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1. 发明申请

WO2012162526A3 CATALYSTS FOR OXIDATIVE COUPLING OF METHANE 审中-公开
标题翻译：甲烷氧化偶联催化剂
公开(公告)号：WO2012162526A3
公开(公告)日：2013-03-21
申请号：PCT/US2012039383
申请日：2012-05-24
申请人： SILURIA TECHNOLOGIES INC , CIZERON JOEL M , SCHER ERIK C , ZURCHER FABIO R , SCHAMMEL WAYNE P , NYCE GREG , RUMPLECKER ANJA , MCCORMICK JAROD , ALCID MARIAN , GAMORAS JOEL , ROSENBURG DANIEL , RAS ERIK-JAN
发明人： CIZERON JOEL M , SCHER ERIK C , ZURCHER FABIO R , SCHAMMEL WAYNE P , NYCE GREG , RUMPLECKER ANJA , MCCORMICK JAROD , ALCID MARIAN , GAMORAS JOEL , ROSENBURG DANIEL , RAS ERIK-JAN
IPC分类号： B01J23/00 , B01J21/02 , B01J21/10 , B01J23/02 , B01J23/10 , B01J23/30 , B01J23/34 , B01J23/38 , B01J23/54 , B01J23/76 , C07C2/84
CPC分类号： C07C2/84 , B01J19/0046 , B01J21/066 , B01J21/08 , B01J23/002 , B01J23/10 , B01J23/34 , B01J23/54 , B01J23/63 , B01J23/76 , B01J23/83 , B01J23/8892 , B01J27/16 , B01J35/0006 , B01J37/031 , B01J37/035 , B01J2219/00527 , B01J2219/00536 , B01J2219/00702 , B01J2219/00747 , B01J2523/00 , C07C2521/10 , C07C2521/14 , C07C2523/10 , C07C2523/18 , C07C2523/34 , C07C2529/072 , C07C2529/076 , C07C2529/89 , Y02P20/52 , B01J2523/24 , B01J2523/3706 , B01J2523/3725 , B01J2523/3712 , B01J2523/54 , B01J2523/23 , B01J2523/11 , B01J2523/22 , B01J2523/305 , B01J2523/72 , B01J2523/845 , B01J2523/12 , B01J2523/69 , C07C11/04
摘要： Metal oxide catalysts comprising various dopants are provided. The catalysts are useful as heterogenous catalysts in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons such as ethane and ethylene. Related methods for use and manufacture of the same are also disclosed.
摘要翻译：提供了包含各种掺杂剂的金属氧化物催化剂。催化剂可用作各种催化反应中的异质催化剂，例如甲烷与C 2烃如乙烷和乙烯的氧化偶联。还公开了相关的使用和制造方法。

2. 发明申请

WO2012162526A2 CATALYSTS FOR PETROCHEMICAL CATALYSIS 审中-公开
标题翻译：石油化工催化剂
公开(公告)号：WO2012162526A2
公开(公告)日：2012-11-29
申请号：PCT/US2012/039383
申请日：2012-05-24
申请人： SILURIA TECHNOLOGIES, INC. , CIZERON, Joel, M. , SCHER, Erik, C. , ZURCHER, Fabio, R. , SCHAMMEL, Wayne, P. , NYCE, Greg , RUMPLECKER, Anja , MCCORMICK, Jarod , ALCID, Marian , GAMORAS, Joel , ROSENBURG, Daniel , RAS, Erik-Jan
发明人： CIZERON, Joel, M. , SCHER, Erik, C. , ZURCHER, Fabio, R. , SCHAMMEL, Wayne, P. , NYCE, Greg , RUMPLECKER, Anja , MCCORMICK, Jarod , ALCID, Marian , GAMORAS, Joel , ROSENBURG, Daniel , RAS, Erik-Jan
IPC分类号： B01J23/00
CPC分类号： C07C2/84 , B01J19/0046 , B01J21/066 , B01J21/08 , B01J23/002 , B01J23/10 , B01J23/34 , B01J23/54 , B01J23/63 , B01J23/76 , B01J23/83 , B01J23/8892 , B01J27/16 , B01J35/0006 , B01J37/031 , B01J37/035 , B01J2219/00527 , B01J2219/00536 , B01J2219/00702 , B01J2219/00747 , B01J2523/00 , C07C2521/10 , C07C2521/14 , C07C2523/10 , C07C2523/18 , C07C2523/34 , C07C2529/072 , C07C2529/076 , C07C2529/89 , Y02P20/52 , B01J2523/24 , B01J2523/3706 , B01J2523/3725 , B01J2523/3712 , B01J2523/54 , B01J2523/23 , B01J2523/11 , B01J2523/22 , B01J2523/305 , B01J2523/72 , B01J2523/845 , B01J2523/12 , B01J2523/69 , C07C11/04
摘要： Metal oxide catalysts comprising various dopants are provided. The catalysts are useful as heterogenous catalysts in a variety of catalytic reactions, for example, the oxidative coupling of methane to C2 hydrocarbons such as ethane and ethylene. Related methods for use and manufacture of the same are also disclosed.
摘要翻译：提供了包含各种掺杂剂的金属氧化物催化剂。催化剂可用作各种催化反应中的异质催化剂，例如甲烷与C 2烃如乙烷和乙烯的氧化偶联。还公开了相关的使用和制造方法。

3. 发明申请

WO2008108639A1 CO-CRYSTALLINE FORMS OF CARBAMAZEPINE 审中-公开
标题翻译：碳水化合物的结晶形式
公开(公告)号：WO2008108639A1
公开(公告)日：2008-09-12
申请号：PCT/NL2008/000076
申请日：2008-03-07
申请人： AVANTIUM HOLDING B.V. , RAS, Erik-Jan
发明人： RAS, Erik-Jan
IPC分类号： C07D223/26 , A61K31/55 , A61P25/08
CPC分类号： C07D223/26
摘要： The present invention provides a novel crystalline form of a cocrystal of carbamazepine : glycolamide and of a co-crystal of carbamazepine : lactamide. The invention further provides methods for the preparation of a co-crystal of carbamazepine: glycolamide and and/or carbamazepine : lactamide, as well as their use in pharmaceutical applications, in particular in medicaments for he treatment of epilepsy, bipolar disorder, schizophrenia and/or trigeminal neuralgia. The co-crystalline form of carbamazepine: glycolamide and/ or carbamazepine : lactamide can be used in combination with other medicaments.
摘要翻译：本发明提供了一种新型的卡马西平：乙二醇酰胺和卡马西平：乳酰胺共结晶的结晶形式。本发明还提供了用于制备卡马西平：乙二醇酰胺和/或卡马西平：乳酰胺的共晶体的方法，以及它们在药物应用中的用途，特别是用于治疗癫痫，双相性精神障碍，精神分裂症和/ 或三叉神经痛。卡马西平：乙二醇酰胺和/或卡马西平：乳酰胺的共晶形式可以与其他药物组合使用。

4. 发明申请

WO2008035960A2 METHOD FOR THE PREPARATION OF A CO-CRYSTAL 审中-公开
标题翻译：制备共晶的方法
公开(公告)号：WO2008035960A2
公开(公告)日：2008-03-27
申请号：PCT/NL2007000226
申请日：2007-09-13
申请人： AVANTIUM INT BV , MCKAY BENJAMIN , RAS ERIK-JAN , MAZUREK JAROSLAW MAREK , CAINS PETER
发明人： MCKAY BENJAMIN , RAS ERIK-JAN , MAZUREK JAROSLAW MAREK , CAINS PETER
IPC分类号： G06F19/00 , G06F19/16
CPC分类号： G06F19/704 , G06F19/701
摘要： Method for the preparation of a co-crystal from an Active Pharmaceutical Ingredient (API) and a co-moiety by providing a molecular model representing at least a part of the physical and chemical properties of the API; providing a molecular model for each of a set of known co-moieties representing at least a part of the physical and chemical properties of each respective co-moiety; for each co-moiety in the set of step (b), determining whether at least one hydrogen-bond between the ACI molecule and the co-moiety is possible by comparing the molecular model of the ACI molecule as provided in step (a) and the molecular model of the co-moiety as provided in step (b); and excluding any co-moiety not capable of hydrogen-bonding with the ACI molecule, thereby obtaining a set of hydrogen-bonding co-moieties, selecting a suitable solvent and performing a set of experiments providing co-crystals of the API.
摘要翻译：通过提供代表API的物理和化学性质的至少一部分的分子模型，由活性药物成分（API）和共同部分制备共晶的方法; 为表示每个相应共部分的物理和化学性质的至少一部分的一组已知共部分中的每一个提供分子模型; 对于步骤（b）的组中的每个共部分，通过比较步骤（a）和步骤（a）中提供的ACI分子的分子模型，确定ACI分子和共部分之间的至少一个氢键是否可能步骤（b）中提供的共部分的分子模型; 并排除任何不能与ACI分子氢键结合的共部分，从而获得一组氢键部分，选择合适的溶剂并进行一系列提供API共晶的实验。

5. 发明申请

WO2008035960A3 METHOD FOR THE PREPARATION OF A CO-CRYSTAL 审中-公开
公开(公告)号：WO2008035960A3
公开(公告)日：2008-03-27
申请号：PCT/NL2007/000226
申请日：2007-09-13
申请人： AVANTIUM INTERNATIONAL B.V. , McKAY, Benjamin , RAS, Erik-Jan , MAZUREK, Jaroslaw, Marek , CAINS, Peter
发明人： McKAY, Benjamin , RAS, Erik-Jan , MAZUREK, Jaroslaw, Marek , CAINS, Peter
IPC分类号： G06F19/00
摘要： Method for the preparation of a co-crystal from an Active Pharmaceutical Ingredient (API) and a co-moiety by providing a molecular model representing at least a part of the physical and chemical properties of the API; providing a molecular model for each of a set of known co-moieties representing at least a part of the physical and chemical properties of each respective co-moiety; for each co-moiety in the set of step (b), determining whether at least one hydrogen-bond between the ACI molecule and the co-moiety is possible by comparing the molecular model of the ACI molecule as provided in step (a) and the molecular model of the co-moiety as provided in step (b); and excluding any co-moiety not capable of hydrogen-bonding with the ACI molecule, thereby obtaining a set of hydrogen-bonding co-moieties, selecting a suitable solvent and performing a set of experiments providing co-crystals of the API.

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