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    • 1. 发明申请
    • VITAMIN D ANALOGS AND METHODS OF PREPARING THESE COMPOUNDS
    • 维生素D类似物和制备这些化合物的方法
    • WO1997042152A1
    • 1997-11-13
    • PCT/EP1997002429
    • 1997-05-02
    • DUPHAR INTERNATIONAL RESEARCH B.V.HALKES, SebastianVAN DE VELDE, Jan, PaulKANZLER, SilviaREISCHL, Wolfgang
    • DUPHAR INTERNATIONAL RESEARCH B.V.
    • C07C33/38
    • C07C33/38C07C2602/08
    • The invention relates to vitamin D analogs of general formula (I) wherein: R1 is a hydrogen atom or a substituent selected from the group consisting of hydroxy, CH2OH, CH2CH2OH, CH2CH2CH2OH, OCH3, OCH2OH, OCH2CH2OH and OCH2CH2CH2OH; R2 is a hydrogen atom or a substituent selected from the group consisting of OCH3, OCH2OH, CHm(CH2OH)n(CH2CH2OH)p, (CH2)qOH and O(CH2)rOH; wherein: m is 0 or 1, p, q and n are 0-3, r is 1-3 and m+n+p=3; with the proviso that R1 and/or R2 contain at least one OH group; R3 is a straight or branched, saturated or unsaturated aliphatic hydrocarbon of 6-13 C atoms which may be substituted with one or more substituents from the group hydroxy or fluoro. The invention further relates to methods of preparing these compounds, a pharmaceutical composition containing these compounds and to their use in pharmacotherapy and cosmetics.
    • 本发明涉及通式(I)的维生素D类似物,其中:R 1是氢原子或选自羟基,CH 2 OH,CH 2 CH 2 OH,CH 2 CH 2 CH 2 OH,OCH 3,OCH 2 OH,OCH 2 CH 2 OH和OCH 2 CH 2 CH 2 OH的取代基; R2是氢原子或选自OCH3,OCH2OH,CHm(CH2OH)n(CH2CH2OH)p,(CH2)qOH和O(CH2)rOH的取代基; 其中:m为0或1,p,q和n为0-3,r为1-3,m + n + p = 3; 条件是R1和/或R2含有至少一个OH基团; R3是6-13个碳原子的直链或支链饱和或不饱和脂族烃基,其可以被一个或多个羟基或氟取代基取代。 本发明还涉及制备这些化合物的方法,含有这些化合物的药物组合物及其在药物治疗和化妆品中的用途。