samples may be cryopreserved before use in the instant invention. In addition, the cryopreserved cells may be given to a researcher as a source of non-controversial biological material (stem cells or other cells). Of course, the present methods also encourage individuals to store their own cells for use in the near future of with future technical advances and to preserve today for tomorrow's technology sm . In one embodiment of the invention, blood samples are: (1) separated into components of the buffy coat and in particular, stem and/or progenitor cells; (2) genetically analyzed to assess genetic predisposition to disease in a donor family history; and (3) are dedicated to use by a donor family member in the event the family member succumbs to a disease state consistent with the genetic analysis.
摘要翻译：本发明提供了能够：（1）供血者利用血液样品的血沉棕黄层提供血沉棕黄层内某些组分的自体和/或同种异体移植的方法，（2）将血液样品分离成包括至少两个样品的组分部分，其中第一样品被引导至血液供体或供体家族成员的自体处理（同种异体处理），另一个样品被引导至同种异体处理为一般人群（非家庭成员）提供疾病或器官创造。血液样品可在本发明使用前冷冻保存。此外，冷冻保存的细胞可以作为无争议的生物材料（干细胞或其他细胞）的来源被给予研究者。当然，目前的方法也鼓励个人在不久的将来存储自己的细胞以供未来的技术进步，并保留今天的未来技术。在本发明的一个实施方案中，血液样品是：（1）分离成血沉棕黄层的成分，特别是茎和/或祖细胞; （2）进行遗传分析，以评估供体家族史中疾病的遗传倾向; 和（3）如果家庭成员屈服于符合遗传分析的疾病状态，则由捐助家庭成员使用。

5. 发明申请

WO1992004978A1 METHOD FOR USE IN PREPARING BIOLOGICAL SAMPLES AND RELATED STORAGE RECEPTACLE 审中-公开
标题翻译：用于制备生物样品和相关储存容器的方法
公开(公告)号：WO1992004978A1
公开(公告)日：1992-04-02
申请号：PCT/US1991007006
申请日：1991-09-25
申请人： CRYO-CELL INTERNATIONAL, INC. , RICHARD, Daniel, D. , KNIPPSCHEER, Herman , KNAUER, Joseph
发明人： CRYO-CELL INTERNATIONAL, INC.
IPC分类号： B01L03/00
CPC分类号： B01L3/50855 , A61B10/0096 , B01L3/5082 , B01L3/5085 , B01L9/06 , B01L2200/028 , B65D21/0231 , B65D71/50
摘要： A method for use in preparing biological samples comprises the steps of (a) upon the birth of an infant, obtaining at least a portion of a placenta and an associated umbilical cord which extended from the infant to the placenta, (b) extracting a first biological specimen from the portion of the placenta and umbilical cord and (c) extracting a second biological specimen from the umbilical cord/placenta or from a parent of the infant. The first biological specimen is deposited in one chamber of a storage receptacle having a plurality of storage chambers, while the second biological specimen is deposited in another of the chambers. The receptacle is then subjected to storage. The biological specimens are preferably blood fluid or DNA. A vial assembly for use in the method comprises a plurality of modular storage units each connected one to the other by cooperating male and female connectors. Alternatively, the vial assembly comprises a vial with multiple discrete ampules inside the vial or by partition inserts having the same transverse cross-section as the cavity defined by the vial. The vial may be further provided with a separate removable flange.
摘要翻译：一种用于制备生物样品的方法包括以下步骤：（a）婴儿出生时获得从婴儿延伸到胎盘的至少一部分胎盘和相关联的脐带，（b）提取第一来自胎盘和脐带部分的生物样本和（c）从脐带/胎盘或从婴儿的父母提取第二生物标本。将第一生物样品沉积在具有多个储存室的存储容器的一个室中，而将第二生物样品沉积在另一个室中。然后将容器进行储存。生物样本优选为血液或DNA。用于该方法的小瓶组件包括多个模块化存储单元，每个模块化存储单元通过配合的公和母连接器彼此连接。或者，小瓶组件包括在小瓶内部具有多个独立安瓿的小瓶或具有与由小瓶限定的空腔相同的横截面的分隔插入件。小瓶可以进一步设置有单独的可移除凸缘。

6. 发明申请

WO2007016245A2 REPROGRAMMING OF ADULT OR NEONIC STEM CELLS AND METHODS OF USE 审中-公开
标题翻译：成人或正常干细胞的重编程和使用方法
公开(公告)号：WO2007016245A2
公开(公告)日：2007-02-08
申请号：PCT/US2006/029193
申请日：2006-07-28
申请人： VIVICELLS INTERNATIONAL, LLC , FITZSIMMONS, Frederick, J. , RICHARD, Daniel, D.
发明人： FITZSIMMONS, Frederick, J. , RICHARD, Daniel, D.
IPC分类号： A61K35/14 , C12N5/08
CPC分类号： C12N5/16 , A61K35/545 , C12N5/0696 , C12N2506/00
摘要： The present invention relates to methods of reprogramming adult stem cells or stem cells obtained from umbilical or placental cord blood or more preferably, the placeta or umbilical cord tissue itself or the amniotic fluid or amnion. The resulting stem cells and methods of using these stem cells represent additional aspects of the present invention. Stem cells according to the present invention, especially neonic stem cells (those obtained/reprogrammed from neonate stem cells), represent great potential in duplicating embryonic stem cell research without utilizing embryonic stems cells which have raised ethical and moral issues. The stem cells of the present invention which are reprogrammed are obtained from adults or from neonates without causing injury or death to a fetus in the case of embryonic stem cells and are non-controversial. In this sense, the present invention avoids many of the legal, ethical or moral considerations which have complicated the use of embryonic stem cells.
摘要翻译：本发明涉及对从脐带或胎盘脐带血获得的成体干细胞或干细胞进行重编程的方法，更优选涉及放置或脐带组织本身或羊水或羊膜。所得干细胞和使用这些干细胞的方法代表了本发明的另外方面。根据本发明的干细胞，特别是新生干细胞（从新生儿干细胞获得/重新编程的那些细胞），在复制胚胎干细胞研究中具有很大的潜力，而不利用已经引起伦理和道德问题的胚胎干细胞。重编程的本发明的干细胞得自成人或新生儿，在胚胎干细胞的情况下不会对胎儿造成伤害或死亡，并且是无争议的。从这个意义上说，本发明避免了使胚胎干细胞的使用复杂化的许多法律，伦理或道德考虑。

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