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1. 发明申请

WO2011162910A1 PHOTODYNAMIC BONE STABILIZATION AND DRUG DELIVERY SYSTEMS 审中-公开
标题翻译：光稳定性骨骼稳定和药物输送系统
公开(公告)号：WO2011162910A1
公开(公告)日：2011-12-29
申请号：PCT/US2011/038389
申请日：2011-05-27
申请人： ILLUMINOSS MEDICAL, INC. , RABINER, Robert, A. , RADER, Richard, Scott
发明人： RABINER, Robert, A. , RADER, Richard, Scott
IPC分类号： A61N1/30
CPC分类号： A61M25/10 , A61B17/7097 , A61B17/7098 , A61B17/7275 , A61B17/8836 , A61B17/8855 , A61B2017/00411 , A61M25/1011 , A61M2025/1013 , A61M2025/105 , A61M2025/1075 , A61M2205/0244 , A61N5/062 , A61N2005/0612 , A61N2005/063
摘要： Photodynamic bone stabilization and drug delivery systems include an insertion catheter (101) having an inner void (110) for passing at least one light-sensitive liquid, and an inner lumen (120); an expandable portion (400) releasably engaging a distal end (114) of the insertion catheter (101), wherein the expandable portion (400) comprises an inner expandable portion (410) in communication with the inner lumen (110) of the insertion catheter (101) and sufficiently designed to maintain a light-sensitive liquid therein; and an outer expandable portion (450), surrounding the inner expandable portion (410), sufficiently designed to house and release at least one additive from the outer expandable portion (450) in an outward direction from the inner expandable portion (410); and a light-conducting fiber sized to pass through the inner lumen (110) of the insertion catheter (101) and into the inner expandable portion (410) for delivering light energy to the light-sensitive liquid.
摘要翻译：光动力学骨骼稳定和药物递送系统包括具有用于使至少一种感光液体通过的内部空隙（110）和内腔（120）的插入导管（101）。可释放地接合所述插入导管（101）的远端（114）的可膨胀部分（400），其中所述可扩张部分（400）包括与所述插入导管（101）的内腔（110）连通的内部可扩张部分（410）（101）并且被充分设计成在其中保持感光液体; 以及围绕所述内部可膨胀部分（410）的外部可膨胀部分（450），所述外部可膨胀部分（450）被充分地设计成在从所述内部可膨胀部分（410）向外的方向上容纳和释放来自所述外部可扩张部分（450）的至少一种添加剂。以及尺寸适于穿过插入导管（101）的内腔（110）并进入内部可膨胀部分（410）的导光纤维，用于将光能传递给感光液体。

2. 发明申请

WO2009026070A1 APPARATUS AND METHODS FOR ATTACHING SOFT TISSUE TO BONE 审中-公开
标题翻译：用于将软组织装入骨的装置和方法
公开(公告)号：WO2009026070A1
公开(公告)日：2009-02-26
申请号：PCT/US2008/073016
申请日：2008-08-13
申请人： ILLUMINOSS MEDICAL, INC. , RABINER, Robert, A. , GREEN, Andrew
发明人： RABINER, Robert, A. , GREEN, Andrew
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/0409 , A61B2017/0424 , A61B2017/0432 , A61B2017/0445
摘要： Suture anchors (100) and methods for using the suture anchors (100) for attaching soft tissue, such as ligaments, tendons, and muscles, to bone are disclosed herein. A suture anchor (100) for attaching soft tissue to bone includes a catheter (130) having an elongated shaft with a proximal end, a distal end, and a longitudinal axis therebetween, wherein the catheter (130) has at least one inner lumen capable of allowing a light curable adhesive to pass therethrough; a balloon portion engaging the distal end of the catheter (130), wherein the balloon portion (136) expands from a deflated state to an inflated state when a light curable adhesive is delivered to the balloon portion (136); and at least one suture material (150) for passing through soft tissue to attach the soft tissue to a bone.
摘要翻译：本文公开了缝合锚（100）和使用缝合锚（100）将软组织（例如韧带，肌腱和肌肉）附着于骨的方法。用于将软组织附接到骨头的缝合锚（100）包括具有细长轴的导管（130），所述细长轴具有近端，远端和在它们之间的纵向轴线，其中所述导管（130）具有至少一个内腔，允许光固化粘合剂通过; 接合所述导管（130）的远端的气囊部分，其中当所述可光固化的粘合剂被输送到所述气囊部分（136）时，所述球囊部分（136）从放气状态膨胀到膨胀状态; 和用于穿过软组织以将软组织附着到骨骼上的至少一个缝线材料（150）。

3. 发明申请

WO2007127260A3 APPARATUS AND METHODS FOR DELIVERY OF REINFORCING MATERIALS TO BONE 审中-公开
标题翻译：用于将骨料加固的装置和方法
公开(公告)号：WO2007127260A3
公开(公告)日：2008-07-10
申请号：PCT/US2007010050
申请日：2007-04-26
申请人： ILLUMINOSS MEDICAL INC , RABINER ROBERT A
发明人： RABINER ROBERT A
IPC分类号： A61B17/58 , A61B17/60
CPC分类号： A61B17/7097 , A61B17/3472 , A61B17/7275 , A61B17/8811 , A61B17/8816 , A61B17/8827 , A61B17/8836 , A61B17/8855 , A61B90/39 , A61B2017/00557 , A61B2017/00867 , A61B2090/036 , A61B2090/037 , A61B2090/306 , A61L29/18 , A61L2430/02
摘要： An apparatus and methods for delivery of reinforcing materials to a weakened or fractured bone is disclosed. An apparatus for delivering a reinforcing mixture to a bone (202) including a tube (100) having a proximal end (102), a distal end (104), and a longitudinal axis therebetween, wherein the tube (100) has at least one inner lumen (120) capable of allowing a bone reinforcing mixture to pass therethrough; a balloon (106) engaging the tube (100) wherein the balloon (106) expands from a substantially deflated state to a substantially inflated state upon the bone reinforcing mixture entering the balloon (106); and at least one light guide (112) extending through the tube (100) into the balloon (106) to guide a light into the balloon (106).
摘要翻译：公开了一种用于将增强材料递送至弱化或断裂骨的装置和方法。一种用于将增强混合物输送到包括具有近端（102），远端（104）和其间的纵向轴线的管（100）的骨（202）的装置，其中所述管（100）具有至少一个能够允许骨增强混合物通过的内腔（120）与所述管（100）接合的气囊（106），其中所述球体（106）在所述骨骼增强混合物进入所述球囊（106）时从基本上放气状态膨胀至基本上膨胀的状态; 以及延伸穿过所述管（100）进入所述球囊（106）以将光引导到所述球囊（106）中的至少一个导光体（112）。

4. 发明申请

WO2006049600A1 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE TO TREAT CORONARY THROMBUS BEARING LESIONS 审中-公开
标题翻译：超声医疗器械治疗冠状动脉轴承损伤的装置及方法
公开(公告)号：WO2006049600A1
公开(公告)日：2006-05-11
申请号：PCT/US2004/035854
申请日：2004-10-28
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A. , KELLEY, Craig, T.
发明人： RABINER, Robert, A. , HARE, Bradley, A. , KELLEY, Craig, T.
IPC分类号： A61B8/00
CPC分类号： A61B17/22012 , A61B2017/00243
摘要： An apparatus and method for using an ultrasonic medical device (11) to treat coronary thrombus bearing lesions (75) comprises an ultrasonic probe (15), a transducer, a coupling (33) engaging a proximal end (31) of the ultrasonic probe (15) to a distal end (24) of the transducer and an ultrasonic energy source (99) engaged to the transducer. The ultrasonic probe (15) is inserted into a vasculature in communication with the coronary thrombus bearing lesion (75). The ultrasonic energy source (99) produces energy that is transmitted to the transducer, which generates a transverse ultrasonic vibration along the ultrasonic probe (15). The transverse ultrasonic vibration creates a plurality of transverse nodes (40)and a plurality of transverse antinodes (42) along the longitudinal axis of the ultrasonic probe(15), creating cavitation along a portion of the longitudinal axis of the ultrasonic probe (15) to ablate the coronary thrombus bearing lesion (75).
摘要翻译：使用超声波医疗装置（11）治疗冠状动脉血栓轴承病变（75）的装置和方法包括超声波探头（15），换能器，接合超声波探头的近端（31）的联接器（33） 15）连接到换能器的远端（24）和与换能器接合的超声能量源（99）。将超声波探头（15）插入到与冠状动脉血栓轴承病变（75）连通的脉管系统中。超声波能量源（99）产生传递到换能器的能量，其产生沿着超声波探头（15）的横向超声波振动。横向超声波振动沿着超声波探头（15）的纵向轴线产生多个横向节点（40）和多个横向波腹（42），沿着超声波探头（15）的纵向轴线的一部分产生气蚀，消融冠状动脉血栓轴承损伤（75）。

5. 发明申请

WO2005034793A2 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE WITH A NON-COMPLIANT BALLOON 审中-公开
标题翻译：具有非合并气囊的超声医疗装置的装置和方法
公开(公告)号：WO2005034793A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/015331
申请日：2004-05-14
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , HARE, Bradley, A. , RABINER, Robert, A.
发明人： HARE, Bradley, A. , RABINER, Robert, A.
IPC分类号： A61F
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/320068 , A61B2017/00137 , A61B2017/00274 , A61B2017/00778 , A61B2017/22007 , A61B2017/22008 , A61B2017/22015 , A61B2017/22018 , A61B2017/22028 , A61B2017/22051 , A61B2017/22081 , A61B2017/320084 , A61B2018/00547 , A61B2018/00982 , A61B2217/005 , A61B2217/007 , A61M1/0084 , A61N7/022
摘要： The present invention provides an apparatus and a method for an ultrasonic medical device (11) with a non-compliant balloon (41) used to ablate a biological material. The ultrasonic medical device (11)comprises an ultrasonic probe (15), a catheter (36) surrounding the ultrasonic probe (15), a balloon (41) supported by the catheter (36) and an inflation lumen (85) located along a longitudinal axis of the catheter (36). The ultrasonic probe (15) is inserted into a vasculature (44) and the catheter (36) comprising the balloon (41) is advanced until the balloon (41) is adjacent to the biological material. The balloon (41) is inflated until at least a portion of an outer surface (53) of the balloon (41) engages the biological material. The ultrasonic probe (15) is energized to produce a transverse ultrasonic vibration that vibrates at least a portion of the balloon (41) to ablate the biological material into a particulate.
摘要翻译：本发明提供一种具有用于烧蚀生物材料的非顺应性球囊（41）的超声波医疗装置（11）的装置和方法。超声波医疗装置（11）包括超声波探头（15），围绕超声波探头（15）的导管（36），由导管（36）支撑的球囊（41）和沿着导管（36）的纵向轴线。将超声波探头（15）插入脉管系统（44）中，并且包括球囊（41）的导管（36）前进直到球囊（41）与生物材料相邻。气球（41）被充气，直到球囊（41）的外表面（53）的至少一部分与生物材料接合。超声波探头（15）被通电以产生横向超声波振动，该振动振动至少一部分球囊（41）以将生物材料烧蚀成颗粒。

6. 发明申请

WO03030777A3 ULTRASONIC PROBE DEVICE WITH RAPID ATTACHMENT AND DETACHMENT MEANS HAVING A LINE CONTACT COLLET 审中-公开
标题翻译：具有快速附着和分离装置的超声探头装置具有线接触套
公开(公告)号：WO03030777A3
公开(公告)日：2003-08-21
申请号：PCT/US0232272
申请日：2002-10-10
申请人： OMNISONICS MEDICAL TECH , HARE BRADLEY A , RABINER ROBERT A , RANUCCI KEVIN J , MARCIANTE REBECCA I , VARADY MARK J , ROBERTSON ROY M , PRASAD JANNIAH S , TALBOT SCOTT A
发明人： HARE BRADLEY A , RABINER ROBERT A , RANUCCI KEVIN J , MARCIANTE REBECCA I , VARADY MARK J , ROBERTSON ROY M , PRASAD JANNIAH S , TALBOT SCOTT A
IPC分类号： A61B18/00 , A61B8/12 , A61B17/00 , A61B17/22 , A61B17/32 , A61N7/02 , H04R17/00
CPC分类号： A61B17/320068 , A61B17/22012 , A61B2017/00137 , A61B2017/00274 , A61B2017/00477 , A61B2017/22007 , A61B2017/22008 , A61B2017/22018 , A61B2017/320084 , A61B2018/00547 , A61N7/022 , A61N2007/0008
摘要： An ultrasonic medical device comprising an ultrasonic probe (25) and a collet assembly for probe attachment and detachment, and a method of removing occlusions in blood vessels using the ultrasonic medical device. The probe (25) detachability allows insertion, manipulation and withdrawal independently of a device body. The collet assembly (5) comprises a compression clamp (10) capable of releasably receiving the probe (25), and a compression housing (14) that initiates a minimal area "line-contact" between the collet assembly segments upon engagement. A line-contact lip (21) ensures consistent and repeatable contact between the compression clamp (10) and the compression housing (14) at a pre-determined location to provide a consistent closing force on the probe (25) for any selected tightening torque. The line- contact between the collet assembly segments provides efficient ultrasonic energy transfer from an ultrasonic energy source (30) to the probe (25) thereby increasing probe efficiency during tissue ablation.
摘要翻译：一种超声波医疗装置，其特征在于，具备超声波探头（25）和探头装卸用夹头组件，以及使用超声波医疗装置去除血管内的堵塞的方法。探头（25）的可拆卸性允许独立于设备主体的插入，操纵和撤回。夹头组件（5）包括能够可释放地接收探头（25）的压紧夹具（10）和压紧壳体（14），该压紧壳体在接合时启动夹头组件段之间的最小面积“线接触”。线接触唇缘（21）确保压缩夹具（10）和压缩壳体（14）之间在预定位置处的一致且可重复的接触，以针对任何选定的拧紧扭矩在探针（25）上提供一致的闭合力。夹头组件段之间的线接触提供从超声能量源（30）到探针（25）的有效超声能量传递，由此在组织消融期间增加探针效率。

7. 发明申请

WO2003039381A1 ULTRASONIC PROBE DEVICE HAVING AN IMPEDANCE MISMATCH WITH RAPID ATTACHMENT AND DETACHMENT MEANS 审中-公开
标题翻译：具有快速连接和分离方式的阻抗失真的超声探头设备
公开(公告)号：WO2003039381A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/032385
申请日：2002-10-10
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , HARE, Bradley, A. , RABINER, Robert, A. , RANUCCI, Kevin, J. , MARCIANTE, Rebecca, I. , VARADY, Mark, J. , ROBERTSON, Roy, M.
发明人： HARE, Bradley, A. , RABINER, Robert, A. , RANUCCI, Kevin, J. , MARCIANTE, Rebecca, I. , VARADY, Mark, J. , ROBERTSON, Roy, M.
IPC分类号： A61B17/22
CPC分类号： A61B17/320068 , A61B17/22012 , A61B2017/00137 , A61B2017/00274 , A61B2017/00477 , A61B2017/22007 , A61B2017/22008 , A61B2017/22018 , A61B2017/320084 , A61B2018/00547 , A61N7/022 , A61N2007/0008
摘要： An ultrasonic tissue ablation device comprising a transversely vibrating small-diameter probe (10) and a coupling assembly for probe attachment and detachment that that enables the probe (10) to disengage from the device body. The probe detachability allows for insertion, manipulation, and withdrawal independently of the device body. The probe (10) can be used with acoustic and/or aspirations sheaths to enhance tissue ablation. The device body includes an ultrasonic energy source and a horn assembly (34). The probe (10) of the present invention is engaged to the device body in a manner which creates an impedance mismatch between the probe (10) and the device body which allows the probe and the device body to operate as separate acoustic systems. The present invention also comprises a method for the removal of vascular occlusions in a blood vessels.
摘要翻译：一种超声波组织消融装置，包括横向振动的小直径探针（10）和用于探针附接和分离的联接组件，其能够使探针（10）脱离装置主体。探头可拆卸性允许独立于设备主体的插入，操作和取出。探针（10）可以与声学和/或吸气鞘一起使用以增强组织消融。装置主体包括超声能量源和喇叭组件（34）。本发明的探头（10）以使得探针和装置主体作为分离的声学系统工作的探针（10）和装置主体之间产生阻抗失配的方式接合到装置主体。本发明还包括用于去除血管中血管闭塞的方法。

8. 发明申请

WO2002070158A1 APPARATUS AND METHOD FOR MANUFACTURING SMALL DIAMETER MEDICAL DEVICES 审中-公开
标题翻译：用于制造小直径医疗装置的装置和方法
公开(公告)号：WO2002070158A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/007135
申请日：2002-03-06
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A. , PRASAD, Janniah, S.
发明人： RABINER, Robert, A. , HARE, Bradley, A. , PRASAD, Janniah, S.
IPC分类号： B21C1/18
CPC分类号： B21C3/02 , A61B17/22012 , A61B2017/22015 , A61B2017/22018 , B21C1/22 , B21C1/30 , B21C9/02 , B21F45/008
摘要： An apparatus and method for manufacturing small diameter ultrasonic probes (1) capable of vibrating in a transverse mode that can be used in ultrasonic tissue ablation. The apparatus includes a die (20), a syle puller (30) which is used to engage a functional end of the medical device, and a die room puller (40) which is used to draw the medical device through the die. The die (20) includes a bell-shaped lead-in (22) on a front side (24) of the die (20) and a bell-shaped lead-in (23) on a back side (25) of the die allowing for reversal of the direction of the draw. The method of manufacturing includes heat treating a large diameter medical device, drawing the large diameter device through a die (20) and reversing the draw of the medical device through the die to provide a medical device having a varying diameter along a length of the device. The method is repeated until a final diameter is reached.
摘要翻译：一种用于制造能够用于超声波组织消融的横向模式的小直径超声波探头（1）的装置和方法。该装置包括用于接合医疗装置的功能端的模具（20），用于接合医疗装置的功能端的提取器（30），以及用于通过模具吸引医疗装置的模具室拉拔器（40）。模具（20）包括在模具（20）的前侧（24）上的钟形引入件（22）和模具的背面（25）上的钟形引入件（23）允许反转方向的画面。制造方法包括对大直径医疗装置进行热处理，通过模具（20）拉伸大直径装置并且通过模具反转医疗装置的牵引，以提供具有沿装置的长度的变化的直径的医疗装置。重复该方法直到达到最终直径。

9. 发明申请

WO2013013069A1 COMBINATION PHOTODYNAMIC DEVICES 审中-公开
标题翻译：组合光电装置
公开(公告)号：WO2013013069A1
公开(公告)日：2013-01-24
申请号：PCT/US2012/047444
申请日：2012-07-19
申请人： ILLUMINOSS MEDICAL, INC. , RABINER, Robert, A. , RADER, Richard, Scott
发明人： RABINER, Robert, A. , RADER, Richard, Scott
IPC分类号： A61B17/68
CPC分类号： A61F2/30724 , A61B17/7097 , A61B17/7233 , A61B17/7258 , A61B17/7275 , A61B17/7283 , A61F2/30749 , A61F2/3804 , A61F2002/30934 , A61F2002/4631 , A61N5/062 , A61N2005/0612
摘要： Combination photodynamic devices (100) for repair and stabilization of a fractured or a weakened bone are disclosed herein. In an embodiment, a combination photodynamic device (100) includes a load bearing member (115) and one or more conformable members (170) connected to the load bearing member (115), the conformable member (170) expandable from a deflated state to an inflated state. The load bearing member (115) is designed to reside inside a cavity of fractured or weakened bone and act as internal bone fixation and stabilization device. The conformable member (170) is designed to anchor the load bearing member (115) inside a bone cavity, transform the load bearing member (115) from a flexible state to a rigid state, contribute to fixating and stabilizing a fractured or a weakened bone, and provide longitudinal and rotational stability to a fractured or a weakened bone during the healing process or combinations thereof.
摘要翻译：本文公开了用于修复和稳定骨折的骨组织光动力装置（100）。在一个实施例中，组合光动力装置（100）包括承载构件（115）和连接到承载构件（115）的一个或多个适形构件（170），适形构件（170）可从放气状态扩展到充气状态。承载构件（115）被设计成位于骨折或骨骼骨的腔内，并且用作内骨固定和稳定装置。适形构件（170）设计成将承载构件（115）锚固在骨腔内，将承载构件（115）从柔性状态转变为刚性状态，有助于固定和稳定骨折或骨化并且在愈合过程或其组合期间向断裂或弱化骨提供纵向和旋转稳定性。

10. 发明申请

WO2012088432A1 SYSTEMS AND METHODS FOR TREATING CONDITIONS AND DISEASES OF THE SPINE 审中-公开
标题翻译：用于治疗脊椎病症和疾病的系统和方法
公开(公告)号：WO2012088432A1
公开(公告)日：2012-06-28
申请号：PCT/US2011/066871
申请日：2011-12-22
申请人： ILLUMINOSS MEDICAL, INC. , RABINER, Robert, A. , DIPOTO, Gene, P.
发明人： RABINER, Robert, A. , DIPOTO, Gene, P.
IPC分类号： A61B17/66
CPC分类号： A61B17/7097 , A61B17/8802 , A61B17/8805 , A61B17/8833 , A61B17/8836 , A61B17/885 , A61B17/8852 , A61B17/8855 , A61B2090/306 , A61F2/441 , A61F2002/30581 , A61F2002/30583 , A61F2002/30971 , A61F2002/4495
摘要： Systems and methods for treating conditions and diseases of the spine are disclosed herein. A device includes a balloon catheter (110) comprising at least one inner lumen incorporated within an elongated shaft (101); a distal end (104) having an inner balloon positioned inside and completely surrounded by an outer balloon; and a proximal end (102) having an adapter for passage of at least one of an inflation fluid or a medical instrument; and an optical fiber (106) comprising an outer diameter sized to pass through the inner lumen of the elongated shaft (101); a nonlinear light-emitting portion (158) of a given length, wherein a portion of a cladding material from the nonlinear light-emitting portion (158) has been removed so that light energy may be emitted along the length of the nonlinear light-emitting portion (158); and a linear elongated portion (148) for guiding light towards the nonlinear light-emitting portion (158).
摘要翻译：本文公开了用于治疗脊柱病症和疾病的系统和方法。装置包括气囊导管（110），其包括结合在细长轴（101）内的至少一个内腔; 远端（104），其具有位于内部并被外球囊完全包围的内气囊; 和具有用于通气膨胀流体或医疗器械中的至少一个的适配器的近端（102）; 以及包括尺寸适于穿过所述细长轴（101）的内腔的外径的光纤（106）; 具有给定长度的非线性发光部分（158），其中去除了来自非线性发光部分（158）的包层材料的一部分，使得沿着非线性发光部分（158）的长度发射光能部分（158）; 以及用于将光引向非线性发光部分（158）的线性细长部分（148）。

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