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1. 发明申请

WO2016112257A1 MODULATION OF ASYMMETRIC PROLIFERATION 审中-公开
标题翻译：不对称增殖的调制
公开(公告)号：WO2016112257A1
公开(公告)日：2016-07-14
申请号：PCT/US2016/012597
申请日：2016-01-08
申请人： RAMASWAMY, Sridhar
发明人： RAMASWAMY, Sridhar
IPC分类号： C12N5/00 , C12N5/02
CPC分类号： C12N5/0693 , A61K2039/505 , C07K16/2842 , C07K2317/75 , C07K2317/76 , C12N5/0695 , C12N2501/04 , C12N2501/727 , G01N33/57484 , G01N2333/9015 , Y02A50/466
摘要： Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells.
摘要翻译：本文提供了与调节癌细胞不对称增殖速率有关的方法和组合物。在一些实施方案中，本文所述的方法涉及至少部分地通过调节癌细胞的不对称增殖速率来治疗癌症。

2. 发明申请

WO2014047398A1 MODULATION OF ASYMMETRIC PROLIFERATION 审中-公开
标题翻译：不对称增殖的调制
公开(公告)号：WO2014047398A1
公开(公告)日：2014-03-27
申请号：PCT/US2013/060842
申请日：2013-09-20
申请人： THE GENERAL HOSPITAL CORPORATION , RAMASWAMY, Sridhar
发明人： RAMASWAMY, Sridhar
IPC分类号： A61K31/352 , A61K31/437 , A61K31/495 , A61K31/5025 , A61P35/00
CPC分类号： A61K31/69
摘要： Provided herein are methods and compositions related to modulation of the rate of asymmetric proliferation of cancer cells. In some embodiments, the methods described herein relate to the treatment of cancer, at least in part, via the modulation of the rate of asymmetric proliferation of cancer cells.
摘要翻译：本文提供了与调节癌细胞不对称增殖速率有关的方法和组合物。在一些实施方案中，本文所述的方法涉及至少部分地通过调节癌细胞的不对称增殖速率来治疗癌症。

3. 发明申请

WO2007050344A2 SYSTEM AND METHOD FOR IDENTIFYING BOUNDS OF A GEOGRAPHICAL AREA 审中-公开
标题翻译：用于识别地理区域界限的系统和方法
公开(公告)号：WO2007050344A2
公开(公告)日：2007-05-03
申请号：PCT/US2006040339
申请日：2006-10-14
申请人： GOOGLE INC , JOSEPH JOSHY , RAMASWAMY SRIDHAR , ROSE MARK
发明人： JOSEPH JOSHY , RAMASWAMY SRIDHAR , ROSE MARK
IPC分类号： G08B5/22
CPC分类号： G09B29/106
摘要： A system and method for determining bounds of a geographical area, such as a city, metropolis, region (e.g., state) or country. From a set of coordinates within the area (e.g., latitude/longitude coordinates), a grid of relatively small cells of geographic data is overlaid upon those coordinates and associated with the area. Each initial cell is iteratively replaced with a larger cell that encompasses the initial cell until the replacement cell intersects a cell associated with some other geographical area or some other boundary condition is met (e.g., a threshold number of replacements).
摘要翻译：用于确定诸如城市，大都市，地区（例如州或国家）的地理区域的边界的系统和方法。根据该区域内的一组坐标（例如，纬度/经度坐标），地理数据的相对较小的网格的网格覆盖在那些坐标上并且与该区域相关联。每个初始小区迭代替换为包含初始小区的较大小区，直到替换小区与与某个其他地理区域相关联的小区相交或满足某个其他边界条件（例如阈值数量的替换）。

4. 发明申请

WO2007050335A2 SYSTEM AND METHOD FOR SELECTING TARGETED INFORMATION FOR SERVING WITH A MAP VIEW 审中-公开
标题翻译：用于选择用地图视图进行服务的目标信息的系统和方法
公开(公告)号：WO2007050335A2
公开(公告)日：2007-05-03
申请号：PCT/US2006040311
申请日：2006-10-14
申请人： GOOGLE INC , JOSEPH JOSHY , RAMASWAMY SRIDHAR , ROSE MARK
发明人： JOSEPH JOSHY , RAMASWAMY SRIDHAR , ROSE MARK
IPC分类号： G06Q30/00
CPC分类号： G06Q30/02 , G06Q30/0251 , G06Q30/0256 , G06Q30/0257 , G06Q30/0259 , G06Q30/0261 , G06Q30/0266 , G06Q30/0267
摘要： A system and method for selecting targeted information (e.g., advertisements) for serving with map views. The information is associated with target geographical areas (e.g., cities, metropolises, regions, countries) identified by the information providers. A given message or other set of information may be served with map views that significantly intersect the message's target area. A target area significantly intersects a map view if it overlaps the map view by at least a threshold percentage of the map view (e.g., 25%). Messages' target areas may first be compared with a map view to identify those that significantly intersect. Then, the messages whose target areas significantly intersect the map view may be filtered or screened based on any search terms or key words received with a request for the map view.
摘要翻译：一种用于选择用于与地图视图一起服务的目标信息（例如，广告）的系统和方法。该信息与由信息提供者识别的目标地理区域（例如，城市，大都会区域，国家）相关联。给定的消息或其他信息集合可以与与消息的目标区域显着相交的地图视图提供。如果与地图视图重叠地图视图的至少阈值百分比（例如，25％），则目标区域与地图视图显着相交。消息的目标区域可以首先与地图视图进行比较，以识别显着相交的信息。然后，其目标区域与地图视图显着相交的消息可以基于通过对地图视图的请求而接收的任何搜索项或关键字进行过滤或筛选。

5. 发明申请

WO2003041562A2 MOLECULAR CANCER DIAGNOSIS USING TUMOR GENE EXPRESSION SIGNATURE 审中-公开
标题翻译：肿瘤基因表达谱的分子癌诊断
公开(公告)号：WO2003041562A2
公开(公告)日：2003-05-22
申请号：PCT/US2002/036392
申请日：2002-11-14
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , DANA-FARBER CANCER INSTITUTE, INC. , GOLUB, Todd, R. , MUKHERJEE, Sayan , RAMASWAMY, Sridhar , RIFKIN, Ryan , TAMAYO, Pablo
发明人： GOLUB, Todd, R. , MUKHERJEE, Sayan , RAMASWAMY, Sridhar , RIFKIN, Ryan , TAMAYO, Pablo
IPC分类号： A61B
CPC分类号： G06F19/20 , G06F19/24
摘要： Methods are provided for the classification of disease tpyes (e.g. cancer types), outcome predictions, and treatment classes based on algorithmic classifiers used to analyze large datasets.
摘要翻译：为基于用于分析大数据集的算法分类器的疾病分类（例如癌症类型），结果预测和治疗分类提供了方法。

6. 发明申请

WO2002024956A3 GENETIC MARKERS FOR TUMORS 审中-公开
公开(公告)号：WO2002024956A3
公开(公告)日：2002-03-28
申请号：PCT/US2001/029287
申请日：2001-09-19
申请人： WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH , DANA-FARBER CANCER INSTITUTE, INC. , RAMASWAMY, Sridhar , GOLUB, Todd, R. , TAMAYO, Pablo , ANGELO, Michael
发明人： RAMASWAMY, Sridhar , GOLUB, Todd, R. , TAMAYO, Pablo , ANGELO, Michael
IPC分类号： C12Q1/68
摘要： Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide arrays comprising these markers.

7. 发明申请

WO0224956A2 GENETIC MARKERS FOR TUMORS 审中-公开
标题翻译：肿瘤基因标记
公开(公告)号：WO0224956A2
公开(公告)日：2002-03-28
申请号：PCT/US0129287
申请日：2001-09-19
申请人： WHITEHEAD BIOMEDICAL INST , DANA FARBER CANCER INST INC , RAMASWAMY SRIDHAR , GOLUB TODD R , TAMAYO PABLO , ANGELO MICHAEL
发明人： RAMASWAMY SRIDHAR , GOLUB TODD R , TAMAYO PABLO , ANGELO MICHAEL
IPC分类号： C12N15/09 , C12M1/00 , C12Q1/68
CPC分类号： C12Q1/6886 , C12Q2600/136 , C12Q2600/158
摘要： Sets of genetic markers for specific tumor classes are described, as well as methods of identifying a biological sample based on these markers. Also described are diagnostic, prognostic, and therapeutic screening uses for these markers, as well as oligonucleotide arrays comprising these markers.
摘要翻译：描述了用于特定肿瘤类别的遗传标记的集合，以及基于这些标记鉴定生物样品的方法。还描述了这些标记物的诊断，预后和治疗筛选用途，以及包含这些标记的寡核苷酸阵列。

8. 发明申请

WO2009105287A1 HYBRID ADVERTISING CAMPAIGN 审中-公开
标题翻译：混合广告运动
公开(公告)号：WO2009105287A1
公开(公告)日：2009-08-27
申请号：PCT/US2009/030339
申请日：2009-01-07
申请人： GOOGLE INC. , RAMASWAMY, Sridhar , LAI, Angela Chunwah , FOLTZ, Mark A. , BARDIN, Ariel H. , BLACK, Julie A. , HEILIG, Joerg , STANIS, Thomas R.
发明人： RAMASWAMY, Sridhar , LAI, Angela Chunwah , FOLTZ, Mark A. , BARDIN, Ariel H. , BLACK, Julie A. , HEILIG, Joerg , STANIS, Thomas R.
IPC分类号： G06Q30/00 , G06F17/30
CPC分类号： G06Q30/0271 , G06Q30/02 , G06Q30/0243 , G06Q30/0251 , G06Q30/0254 , G06Q30/0277
摘要： Keywords and placement criteria related to a campaign are received. An advertisement request that specifies a web property, e.g., a web page, is received, and keywords and placement criteria that are satisfied by the web property are identified. Based on the identified keywords and placement criteria, an advertisement to be provided with the web property is selected.
摘要翻译：收到与广告系列相关的关键字和刊登位置标准。接收到指定web属性（例如网页）的广告请求，并且识别由web属性所满足的关键字和放置标准。根据确定的关键字和放置标准，选择要提供的网络媒体资源的广告。

9. 发明申请

WO2008021906A3 INTEREST TARGETING 审中-公开
标题翻译：兴趣迎接
公开(公告)号：WO2008021906A3
公开(公告)日：2009-04-16
申请号：PCT/US2007075514
申请日：2007-08-08
申请人： GOOGLE INC , WISEMAN LEORA RUTH , VENKATARAMA SHIVAKUMAR , RAMASWAMY SRIDHAR
发明人： WISEMAN LEORA RUTH , VENKATARAMA SHIVAKUMAR , RAMASWAMY SRIDHAR
IPC分类号： G06F17/30
CPC分类号： G06F17/30398 , G06F3/0482 , G06F3/04842 , G06F17/30554 , G06F17/30867 , G06Q30/02 , G06Q30/0256 , G06Q30/0275 , G06Q30/0277 , G06Q40/04
摘要： An advertisement can be presented by associating a label with an advertisement, receiving input from a user, wherein the input comprises one or more labels, identifying a match between the label associated with the advertisement and the input, and presenting the advertisement to the user. A bid further can be received for presenting the advertisement in response to input from a user that includes the associated label and an advertisement presentation order can be determined based on one or more of the bid, a click-through rate of the advertisement, and a conversion rate of the advertisement. Additionally, a negative label can be associated with the advertisement. Further, an additional input comprising one or more labels can be received from the user, a match can be identified between the negative label and the received additional input, and it can be determined not to present the advertisement based on the identified match.
摘要翻译：可以通过将标签与广告相关联，从用户接收输入来呈现广告，其中输入包括一个或多个标签，标识与广告相关联的标签与输入之间的匹配，以及向用户呈现广告。还可以收到用于响应于包括关联标签的用户的输入来呈现广告的投标，并且可以基于投标中的一个或多个，广告的点击率和广告显示顺序来确定广告呈现顺序广告转换率。另外，负面标签可以与广告相关联。此外，可以从用户接收包括一个或多个标签的附加输入，可以在负标签和接收的附加输入之间识别匹配，并且可以基于所识别的匹配来确定不呈现广告。

10. 发明申请

WO2007070358A2 DETERMINING ADVERTISEMENTS USING USER INTEREST INFORMATION AND MAP-BASED LOCATION INFORMATION 审中-公开
标题翻译：使用用户兴趣信息和基于地图的位置信息确定广告
公开(公告)号：WO2007070358A2
公开(公告)日：2007-06-21
申请号：PCT/US2006046782
申请日：2006-12-08
申请人： GOOGLE INC , GLASSMAN STEVE , JOSEPH JOSHY , KILDAY BILL , NGUYEN GIAO , PREUSS DOMINIC , RAMASWAMY SRIDHAR
发明人： GLASSMAN STEVE , JOSEPH JOSHY , KILDAY BILL , NGUYEN GIAO , PREUSS DOMINIC , RAMASWAMY SRIDHAR
IPC分类号： G06G1/14
CPC分类号： G06Q30/02 , G06Q30/0242
摘要： In response to a query for information in a geographic region or at a location, ranked ads may be plotted on, or in association with, a map (e.g., as a list beside the map), satellite photo, or any other form of visual representation of geographic information (referred to generally as "maps"). Sponsored ads might be shown in a dedicated place and/or might be elevated above other non-sponsored search results (e.g., Yellow Page listings). The number of ads shown in the list and/or plotted on the map could vary as a function of the resolution of the map or geographic image. The ads could be ranked or scored, and attributes or features of various ads may be a function of such a score or ranking. The plots on the map might be selectable to provide a pop-up with further information and possibly sponsored information (such as images, further ads, etc).
摘要翻译：响应于对地理区域或位置中的信息的查询，排序的广告可以绘制在地图上或与地图相关联（例如，作为地图旁边的列表），卫星照片或任何其他形式的视觉地理信息的表示（一般称为“地图”）。赞助广告可能会显示在专门的地方，和/或可能会高于其他非赞助搜索结果（例如黄页列表）。列表中显示的广告数量和/或在地图上绘制的广告数量可能会随地图或地理图像的分辨率而变化。广告可以被排名或得分，并且各种广告的属性或特征可以是这样的分数或排名的函数。地图上的图可能是可选择的，以向弹出窗口提供更多信息和可能的赞助信息（如图像，更多广告等）。

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