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1. 发明申请

WO2015135907A1 MENISCUS PROSTHESIS 审中-公开
公开(公告)号：WO2015135907A1
公开(公告)日：2015-09-17
申请号：PCT/EP2015/054906
申请日：2015-03-10
申请人： STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN , DSM IP ASSETS B.V.
发明人： KOENEN, Jacob , DAAMEN, Edwin , VAN TIENEN, Tony , BUMA, Pieter
IPC分类号： A61F2/38 , A61F2/30
CPC分类号： A61F2/3872 , A61B34/10 , A61B2034/108 , A61F2/30756 , A61F2/30965 , A61F2002/30014 , A61F2002/30016 , A61F2002/30065 , A61F2002/30067 , A61F2002/30069 , A61F2002/3008 , A61F2002/30131 , A61F2002/30578 , A61F2002/30754 , A61F2002/30757
摘要： The invention is directed to a meniscus prosthesis comprising an arc-shaped meniscus prosthesis body having a main portion (1) comprising a reinforcing part (2) and two end portions (1A, 1B) comprising fixation parts (2A, 2B), wherein the main portion (1) comprises a part made of a first biocompatible, non- resorbable material extending between the two end portions (1A, 1B), wherein the reinforcing part (2) and the fixation parts (2A, 2B) are made of a second biocompatible, non-resorbable material and wherein the reinforcing part (2) extends between the fixation parts (2A, 2B) and wherein the fixation parts (2A, 2B) have a through hole (3A, 3B), the first biocompatible, non-resorbable material has a tensile modulus of at most 100 MPa as determined by ISO 527-1 and the second biocompatible, non-resorbable material has a tensile modulus of at least 01 MPa as determined by ISO 527-1.
摘要翻译：本发明涉及一种弯液面假体，其包括具有包括加强部分（2）的主要部分（1）和包括固定部分（2A，2B）的两个端部部分（1A，1B）的弧形弯月面假体，其中，主要部分（1）包括在两个端部（1A，1B）之间延伸的第一生物相容不可吸收材料制成的部分，其中加强部分（2）和固定部分（2A，2B）由第二生物相容性不可再吸收材料，并且其中所述加强部分（2）在所述固定部分（2A，2B）之间延伸，并且其中所述固定部分（2A，2B）具有通孔（3A，3B），所述第一生物相容的， - 可吸收材料具有根据ISO 527-1确定的至多100MPa的拉伸模量，并且第二生物相容性不可再吸收材料的拉伸模量通过ISO 527-1确定为至少01MPa。

2. 发明申请

WO2015007771A1 POLYMER SUITABLE FOR USE IN CELL CULTURE 审中-公开
标题翻译：聚合物适用于细胞培养
公开(公告)号：WO2015007771A1
公开(公告)日：2015-01-22
申请号：PCT/EP2014/065233
申请日：2014-07-16
申请人： STICHTING KATHOLIEKE UNIVERSITEIT, MORE PARTICULARLY RADBOUD UNIVERSITEIT NIJMEGEN
发明人： ROWAN, Alan Edward , EKSTEEN AKEROYD, Zaskia Hillet , WILSON, Christopher , GEUTJES, Petrus Johannes , FEITZ, Wouter F.j. , OOSTERWIJK, Egbert
IPC分类号： A61K47/48 , C08G73/00 , C08G65/325 , C08G65/333
CPC分类号： C12N5/069 , C07K5/06026 , C08G65/325 , C08G65/33324 , C08G69/10 , C08G69/40 , C12N5/0691 , C12N2502/28 , C12N2533/50
摘要： The invention relates to a process for making an oligo(alkylene glycol) functionalized co-polyisocyanopeptide, wherein the process comprises the steps of: i) copolymerizing - a first comonomer of an oligo(alkylene glycol) functionalized isocyanopeptide grafted with a linking group and - a second comonomer of a non-grafted oligo(alkylene glycol) functionalized isocyanopeptide, wherein the molar ratio between the first comonomer and the second comonomer is :500 and 1:30 and ii) adding a reactant of a spacer unit and a cell adhesion factor to the copolymer obtained by step i), wherein the spacer unit is represented by general formula A-L-B, wherein the linking group and group A are chosen to react and form a first coupling and the cell adhesion factor and group B are chosen to react and form a second coupling, wherein the first coupling and the second coupling are independently selected from the group consisting of alkyne-azide coupling, dibenzocyclooctyne-azide coupling, oxanorbornadiene-based-azide couplings, vinylsulphone-thiol coupling, maleimide-thiol coupling, methyl methacrylate-thiol coupling, ether coupling, thioether coupling, biotin- strepavidin coupling, amine-carboxylic acid resulting in amides linkages, alcohol- carboxylic acid coupling resulting in esters linkages and NHS-Ester (N- Hydroxysuccinimide ester)-amine coupling and wherein group L is a linear chain segment having 10-60 bonds between atoms selected from C, N, O and S in the main chain.
摘要翻译：本发明涉及一种制备低聚（亚烷基二醇）官能化共聚异氰尿苷的方法，其中该方法包括以下步骤：i）共聚 - 接枝有连接基团的寡（亚烷基二醇）官能化异氰脲酸的第一共聚单体和 - 非接枝的寡（亚烷基二醇）官能化的异氰尿苷的第二共聚单体，其中第一共聚单体和第二共聚单体之间的摩尔比为：500和1:30，和ii）添加间隔单元的反应物和细胞粘附因子对于由步骤i）获得的共聚物，其中间隔单元由通式ALB表示，其中选择连接基团和基团A进行反应并形成第一偶联，并且选择细胞粘附因子和组B反应并形成第二耦合，其中所述第一耦合和所述第二耦合独立地选自炔 - 叠氮偶合，二苯并环辛炔 - 叠氮偶联，基 - 叠氮化物偶联，乙烯基砜 - 硫醇偶联，马来酰亚胺 - 硫醇偶联，甲基丙烯酸甲酯 - 硫醇偶联，醚偶联，硫醚偶联，生物素 - 链霉亲和素偶联，胺 - 羧酸导致酰胺键，醇 - 羧酸偶合，产生酯连接和NHS-酯（N-羟基琥珀酰亚胺酯） - 胺偶联，其中基团L是在主链中选自C，N，O和S的原子之间具有10-60个键的直链链段。

3. 发明申请

WO2011049442A2 BLOOD COAGULATION STATUS MEASUREMENT IN SALIVA 审中-公开
标题翻译：血液凝血状态测量在萨拉维亚
公开(公告)号：WO2011049442A2
公开(公告)日：2011-04-28
申请号：PCT/NL2010/050693
申请日：2010-10-19
申请人： STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITEIT NIJMEGEN , LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
发明人： LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/6848
摘要： The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.
摘要翻译：本发明涉及通过测量已经被证明与所述唾液中的国际标准化比例相关联的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。本发明还涉及一种用于执行所述方法的非侵入性装置，以及适于执行所述方法的套件。

4. 发明申请

WO2013095139A2 MAGNETIZATION REVERSAL 审中-公开
标题翻译：磁化反转
公开(公告)号：WO2013095139A2
公开(公告)日：2013-06-27
申请号：PCT/NL2012/050912
申请日：2012-12-21
申请人： RADBOUD UNIVERSITEIT NIJMEGEN
发明人： RASING, Theodorus Henricus Maria , MENTINK, Johan , KIRILYUK, Andrei , KIMEL, Alexey , EVANS, Richard Francis Llewelyn , CHANTRELL, Roy William , OSTLER, Thomas Andrew , BARKER, Joseph
IPC分类号： G11C11/14 , G11C11/16
CPC分类号： H01F13/00 , G11C11/14 , G11C11/16
摘要： The present invention is in the field of a method of magnetization reversal, time stable ferrimagnetic material, a product and a domain comprising said material, a system for magnetization reversal, and information storage. Therein, a ferrimagnetic material is one in which magnetic moments of the atoms on different sublattices are opposed, as in antiferromagnetism; however, in ferrimagnetic materials, the opposing moments are unequal and a spontaneous magnetization remains.
摘要翻译：本发明涉及磁化反转，时间稳定的亚铁磁材料，产品和包括所述材料的领域，用于磁化反转的系统和信息存储的方法领域。其中，铁磁材料是其中不同亚晶格上的原子的磁矩相反的，如反铁磁性; 然而，在亚铁磁材料中，相反的力矩是不相等的，并且自发磁化保持不变。

5. 发明申请

WO2011007012A8 METHOD FOR THE PREPARATION OF HIGH MOLECULAR WEIGHT OLIGO(ALKYLENE GLYCOL) FUNCTIONALIZED POLYISOCYANOPEPTIDES 审中-公开
公开(公告)号：WO2011007012A8
公开(公告)日：2011-01-20
申请号：PCT/EP2010/060373
申请日：2010-07-16
申请人： STICHTING KATHOLIEKE UNIVERSITEIT MEER IN HET BIJZONDER RADBOUD UNIVERSITEIT NIJMEGEN , ROWAN, Alan Edward , NOLTE, Roeland Johannes Maria , CORNELISSEN, Jeroen Johannes Lambertus Maria , KITTO, Heather Joy , SCHWARTZ, Erik , KOEPF, Matthieu
发明人： ROWAN, Alan Edward , NOLTE, Roeland Johannes Maria , CORNELISSEN, Jeroen Johannes Lambertus Maria , KITTO, Heather Joy , SCHWARTZ, Erik , KOEPF, Matthieu
IPC分类号： C08G18/09 , C08G18/50
摘要： The present invention relates to a process for the preparation of oligo(alkylene glycol) functionalized polyisocyanopeptides comprising the steps of functionalizing an isocyanopeptide with oligo-(alkylene glycol) side chains and subsequently polymerizing the oligo-alkylene glycol functionalized isocyanopeptides. Several isocyanopeptide may be functionalized with various linear or non-linear oligo-(alkylene glycol) side chains having variable chain length. The alkylene glycol may be selected from the group consisting of ethylene-, propylene-, butylene- or pentylene glycol. Preferably the isocyanopeptides are functionalized with at least 3 ethylene glycol side chains. The peptides may comprise L aminoacids, D-aminoacids or D, L-aminoacids. The obtained oligoalkylene functionalized polyisocyanopeptides are a new class of materials with unique thermo-responsive properties.

6. 发明申请

WO2012004369A1 IMMUNOMODULATORY PROTEIN CONSTRUCTS WITH A HELICAL POLYMERIC BACKBONE 审中-公开
标题翻译：免疫组织蛋白质结构与螺旋聚合物底骨
公开(公告)号：WO2012004369A1
公开(公告)日：2012-01-12
申请号：PCT/EP2011/061559
申请日：2011-07-07
申请人： STICHTING KATHOLIEKE UNIVERSITEIT, MEER IN HET BIJZONDER RADBOUD UNIVERSITEIT NIJMEGEN , STICHTING KATHOLIEKE UNIVERSITEIT , ROWAN, Alan Edward , FIGDOR, Carl Gustav
发明人： ROWAN, Alan Edward , FIGDOR, Carl Gustav
IPC分类号： A61K47/48 , A61P37/02
CPC分类号： A61K47/48192 , A61K47/59 , A61K47/60 , A61K47/646
摘要： The present invention relates to protein constructs that comprise one or more peptides, proteins, factors, compounds or other components as further described herein that are linked to and/or are linked to each other via a helical polymeric backbone. The constructs of the invention are suitable for administration to a human or animal body and can be used for pharmaceutical purposes, for example for immunotherapy such as for treating cancer and for other immunological applications, as well as for other therapeutic, prophylactic and/or diagnostic purposes.
摘要翻译：本发明涉及包含一个或多个肽，蛋白质，因子，化合物或本文进一步描述的其它组分的蛋白质构建体，其通过螺旋聚合物主链相互连接和/或彼此连接。本发明的构建体适用于给予人或动物体并且可用于药物目的，例如用于免疫治疗，例如用于治疗癌症和其它免疫应用，以及其它治疗，预防和/或诊断目的。

7. 发明申请

WO2013095139A3 MAGNETIZATION REVERSAL 审中-公开
标题翻译：磁化反转
公开(公告)号：WO2013095139A3
公开(公告)日：2013-08-15
申请号：PCT/NL2012050912
申请日：2012-12-21
申请人： RADBOUD UNIVERSITEIT NIJMEGEN
发明人： RASING THEODORUS HENRICUS MARIA , MENTINK JOHAN , KIRILYUK ANDREI , KIMEL ALEXEY , EVANS RICHARD FRANCIS LLEWELYN , CHANTRELL ROY WILLIAM , OSTLER THOMAS ANDREW , BARKER JOSEPH
IPC分类号： G11C11/14 , G11C11/16
CPC分类号： H01F13/00 , G11C11/14 , G11C11/16
摘要： The present invention is in the field of a method of magnetization reversal, time stable ferrimagnetic material, a product and a domain comprising said material, a system for magnetization reversal, and information storage. Therein, a ferrimagnetic material is one in which magnetic moments of the atoms on different sublattices are opposed, as in antiferromagnetism; however, in ferrimagnetic materials, the opposing moments are unequal and a spontaneous magnetization remains.
摘要翻译：本发明属于磁化反转方法，时间稳定的铁磁材料，包含所述材料的产品和领域，磁化反转系统和信息存储的领域。其中，亚铁磁材料是其中不同子晶格上的原子的磁矩相反的材料，如反铁磁性; 然而，在亚铁磁材料中，反向磁矩不相等，并且自发磁化仍然存在。

8. 发明申请

WO2011049431A1 BLOOD COAGULATION STATUS MEASUREMENT IN SALIVA 审中-公开
标题翻译：唾液中的血液凝固状况测量
公开(公告)号：WO2011049431A1
公开(公告)日：2011-04-28
申请号：PCT/NL2009/050629
申请日：2009-10-19
申请人： Stichting Katholieke Universiteit, Radboud Universiteit Nijmegen , LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
发明人： LOOF, Arnoud Harmen , VAN HEERDE, Waander Laurens
IPC分类号： G01N33/86
CPC分类号： G01N33/86 , G01N33/6848
摘要： The present invention is concerned with a method for measuring blood coagulation status in a saliva sample from a subject by measuring the concentration of various proteins which have been demonstrated to correlate with the international normalized ratio in said saliva. The invention further relates to a non-invasive device for performing said method, as well as a kit suitable for performing said method.
摘要翻译：本发明涉及通过测量已证实与所述唾液中的国际标准化比率相关的各种蛋白质的浓度来测量来自受试者的唾液样品中的凝血状态的方法。本发明进一步涉及用于执行所述方法的非侵入式装置，以及适于执行所述方法的套件。

9. 发明申请

WO2010117264A1 METHOD AND SYSTEM FOR TRAINING OF PERCEPTUAL SKILLS USING NEUROFEEDBACK 审中-公开
标题翻译：使用神经反馈训练智力技能的方法和系统
公开(公告)号：WO2010117264A1
公开(公告)日：2010-10-14
申请号：PCT/NL2010/050171
申请日：2010-04-02
申请人： Stichting Katholieke Universiteit, Radboud Universiteit Nijmegen , DESAIN, Petrus Wilhelmus Maria , MCQUEEN, James Maurice
发明人： DESAIN, Petrus Wilhelmus Maria , MCQUEEN, James Maurice
IPC分类号： A61B5/00 , A61B5/0484 , A61B5/16
CPC分类号： A61B5/04845 , A61B5/16 , A61B5/486
摘要： Method for training of a perceptual skill, e.g. using a brain computer interface, which method comprises measuring electrophysiological activity in reaction to a sequence of perceptual stimuli. Furthermore, matching the measured electrophysiological activity signal with a predefined electrophysiological signature signal is performed, in which the predefined electrophysiological signature signal corresponds to an early electrophysiological component. Feedback is provided when a match is detected.
摘要翻译：用于训练感知技能的方法，例如使用脑计算机界面，该方法包括测量对感知刺激序列的反应的电生理活性。此外，执行将测量的电生理活动信号与预定的电生理学签名信号进行匹配，其中预定的电生理特征信号对应于早期的电生理学成分。检测到匹配时提供反馈。

10. 发明申请

WO2010008276A1 METHOD FOR PROCESSING A BRAIN WAVE SIGNAL AND BRAIN COMPUTER INTERFACE 审中-公开
标题翻译：用于处理脑波信号和脑电脑接口的方法
公开(公告)号：WO2010008276A1
公开(公告)日：2010-01-21
申请号：PCT/NL2009/050421
申请日：2009-07-10
申请人： STICHTING KATHOLIEKE UNIVERSITEIT, RADBOUD UNIVERSITEIT NIJMEGEN , DESAIN, Petrus Wilhelmus Maria , FURQUHAR, Jason
发明人： DESAIN, Petrus Wilhelmus Maria , FURQUHAR, Jason
IPC分类号： A61B5/0484 , G06F17/00
CPC分类号： A61B5/04845 , G06F3/015 , G06K9/00496
摘要： Method and brain computer interface for processing a brain wave signal (14) obtained from a person using a brain wave detector (5). One or more stimuli are applied to the person which each comprise a pseudo random noise component (11a, 11b). A brain wave signal (14) is detected and mental processing of the one or more stimuli (11a, 11b) is tracked by correlating the pseudo random noise component and the brain wave signal.
摘要翻译：用于处理从使用脑波检测器的人获得的脑波信号（14）的方法和脑计算机接口（5）。一个或多个刺激被应用于每个包括伪随机噪声分量（11a，11b）的人。检测脑波信号（14），并通过将伪随机噪声分量与脑波信号相关联来跟踪一个或多个刺激（11a，11b）的心理处理。

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