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1. 发明申请

WO2007122581A2 COMPOSITIONS AND KITS USEFUL FOR TREATMENT OF RESPIRATORY ILLNESS 审中-公开
标题翻译：用于治疗呼吸道疾病的组合物和试剂盒
公开(公告)号：WO2007122581A2
公开(公告)日：2007-11-01
申请号：PCT/IB2007051470
申请日：2007-04-20
申请人： PROCTER & GAMBLE , MARTIN KELLY LEE , KHANOLKAR JAYANT EKNATH , GLEDHILL DOUGLAS WILLIAM , CRISS SUSAN ELAINE , RAMJI NIRANJAN , COSTEINES ELAINE ROSE , HUETTER THOMAS EDWARD , IYER RADHIKA R , ANNESS DAREN K
发明人： MARTIN KELLY LEE , KHANOLKAR JAYANT EKNATH , GLEDHILL DOUGLAS WILLIAM , CRISS SUSAN ELAINE , RAMJI NIRANJAN , COSTEINES ELAINE ROSE , HUETTER THOMAS EDWARD , IYER RADHIKA R , ANNESS DAREN K
CPC分类号： A61K31/485 , A61J1/05 , A61K9/0095 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/473 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/22 , A61K47/26 , A61K2300/00
摘要： The invention relates to a clear device: comprising a composition contained in a device; wherein said composition comprising a pharmaceutical active selected from the group consisting of phenylephrine, its free and addition salt forms, and mixtures thereof. Also disclosed are kits comprising: a composition contained in a device; wherein said composition comprising a pharmaceutical active selected from the group consisting of phenylephrine, its free and addition salt forms, and mixtures thereof;.
摘要翻译：本发明涉及一种清洁装置：包括装在装置中的组合物; 其中所述组合物包含选自去氧肾上腺素，其游离和加成盐形式及其混合物的药物活性物质。还公开了试剂盒，其包含：包含在装置中的组合物; 其中所述组合物包含选自去氧肾上腺素，其游离和加成盐形式及其混合物的药物活性物质。

2. 发明申请

WO2011123601A2 WHOLE MOUTH MALODOR CONTROL BY A COMBINATION OF ANTIBACTERIAL AND DEODORIZING AGENTS 审中-公开
标题翻译：通过抗菌和除臭剂联合治疗的整体恶性肿瘤
公开(公告)号：WO2011123601A2
公开(公告)日：2011-10-06
申请号：PCT/US2011/030665
申请日：2011-03-31
申请人： THE PROCTER & GAMBLE COMPANY , RAMJI, Niranjan , SNIDER, Ann, Gilligan , WITTE, Lina, Aurora , BECKER, Beverly, D. , STATT, Beth, Hansell , NOLAND, Andrea, L. , MCKINNEY, Kristi
发明人： RAMJI, Niranjan , SNIDER, Ann, Gilligan , WITTE, Lina, Aurora , BECKER, Beverly, D. , STATT, Beth, Hansell , NOLAND, Andrea, L. , MCKINNEY, Kristi
IPC分类号： G01N33/00 , A61K8/37 , A61K8/368 , A61K8/35 , A61K8/33 , A61K8/34 , A61K8/41 , A61K8/49 , A61Q11/00
CPC分类号： A61K8/347 , A61K8/33 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/41 , A61Q11/00
摘要： Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure (I) wherein R 1 , R 2 , R 3 , and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, -OH or -OR a ; R 4 is -OH, -OR a , phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and R a is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from α-damascenone, α-isomethylionone, α-ionone, β-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde. The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.
摘要翻译：公开了有效控制口服和呼吸道恶臭的口腔护理组合物，其包含在药学上可接受的载体中，抗菌剂和除臭或气味中和剂的组合，其包含具有结构（I）的化合物，其中R1，R2，R3和 R 5可以相同或不同，各自表示H，直链或支链C 1 -C 6烷基或烯基，苯基，-OH或-OR a; R 4是-OH，-OR，苯基或直链或支链C 1 -C 6烷基或链烯基; 并且R a是苯基或直链或支链C 1 -C 6烷基或链烯基。气味中和剂可以进一步包含一种或多种另外的气味中和化合物，其选自大黄酮酮，α-甲基甲氧基酮，α-紫罗兰酮，β-紫罗兰酮，胡椒碱，胡椒酮，香芹酮，辅酶Q10或肉桂醛。抗菌剂可以包含选自氯化十六烷基吡啶，氯化十四烷基吡啶，N-十四烷基-4-乙基氯化吡啶或溴化三苯胺的季铵化合物的一种或混合物; 金属离子如亚锡，锌或铜; 洗必泰; 三氯生; 三氯生单磷酸盐或选择的精油。

3. 发明申请

WO2008087609A3 STABLE PEROXIDE CONTAINING ORAL CARE COMPOSITIONS 审中-公开
标题翻译：稳定的过氧化物包含口服护理组合物
公开(公告)号：WO2008087609A3
公开(公告)日：2008-10-16
申请号：PCT/IB2008050182
申请日：2008-01-17
申请人： PROCTER & GAMBLE , RAMJI NIRANJAN
发明人： RAMJI NIRANJAN
IPC分类号： A61K8/19 , A61K8/22 , A61Q11/00
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/22
摘要： The present invention relates to stable personal care composition, including oral care compositions containing a peroxide source. The compositions are stabilized by eliminating or minimizing the presence in the composition of metals having radical forming potential with the peroxide. Preferably, the metals that are eliminated or reduced are cobalt, copper, palladium, nickel and iron. The compositions are further stabilized by the addition of agents having scavenging or quenching activity for free radicals. Reducing free radical activity in the product matrix prevents radical- mediated loss and degradation of peroxide and other ingredients, in particular organic compounds added as active or aesthetic agents, including flavors, perfumes, colorants and thickeners. Provided are peroxide containing oral care products with enhanced consumer appeal in terms of taste, mouthfeel and appearance, thereby encouraging compliance and regular use. Such attributes are important since use of these products may involve fairly long residence time in the mouth for efficacy.
摘要翻译：本发明涉及稳定的个人护理组合物，包括含有过氧化物源的口腔护理组合物。组合物通过消除或最小化组合物中通过过氧化物具有自由基形成潜能的金属来稳定化。优选地，被除去或还原的金属是钴，铜，钯，镍和铁。通过添加对自由基具有清除或猝灭活性的试剂来进一步稳定组合物。减少产物基质中的自由基活性可防止过氧化物和其他成分，特别是作为活性或美容剂（包括香料，香料，着色剂和增稠剂）加入的有机化合物的自由基介导的损失和降解。提供的是含有口味护理产品的过氧化物，在味道，口感和外观方面具有增强的消费者吸引力，从而鼓励顺应性和常规使用。这些属性是重要的，因为这些产品的使用可能涉及相当长的在口腔中的停留时间。

4. 发明申请

WO2008005548A2 FLAVORS FOR ORAL COMPOSITIONS 审中-公开
标题翻译：口味组合物的味道
公开(公告)号：WO2008005548A2
公开(公告)日：2008-01-10
申请号：PCT/US2007015600
申请日：2007-07-06
申请人： PROCTER & GAMBLE , SWAINE ROBERT LESLIE JR , ZEHENTBAUER GERHARD NORBERT , HOKE STEVE , RAMJI NIRANJAN , HESTER MARC
发明人： SWAINE ROBERT LESLIE JR , ZEHENTBAUER GERHARD NORBERT , HOKE STEVE , RAMJI NIRANJAN , HESTER MARC
IPC分类号： A61K8/00
CPC分类号： A23L1/222 , A23L27/12 , A23V2002/00 , A61K8/19 , A61K8/33 , A61K8/347 , A61K8/35 , A61K8/4973 , A61K8/676 , A61K8/922 , A61K2800/52 , A61Q11/00 , A23V2200/15 , A23V2250/5036 , A23V2250/2116 , A23V2250/214
摘要： The present invention relates to oral care compositions comprising stannous ions, a mint-type flavor oil, a protectant component that prevents generation of off odor and off taste in the composition, and orally acceptable carriers. The mint-type oils include peppermint, spearmint and corn mint. Suitable protectant components include copper salts and carbonyl compounds such as ascorbic acid; cis-jasmone; 2,5-dimethyl-4-hydroxy-3(2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone; vanillin; ethyl vanillin; anisaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 4-hydroxybenzaldehyde; 2-methyoxybenzaldehyde; 4-methoxybenzaldehyde; benzaldehyde; cinnamaldehyde (3-phenyl-2-propenal); hexyl cinnamaldehyde; ?-methyl cinnamaldehyde; ortho-methoxy cinnamaldehyde; ?-amyl cinnamaldehyde; and combinations thereof. The oral care composition may be a dentifrice.
摘要翻译：本发明涉及包含亚锡离子的口腔护理组合物，薄荷型风味油，防止组合物中产生异味和脱味味的保护成分，以及口服可接受的载体。薄荷油包括薄荷，薄荷和玉米薄荷。合适的保护剂组分包括铜盐和羰基化合物如抗坏血酸; 顺茉莉酮; 2,5-二甲基-4-羟基-3（2H） - 呋喃酮; 5-乙基-3-羟基-4-甲基-2（5H） - 呋喃酮; 香兰素; 乙基香兰素; 茴香醛; 3,4-亚甲; 3,4-二甲氧基苯甲醛; 4-羟基苯甲醛; 2- methyoxybenzaldehyde; 4-甲氧基苯甲醛; 苯甲醛; 肉桂醛（3-苯基-2-丙烯醛）; 己基肉桂醛; α-甲基肉桂醛; 邻甲氧基肉桂醛; 戊酰肉桂醛; 及其组合。口腔护理组合物可以是洁齿剂。

5. 发明申请

WO2011123601A3 WHOLE MOUTH MALODOR CONTROL BY A COMBINATION OF ANTIBACTERIAL AND DEODORIZING AGENTS 审中-公开
标题翻译：通过抗菌和除臭剂联合治疗的整体恶性肿瘤
公开(公告)号：WO2011123601A3
公开(公告)日：2013-05-16
申请号：PCT/US2011030665
申请日：2011-03-31
申请人： PROCTER & GAMBLE , RAMJI NIRANJAN , SNIDER ANN GILLIGAN , WITTE LINA AURORA , BECKER BEVERLY D , STATT BETH HANSELL , NOLAND ANDREA L , MCKINNEY KRISTI
发明人： RAMJI NIRANJAN , SNIDER ANN GILLIGAN , WITTE LINA AURORA , BECKER BEVERLY D , STATT BETH HANSELL , NOLAND ANDREA L , MCKINNEY KRISTI
IPC分类号： A61K8/33 , A61K8/34 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/41 , A61K8/49 , A61Q11/00 , G01N33/00
CPC分类号： A61K8/347 , A61K8/33 , A61K8/35 , A61K8/368 , A61K8/37 , A61K8/41 , A61Q11/00
摘要： Disclosed are oral care compositions effective to control mouth and breath malodour comprising in a pharmaceutically acceptable carrier, a combination of an antibacterial agent and a deodorizing or odor-neutralizing agent comprising a compound having the structure (I) wherein R1, R2, R3, and R5 may be identical or different, each representing H, a linear or branched C1-C6 alkyl or alkenyl, phenyl, -OH or -ORa; R4 is -OH, -ORa, phenyl, or a linear or branched C1-C6 alkyl or alkenyl; and Ra is phenyl or a linear or branched C1-C6 alkyl or alkenyl. The odor-neutralizing agent may further comprise one or more of an additional odor-neutralizing compound selected from alpha-damascenone, alpha-isomethylionone, alpha-ionone, beta-ionone, pulegone, piperitone, carvone, coenzyme Q10 or cinnamaldehyde. The antibacterial agent may comprise one or a mixture of a quaternary ammonium compound selected from cetylpyridinium chloride, tetradecylpyridinium chloride, N-tetradecyl-4-ethyl pyridinium chloride or domiphen bromide; metal ions such as stannous, zinc or copper; chlorhexidine; triclosan; triclosan monophosphate; or selected essential oils.
摘要翻译：公开了有效控制口服和呼吸道恶臭的口腔护理组合物，其包含在药学上可接受的载体中，抗菌剂和除臭或气味中和剂的组合，其包含具有结构（I）的化合物，其中R1，R2，R3和 R 5可以相同或不同，各自表示H，直链或支链C 1 -C 6烷基或烯基，苯基，-OH或-OR a; R 4是-OH，-OR，苯基或直链或支链C 1 -C 6烷基或链烯基; 并且R a是苯基或直链或支链C 1 -C 6烷基或链烯基。气味中和剂可进一步包含一种或多种选自α-大马士康酮，α-甲氧基酮，α-紫罗酮，β-紫罗兰酮，胡椒碱，胡椒酮，香芹酮，辅酶Q10或肉桂醛的另外的气味中和化合物。抗菌剂可以包含选自氯化十六烷基吡啶，氯化十四烷基吡啶，N-十四烷基-4-乙基氯化吡啶或溴化三苯胺的季铵化合物的一种或混合物; 金属离子如亚锡，锌或铜; 洗必泰; 三氯生; 三氯生单磷酸盐或选择的精油。

6. 发明申请

WO2008005548A3 FLAVORS FOR ORAL COMPOSITIONS 审中-公开
公开(公告)号：WO2008005548A3
公开(公告)日：2008-01-10
申请号：PCT/US2007/015600
申请日：2007-07-06
申请人： THE PROCTER & GAMBLE COMPANY , SWAINE, Robert, Leslie, Jr. , ZEHENTBAUER, Gerhard, Norbert , HOKE, Steve , RAMJI, Niranjan , HESTER, Marc
发明人： SWAINE, Robert, Leslie, Jr. , ZEHENTBAUER, Gerhard, Norbert , HOKE, Steve , RAMJI, Niranjan , HESTER, Marc
IPC分类号： A61K8/19 , A61K8/33 , A61K8/34 , A61K8/35 , A61K8/49 , A61K8/67 , A61K8/92 , A61Q11/00
摘要： The present invention relates to oral care compositions comprising stannous ions, a mint-type flavor oil, a protectant component that prevents generation of off odor and off taste in the composition, and orally acceptable carriers. The mint-type oils include peppermint, spearmint and corn mint. Suitable protectant components include copper salts and carbonyl compounds such as ascorbic acid; cis-jasmone; 2,5-dimethyl-4-hydroxy-3(2H)-furanone; 5-ethyl-3-hydroxy-4-methyl-2(5H)-furanone; vanillin; ethyl vanillin; anisaldehyde; 3,4-methylenedioxybenzaldehyde; 3,4-dimethoxybenzaldehyde; 4-hydroxybenzaldehyde; 2-methyoxybenzaldehyde; 4-methoxybenzaldehyde; benzaldehyde; cinnamaldehyde (3-phenyl-2-propenal); hexyl cinnamaldehyde; ∝-methyl cinnamaldehyde; ortho-methoxy cinnamaldehyde; ∝-amyl cinnamaldehyde; and combinations thereof. The oral care composition may be a dentifrice.

7. 发明申请

WO2007122580A3 COMPOSITIONS OF PHENYLEPHRINE USEFUL FOR TREATMENT OF RESPIRATORY ILLNESS 审中-公开
标题翻译：用于治疗呼吸道感染的苯丙酮的组合物
公开(公告)号：WO2007122580A3
公开(公告)日：2009-03-19
申请号：PCT/IB2007051469
申请日：2007-04-20
申请人： PROCTER & GAMBLE , MARTIN KELLY LEE , KHANOLKAR JAYANT EKNATH , GLEDHILL DOUGLAS WILLIAM , CRISS SUSAN ELAINE , RAMJI NIRANJAN , COSTEINES ELAINE ROSE
发明人： MARTIN KELLY LEE , KHANOLKAR JAYANT EKNATH , GLEDHILL DOUGLAS WILLIAM , CRISS SUSAN ELAINE , RAMJI NIRANJAN , COSTEINES ELAINE ROSE
IPC分类号： A61K31/137 , A61P11/02
CPC分类号： A61K31/137 , A61K31/473 , A61K31/485 , A61K31/495 , A61K31/519 , A61K31/522 , A61K31/55 , A61K31/616 , A61K45/06 , A61K2300/00
摘要： Disclosed are compositions including phenylephrine, its free and addition salt forms, and mixtures thereof, alone, or in combination with other pharmaceutical actives. The compositions have a pH of about 2 to about 5 and are substantially free of aldehydes. Also disclosed are methods of treating respiratory illness through administration of a composition comprising phenylephrine, its free and addition salt forms, and mixtures thereof alone, or in combination with other pharmaceutical actives, wherein the composition has a pH of from about 2 to about 5 and is substantially free of aldehydes.
摘要翻译：公开了包括去氧肾上腺素，其游离和加成盐形式及其混合物，单独或与其它药物活性物质组合的组合物。组合物具有约2至约5的pH并且基本上不含醛。还公开了通过施用组合物来治疗呼吸系统疾病的方法，所述组合物包含去氧肾上腺素，其游离和加成盐形式及其单独的混合物，或与其它药物活性物质组合，其中所述组合物的pH为约2至约5，基本上不含醛。

8. 发明申请

WO2008087609A2 STABLE PEROXIDE CONTAINING PERSONAL CARE COMPOSITIONS 审中-公开
标题翻译：稳定的过氧化物包含个人护理组合物
公开(公告)号：WO2008087609A2
公开(公告)日：2008-07-24
申请号：PCT/IB2008/050182
申请日：2008-01-17
申请人： THE PROCTER & GAMBLE COMPANY , RAMJI, Niranjan
发明人： RAMJI, Niranjan
IPC分类号： A61Q11/00 , A61K8/22 , A61K8/19
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/22
摘要： The present invention relates to stable personal care composition, including oral care compositions containing a peroxide source. The compositions are stabilized by eliminating or minimizing the presence in the composition of metals having radical forming potential with the peroxide. Preferably, the metals that are eliminated or reduced are cobalt, copper, palladium, nickel and iron. The compositions are further stabilized by the addition of agents having scavenging or quenching activity for free radicals. Reducing free radical activity in the product matrix prevents radical- mediated loss and degradation of peroxide and other ingredients, in particular organic compounds added as active or aesthetic agents, including flavors, perfumes, colorants and thickeners. Provided are peroxide containing oral care products with enhanced consumer appeal in terms of taste, mouthfeel and appearance, thereby encouraging compliance and regular use. Such attributes are important since use of these products may involve fairly long residence time in the mouth for efficacy.
摘要翻译：本发明涉及稳定的个人护理组合物，包括含有过氧化物源的口腔护理组合物。组合物通过消除或最小化组合物中通过过氧化物具有自由基形成潜能的金属来稳定化。优选地，被去除或还原的金属是钴，铜，钯，镍和铁。通过添加对自由基具有清除或猝灭活性的试剂来进一步稳定组合物。减少产物基质中的自由基活性可防止过氧化物和其他成分，特别是作为活性或美容剂（包括香料，香料，着色剂和增稠剂）加入的有机化合物的自由基介导的损失和降解。提供的是含有口味护理产品的过氧化物，在味道，口感和外观方面具有增强的消费者吸引力，从而鼓励顺应性和常规使用。这些属性是重要的，因为这些产品的使用可能涉及相当长的在口腔中的停留时间。

9. 发明申请

WO2008005550A2 FLAVOR OILS WITH REDUCED SULFUR CONTENT AND USE IN ORAL CARE COMPOSITIONS 审中-公开
标题翻译：含硫量降低的口味油以及口服护理组合物中的用途
公开(公告)号：WO2008005550A2
公开(公告)日：2008-01-10
申请号：PCT/US2007/015603
申请日：2007-07-06
申请人： THE PROCTER & GAMBLE COMPANY , HOKE II, Steven Hamilton , HESTER, Marc, Alan , RAMJI, Niranjan
发明人： HOKE II, Steven Hamilton , HESTER, Marc, Alan , RAMJI, Niranjan
CPC分类号： A23L1/222 , A23L27/12 , A23V2002/00 , A61K8/19 , A61K8/33 , A61K8/347 , A61K8/35 , A61K8/4973 , A61K8/676 , A61K8/922 , A61K2800/52 , A61Q11/00 , A23V2200/15 , A23V2250/5036 , A23V2250/2116 , A23V2250/214
摘要： The present invention relates to flavor oils including mint-, fruit- and spice-type flavors that are specially processed to substantially eliminate low-molecular weight sulfur compounds, in particular dimethyl sulfoxide (DMSO), which has been found to be the main precursor of malodorous species such as dimethyl sulfide and methyl mercaptan. These malodorous species are produced via oxidation-reduction reactions involving such sulfur-containing compounds present in flavor oils. A preferred processing method is an aqueous-washing process, which has advantages of being simple, inexpensive and easy to implement while importantly avoiding the problems of typical processes including non-selective removal of desirable components and subjecting the flavor oils to extreme conditions that may destroy other components and result in undesirable changes in flavor or odor character. Other processing methods to selectively remove non-desired components include (1) distillation to remove polar low boiling point components, (2) filtration through adsorbents selective for sulfur compounds, (3) countercurrent extraction and (4) column chromatography. The processing methods may optionally be followed by reengineering to add back desired components that may have been removed or altered during the processing. The specially processed flavor oils are particularly useful in oral care compositions comprising components with chemical reducing capability such as stannous ions, which react with the sulfur-containing compounds to produce malodorous products.
摘要翻译：本发明涉及包含薄荷香料，水果香料和香料型香料的香料油，其经过特别处理以基本上消除低分子量硫化合物，特别是二甲基亚砜（DMSO），其具有被发现是恶臭物种的主要前体，如二甲硫和甲硫醇。这些恶臭物质通过氧化还原反应产生，所述氧化还原反应涉及香料油中存在的这种含硫化合物。一种优选的加工方法是水洗方法，其具有简单，便宜和易于实施的优点，同时重要地避免了典型方法的问题，包括非选择性地去除所需组分，并使风味油经受可能破坏其他成分，并导致风味或气味特性的不希望的变化。选择性去除不需要的组分的其他处理方法包括（1）蒸馏以除去极性低沸点组分，（2）通过硫化合物选择性吸附剂过滤，（3）逆流萃取和（4）柱色谱法。处理方法可以可选地随后进行重新设计以加回在处理期间可能已经被移除或改变的期望组件。经过特殊处理的风味油特别适用于包含具有化学还原能力的组分如亚锡离子的口腔护理组合物，其与含硫化合物反应以产生恶臭产物。

10. 发明申请

WO2008005549A2 FLAVOR OILS WITH REDUCED SULFUR CONTENT AND USE IN ORAL CARE COMPOSITIONS 审中-公开
标题翻译：具有减少硫含量的油脂和口服护理组合物中的用途
公开(公告)号：WO2008005549A2
公开(公告)日：2008-01-10
申请号：PCT/US2007015601
申请日：2007-07-06
申请人： PROCTER & GAMBLE , SWAINE ROBERT LESLIE JR , ZEHENTBAUER GERHARD NORBERT , HOKE II STEVEN HAMILTON , HESTER MARC ALAN , RAMJI NIRANJAN , MCCLENATHAN DENISE MARIE
发明人： SWAINE ROBERT LESLIE JR , ZEHENTBAUER GERHARD NORBERT , HOKE II STEVEN HAMILTON , HESTER MARC ALAN , RAMJI NIRANJAN , MCCLENATHAN DENISE MARIE
CPC分类号： A23L1/222 , A23L27/12 , A23V2002/00 , A61K8/19 , A61K8/33 , A61K8/347 , A61K8/35 , A61K8/4973 , A61K8/676 , A61K8/922 , A61K2800/52 , A61Q11/00 , A23V2200/15 , A23V2250/5036 , A23V2250/2116 , A23V2250/214
摘要： The present invention relates to flavor oils including mint-, fruit- and spice-type flavors that are specially processed to substantially eliminate low-molecular weight sulfur compounds, in particular dimethyl sulfoxide (DMSO), which has been found to be the main precursor of malodorous species such as dimethyl sulfide and methyl mercaptan. These malodorous species are produced via oxidation-reduction reactions involving such sulfur-containing compounds present in flavor oils. A preferred processing method is an aqueous-washing process, which has advantages of being simple, inexpensive and easy to implement while importantly avoiding the problems of typical processes including non-selective removal of desirable components and subjecting the flavor oils to extreme conditions that may destroy other components and result in undesirable changes in flavor or odor character. Other processing methods to selectively remove non-desired components include (1) distillation to remove polar low boiling point components, (2) filtration through adsorbents selective for sulfur compounds, (3) countercurrent extraction and (4) column chromatography. The processing methods may optionally be followed by reengineering to add back desired components that may have been removed or altered during the processing. The specially processed flavor oils are particularly useful in oral care compositions comprising components with chemical reducing capability such as stannous ions, which react with the sulfur-containing compounds to produce malodorous products.
摘要翻译：本发明涉及风味油，其包括经特别加工以基本上消除低分子量硫化合物，特别是二甲基亚砜（DMSO）的薄荷，水果和香料型香料，其已被发现是主要前体恶臭物质如二甲硫醚和甲硫醇。这些恶臭物质通过涉及风味油中存在的含硫化合物的氧化还原反应产生。优选的处理方法是水洗方法，其优点是简单，便宜且易于实施，同时重要地避免了典型方法的问题，包括非选择性除去所需组分并使风味油经受可能破坏的极端条件其他组分，并导致风味或气味特征的不良变化。选择性除去不需要的组分的其它处理方法包括（1）蒸馏以除去极性低沸点组分，（2）通过对硫化合物选择性的吸附剂进行过滤，（3）逆流提取和（4）柱色谱法。处理方法可以可选地随后重新设计以添加可能在处理期间被移除或改变的期望的部件。经特殊处理的风味油特别适用于包含具有化学还原能力的组分的口腔护理组合物，例如亚锡离子，其与含硫化合物反应产生恶臭产物。

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