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1. 发明申请

WO0040727A3 RECOMBINANT GROWTH FACTOR WITH THE BIOLOGICAL ACTIVITY OF A G-CSF (GRANULOCYTE COLONY STIMULATING FACTOR) 审中-公开
标题翻译：重组生长因子与G-CSF（粒细胞集落刺激因子）的生物活性
公开(公告)号：WO0040727A3
公开(公告)日：2000-10-26
申请号：PCT/EP9910466
申请日：1999-12-29
申请人： RHEIN BIOTECH PROZ & PROD GMBH , FISCHER JOHANNES , WERNET PETER , GELLISSEN GERD , JENZELEWSKI VOLKER , PIONTEK MICHAEL , STRASSER ALEXANDER W , WEYDEMANN ULRIKE
发明人： FISCHER JOHANNES , WERNET PETER , GELLISSEN GERD , JENZELEWSKI VOLKER , PIONTEK MICHAEL , STRASSER ALEXANDER W , WEYDEMANN ULRIKE
IPC分类号： C07K14/535 , C12N1/21 , C12N15/12 , C12N15/27 , A61K31/70 , A61K38/19 , A61K48/00 , C07K1/14 , C12N1/15 , C12N1/19 , C12N5/10 , C12N15/62
CPC分类号： C07K14/535
摘要： The invention relates to growth factors with granulocyte colony stimulating activity and to nucleic acid molecules which comprise a sequence coding for said growth factor. The invention also relates to a method for producing the inventive growth factor, to pharmaceutical compositions which comprise the inventive proteins or nucleic acids and to the therapeutical utilisation thereof. The growth factors have cytokine effects of different degrees and can stimulate the maturation of blood cells. The inventive molecules are particularly useful for treating diseases and wounds which are related to a blood cell deficiency such as cancer, leukemia, severe burns and opportunistic infections and after bone marrow transplantations.
摘要翻译：本发明提供了具有粒细胞集落刺激活性的生长因子以及包含编码该生长因子的序列的核酸分子。本发明还涉及用于产生根据本发明的生长因子的方法，涉及包含根据本发明的蛋白质或核酸的药物组合物以及它们的治疗用途。生长因子具有不同的细胞因子效应，并且能够刺激血细胞的成熟。因此设想使用本发明的分子，特别是用于治疗与血细胞缺乏相关的疾病和损伤，例如，癌症，白血病，严重烧伤，机会性感染和骨髓移植。

2. 发明申请

WO1995007356A1 METHOD FOR THE RECOMBINANT PREPARATION OF PROTEINS IN HANSENULA YEAST 审中-公开
标题翻译：用于在重组酵母菌汉逊酵母中生产蛋白质
公开(公告)号：WO1995007356A1
公开(公告)日：1995-03-16
申请号：PCT/EP1994002897
申请日：1994-09-01
申请人： BASF AKTIENGESELLSCHAFT , RHEIN BIOTECH GESELLSCHAFT FÜR NEUE BIOTECHNOLOGISCHE PROZESSE UND PRODUKTE MBH , SCHWEDEN, Jürgen , BOLLSCHWEILER, Claus , PIONTEK, Michael , WEYDEMANN, Ulrike , JANOWICZ, Zbigniew, A. , STRASSER, Alexander, W.M.
发明人： BASF AKTIENGESELLSCHAFT , RHEIN BIOTECH GESELLSCHAFT FÜR NEUE BIOTECHNOLOGISCHE PROZESSE UND PRODUKTE MBH
IPC分类号： C12N15/81
CPC分类号： C12N9/2428 , C07K14/815 , C07K2319/00 , C07K2319/02 , C12N15/625 , C12N15/815
摘要： Described is a method for the recombinant preparation of proteins in Hansenula yeast, the method being characterized in that Hansenula is transformed using an expression cassette which includes encoded in it the following structural elements: L - A - P - GEN in which L is a leader sequence, A is an adaptor generating an alpha-helix structure, P is a processing signal and GEN is a structural gene for the protein required.
摘要翻译： α-螺旋： - A - - P GEN其中L是前导序列，A L：一种用于在酵母汉逊酵母重组生产的蛋白，其特征在于，转化汉逊酵母用表达盒编码以下的结构元件的方法代表的结构基因的所需的蛋白质：结构适配器制造，P是这样的处理信号和GEN。

3. 发明申请

WO2011094011A1 MODULAR MERCHANDISER SYSTEM AND METHOD OF PROVIDING THE SAME 审中-公开
标题翻译：模块化商品系统及其提供方法
公开(公告)号：WO2011094011A1
公开(公告)日：2011-08-04
申请号：PCT/US2011/000157
申请日：2011-01-29
申请人： CANNON EQUIPMENT COMPANY , TURNER, Harold, L. Jr. , BAUER, Joseph, Theodore , GARDUNO, Gabriel , REIER, Matthew, Douglas , POLK, Louis, Frederick , RAMSEY, Kenneth, Earl , GRUBER, Charles, M. , HAMMOND, Howard, Lynn , SHAVER, Michael, Lynn , PIONTEK, Michael
发明人： TURNER, Harold, L. Jr. , BAUER, Joseph, Theodore , GARDUNO, Gabriel , REIER, Matthew, Douglas , POLK, Louis, Frederick , RAMSEY, Kenneth, Earl , GRUBER, Charles, M. , HAMMOND, Howard, Lynn , SHAVER, Michael, Lynn , PIONTEK, Michael
IPC分类号： F16B12/00 , A47B85/00
CPC分类号： A47F5/0018 , A47B55/02 , A47B91/00 , A47F5/083 , A47F5/10 , E04B2/7431 , E04B2002/7483 , F16B12/02 , G06Q30/00 , Y10T29/49947
摘要： A modular merchandiser and system with a frame of vertical posts and horizontal bars is carried on legs and carries grid elements sandwiching an indicia panel. Adjacent merchandiser panels can be linearly, perpendicularly or angularly joined. A hinge coupler is also provided for joining two panels together, one of a male projection and complimentary female socket is provided on each of the panels, and a connecting hinge link is provided having the other of a male projection and complimentary female socket to hold the hinge coupler and the two panels in the desired angular position. Various parts of the merchandiser and the accessories therefor may be obtained in a first financial transaction and others in subsequent financial transactions to update the same.
摘要翻译：具有垂直杆和水平杆的框架的模块化商品销售商和系统承载在腿上并且携带夹着标记面板的网格元件。相邻的商品面板可以线性，垂直或角度连接。还提供铰链联接器用于将两个面板连接在一起，在每个面板上设置凸形凸起和互补凹形插座中的一个，并且提供连接铰链连接件，其具有凸形凸起和互补的凹形插座中的另一个以保持铰链联轴器和两个面板处于所需的角度位置。在第一次金融交易中可以获得商品的各个部分及其配件，以便在后续的金融交易中获得更新。

4. 发明申请

WO1995001443A1 MICROBIAL TRANSFORMANTS OF HANSENULA THAT EXPRESS GLYCOLATE OXIDASE AND CATALASE 审中-公开
标题翻译：明胶甘油酯氧化酶和催化剂的汉斯龙的微生物转化
公开(公告)号：WO1995001443A1
公开(公告)日：1995-01-12
申请号：PCT/US1994007080
申请日：1994-06-29
申请人： E.I. DU PONT DE NEMOURS AND COMPANY , ANTON, David, Leroy , DiCOSIMO, Robert , DAHLEMS, Ulrike, Magdalene , GELLISSEN, Gerd, Johann , JONOWICZ, Zbigniew, Alojzy , PIONTEK, Michael
发明人： E.I. DU PONT DE NEMOURS AND COMPANY
IPC分类号： C12N15/53
CPC分类号： C12N9/0065 , C12N9/0006 , C12N15/815
摘要： This invention relates to Hansenula strains that have been genetically engineered to produce glycolate oxidase, optionally to also produce catalase, which serve as biocatalysts in the conversion of glycolic acid to glyoxylic acid.
摘要翻译：本发明涉及经遗传工程改造以生产乙醇酸氧化酶的汉逊酵母菌株，任选地也产生过氧化氢酶，其用作将乙醇酸转化为乙醛酸的生物催化剂。

5. 发明申请

WO2008112312A1 APPARATUS AND METHOD FOR PHASE-SPACE REDUCTION FOR IMAGING OF FLUORESCING, SCATTERING AND/OR ABSORBING STRUCTURES 审中-公开
标题翻译：用于成像，分散和/或吸收结构的相空间减少的装置和方法
公开(公告)号：WO2008112312A1
公开(公告)日：2008-09-18
申请号：PCT/US2008/003445
申请日：2008-03-14
申请人： GENEVA MEDICAL IMAGING, LLC , WANG, Lifan , PENNYPACKER, Carl , SHEEHAN, William , GEE, James, W., Jr. , PIONTEK, Michael
发明人： WANG, Lifan , PENNYPACKER, Carl , SHEEHAN, William , GEE, James, W., Jr. , PIONTEK, Michael
IPC分类号： A61B5/0452 , A61B5/00
CPC分类号： A61B1/043 , A61B1/042 , A61B5/0071 , A61B5/0084 , A61B5/0091 , A61B5/42 , A61B5/4312 , A61B5/6814
摘要： A method and apparatus are disclosed for utilizing light, including ultraviolet, optical and/or infrared, for detecting a body in an object, such as biomaterial or tissue, animal and/or human tissue. The body or object may be made fluorescent by the use of dyes or agent. Light is used to illuminate the body and object and the scattered light, fluorescent and/or emitted light, reflected light and transmitted light are detected and used to reconstruct the body and/or object using an iterative analysis. Further, the method and apparatus may be extended to endoscopic applications to make subcutaneous images of internal tissue above, on, in or beyond endoscopic pathways such as esophagus, stomach, colon, bronchial tubes and/or other openings, cavities and spaces animate or inanimate, and in man-made or industrial materials as carbon/resin structures.
摘要翻译：公开了一种利用包括紫外线，光学和/或红外线在内的用于检测物体（例如生物材料或组织，动物和/或人体组织）中的身体的光的方法和装置。身体或物体可以通过使用染料或试剂制成荧光。光用于照亮身体和物体，并且检测散射光，荧光和/或发射光，反射光和透射光，并使用光来重建身体和/或物体，使用迭代分析。此外，该方法和装置可以扩展到内窥镜应用，以在内窥镜途径，例如食管，胃，结肠，支气管和/或其他开口，空腔和空间之上，之上，之中或之上的内部组织的皮下图像，空气或无生命，以人造或工业材料为碳/树脂结构。

6. 发明申请

WO2005125195B1 TRAVELER CAR ASSEMBLY FOR INCREASING EFFICIENCY OF SELF-CONTAINED BEARINGS 审中-公开
标题翻译：旅行车组合提高自承式轴承的效率
公开(公告)号：WO2005125195B1
公开(公告)日：2006-07-27
申请号：PCT/US2005020686
申请日：2005-06-10
申请人： HARKEN INC , LOB CHARLES J , PIONTEK MICHAEL
发明人： LOB CHARLES J , PIONTEK MICHAEL
IPC分类号： F16C29/06 , B63H9/10 , H04N5/91
CPC分类号： B63H9/10
摘要： A traveler car assembly is characterized by a car (10) slidably carried on an elongate track (13), bearings (11) for facilitating sliding movement of the car along the track and a coupling (14) for mounting the car and track for conjoint rotational movement about an axis. In use, the car is subjected to tensional loads (22) along a load line of force having a directional component that extends generally perpendicular to and away from the car and track and that varies in direction arcuately about the axis. The coupling accommodates conjoint rotation of the car and track with and in response to changes in the arcuate direction of the load line of force about the axis while at the same time the car and track remain in generally fixed orientation relative to the load line of force. The bearings lie in a plane perpendicular to the load line of force and, advantageously, so do races (13a) for the bearings, so that not only is there uniform loading of the bearings in response to tensional loads on the car but also the maximum capacity of the bearings is available for utilization at any angle of the load line of force relative to the axis.
摘要翻译：旅行车组件的特征在于可滑动地承载在细长轨道（13）上的轿厢（10），用于促进轿厢沿着轨道的滑动运动的轴承（11）和用于将汽车和轨道安装在一起的联轴器（14）围绕轴的旋转运动。在使用中，轿厢沿着具有大致垂直于和远离轿厢和轨道延伸的方向分量的负载线受到张力负载（22），并且在方向上围绕轴线弧形地改变。耦合器适应轿厢和轨道的共同旋转，并且响应于围绕轴线的载荷线的弓形方向的变化，同时汽车和轨道相对于载荷线的力保持大致固定的方向。轴承位于垂直于负载线的平面的平面中，并且有利地用于轴承的座圈（13a），使得不仅轴承响应于汽车上的张力负载而且具有最大值轴承的容量可以在负载线相对于轴线的任何角度使用。

7. 发明申请

WO2005125195A2 TRAVELER CAR ASSEMBLY FOR INCREASING EFFICIENCY OF SELF-CONTAINED BEARINGS 审中-公开
标题翻译：旅行车组合提高自承式轴承的效率
公开(公告)号：WO2005125195A2
公开(公告)日：2005-12-29
申请号：PCT/US2005020686
申请日：2005-06-10
申请人： HARKEN INC , LOB CHARLES J , PIONTEK MICHAEL
发明人： LOB CHARLES J , PIONTEK MICHAEL
IPC分类号： B63H9/10 , H04N5/91
CPC分类号： B63H9/10
摘要： A traveler car assembly is characterized by a car slidably carried on an elongate track, bearings for facilitating sliding movement of the car along the track and a coupling for mounting the car and track for conjoint rotational movement about an axis. In use, the car is subjected to tensional loads along a load line of force having a directional component that extends generally perpendicular to and away from the car and track and that varies in direction arcuately about the axis. The coupling accommodates conjoint rotation of the car and track with and in response to changes in the arcuate direction of the load line of force about the axis while at the same time the car and track remain in generally fixed orientation relative to the load line of force. The bearings lie in a plane perpendicular to the load line of force and, advantageously, so do races for the bearings, so that not only is there uniform loading of the bearings in response to tensional loads on the car but also the maximum capacity of the bearings is available for utilization at any angle of the load line of force relative to the axis.
摘要翻译：旅行车组件的特征在于可滑动地承载在细长轨道上的轿厢，用于促进轿厢沿着轨道的滑动运动的轴承和用于安装轿厢和轨道以用于围绕轴线的联合旋转运动的联接件。在使用中，轿厢沿着具有方向分量的负载线受到拉伸载荷，该方向分量大致垂直于和远离汽车和轨道延伸，并且在方向上围绕轴线弧形地变化。耦合器适应轿厢和轨道的共同旋转，并且响应于围绕轴线的载荷线的弓形方向的变化，同时汽车和轨道相对于载荷线的力保持大致固定的方向。轴承位于垂直于负载线的平面的平面中，并且有利地用于轴承的滚道，使得不仅轴承响应于汽车上的张力负载而具有均匀的载荷，而且还具有轴承可以在负载线相对于轴线的任意角度使用。

8. 发明申请

WO2007058870A3 METHOD AND APPARATUS FOR COMPACTING SAIL CARS 审中-公开
标题翻译：用于养护沙滩车的方法和装置
公开(公告)号：WO2007058870A3
公开(公告)日：2008-10-16
申请号：PCT/US2006043578
申请日：2006-11-08
申请人： HARKEN INC , LUEDTKE MATTHEW , BLACKBURN DANE , PIONTEK MICHAEL
发明人： LUEDTKE MATTHEW , BLACKBURN DANE , PIONTEK MICHAEL
IPC分类号： B63H9/04
CPC分类号： B63H9/1092 , B63H9/0642 , B63H9/08 , B63H9/1021 , B63H2009/086
摘要： The invention relates to method and apparatus for compactly stacking a sail having a tack, clew and head, said sail being mounted to batten or sail cars above a boom when a very tall sail is stowed, furled or fully lowered. More specifically, most of the cars are compacted or stacked by diverting cars onto several lower tracks, such that the height of the stacked cars is approximately halved. Cars adjacent the boom and tack of the sail being slidably mounted on at least two of said lower tracks, and carrying said sail between said at least two of said lower tracks. If more than two lower storage tracks are used, the height reduction of the stacked cars can be greater.
摘要翻译：本发明涉及一种用于紧凑堆叠具有钉头和头部的帆的方法和装置，当非常高的帆被收起，卷起或完全降低时，所述帆被安装成在吊杆上方绞合或起吊轿厢。更具体地，大多数汽车通过将汽车转向几个下轨道而被压实或堆叠，使得堆叠的轿厢的高度大约减半。靠近吊杆的吊杆和可滑动地安装在至少两个所述下轨道上的帆，并且在所述至少两个所述下轨道之间承载所述帆。如果使用多于两个较低的存储轨道，则堆叠的轿厢的高度减小可以更大。

9. 发明申请

WO2007058870A2 METHOD AND APPARATUS FOR COMPACTING SAIL CARS 审中-公开
标题翻译：用于养护沙滩车的方法和装置
公开(公告)号：WO2007058870A2
公开(公告)日：2007-05-24
申请号：PCT/US2006/043578
申请日：2006-11-08
申请人： HARKEN, INC. , LUEDTKE, Matthew , BLACKBURN, Dane , PIONTEK, Michael
发明人： LUEDTKE, Matthew , BLACKBURN, Dane , PIONTEK, Michael
IPC分类号： B63H9/04
CPC分类号： B63H9/1092 , B63H9/0642 , B63H9/08 , B63H9/1021 , B63H2009/086
摘要： The invention relates to method and apparatus for compactly stacking a sail having a tack, clew and head, said sail being mounted to batten or sail cars above a boom when a very tall sail is stowed, furled or fully lowered. More specifically, most of the cars are compacted or stacked by diverting cars onto several lower tracks, such that the height of the stacked cars is approximately halved. Cars adjacent the boom and tack of the sail being slidably mounted on at least two of said lower tracks, and carrying said sail between said at least two of said lower tracks. If more than two lower storage tracks are used, the height reduction of the stacked cars can be greater.
摘要翻译：本发明涉及一种用于紧凑堆叠具有钉头和头部的帆的方法和装置，当非常高的帆被收起，卷起或完全降低时，所述帆被安装成在吊杆上方绞合或起吊轿厢。更具体地，大多数汽车通过将汽车转向几个下轨道而被压实或堆叠，使得堆叠的轿厢的高度大约减半。靠近吊杆的吊杆和可滑动地安装在至少两个所述下轨道上的帆，并且在所述至少两个所述下轨道之间承载所述帆。如果使用多于两个较低的存储轨道，则堆叠的轿厢的高度减小可以更大。

10. 发明申请

WO2005125195A3 TRAVELER CAR ASSEMBLY FOR INCREASING EFFICIENCY OF SELF-CONTAINED BEARINGS 审中-公开
公开(公告)号：WO2005125195A3
公开(公告)日：2005-12-29
申请号：PCT/US2005/020686
申请日：2005-06-10
申请人： HARKEN, INC. , LOB, Charles, J. , PIONTEK, Michael
发明人： LOB, Charles, J. , PIONTEK, Michael
IPC分类号： F16C29/06
摘要： A traveler car assembly is characterized by a car (10) slidably carried on an elongate track (13), bearings (11) for facilitating sliding movement of the car along the track and a coupling (14) for mounting the car and track for conjoint rotational movement about an axis. In use, the car is subjected to tensional loads (22) along a load line of force having a directional component that extends generally perpendicular to and away from the car and track and that varies in direction arcuately about the axis. The coupling accommodates conjoint rotation of the car and track with and in response to changes in the arcuate direction of the load line of force about the axis while at the same time the car and track remain in generally fixed orientation relative to the load line of force. The bearings lie in a plane perpendicular to the load line of force and, advantageously, so do races (13a) for the bearings, so that not only is there uniform loading of the bearings in response to tensional loads on the car but also the maximum capacity of the bearings is available for utilization at any angle of the load line of force relative to the axis.

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