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1. 发明申请

WO2004028580A1 BONE-FILLING COMPOSITION FOR STIMULATING BONE-FORMING AND BONE-CONSOLIDATION COMPRISING CALCIUM SULFATE AND VISCOUS BIOPOLYMERS 审中-公开
标题翻译：用于刺激骨形成的骨填充组合物和包含硫酸钙和粘弹性生物反应器的骨质疏松
公开(公告)号：WO2004028580A1
公开(公告)日：2004-04-08
申请号：PCT/KR2002/001839
申请日：2002-09-30
申请人： REGEN BIOTECH, INC. , KIM, In-San , CHO, Byung Chae
发明人： KIM, In-San , CHO, Byung Chae
IPC分类号： A61L27/44
CPC分类号： A61K33/06 , A61K33/10 , A61L27/446 , A61L2430/02 , A61K2300/00
摘要： The present invention relates to a composition for bone-filling, more particularly, to a bone-filling composition for stimulating bone-formation and bone consolidation comprising calcium sulfate and viscous biopolymers. The composition of the present invention can easily be administered into the missing part of injured bone. Since the composition of the present invention does not diffuse to surrounding organs, it can effectively be used for bone-filling material suitable for body.
摘要翻译：本发明涉及一种用于骨填充的组合物，更具体地涉及一种用于刺激骨形成和骨固定的骨填充组合物，其包含硫酸钙和粘性生物聚合物。本发明的组合物可以容易地施用于受损骨的缺损部分。由于本发明的组合物不会扩散到周围的器官，所以可以有效地用于适合身体的骨填充材料。

2. 发明申请

WO2003089935A1 THE METHOD FOR MEASURING THE AMOUNT OF βiG-H3 PROTEIN AND DIAGNOSTIC KIT USING THE SAME 审中-公开
标题翻译：测量βGG-H3蛋白和诊断试剂盒的方法
公开(公告)号：WO2003089935A1
公开(公告)日：2003-10-30
申请号：PCT/KR2002/001975
申请日：2002-10-22
申请人： REGEN BIOTECH, INC. , KIM, In-San , BAE, Jong-Sub
发明人： KIM, In-San , BAE, Jong-Sub
IPC分类号： G01N33/68
CPC分类号： G01N33/6887 , G01N2333/78
摘要： The present invention relates to the method for measuring the amount of β ig-h3 protein and diagnostic kit using the same. Particularly, it relates to the method for measuring the amount of β ig-h3 protein in the body fluids by specific binding reaction between β ig-h3 protein or recombinant proteins of fas-1 domain in the β ig-h3 protein (including their fragments or their derivatives) and their ligands and relates to diagnostic kit for the renal diseases, hepatic diseases, rheumatoid arthritis or cardiovascular diseases comprising β ig-h3 protein or recombinant proteins of fas-1 domain in the β ig-h3 protein (including their fragments or their derivatives) and their ligands. The method and kit of the present invention can be effectively used as sensitive diagnostic method for the extent of damage or progress of the renal diseases, hepatic diseases, rheumatoid arthritis or cardiovascular diseases.
摘要翻译：本发明涉及测量βig-h3蛋白的量的方法及其使用的诊断试剂盒。特别涉及通过βig-h3蛋白或βig-h3蛋白（包括它们的片段中的fas-1结构域的重组蛋白）之间的特异性结合反应来测量体液中βig-h3蛋白的量的方法或其衍生物）及其配体，涉及包含βig-h3蛋白的肾脏疾病，肝脏疾病，类风湿性关节炎或心血管疾病的诊断试剂盒或βig-h3蛋白中的fas-1结构域的重组蛋白（包括其片段或其衍生物）及其配体。本发明的方法和试剂盒可以有效地用作肾脏疾病，肝脏疾病，类风湿性关节炎或心血管疾病的损伤或进展程度的敏感诊断方法。

3. 发明申请

WO2006049440A1 METHOD FOR PRODUCING EPIDERMAL GROWTH FACTOR USING FUSION PROTEINS COMPRISING F A S-1 DOMAIN 审中-公开
标题翻译：使用包含F-S-1域的融合蛋白生产人造山生长因子的方法
公开(公告)号：WO2006049440A1
公开(公告)日：2006-05-11
申请号：PCT/KR2005/003696
申请日：2005-11-03
申请人： NEXGEN BIOTECHNOLOGIES, INC. , REGEN BIOTECH, INC. , LEE, Sun , YOO, Jae Geun , KIM, In San , BAE, Eun Hee , LEE, Dong Sin
发明人： LEE, Sun , YOO, Jae Geun , KIM, In San , BAE, Eun Hee , LEE, Dong Sin
IPC分类号： C07K19/00 , C07K16/26 , C12N15/18
CPC分类号： C07K14/485 , C07K14/4718 , C07K2319/74 , C12N15/8257
摘要： The present invention provides a fusion protein in which a polypeptide comprising Fas-1 domain is fused in frame to N-terminal or C-terminal of human EGF, a nucleotide sequence encoding the fusion protein, an expression vector containing the nucleotide sequence, a transformant transformed by the nucleotide sequence and a method for producing human EGF, improving stability of the protein and enhancing the functions of the same. The present invention provides human EGF with improved stability and enhanced functions by fusing a polypeptide comprising Fas-1 domain having the activities of cell adhesion and wound healing to human EGF.
摘要翻译：本发明提供了一种融合蛋白，其中包含Fas-1结构域的多肽与人EGF的N-末端或C-末端融合，编码融合蛋白的核苷酸序列，含有该核苷酸序列的表达载体，转化体通过核苷酸序列转化和产生人EGF的方法，提高蛋白质的稳定性并增强其功能。本发明通过将包含具有细胞粘附和伤口愈合活性的Fas-1结构域的多肽融合到人EGF来提供具有改善的稳定性和增强功能的人EGF。

4. 发明申请

WO2005118685A1 HIGH MOLECULAR SUBSTANCE BEADS HAVING WATER-INSOLUBLE INORGANIC COMPOUNDS ENCAPSULATED THEREIN, THEIR PREPARATION METHOD AND USE 审中-公开
标题翻译：含有无水无机化合物的高分子物质珠，其制备方法和用途
公开(公告)号：WO2005118685A1
公开(公告)日：2005-12-15
申请号：PCT/KR2005/001651
申请日：2005-06-02
申请人： REGEN BIOTECH, INC. , BAE, Eunhee , LEE, Dongsin , CHOI, Jisuk , ROH, Kyung-Ho
发明人： BAE, Eunhee , LEE, Dongsin , CHOI, Jisuk , ROH, Kyung-Ho
IPC分类号： C08J3/215
CPC分类号： C08J3/212 , C08J2305/00 , C08K3/22 , C08K3/26 , C08K3/30 , C08K3/32 , C08L5/08
摘要： The present invention relates to polymer beads having a water-insoluble inorganic compound encapsulated therein, and their preparation method and use. In the present invention, the water-insoluble inorganic compound which has limitations on its use because of the characteristic of precipitates in an aqueous solution is encapsulated in the polymer beads. This encapsulation provides an increase in the utility of the water-insoluble inorganic compound and at the same time, imparts the activity of the water-insoluble inorganic compound to the polymer, thus increasing the function of the polymer. Accordingly, the polymer beads having the water-insoluble inorganic compound encapsulated therein, which are prepared by the inventive method, can be advantageously used in various fields, including medical and electronic industries.
摘要翻译：本发明涉及包封有水不溶性无机化合物的聚合物珠粒及其制备方法和用途。在本发明中，由于在水溶液中析出物的特征，其使用限制的水不溶性无机化合物被包封在聚合物珠粒中。这种封装提高了水不溶性无机化合物的用途，同时赋予了水不溶性无机化合物对聚合物的活性，从而增加了聚合物的功能。因此，通过本发明方法制备的具有包封在其中的水不溶性无机化合物的聚合物珠可以有利地用于包括医疗和电子工业在内的各种领域。

5. 发明申请

WO2004087193A1 USE OF A PEPTIDE THAT INTERACTS WITH ALPHA V BETA3 INTEGRIN OF ENDOTHELIAL CELL 审中-公开
标题翻译：使用与ALPHA V BETA3内皮细胞相互作用的肽
公开(公告)号：WO2004087193A1
公开(公告)日：2004-10-14
申请号：PCT/KR2004/000774
申请日：2004-04-02
申请人： REGEN BIOTECH INC.. , NAM, Ju-Ock , KIM, Jung-Eun , JEONG, Ha-Won , LEE, Sung-Jin , LEE, Byung-Heon , CHOI, Je-Yong , PARK, Rang-Woon , PARK, Jae-Yong , KIM, In-San
发明人： NAM, Ju-Ock , KIM, Jung-Eun , JEONG, Ha-Won , LEE, Sung-Jin , LEE, Byung-Heon , CHOI, Je-Yong , PARK, Rang-Woon , PARK, Jae-Yong , KIM, In-San
IPC分类号： A61K38/16
CPC分类号： A61K38/10
摘要： The present invention relates to the novel use of a peptide that interacts with the αvβ3 integrin of endothelial cells. More particularly, the invention relates to a method for inhibiting endothelial cell adhesion, endothelial cell migration and/or angiogenesis, using a peptide consisting of at least 18 amino acids, comprising tyrosine-histidine (YH) or asparagine-histidine (NH), and at least three hydrophobic amino acids with bulky side chains; or equivalents thereof. Furthermore, the invention provides a method for treating or preventing angiogenesis-related diseases, using the peptide.
摘要翻译：本发明涉及与内皮细胞的alphavbeta3整联蛋白相互作用的肽的新用途。更具体地说，本发明涉及使用包含酪氨酸 - 组氨酸（YH）或天冬酰胺 - 组氨酸（NH）的至少18个氨基酸的肽来抑制内皮细胞粘附，内皮细胞迁移和/或血管发生的方法，以及至少三个具有庞大侧链的疏水性氨基酸; 或其等同物。此外，本发明提供了使用肽治疗或预防血管生成相关疾病的方法。

6. 发明申请

WO2010140865A3 BIODEGRADABLE POLYMER MICROPARTICLES AND PREPARATION METHOD THEREOF 审中-公开
标题翻译：生物可降解聚合物微生物及其制备方法
公开(公告)号：WO2010140865A3
公开(公告)日：2011-03-31
申请号：PCT/KR2010003610
申请日：2010-06-04
申请人： REGEN BIOTECH INC , KIM GUN POONG , LEE YONG HOON , LEE KUN PIL
发明人： KIM GUN POONG , LEE YONG HOON , LEE KUN PIL
IPC分类号： C08J3/12 , C08K5/42 , C08L67/04
CPC分类号： C08F6/00 , B29B9/12 , B29B2009/125 , C08G63/06 , C08J3/122 , C08J3/14 , C08J2367/04 , Y10T428/2989
摘要： The present invention relates to a preparation method for biodegradable polymer microparticles and the microparticles prepared by the method. More specifically, the preparation method for polymer microparticles, comprises: dissolving a biodegradable polyester-based polymer in DMSO, dispersing the resulting solution in a low-temperature hydrocarbon solution to obtain frozen DMSO microparticles and then introducing the DMSO microparticles into a low-temperature aqueous salt solution to dissolve the DMSO and remove the salt. The present invention provides a preparation method for novel polymer microspheres that are excellent in biocompatibility, biodegradability, porosity and mechanical strength, can be injected with a syringe by controlling the size of microcarriers and are mass-producible. Since the microparticles obtained with the preparation method of the present invention are biodegradable, biocompatible and come in diverse sizes, they can be used effectively as messengers for damaged or tissue regeneration cells by in vivo injection with a syringe.
摘要翻译：本发明涉及可生物降解的聚合物微粒的制备方法和通过该方法制备的微粒。更具体地说，聚合物微粒的制备方法包括：将可生物降解的聚酯类聚合物溶解在DMSO中，将所得溶液分散在低温烃溶液中，得到冷冻的DMSO微粒，然后将DMSO微粒引入低温水溶液盐溶液溶解DMSO并除去盐。本发明提供了生物相容性，生物降解性，孔隙率和机械强度优异的新型聚合物微球的制备方法，可以通过控制微载体的尺寸而注射注射器，并且可大量生产。由于通过本发明的制备方法获得的微粒是可生物降解的，生物相容的并且具有不同的尺寸，因此通过用注射器体内注射可有效地用作损伤或组织再生细胞的信使。

7. 发明申请

WO2004075665A1 COMPOSITION OF FUNCTIONAL FOODS HAVING EFFECTS OF COTININE INDUCTION AND ANTIOXIDATION 审中-公开
标题翻译：功能性食物组合物，具有促进感染和抗氧化作用
公开(公告)号：WO2004075665A1
公开(公告)日：2004-09-10
申请号：PCT/KR2004/000411
申请日：2004-02-27
申请人： REGEN BIOTECH INC. , JUNG, Jongmoon , KIM, Kyungbum , LEE, Sungsuk
发明人： KIM, Kyungbum , LEE, Sungsuk
IPC分类号： A23L1/30
CPC分类号： A23L33/105 , A23V2002/00 , A23V2200/02 , A23V2250/214 , A23V2250/21
摘要： The present invention relates to a functional food composition having effects of nicotine conversion into cotinine and antioxidation, which comprises extracts from green tea leaves, Artemisia capillaris, Oenanthe javanica, Siberian ginseng, Chinese quince, Houttuynia cordata, ginger and onion. The composition has the excellent effects of inhibiting the conversion of nicotine into nicotine-derived N-nitrosamines as carcinogens while increasing the conversion of nicotine into cotinine. Also, the composition has the excellent effect of inhibiting the mutagenicity of 4-methylnitrosamino-l-3-pyridyl-l-butanone (NKK) as a nicotine metabolite. Owing to such effects, the composition can be used as a raw material for functional food production.
摘要翻译：本发明涉及具有尼古丁转化为可替宁和抗氧化作用的功能性食品组合物，其包括来自绿茶叶，青蒿，西葫芦，西伯利亚人参，中国柑橘，鱼腥草，姜和洋葱的提取物。该组合物具有抑制尼古丁转化成尼古丁衍生的N-亚硝胺作为致癌物质的优异效果，同时增加尼古丁转化为可替宁。此外，该组合物具有抑制4-甲基亚硝基氨基-1-吡啶基-1-丁酮（NKK）作为尼古丁代谢物的致突变性的优异效果。由于这样的效果，组合物可以用作功能性食品生产的原料。

8. 发明申请

WO2005074964A1 EXTRACTS OF HOUTTUYNIA CORDATA AND RUBUS COREANUS AND THEIR COMPOSITION FOR PREVENTING AND TREATING ALLERGIC DISEASES 审中-公开
标题翻译： OUT IA IA ATA ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES ES
公开(公告)号：WO2005074964A1
公开(公告)日：2005-08-18
申请号：PCT/KR2005/000339
申请日：2005-02-04
申请人： REGEN BIOTECH, INC. , SONG, Chang-Ho , CHAI, Ok-Hee , PARK, Yong-In , LEE, Dong-Sin
发明人： SONG, Chang-Ho , CHAI, Ok-Hee , PARK, Yong-In , LEE, Dong-Sin
IPC分类号： A61K35/78
CPC分类号： A61K36/734 , A23L33/105 , A61K36/185 , A61K36/40 , A61K36/605 , A61K36/73 , A61K2300/00
摘要： The present invention relates to an extract of Houttuynia cordata and Rubus coreanus , and a composition for the prevention and treatment of allergic diseases, comprising the same. The inventive extract and the composition comprising the same have the effect of preventing and treating allergic diseases by inhibiting the degranulation and histamine release of mast cells. Also, they show no cytotoxicity and thus can be safely use in vivo .
摘要翻译：本发明涉及鱼腥草提取物和木鳖子，以及包含其的用于预防和治疗过敏性疾病的组合物。本发明的提取物及其组合物具有通过抑制肥大细胞的脱粒和组胺释放来预防和治疗过敏性疾病的效果。此外，它们不显示细胞毒性，因此可以在体内安全使用。

9. 发明申请

WO2004028578A1 COMPOSITION FOR STIMULATING BONE-FORMATION AND BONE CONSOLIDATION 审中-公开
标题翻译：用于刺激骨形成和骨骼综合的组合物
公开(公告)号：WO2004028578A1
公开(公告)日：2004-04-08
申请号：PCT/KR2002/001837
申请日：2002-09-30
申请人： REGEN BIOTECH, INC. , KIM, In-San , CHO, Byung, Chae
发明人： KIM, In-San , CHO, Byung, Chae
IPC分类号： A61L27/14
CPC分类号： A61K38/1825 , A61K31/722 , A61K33/42 , A61K38/1841 , A61K38/1858 , A61K38/1875 , A61K38/30 , A61L24/0063 , A61L27/46 , A61K2300/00 , C08L5/08
摘要： The present invention relates to a composition for stimulating bone-formation and bone-consolidation, more particularly, to a composition for stimulating bone-formation and bone-consolidation by adding a material for stimulating bone-forming and bone-consolidation to the mixture of tripolyphosphate and water-soluble chitosan. The composition of the present invention can stimulate bone-formation and bone-consolidation in early stages.
摘要翻译：本发明涉及一种用于刺激骨形成和骨固结的组合物，更具体地，涉及通过向三聚磷酸盐混合物中加入刺激骨形成和骨固化的材料来刺激骨形成和骨固化的组合物和水溶性壳聚糖。本发明的组合物可以在早期阶段刺激骨形成和骨固结。

10. 发明申请

WO2003024615A1 AUTOMATIC COATING MACHINE 审中-公开
标题翻译：自动涂布机
公开(公告)号：WO2003024615A1
公开(公告)日：2003-03-27
申请号：PCT/KR2002/001735
申请日：2002-09-17
申请人： REGEN BIOTECH, INC. , BAE, Tae-Soo , LEE, Dong-Sin
发明人： BAE, Tae-Soo , LEE, Dong-Sin
IPC分类号： B05C3/09
CPC分类号： B05C3/09 , B05C13/00
摘要： The present invention relates to an automatic coating machine, and more particularly, to an automatic coating machine for coating a surgical implant with polymer material, which can ensure a uniform coating in thickness and degree. The automatic coating machine includes a box-shaped body (1), an elevating member (2) elevatingly mounted above the body (1) within a predetermined stroke and having a plurality of containers (3) formed at the peripheral portion thereof to receive polymer material, elevation driving means (4) adapted to vertically move the elevating member (2), an upper member (5) mounted above the elevating member in such a manner as to be fixed to the body (1) by means of guide rods (6) and having a plurality of rotating bodies (7) formed at the peripheral portion thereof to be opposite to the plurality of containers (3), actuating means (8) adapted to rotate the plurality of rotating bodies (7) of the upper member(5) in the positive and negative directions, and a controller (9) adapted to control the overall operation of the automatic coating machine.
摘要翻译：本发明涉及一种自动涂布机，更具体地，涉及一种用聚合物材料涂覆外科植入物的自动涂布机，其可以确保均匀的涂层厚度和程度。该自动涂布机包括箱体（1），在预定行程内升降安装在主体（1）上方的升降构件（2），并具有形成在其周边部分处的多个容器（3），以容纳聚合物材料，升降驱动装置（4），其适于垂直移动升降构件（2）;上部构件（5），其安装在升降构件上方，以便通过导向杆（1）固定到主体（1） 6），并且具有形成在其周边部分上与多个容器（3）相对的多个旋转体（7），适于使上部构件的多个旋转体（7）旋转的致动装置（8）（5），以及适于控制自动涂布机的整体操作的控制器（9）。

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