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1. 发明申请

WO1997042152A1 VITAMIN D ANALOGS AND METHODS OF PREPARING THESE COMPOUNDS 审中-公开
标题翻译：维生素D类似物和制备这些化合物的方法
公开(公告)号：WO1997042152A1
公开(公告)日：1997-11-13
申请号：PCT/EP1997002429
申请日：1997-05-02
申请人： DUPHAR INTERNATIONAL RESEARCH B.V. , HALKES, Sebastian , VAN DE VELDE, Jan, Paul , KANZLER, Silvia , REISCHL, Wolfgang
发明人： DUPHAR INTERNATIONAL RESEARCH B.V.
IPC分类号： C07C33/38
CPC分类号： C07C33/38 , C07C2602/08
摘要： The invention relates to vitamin D analogs of general formula (I) wherein: R1 is a hydrogen atom or a substituent selected from the group consisting of hydroxy, CH2OH, CH2CH2OH, CH2CH2CH2OH, OCH3, OCH2OH, OCH2CH2OH and OCH2CH2CH2OH; R2 is a hydrogen atom or a substituent selected from the group consisting of OCH3, OCH2OH, CHm(CH2OH)n(CH2CH2OH)p, (CH2)qOH and O(CH2)rOH; wherein: m is 0 or 1, p, q and n are 0-3, r is 1-3 and m+n+p=3; with the proviso that R1 and/or R2 contain at least one OH group; R3 is a straight or branched, saturated or unsaturated aliphatic hydrocarbon of 6-13 C atoms which may be substituted with one or more substituents from the group hydroxy or fluoro. The invention further relates to methods of preparing these compounds, a pharmaceutical composition containing these compounds and to their use in pharmacotherapy and cosmetics.
摘要翻译：本发明涉及通式（I）的维生素D类似物，其中：R 1是氢原子或选自羟基，CH 2 OH，CH 2 CH 2 OH，CH 2 CH 2 CH 2 OH，OCH 3，OCH 2 OH，OCH 2 CH 2 OH和OCH 2 CH 2 CH 2 OH的取代基; R2是氢原子或选自OCH3，OCH2OH，CHm（CH2OH）n（CH2CH2OH）p，（CH2）qOH和O（CH2）rOH的取代基; 其中：m为0或1，p，q和n为0-3，r为1-3，m + n + p = 3; 条件是R1和/或R2含有至少一个OH基团; R3是6-13个碳原子的直链或支链饱和或不饱和脂族烃基，其可以被一个或多个羟基或氟取代基取代。本发明还涉及制备这些化合物的方法，含有这些化合物的药物组合物及其在药物治疗和化妆品中的用途。

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