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1. 发明申请

WO2006049600A1 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE TO TREAT CORONARY THROMBUS BEARING LESIONS 审中-公开
标题翻译：超声医疗器械治疗冠状动脉轴承损伤的装置及方法
公开(公告)号：WO2006049600A1
公开(公告)日：2006-05-11
申请号：PCT/US2004/035854
申请日：2004-10-28
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A. , KELLEY, Craig, T.
发明人： RABINER, Robert, A. , HARE, Bradley, A. , KELLEY, Craig, T.
IPC分类号： A61B8/00
CPC分类号： A61B17/22012 , A61B2017/00243
摘要： An apparatus and method for using an ultrasonic medical device (11) to treat coronary thrombus bearing lesions (75) comprises an ultrasonic probe (15), a transducer, a coupling (33) engaging a proximal end (31) of the ultrasonic probe (15) to a distal end (24) of the transducer and an ultrasonic energy source (99) engaged to the transducer. The ultrasonic probe (15) is inserted into a vasculature in communication with the coronary thrombus bearing lesion (75). The ultrasonic energy source (99) produces energy that is transmitted to the transducer, which generates a transverse ultrasonic vibration along the ultrasonic probe (15). The transverse ultrasonic vibration creates a plurality of transverse nodes (40)and a plurality of transverse antinodes (42) along the longitudinal axis of the ultrasonic probe(15), creating cavitation along a portion of the longitudinal axis of the ultrasonic probe (15) to ablate the coronary thrombus bearing lesion (75).
摘要翻译：使用超声波医疗装置（11）治疗冠状动脉血栓轴承病变（75）的装置和方法包括超声波探头（15），换能器，接合超声波探头的近端（31）的联接器（33） 15）连接到换能器的远端（24）和与换能器接合的超声能量源（99）。将超声波探头（15）插入到与冠状动脉血栓轴承病变（75）连通的脉管系统中。超声波能量源（99）产生传递到换能器的能量，其产生沿着超声波探头（15）的横向超声波振动。横向超声波振动沿着超声波探头（15）的纵向轴线产生多个横向节点（40）和多个横向波腹（42），沿着超声波探头（15）的纵向轴线的一部分产生气蚀，消融冠状动脉血栓轴承损伤（75）。

2. 发明申请

WO2005034793A2 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE WITH A NON-COMPLIANT BALLOON 审中-公开
标题翻译：具有非合并气囊的超声医疗装置的装置和方法
公开(公告)号：WO2005034793A2
公开(公告)日：2005-04-21
申请号：PCT/US2004/015331
申请日：2004-05-14
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , HARE, Bradley, A. , RABINER, Robert, A.
发明人： HARE, Bradley, A. , RABINER, Robert, A.
IPC分类号： A61F
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/320068 , A61B2017/00137 , A61B2017/00274 , A61B2017/00778 , A61B2017/22007 , A61B2017/22008 , A61B2017/22015 , A61B2017/22018 , A61B2017/22028 , A61B2017/22051 , A61B2017/22081 , A61B2017/320084 , A61B2018/00547 , A61B2018/00982 , A61B2217/005 , A61B2217/007 , A61M1/0084 , A61N7/022
摘要： The present invention provides an apparatus and a method for an ultrasonic medical device (11) with a non-compliant balloon (41) used to ablate a biological material. The ultrasonic medical device (11)comprises an ultrasonic probe (15), a catheter (36) surrounding the ultrasonic probe (15), a balloon (41) supported by the catheter (36) and an inflation lumen (85) located along a longitudinal axis of the catheter (36). The ultrasonic probe (15) is inserted into a vasculature (44) and the catheter (36) comprising the balloon (41) is advanced until the balloon (41) is adjacent to the biological material. The balloon (41) is inflated until at least a portion of an outer surface (53) of the balloon (41) engages the biological material. The ultrasonic probe (15) is energized to produce a transverse ultrasonic vibration that vibrates at least a portion of the balloon (41) to ablate the biological material into a particulate.
摘要翻译：本发明提供一种具有用于烧蚀生物材料的非顺应性球囊（41）的超声波医疗装置（11）的装置和方法。超声波医疗装置（11）包括超声波探头（15），围绕超声波探头（15）的导管（36），由导管（36）支撑的球囊（41）和沿着导管（36）的纵向轴线。将超声波探头（15）插入脉管系统（44）中，并且包括球囊（41）的导管（36）前进直到球囊（41）与生物材料相邻。气球（41）被充气，直到球囊（41）的外表面（53）的至少一部分与生物材料接合。超声波探头（15）被通电以产生横向超声波振动，该振动振动至少一部分球囊（41）以将生物材料烧蚀成颗粒。

3. 发明申请

WO2003039381A1 ULTRASONIC PROBE DEVICE HAVING AN IMPEDANCE MISMATCH WITH RAPID ATTACHMENT AND DETACHMENT MEANS 审中-公开
标题翻译：具有快速连接和分离方式的阻抗失真的超声探头设备
公开(公告)号：WO2003039381A1
公开(公告)日：2003-05-15
申请号：PCT/US2002/032385
申请日：2002-10-10
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , HARE, Bradley, A. , RABINER, Robert, A. , RANUCCI, Kevin, J. , MARCIANTE, Rebecca, I. , VARADY, Mark, J. , ROBERTSON, Roy, M.
发明人： HARE, Bradley, A. , RABINER, Robert, A. , RANUCCI, Kevin, J. , MARCIANTE, Rebecca, I. , VARADY, Mark, J. , ROBERTSON, Roy, M.
IPC分类号： A61B17/22
CPC分类号： A61B17/320068 , A61B17/22012 , A61B2017/00137 , A61B2017/00274 , A61B2017/00477 , A61B2017/22007 , A61B2017/22008 , A61B2017/22018 , A61B2017/320084 , A61B2018/00547 , A61N7/022 , A61N2007/0008
摘要： An ultrasonic tissue ablation device comprising a transversely vibrating small-diameter probe (10) and a coupling assembly for probe attachment and detachment that that enables the probe (10) to disengage from the device body. The probe detachability allows for insertion, manipulation, and withdrawal independently of the device body. The probe (10) can be used with acoustic and/or aspirations sheaths to enhance tissue ablation. The device body includes an ultrasonic energy source and a horn assembly (34). The probe (10) of the present invention is engaged to the device body in a manner which creates an impedance mismatch between the probe (10) and the device body which allows the probe and the device body to operate as separate acoustic systems. The present invention also comprises a method for the removal of vascular occlusions in a blood vessels.
摘要翻译：一种超声波组织消融装置，包括横向振动的小直径探针（10）和用于探针附接和分离的联接组件，其能够使探针（10）脱离装置主体。探头可拆卸性允许独立于设备主体的插入，操作和取出。探针（10）可以与声学和/或吸气鞘一起使用以增强组织消融。装置主体包括超声能量源和喇叭组件（34）。本发明的探头（10）以使得探针和装置主体作为分离的声学系统工作的探针（10）和装置主体之间产生阻抗失配的方式接合到装置主体。本发明还包括用于去除血管中血管闭塞的方法。

4. 发明申请

WO2002070158A1 APPARATUS AND METHOD FOR MANUFACTURING SMALL DIAMETER MEDICAL DEVICES 审中-公开
标题翻译：用于制造小直径医疗装置的装置和方法
公开(公告)号：WO2002070158A1
公开(公告)日：2002-09-12
申请号：PCT/US2002/007135
申请日：2002-03-06
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A. , PRASAD, Janniah, S.
发明人： RABINER, Robert, A. , HARE, Bradley, A. , PRASAD, Janniah, S.
IPC分类号： B21C1/18
CPC分类号： B21C3/02 , A61B17/22012 , A61B2017/22015 , A61B2017/22018 , B21C1/22 , B21C1/30 , B21C9/02 , B21F45/008
摘要： An apparatus and method for manufacturing small diameter ultrasonic probes (1) capable of vibrating in a transverse mode that can be used in ultrasonic tissue ablation. The apparatus includes a die (20), a syle puller (30) which is used to engage a functional end of the medical device, and a die room puller (40) which is used to draw the medical device through the die. The die (20) includes a bell-shaped lead-in (22) on a front side (24) of the die (20) and a bell-shaped lead-in (23) on a back side (25) of the die allowing for reversal of the direction of the draw. The method of manufacturing includes heat treating a large diameter medical device, drawing the large diameter device through a die (20) and reversing the draw of the medical device through the die to provide a medical device having a varying diameter along a length of the device. The method is repeated until a final diameter is reached.
摘要翻译：一种用于制造能够用于超声波组织消融的横向模式的小直径超声波探头（1）的装置和方法。该装置包括用于接合医疗装置的功能端的模具（20），用于接合医疗装置的功能端的提取器（30），以及用于通过模具吸引医疗装置的模具室拉拔器（40）。模具（20）包括在模具（20）的前侧（24）上的钟形引入件（22）和模具的背面（25）上的钟形引入件（23）允许反转方向的画面。制造方法包括对大直径医疗装置进行热处理，通过模具（20）拉伸大直径装置并且通过模具反转医疗装置的牵引，以提供具有沿装置的长度的变化的直径的医疗装置。重复该方法直到达到最终直径。

5. 发明申请

WO2006041475A1 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE HAVING A PROBE WITH A SMALL PROXIMAL END 审中-公开
标题翻译：具有小临床终点的探针的超声医疗装置的装置和方法
公开(公告)号：WO2006041475A1
公开(公告)日：2006-04-20
申请号：PCT/US2004/032858
申请日：2004-10-06
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A.
发明人： RABINER, Robert, A. , HARE, Bradley, A.
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B2017/00477 , A61B2017/22015 , A61B2017/22018
摘要： An apparatus and method for an ultrasonic medical device having an ultrasonic probe (15) with a small proximal end (31) to facilitate over the ultrasonic probe (15) exchanges in a time efficient manner. The ultrasonic probe (15) is inserted into a vasculature and moved to a treatment site of an occlusion (16). A coupling (33) engaging the ultrasonic probe (15) to a transducer is disengaged to expose a small diameter at the proximal end (31) of the ultrasonic probe (15). A vascular intervention device (51) is placed over the small diameter at the proximal end (31) and moved along a longitudinal axis of the ultrasonic probe (15) while the ultrasonic probe (15) remains in an approximately fixed position in the vasculature. In a preferred embodiment, the ultrasonic probe (15) acts a guidewire for over the ultrasonic probe (15) exchanges of various vascular intervention devices (51).
摘要翻译：一种具有超声波探头（15）的超声波医疗装置的装置和方法，所述超声波探头（15）具有小的近端（31）以便超过所述超声波探头（15）以有效的方式进行交换。将超声波探头（15）插入脉管系统并移动到闭塞（16）的治疗部位。将超声波探头（15）接合到换能器的耦合器（33）被分离以暴露在超声波探头（15）的近端（31）处的小直径。血管介入装置（51）放置在近端（31）的小直径上，并且沿着超声波探头（15）的纵向轴线移动，同时超声波探头（15）保持在脉管系统中的大致固定位置。在优选实施例中，超声波探头（15）用于超声波探头（15）上的导丝，用于交换各种血管介入装置（51）。

6. 发明申请

WO2005084553A1 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE OPERATING IN A TORSIONAL MODE 审中-公开
标题翻译：用于在扭转模式下操作的超声医疗装置的装置和方法
公开(公告)号：WO2005084553A1
公开(公告)日：2005-09-15
申请号：PCT/US2004/003695
申请日：2004-02-09
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A. , MARCIANTE, Rebecca, I. , VARADY, Mark, J.
发明人： RABINER, Robert, A. , HARE, Bradley, A. , MARCIANTE, Rebecca, I. , VARADY, Mark, J.
IPC分类号： A61B8/00
CPC分类号： A61B17/22012 , A61B2017/00778 , A61B2017/22001 , A61B2017/22008 , A61B2017/22015 , A61B2017/320072 , A61B2017/320098
摘要： The present invention provides an apparatus and a method for an ultrasonic medical device (11) operating in a torsional mode and a transverse mode. An ultrasonic probe (15) of the ultrasonic medical device (11) is placed in communication with a biological material. An ultrasonic energy source (99) is activated to produce an electrical signal that drives a transducer to produce a torsional vibration of the ultrasonic probe (15). The torsional vibration produces a component of force in a transverse direction relative to a longitudinal axis of the ultrasonic probe (15), thereby exciting a transverse vibration along the longitudinal axis causing the ultrasonic probe (15) to undergo both a torsional vibration and a transverse vibration. The torsional vibration and the transverse vibration cause cavitation in a medium surrounding the ultrasonic probe (15) to ablate the biological material.
摘要翻译：本发明提供一种以扭转模式和横向模式操作的超声波医疗装置（11）的装置和方法。将超声波医疗装置（11）的超声波探头（15）放置成与生物材料连通。激活超声能量源（99）以产生驱动换能器以产生超声波探头（15）的扭转振动的电信号。扭转振动产生相对于超声波探头（15）的纵向轴线的横向方向的力的分量，从而激励沿着纵向轴线的横向振动，使得超声波探头（15）同时经受扭转振动和横向振动振动。扭转振动和横向振动导致围绕超声波探头（15）的介质中的空化以消融生物材料。

7. 发明申请

WO2005084552A1 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE OPERATING IN TORSIONAL AND TRANSVERSE MODES 审中-公开
标题翻译：用于扭转和横向模式操作的超声医疗装置的装置和方法
公开(公告)号：WO2005084552A1
公开(公告)日：2005-09-15
申请号：PCT/US2004/003694
申请日：2004-02-09
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A. , MARCIANTE, Rebecca, I. , VARADY, Mark, J.
发明人： RABINER, Robert, A. , HARE, Bradley, A. , MARCIANTE, Rebecca, I. , VARADY, Mark, J.
IPC分类号： A61B8/00
CPC分类号： A61B17/22012 , A61B2017/22015 , A61B2017/320098
摘要： The present invention provides an apparatus and a method for an ultrasonic medical device (11) operating in a torsional mode and a transverse mode. An ultrasonic probe (15) of the ultrasonic medical device (11) is placed in communication with a biological material. An ultrasonic energy source (99) is activated to produce an electrical signal that drives a transducer to produce a torsional vibration of the ultrasonic probe (15). The torsional vibration produces a component of force in a transverse direction relative to a longitudinal axis of the ultrasonic probe (15), thereby exciting a transverse vibration along the longitudinal axis causing the ultrasonic probe (15) to undergo both a torsional vibration and a transverse vibration. The torsional vibration and the transverse vibration cause cavitation in a medium surrounding the ultrasonic probe (15) to ablate the biological material.
摘要翻译：本发明提供一种以扭转模式和横向模式操作的超声波医疗装置（11）的装置和方法。将超声波医疗装置（11）的超声波探头（15）放置成与生物材料连通。激活超声能量源（99）以产生驱动换能器以产生超声波探头（15）的扭转振动的电信号。扭转振动产生相对于超声波探头（15）的纵向轴线的横向方向的力的分量，从而激励沿着纵向轴线的横向振动，使得超声波探头（15）同时经受扭转振动和横向振动振动。扭转振动和横向振动导致围绕超声波探头（15）的介质中的空化以消融生物材料。

8. 发明申请

WO2005037086A2 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE TO TREAT DEEP VEIN THROMBOSIS 审中-公开
标题翻译：用于超声医疗装置治疗深静脉血栓的装置和方法
公开(公告)号：WO2005037086A2
公开(公告)日：2005-04-28
申请号：PCT/US2004/004379
申请日：2004-02-13
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , RABINER, Robert, A. , HARE, Bradley, A.
发明人： RABINER, Robert, A. , HARE, Bradley, A.
IPC分类号： A61B
CPC分类号： A61B17/22004 , A61B17/22012 , A61B17/320068 , A61B2017/00137 , A61B2017/00274 , A61B2017/00778 , A61B2017/22007 , A61B2017/22008 , A61B2017/22015 , A61B2017/22018 , A61B2017/22028 , A61B2017/22051 , A61B2017/22081 , A61B2017/320084 , A61B2018/00547 , A61B2018/00982 , A61B2217/005 , A61B2217/007 , A61M1/0084 , A61N7/022
摘要： An apparatus and method for an ultrasonic medical device (11) to treat deep vein thrombosis. The ultrasonic medical device 11 comprises an ultrasonic probe (15) having a proximal end (31), a distal end (24) and a longitudinal axis therebetween. The ultrasonic probe (15) is inserted into a deep vein (75) of a leg(74), navigated adjacent to a thrombus (80) in the depp vein (75) and placed in communication with the thrombus (80). An ultrasonic energy source (99) is activated to generate a transverse ultrasonic vibration along at least a portion of the longitudinal axis of the ultrasonic probe (15). The transverse ultrasonic vibration creates a plurality of transverse nodes (40) and a plurality of transverse anti-nodes (42) along the longitudinal axis of the ultrasonic probe (15), generating cavitation in a medium surrounding the ultrasonic probe (15) to ablate the thrombus (80) and treat deep vein thrombosis.
摘要翻译：超声医疗装置（11）用于治疗深静脉血栓形成的装置和方法。超声波医疗装置11包括具有近端（31），远端（24）和位于其间的纵向轴线的超声探头（15）。超声波探头15被插入腿部74的深静脉75中，在临近静脉75的血栓80处导航并与血栓80连通。超声波能量源（99）被激活以沿超声波探头（15）的纵向轴线的至少一部分产生横向超声波振动。横向超声波振动沿着超声波探头（15）的纵向轴线产生多个横向节点（40）和多个横向波腹（42），在包围超声波探头（15）的介质中产生气蚀以消融血栓（80）并治疗深静脉血栓形成。

9. 发明申请

WO2005027756A1 APPARATUS AND METHOD FOR AN ULTRASONIC MEDICAL DEVICE ENGAGING A FLEXIBLE MATERIAL 审中-公开
标题翻译：一种超声波医疗装置与柔性材料的装置和方法
公开(公告)号：WO2005027756A1
公开(公告)日：2005-03-31
申请号：PCT/US2003/026447
申请日：2003-08-22
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , MARCIANTE, Rebecca, I. , HARE, Bradley, A. , RABINER, Robert, A. , O'LEARY, Anthony, W. , VARADY, Mark, J. , PRASAD, Janniah, S. , CHUANG, Anita, J.
发明人： MARCIANTE, Rebecca, I. , HARE, Bradley, A. , RABINER, Robert, A. , O'LEARY, Anthony, W. , VARADY, Mark, J. , PRASAD, Janniah, S. , CHUANG, Anita, J.
IPC分类号： A61B17/22
CPC分类号： A61B17/22012 , A61B2017/22015 , A61B2017/320088 , A61B2090/08021
摘要： The present invention provides an apparatus and a method for an ultrasonic medical device 11 having a flexible material 55 engaging an ultrasonic probe 15. The flexible material 55 surrounds a portion of a longitudinal axis of an ultrasonic probe 15 of the ultrasonic medical device 11. The flexible material 55 may extend beyond a probe tip 9. The flexible material 55 cushions a tip 9 of the ultrasonic probe 15 and reduces the stresses on the ultrasonic probe 15 as the ultrasonic probe 15 is navigated within the vasculature 44. The ultrasonic probe 15 may be shaped to increase a radial span of the ultrasonic medical device 11. In a preferred embodiment of the present invention, the flexible material 55 comprises a polymer material. Additionally, the flexible material 55 may have a high radiopacity.
摘要翻译：本发明提供一种具有与超声波探头15接合的柔性材料55的超声波医疗装置11的装置和方法。柔性材料55包围超声波医疗装置11的超声波探头15的纵轴的一部分。柔性材料55可以延伸超过探针尖端9.当超声波探头15在脉管系统44内导航时，柔性材料55缓冲超声波探头15的尖端9并减小超声波探头15上的应力。超声波探头15可以成形为增加超声波医疗装置11的径向跨度。在本发明的优选实施例中，柔性材料55包括聚合物材料。另外，柔性材料55可以具有高的不透射线性。

10. 发明申请

WO2003030777A2 ULTRASONIC PROBE DEVICE WITH RAPID ATTACHMENT AND DETACHMENT MEANS HAVING A LINE CONTACT COLLET 审中-公开
标题翻译：具有快速连接的超声探头装置和具有线接触胶片的分离装置
公开(公告)号：WO2003030777A2
公开(公告)日：2003-04-17
申请号：PCT/US2002/032272
申请日：2002-10-10
申请人： OMNISONICS MEDICAL TECHNOLOGIES, INC. , HARE, Bradley, A. , RABINER, Robert, A. , RANUCCI, Kevin, J. , MARCIANTE, Rebecca, I. , VARADY, Mark, J. , ROBERTSON, Roy, M. , PRASAD, Janniah, S. , TALBOT, Scott, A.
发明人： HARE, Bradley, A. , RABINER, Robert, A. , RANUCCI, Kevin, J. , MARCIANTE, Rebecca, I. , VARADY, Mark, J. , ROBERTSON, Roy, M. , PRASAD, Janniah, S. , TALBOT, Scott, A.
IPC分类号： A61F
CPC分类号： A61B17/320068 , A61B17/22012 , A61B2017/00137 , A61B2017/00274 , A61B2017/00477 , A61B2017/22007 , A61B2017/22008 , A61B2017/22018 , A61B2017/320084 , A61B2018/00547 , A61N7/022 , A61N2007/0008
摘要： An ultrasonic medical device comprising an ultrasonic probe (25) and a collet assembly for probe attachment and detachment, and a method of removing occlusions in blood vessels using the ultrasonic medical device. The probe (25) detachability allows insertion, manipulation and withdrawal independently of a device body. The collet assembly (5) comprises a compression clamp (10) capable of releasably receiving the probe (25), and a compression housing (14) that initiates a minimal area "line-contact" between the collet assembly segments upon engagement. A line-contact lip (21) ensures consistent and repeatable contact between the compression clamp (10) and the compression housing (14) at a pre-determined location to provide a consistent closing force on the probe (25) for any selected tightening torque. The line- contact between the collet assembly segments provides efficient ultrasonic energy transfer from an ultrasonic energy source (30) to the probe (25) thereby increasing probe efficiency during tissue ablation.
摘要翻译：一种超声波医疗装置，包括超声波探头（25）和用于探针附着和分离的夹头组件，以及使用超声波医疗装置去除血管中的闭塞的方法。探头（25）的可拆卸性允许独立于设备主体的插入，操纵和取出。夹头组件（5）包括能够可释放地接收探头（25）的压缩夹具（10）和在接合时启动夹头组件段之间的最小区域“线接触”的压缩壳体（14）。线接触唇缘（21）确保在预定位置处压缩夹具（10）和压缩壳体（14）之间的一致和可重复的接触，以便为任何选定的紧固扭矩提供在探针（25）上的一致的关闭力。夹头组件段之间的线接触提供从超声能量源（30）到探针（25）的有效的超声波能量传递，从而在组织消融期间增加探针效率。

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