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1. 发明申请

WO2010040508A8 BISPECIFIC ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 审中-公开
标题翻译：双相抗VEGF /抗ANG-2抗体
公开(公告)号：WO2010040508A8
公开(公告)日：2011-02-24
申请号：PCT/EP2009007182
申请日：2009-10-07
申请人： HOFFMANN LA ROCHE , BAEHNER MONIKA , BRINKMANN ULRICH , GEORGES GUY , GRIEP REMKO ALBERT , IMHOF-JUNG SABINE , KAVLIE ANITA , KETTENBERGER HUBERT , KLEIN CHRISTIAN , REGULA JOERG THOMAS , SCHAEFER WOLFGANG , SCHANZER JUERGEN MICHAEL , SCHEUER WERNER , SEEBER STEFAN , THOMAS MARKUS
发明人： BAEHNER MONIKA , BRINKMANN ULRICH , GEORGES GUY , GRIEP REMKO ALBERT , IMHOF-JUNG SABINE , KAVLIE ANITA , KETTENBERGER HUBERT , KLEIN CHRISTIAN , REGULA JOERG THOMAS , SCHAEFER WOLFGANG , SCHANZER JUERGEN MICHAEL , SCHEUER WERNER , SEEBER STEFAN , THOMAS MARKUS
IPC分类号： C07K16/22 , A61K39/395 , C07K14/00 , C07K16/46 , C07K19/00
CPC分类号： C07K16/22 , A61K2039/505 , A61K2039/507 , C07K2317/21 , C07K2317/31 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/00 , C07K2319/30
摘要： The present invention relates to bispecific antibodies against human VEGF and against human ANG-2, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人VEGF和针对人ANG-2的双特异性抗体，其制备方法，含有所述抗体的药物组合物及其用途。

2. 发明申请

WO2010145793A1 BISPECIFIC, TETRAVALENT ANTIGEN BINDING PROTEINS 审中-公开
标题翻译： BISPECIFIC，抗体抗原结合蛋白
公开(公告)号：WO2010145793A1
公开(公告)日：2010-12-23
申请号：PCT/EP2010/003560
申请日：2010-06-14
申请人： F. HOFFMANN-LA ROCHE AG , IMHOF-JUNG, Sabine , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael
发明人： IMHOF-JUNG, Sabine , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael
IPC分类号： C07K16/46 , C07K16/22
CPC分类号： C07K16/468 , C07K16/22 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： Bispecific, tetravalent antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：双特异性，四价抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。

3. 发明申请

WO2012116926A1 ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：抗原结合蛋白
公开(公告)号：WO2012116926A1
公开(公告)日：2012-09-07
申请号：PCT/EP2012/053118
申请日：2012-02-24
申请人： F. HOFFMANN-LA ROCHE AG , BOSSENMAIER, Birgit , KETTENBERGER, Hubert , KLEIN, Christian , KUENKELE, Klaus-Peter , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , SCHWAIGER, Manfred , SUSTMANN, Claudio
发明人： BOSSENMAIER, Birgit , KETTENBERGER, Hubert , KLEIN, Christian , KUENKELE, Klaus-Peter , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , SCHWAIGER, Manfred , SUSTMANN, Claudio
IPC分类号： C07K16/00 , C07K16/22
CPC分类号： C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/41 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof. The antigen binding protein comprise a) two modified heavy chains of an antibody which specifically binds to an antigen, wherein VH of each heavy chain is replaced by the VL of said antibody, said modified heavy chains being associated with each other via their CH3 domains of the Fc part; b) two modified heavy chains of said antibody wherein CHI of each heavy chain is replaced by CL of said antibody, said modified heavy chains being associated with each other via their CH3 domains of the Fc part; and wherein the VL domains of the heavy chains of a) are associated with the VH domains of the heavy chains of b), and the CHI domains of the heavy chains of a) are associated with the CL domains of the heavy chains of b).
摘要翻译：本发明涉及包含两个Fc部分的抗原结合蛋白，其制备方法，含有所述抗原结合蛋白的药物组合物及其用途。抗原结合蛋白包含a）两个特异性结合抗原的修饰的重链，其中每条重链的VH被所述抗体的VL代替，所述修饰的重链通过它们的CH3结构域相互关联 Fc部分; b）所述抗体的两个修饰的重链，其中每个重链的CHI被所述抗体的CL替代，所述修饰的重链通过其Fc部分的CH3结构域相互关联; 并且其中a）的重链的VL结构域与b）的重链的VH结构域相关联，并且a）的重链的CH1结构域与b）重链的CL结构域相关联，。

4. 发明申请

WO2011101370A1 METHOD FOR THE DETERMINATION OF SEQUENCE VARIANTS OF POLYPEPTIDES 审中-公开
标题翻译：用于确定多肽序列变异体的方法
公开(公告)号：WO2011101370A1
公开(公告)日：2011-08-25
申请号：PCT/EP2011/052282
申请日：2011-02-16
申请人： F. HOFFMANN-LA ROCHE AG , KOLL, Hans , REGULA, Joerg Thomas , WIEGESHOFF, Frank , ZECK, Anne
发明人： KOLL, Hans , REGULA, Joerg Thomas , WIEGESHOFF, Frank , ZECK, Anne
IPC分类号： G01N33/68
CPC分类号： C12Q1/37 , G01N33/6848 , G01N2560/00
摘要： The current invention is directed to a method for determining amino acid sequence mutations in a produced polypeptide, comprising the following steps of a) providing a sample of a produced polypeptide, b) incubating the polypeptide in the sample with a protease, c) performing a two dimensional analysis using reversed phase chromatography coupled with a high resolution mass spectroscopy (FT-ICR / FT-orbitrap) and MS/MS analysis of the amino acid sequence fragments of the peptides, d) data evaluation by comparing the LC-MS data sets obtained for the samples side by side with the data set of a reference sample, by searching for differences in the signal intensities at given retention times and by evaluation of differential signals with respect to amino acid sequence mutations. The reference sample for data evaluation (d) can be either a well characterized standard or one of the samples to be analyzed.
摘要翻译：本发明涉及一种用于测定产生的多肽中的氨基酸序列突变的方法，包括以下步骤：a）提供产生的多肽的样品，b）将样品中的多肽与蛋白酶一起孵育，c）使用反相色谱与高分辨率质谱（FT-ICR / FT-orbitrap）相结合的二维分析和肽的氨基酸序列片段的MS / MS分析，d）通过比较LC-MS数据集进行数据评估通过在给定的保留时间上搜索信号强度的差异，并且通过评估关于氨基酸序列突变的差异信号，将样品与参考样品的数据集并排获得。用于数据评估的参考样本（d）可以是一个良好表征的标准或要分析的样品之一。

5. 发明申请

WO2010145792A1 BISPECIFIC ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：双重抗原结合蛋白
公开(公告)号：WO2010145792A1
公开(公告)日：2010-12-23
申请号：PCT/EP2010/003559
申请日：2010-06-14
申请人： F. HOFFMANN-LA ROCHE AG , IMHOF-JUNG, Sabine , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael
发明人： IMHOF-JUNG, Sabine , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael
IPC分类号： C07K16/46 , C07K16/22
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： Bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：双特异性抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。

6. 发明申请

WO2010089126A3 IMMUNOGLOBULIN GLYCOSYLATION PATTERN ANALYSIS 审中-公开
标题翻译：免疫球蛋白糖基化模式分析
公开(公告)号：WO2010089126A3
公开(公告)日：2010-11-11
申请号：PCT/EP2010000710
申请日：2010-02-05
申请人： ROCHE GLYCART AG , KOLL HANS , REGULA JOERG THOMAS , SONDERMANN PETER , ZECK ANNE
发明人： KOLL HANS , REGULA JOERG THOMAS , SONDERMANN PETER , ZECK ANNE
IPC分类号： G01N33/68 , C07K1/00 , C07K1/14 , C07K1/16 , C07K1/22 , C07K16/06
CPC分类号： G01N33/6854 , C07K1/20 , C07K1/34 , C07K16/00 , C07K2317/24 , C07K2317/41 , C07K2317/50 , G01N33/6848 , G01N2400/00
摘要： The current invention is directed to a method for the determination of the glycosylation pattern of a human immunoglobulin of the subclass IgG1 or IgG4 or of a murine immunoglobulin of the subclass IgG2a or IgG3 comprising the following steps: a) cleaving said immunoglobulin into fragments by enzymatic digestion with the enzyme IdeS, b) separating the fragments of said immunoglobulin obtained by the enzymatic digestion by reversed phase high performance liquid chromatography, c) subjecting the separated fragments of said immunoglobulin obtained in step b) to a mass spectrometric analysis, and d) determining the glycosylation pattern of said immunoglobulin from the mass spectrometric data obtained in step c).
摘要翻译：本发明涉及用于测定亚类IgG1或IgG4或亚类IgG2a或IgG3的鼠免疫球蛋白的人免疫球蛋白的糖基化模式的方法，其包括以下步骤：a）通过酶促切割所述免疫球蛋白为片段 b）通过反相高效液相色谱法分离通过酶消化获得的所述免疫球蛋白的片段，c）对步骤b）中获得的所述免疫球蛋白的分离片段进行质谱分析，和d）从步骤c）中获得的质谱数据确定所述免疫球蛋白的糖基化模式。

7. 发明申请

WO2011117329A1 BISPECIFIC, BIVALENT ANTI-VEGF/ANTI-ANG-2 ANTIBODIES 审中-公开
标题翻译： BISPECIFIC，BIVALENT ANTI-VEGF / ANTI-ANG-2 ANTIBODIES
公开(公告)号：WO2011117329A1
公开(公告)日：2011-09-29
申请号：PCT/EP2011/054504
申请日：2011-03-24
申请人： F. HOFFMANN-LA ROCHE AG , BAEHNER, Monika , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , STUBENRAUCH, Kay-Gunnar , THOMAS, Markus
发明人： BAEHNER, Monika , IMHOF-JUNG, Sabine , KAVLIE, Anita , KETTENBERGER, Hubert , KLEIN, Christian , REGULA, Joerg, Thomas , SCHAEFER, Wolfgang , SCHANZER, Juergen, Michael , SCHEUER, Werner , STUBENRAUCH, Kay-Gunnar , THOMAS, Markus
IPC分类号： C07K16/22
CPC分类号： C07K16/22 , A61K2039/505 , C07K16/3015 , C07K16/3046 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/52 , C07K2317/522 , C07K2317/56 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to bispecific, bivalent antibodies against human vascular endothelial growth factor (VEGF/VEGF-A) and against human angiopoietin-2 (ANG-2), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及针对人血管内皮生长因子（VEGF / VEGF-A）和针对人血管生成素-2（ANG-2）的双特异性二价抗体，其制备方法，含有所述抗体的药物组合物及其用途。

8. 发明申请

WO2012116927A1 MONOVALENT ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：单一抗原结合蛋白
公开(公告)号：WO2012116927A1
公开(公告)日：2012-09-07
申请号：PCT/EP2012/053119
申请日：2012-02-24
申请人： F. HOFFMANN-LA ROCHE AG , BOSSENMAIER, Birgit , KETTENBERGER, Hubert , KLEIN, Christian , KEUNKELE, Klaus-Peter , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , SCHWAIGER, Manfred , SUSTMANN, Claudio
发明人： BOSSENMAIER, Birgit , KETTENBERGER, Hubert , KLEIN, Christian , KEUNKELE, Klaus-Peter , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , SCHWAIGER, Manfred , SUSTMANN, Claudio
IPC分类号： C07K16/00 , C07K16/18 , C07K16/30
CPC分类号： C07K16/00 , C07K16/2863 , C07K2317/35 , C07K2317/64 , C07K2317/66 , C07K2317/732 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C07K2317/94
摘要： The present invention relates to monovalent antigen binding proteins with a CH1-CL domain exchange, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及具有CH1-CL结构域交换的单价抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。

9. 发明申请

WO2010069532A8 ANTIBODIES AGAINST HUMAN ANGIOPOIETIN 2 审中-公开
标题翻译：抗体人类抗体2
公开(公告)号：WO2010069532A8
公开(公告)日：2012-05-10
申请号：PCT/EP2009008930
申请日：2009-12-14
申请人： HOFFMANN LA ROCHE , BRINKMANN ULRICH , GRIEP REMKO ALBERT , KALUZA KLAUS , KAVLIE ANITA , KLEIN CHRISTIAN , REGULA JOERG THOMAS , SCHEUER WERNER
发明人： BRINKMANN ULRICH , GRIEP REMKO ALBERT , KALUZA KLAUS , KAVLIE ANITA , KLEIN CHRISTIAN , REGULA JOERG THOMAS , SCHEUER WERNER
IPC分类号： C07K16/22 , A61K39/395 , A61P35/00
CPC分类号： C07K16/22 , A61K39/00 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C12N15/85
摘要： The present invention relates to antibodies against human Angiopoietin 2 (anti- ANG-2 antibodies), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：本发明涉及抗人血管生成素2（抗ANG-2抗体）的抗体，其生产方法，含有所述抗体的药物组合物及其应用。

10. 发明申请

WO2010145792A8 BISPECIFIC ANTIGEN BINDING PROTEINS 审中-公开
标题翻译：双重抗原结合蛋白
公开(公告)号：WO2010145792A8
公开(公告)日：2011-10-06
申请号：PCT/EP2010003559
申请日：2010-06-14
申请人： HOFFMANN LA ROCHE , IMHOF-JUNG SABINE , KLEIN CHRISTIAN , REGULA JOERG THOMAS , SCHAEFER WOLFGANG , SCHANZER JUERGEN MICHAEL
发明人： IMHOF-JUNG SABINE , KLEIN CHRISTIAN , REGULA JOERG THOMAS , SCHAEFER WOLFGANG , SCHANZER JUERGEN MICHAEL
IPC分类号： C07K16/46 , C07K16/22
CPC分类号： C07K16/22 , C07K16/468 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/64 , C07K2317/66 , C07K2317/73 , C07K2317/76 , C07K2319/00
摘要： Bispecific antigen binding proteins, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译：双特异性抗原结合蛋白，其制备方法，含有所述抗体的药物组合物及其用途。

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