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1. 发明申请

WO2005087920A3 RECOMBINANT CHONDROITINASE ABC I AND USES THEREOF 审中-公开
标题翻译：重组CHONDROITINASE ABC I及其用途
公开(公告)号：WO2005087920A3
公开(公告)日：2006-02-02
申请号：PCT/US2005008194
申请日：2005-03-10
申请人： MASSACHUSETTS INST TECHNOLOGY , PRABHAKAR VIKAS , CAPILA ISHAN , RAMAN RAHUL , BOSQUES CARLOS , POJASEK KEVIN , SASISEKHARAN RAM
发明人： PRABHAKAR VIKAS , CAPILA ISHAN , RAMAN RAHUL , BOSQUES CARLOS , POJASEK KEVIN , SASISEKHARAN RAM
IPC分类号： A61K38/00 , C12N9/88
CPC分类号： C12N9/88 , A61K38/47
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译：本发明涉及软骨素酶ABCⅠ及其用途。特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。

2. 发明申请

WO2002014480A3 DECELLULARIZED TISSUE ENGINEERED CONSTRUCTS AND TISSUES 审中-公开
公开(公告)号：WO2002014480A3
公开(公告)日：2002-02-21
申请号：PCT/US2001/025628
申请日：2001-08-16
申请人： DUKE UNIVERSITY , MITCHELL, Shannon , KOH, Jennifer , NIKLASON, Laura, E. , PRABHAKAR, Vikas
发明人： MITCHELL, Shannon , KOH, Jennifer , NIKLASON, Laura, E. , PRABHAKAR, Vikas
IPC分类号： C12N5/06
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct bz growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can bu used immediatley or stored unitl needed. The decellularized construct can be used for further tissue eingineering, which may include seeding the construct with cells obtained from the intended receipient of hte construct. During any of the growth phases required for production of the construct, the developing construct maz be subjected to various tissue engineering steps such as applciation of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.

3. 发明申请

WO0214480A9 DECELLULARIZED TISSUE ENGINEERED CONSTRUCTS AND TISSUES 审中-公开
标题翻译：细致的组织工程结构和组织
公开(公告)号：WO0214480A9
公开(公告)日：2003-03-27
申请号：PCT/US0125628
申请日：2001-08-16
申请人： UNIV DUKE , MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
发明人： MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
IPC分类号： A61L27/38 , C12N5/00 , C12N5/06 , A61L27/28 , A61L27/50
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct bz growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can bu used immediatley or stored unitl needed. The decellularized construct can be used for further tissue eingineering, which may include seeding the construct with cells obtained from the intended receipient of hte construct. During any of the growth phases required for production of the construct, the developing construct maz be subjected to various tissue engineering steps such as applciation of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.
摘要翻译：公开了用于生产组织工程化构建体和工程化天然组织的新方法。所述方法包括在体外产生组织工程化构建体bz在体外培养细胞，然后使构建体脱细胞化以产生主要由细胞外基质组分组成的脱细胞化构建体。该构造可以使用immediatley或存储unitl所需。脱细胞构建体可用于进一步的组织排卵，其可以包括用从hTE构建体的预期接收体获得的细胞接种构建体。在生产构件所需的任何生长阶段期间，显影构件都经受各种组织工程步骤，例如包括脉动力的机械刺激的应用。所述方法还包括通过从动物或人收集组织来产生工程化的天然组织，在组织上执行一个或多个组织工程步骤，以及对组织进行脱细胞化。然后可以将脱细胞化的工程化天然组织进行进一步的组织工程步骤。

4. 发明申请

WO0214480A2 DECELLULARIZED TISSUE ENGINEERED CONSTRUCTS AND TISSUES 审中-公开
标题翻译：去细胞化的组织工程结构和组织
公开(公告)号：WO0214480A2
公开(公告)日：2002-02-21
申请号：PCT/US0125628
申请日：2001-08-16
申请人： UNIV DUKE , MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
发明人： MITCHELL SHANNON , KOH JENNIFER , NIKLASON LAURA E , PRABHAKAR VIKAS
IPC分类号： A61L27/38 , C12N5/00 , C12N5/06 , A61L27/28 , A61L27/50
CPC分类号： A61L27/3839 , A61L27/3691 , C12N5/0068 , C12N2533/30 , C12N2533/40 , C12N2533/90
摘要： New methods for producing tissue engineered constructs and engineered native tissues are disclosed. The methods include producing a tissue engineered construct bz growing cells in vitro on a substrate and then decellularizing the construct to produce a decellularized construct consisting largely of extracellular matrix components. The construct can bu used immediatley or stored unitl needed. The decellularized construct can be used for further tissue eingineering, which may include seeding the construct with cells obtained from the intended receipient of hte construct. During any of the growth phases required for production of the construct, the developing construct maz be subjected to various tissue engineering steps such as applciation of mechanical stimuli including pulsatile forces. The methods also include producing an engineered native tissue by harvesting tissue from an animal or human, performing one or more tissue engineering steps on the tissue, and subjecting the tissue to decellularization. The decellularized, engineered native tissue may then be subjected to further tissue engineering steps.
摘要翻译：公开了生产组织工程构建体和工程化天然组织的新方法。所述方法包括在基底上体外生成组织工程化构建体，然后使该构建体去细胞化以产生主要由细胞外基质组分组成的脱细胞构建体。该构造可以使用立即数或所需的存储单元。脱细胞构建体可以用于进一步的组织工程化，其可以包括用从hte构建体的预期接收体获得的细胞接种构建体。在生产该构建体所需的任何生长阶段期间，发育中的构建体可以经受各种组织工程步骤，例如应用包括脉动力的机械刺激。所述方法还包括通过从动物或人获取组织来制造工程化天然组织，在组织上进行一个或多个组织工程步骤，并使组织脱细胞化。然后，脱细胞的工程化天然组织可以进行进一步的组织工程步骤。

5. 发明申请

WO2005087920A2 RECOMBINANT CHONDROITINASE ABC I AND USES THEREOF 审中-公开
标题翻译：重组CHONDROITINASE ABC I及其用途
公开(公告)号：WO2005087920A2
公开(公告)日：2005-09-22
申请号：PCT/US2005/008194
申请日：2005-03-10
申请人： MASSACHUSETTS INSTITUTE OF TECHNOLOGY , PRABHAKAR, Vikas , CAPILA, Ishan , RAMAN, Rahul , BOSQUES, Carlos , POJASEK, Kevin , SASISEKHARAN, Ram
发明人： PRABHAKAR, Vikas , CAPILA, Ishan , RAMAN, Rahul , BOSQUES, Carlos , POJASEK, Kevin , SASISEKHARAN, Ram
IPC分类号： C12N9/88
CPC分类号： C12N9/88 , A61K38/47 , Y02A50/411
摘要： The invention relates to chondroitinase ABC I and uses thereof. In particular, the invention relates to recombinant and modified chondroitinase ABC I, their production and their uses. The chondroitinase ABC I enzymes of the invention are useful for a variety of purposes, including degrading and analyzing polysaccharides such as glycosaminoglycans (GAGs). These GAGs can include chondroitin sulfate, dermatan sulfate, unsulfated chondroitin and hyaluronan. The chondroitinase ABC I enzymes can also be used in therapeutic methods such as promoting nerve regeneration, promoting stroke recovery, treating spinal cord injury, treating epithelial disease, treating infections and treating cancer.
摘要翻译：本发明涉及软骨素酶ABCⅠ及其用途。特别地，本发明涉及重组和修饰的软骨素酶ABCⅠ，其生产及其用途。本发明的软骨素酶ABC I酶可用于多种目的，包括降解和分析多糖如糖胺聚糖（GAG）。这些GAG可以包括硫酸软骨素，硫酸皮肤素，未硫酸化的软骨素和透明质酸。软骨素酶ABC I酶也可用于促进神经再生，促进中风恢复，治疗脊髓损伤，治疗上皮疾病，治疗感染和治疗癌症等治疗方法。

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