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1. 发明申请

WO2007013041A3 MONITORING OF CARDIAC NATRIURETIC PEPTIDES DURING DIAGNOSIS, MANAGMENT, AND TREATMENT OF CARDIAC DISEASES 审中-公开
公开(公告)号：WO2007013041A3
公开(公告)日：2007-02-01
申请号：PCT/IB2006/052578
申请日：2006-07-27
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , SEHER, Jens-Peter , PLUSKAL, Malcolm, G.
发明人： SEHER, Jens-Peter , PLUSKAL, Malcolm, G.
IPC分类号： G01N33/68 , G01N33/74
摘要： In a cardiac monitoring method, at least an inactive natriuretic peptide (22) and an active natriuretic peptide (20) are assayed in a biological sample taken from a patient. Both the inactive and active natriuretic peptides are produced in the patient responsive to cardiac stress. A therapeutic agent (26), such as a synthetic or mimetic natriuretic peptide, is administered to the patient. The administered therapeutic agent substantially interferes with the active natriuretic peptide assay but does not substantially interfere with the inactive natriuretic peptide assay. Kinetics of the administered therapeutic agent are determined based on at least the active natriuretic peptide assay. Cardiac diagnostic information is determined based on at least the inactive natriuretic peptide assay.

2. 发明申请

WO2012027219A1 PRE-ASSEMBLED AND PRE-WET MULTILAYER SUBSTRATE FOR WESTERN BLOTTING 审中-公开
标题翻译：预先组装和预浸多层底物用于西式喷涂
公开(公告)号：WO2012027219A1
公开(公告)日：2012-03-01
申请号：PCT/US2011/048402
申请日：2011-08-19
申请人： ADVANCED BIOSCIENCE TECHNOLOGIES, LLC , PLUSKAL, Malcolm, G.
发明人： PLUSKAL, Malcolm, G.
IPC分类号： G01N33/53
CPC分类号： G01N33/525
摘要： The invention pertains to packaged, pre-assembled and pre-wet multilayer substrates for analyte transfer, particularly for use with Western Blotting techniques. The multilayer substrate comprises components of traditional Western Blotting but it is pre-assembled into a laminated unit that stays together after assembly and storage. The multilayer substrate comprises a vapor barrier layer contiguously disposed on the outermost layer of the substrate; and a layer comprising blotting material that is pre-wet, the multilayer substrate being assembled in a laminated unit.
摘要翻译：本发明涉及用于分析物转移的包装，预组装和预湿多层底物，特别是用于Western Blotting技术。多层基材包括传统的Western Blotting的组分，但它被预组装成组装和储存后保持在一起的层压单元。多层基板包括连续地设置在基板的最外层上的蒸气阻挡层; 以及包括预浸渍的印迹材料的层，多层基板被组装成层压单元。

3. 发明申请

WO2007013041A2 MONITORING OF CARDIAC NATRIURETIC PEPTIDES DURING DIAGNOSIS, MANAGMENT, AND TREATMENT OF CARDIAC DISEASES 审中-公开
标题翻译：在心脏病的诊断，治疗和治疗期间监测心脏病患者的临床特征
公开(公告)号：WO2007013041A2
公开(公告)日：2007-02-01
申请号：PCT/IB2006052578
申请日：2006-07-27
申请人： KONINKL PHILIPS ELECTRONICS NV , SEHER JENS-PETER , PLUSKAL MALCOLM G
发明人： SEHER JENS-PETER , PLUSKAL MALCOLM G
CPC分类号： G01N33/6887 , G01N33/74
摘要： In a cardiac monitoring method, at least an inactive natriuretic peptide (22) and an active natriuretic peptide (20) are assayed in a biological sample taken from a patient. Both the inactive and active natriuretic peptides are produced in the patient responsive to cardiac stress. A therapeutic agent (26), such as a synthetic or mimetic natriuretic peptide, is administered to the patient. The administered therapeutic agent substantially interferes with the active natriuretic peptide assay but does not substantially interfere with the inactive natriuretic peptide assay. Kinetics of the administered therapeutic agent are determined based on at least the active natriuretic peptide assay. Cardiac diagnostic information is determined based on at least the inactive natriuretic peptide assay.
摘要翻译：在心脏监测方法中，在取自患者的生物样品中测定至少一种无效利尿钠肽（22）和活性利尿钠肽（20）。无活性和活性利钠肽都是在患者心脏应激反应中产生的。向患者施用治疗剂（26），例如合成的或模拟的利尿钠肽。施用的治疗剂基本上干扰活性利钠肽测定，但实质上不干扰无活性利钠肽测定。至少基于活性利尿钠肽测定来确定施用的治疗剂的动力学。至少基于无活性利尿钠肽测定确定心脏诊断信息。

4. 发明申请

WO2010017109A1 SYSTEMS AND METHODS FOR QUANTITATIVE ANALYTE TRANSFER 审中-公开
标题翻译：定量分析转移的系统和方法
公开(公告)号：WO2010017109A1
公开(公告)日：2010-02-11
申请号：PCT/US2009/052460
申请日：2009-07-31
申请人： PROTEIN FOREST, INC. , PLUSKAL, Malcolm, G. , MILLER, Thomas , DASCH, James
发明人： PLUSKAL, Malcolm, G. , MILLER, Thomas , DASCH, James
IPC分类号： G01N27/447 , G01N33/558
CPC分类号： G01N27/4473 , G01N27/44747 , Y10T428/249981
摘要： Systems and methods for enhancing quantitative transfer of analytes from an electrophoretic gel (12) to an adsorptive substrate (14) are provided. A preferred embodiment provides an improved transfer system (10) and method that reduces "blow through" of low molecular weight analytes and increases the adsorption of low molecular weight, for example proteins of about 3OkDa or less compared to conventional transfer techniques. It has been discovered that using a secondary porous backing membrane (16) in conjunction with an adsorptive membrane (14) such as nitrocellulose or polvinylidene fluoride increases the efficiency of analyte interaction with the adsorption membrane compared to ' transfers techniques using the adsorption membrane without the secondary backing membrane. This improvement of quantitative analyte transfer efficiency facilitates a wider range of detection processes, such as direct analysis by MALDI mass spectrometry than in earlier applications of the process without the secondary backing membrane.
摘要翻译：提供了用于增强分析物从电泳凝胶（12）到吸附性基质（14）的定量转移的系统和方法。优选的实施方案提供了改进的转移系统（10）和方法，其减少了低分子量分析物的“吹穿”，并增加了低分子量的吸附，例如与常规转移技术相比，约30kDa或更少的蛋白质。已经发现，与使用不使用吸附膜的吸附膜的转移技术相比，使用辅助多孔背衬膜（16）与吸附膜（14）如硝酸纤维素或聚偏二氟乙烯结合提高分析物与吸附膜的相互作用的效率二次背衬膜。定量分析物转移效率的这种改进有助于更广泛的检测过程，例如通过MALDI质谱法的直接分析，而不是先前没有第二背衬膜的方法的应用。

5. 发明申请

WO2003106002A1 COATED HYDROPHILIC MEMBRANES FOR ELECTROPHORESIS APPLICATIONS 审中-公开
标题翻译：用于电泳应用的包覆水解膜
公开(公告)号：WO2003106002A1
公开(公告)日：2003-12-24
申请号：PCT/AU2003/000750
申请日：2003-06-16
申请人： PROTEOME SYTEMS INTELLECTUAL PROPERTY PTY LTD , PLUSKAL, Malcolm, G.
发明人： PLUSKAL, Malcolm, G.
IPC分类号： B01D57/02
CPC分类号： G01N27/44795 , B01D57/02 , C07K1/26
摘要： The present invention is directed to an electrophoresis gel plate for analysing or separating macromolecules in a mixture comprising a polymerised gel matrix supported by a hydrophilic microporous membrane.
摘要翻译：本发明涉及用于分析或分离包含由亲水微孔膜支撑的聚合凝胶基质的混合物中的大分子的电泳凝胶板。

6. 发明申请

WO2008139367A1 BIOSENSOR DEVICE, METHOD OF MANUFACTURING A BIOSENSOR DEVICE AND METHOD OF DETECTING TARGET MOLECULES IN AN ANALYTE 审中-公开
标题翻译：生物传感器装置，制造传感器装置的方法和检测分析仪中的目标分子的方法
公开(公告)号：WO2008139367A1
公开(公告)日：2008-11-20
申请号：PCT/IB2008/051751
申请日：2008-05-06
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , SEHER, Jens-peter , PLUSKAL, Malcolm, G.
发明人： SEHER, Jens-peter , PLUSKAL, Malcolm, G.
IPC分类号： G01N33/50 , G01N33/543
CPC分类号： G01N33/54393
摘要： The biosensor device (10) for detecting target molecules (12) in an analyte (14) comprises a substrate (18) which can be brought into contact with the analyte (14) for binding the target molecules (12) thereto. Capture molecules (36) for the target molecules (12) are immobilized in at least one defined area (30 a-k) of the substrate (18). The remaining area (32) of the substrate (18) is covered with a coating layer (26) which acts as a blocking agent for the target molecules (12).
摘要翻译：用于检测分析物（14）中的目标分子（12）的生物传感器装置（10）包括可与分析物（14）接触以将目标分子（12）与其结合的基底（18）。用于靶分子（12）的捕获分子（36）固定在基底（18）的至少一个限定区域（30a-k）中。衬底（18）的剩余区域（32）被用作靶分子（12）的封闭剂的涂层（26）覆盖。

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