基本信息:
- 专利标题： ANTIGEN BINDING PROTEINS
- 专利标题（中）：抗原结合蛋白
- 申请号：PCT/EP2012/053118 申请日：2012-02-24
- 公开(公告)号：WO2012116926A1 公开(公告)日：2012-09-07
- 发明人： BOSSENMAIER, Birgit , KETTENBERGER, Hubert , KLEIN, Christian , KUENKELE, Klaus-Peter , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , SCHWAIGER, Manfred , SUSTMANN, Claudio
- 申请人： F. HOFFMANN-LA ROCHE AG , BOSSENMAIER, Birgit , KETTENBERGER, Hubert , KLEIN, Christian , KUENKELE, Klaus-Peter , REGULA, Joerg Thomas , SCHAEFER, Wolfgang , SCHWAIGER, Manfred , SUSTMANN, Claudio
- 申请人地址： Grenzacher Strasse 124 CH-4070 Basel CH
- 专利权人： F. HOFFMANN-LA ROCHE AG,BOSSENMAIER, Birgit,KETTENBERGER, Hubert,KLEIN, Christian,KUENKELE, Klaus-Peter,REGULA, Joerg Thomas,SCHAEFER, Wolfgang,SCHWAIGER, Manfred,SUSTMANN, Claudio
- 当前专利权人： F. HOFFMANN-LA ROCHE AG,BOSSENMAIER, Birgit,KETTENBERGER, Hubert,KLEIN, Christian,KUENKELE, Klaus-Peter,REGULA, Joerg Thomas,SCHAEFER, Wolfgang,SCHWAIGER, Manfred,SUSTMANN, Claudio
- 当前专利权人地址： Grenzacher Strasse 124 CH-4070 Basel CH
- 代理机构： JENNI, Wolfgang et al.
- 优先权： EP11156320.1 20110228
- 主分类号： C07K16/00
- IPC分类号： C07K16/00 ; C07K16/22
摘要：
The present invention relates to antigen binding proteins comprising two Fc parts, methods for their production, pharmaceutical compositions containing said antigen binding proteins, and uses thereof. The antigen binding protein comprise a) two modified heavy chains of an antibody which specifically binds to an antigen, wherein VH of each heavy chain is replaced by the VL of said antibody, said modified heavy chains being associated with each other via their CH3 domains of the Fc part; b) two modified heavy chains of said antibody wherein CHI of each heavy chain is replaced by CL of said antibody, said modified heavy chains being associated with each other via their CH3 domains of the Fc part; and wherein the VL domains of the heavy chains of a) are associated with the VH domains of the heavy chains of b), and the CHI domains of the heavy chains of a) are associated with the CL domains of the heavy chains of b).
摘要（中）：
本发明涉及包含两个Fc部分的抗原结合蛋白，其制备方法，含有所述抗原结合蛋白的药物组合物及其用途。 抗原结合蛋白包含a）两个特异性结合抗原的修饰的重链，其中每条重链的VH被所述抗体的VL代替，所述修饰的重链通过它们的CH3结构域相互关联 Fc部分; b）所述抗体的两个修饰的重链，其中每个重链的CHI被所述抗体的CL替代，所述修饰的重链通过其Fc部分的CH3结构域相互关联; 并且其中a）的重链的VL结构域与b）的重链的VH结构域相关联，并且a）的重链的CH1结构域与b）重链的CL结构域相关联， 。