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1. 发明申请

WO2005021562A2 NOVEL ORGANIC COMPOUNDS AND METAL COMPLEXES 审中-公开
标题翻译：新型有机化合物和金属复合物
公开(公告)号：WO2005021562A2
公开(公告)日：2005-03-10
申请号：PCT/EP2004051915
申请日：2004-08-26
申请人： SOLVIAS AG , MENGES FREDERIK , PFALTZ ANDREAS
发明人： MENGES FREDERIK , PFALTZ ANDREAS
IPC分类号： C07B53/00 , C07C5/03 , C07C29/17 , C07C41/20 , C07C43/205 , C07C43/21 , C07C67/303 , C07C251/04 , C07F9/6506 , C07F15/00 , C07C251/00
CPC分类号： C07F15/004 , C07B53/00 , C07B2200/07 , C07C5/03 , C07C29/17 , C07C41/20 , C07C67/303 , C07C251/04 , C07C2531/24 , C07C2602/10 , C07F9/65062 , C07F15/0033 , C07C15/18 , C07C69/612 , C07C43/205 , C07C43/21 , C07C33/20
摘要： Compounds of the formulae (I) and (Ia) where X1 is secondary phosphino; R3 is a hydrocarbon radical having from 1 to 20 C atoms, a heterohydrocarbon radical which has from 2 to 20 atoms and at least one heteroatorn selected from the group consisting of 0, S, NH and NR, or an -S02-R radical; R is C1-C18-alkyl, phenyl or benzyl; the radicals R4 are each, or the two radicals R4 together a hydrocarbon radical having from 1 to 20 C atoms; R01 is a hydrocarbon radical having from 1 to 20 C atoms; and R02 and R'o2 are each, independently of one another, a hydrogen atom or independently have the meaning of R01, or R01 and R02 together with the C atom to which they are bound form a three- to eight-membered hydrocarbon or hetero hydrocarbon ring. The compounds are chiral ligands for complexes of metals of transition groups I and VIll which act as catalysts for asymmetric additions, for example of hydrogen, onto prochiral unsaturated organic compounds.
摘要翻译：其中X1是二次膦基的式（I）和（Ia）的化合物; R3是具有1至20个C原子的烃基，具有2至20个原子的杂烃基和至少一个选自0，S，NH和NR或-SO 2 -R基的杂原子; R是C 1 -C 18烷基，苯基或苄基; 基团R 4各自或两个基团R 4一起是具有1至20个C原子的烃基; R01是具有1至20个C原子的烃基; R02和R'o2各自独立地为氢原子或独立地具有R01或R 01和R 02的含义与它们所连接的C原子一起形成三至八元烃或杂原子烃环。这些化合物是转移基团I和VIII的金属络合物的手性配体，其作为用于不对称加成的催化剂，例如氢，在前手性不饱和有机化合物上。

2. 发明申请

WO2007135179A1 CHIRAL LIGANDS USED IN TRANSITION METAL CATALYSTS FOR ASYMMETRIC ADDITION REACTIONS ESPECIALLY HYDROGENATION 审中-公开
标题翻译：用于非对称添加反应的过渡金属催化剂中的CHIRAL LIGANDS特别加氢
公开(公告)号：WO2007135179A1
公开(公告)日：2007-11-29
申请号：PCT/EP2007/055026
申请日：2007-05-23
申请人： Solvias AG , PFALTZ, Andreas , RIBOURDOUILLE, Yann , FENG, Xiangdong , RAMALINGAM, Balamurugan , PUGIN, Benoît , SPINDLER, Felix
发明人： PFALTZ, Andreas , RIBOURDOUILLE, Yann , FENG, Xiangdong , RAMALINGAM, Balamurugan , PUGIN, Benoît , SPINDLER, Felix
IPC分类号： C07F9/46 , C07C51/36 , C07C67/28 , C07C67/283 , C07C213/02 , C07C221/00 , C07F15/00 , C07F17/02
CPC分类号： C07F9/5022 , B01J31/1875 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/821 , B01J2531/822 , B01J2531/827 , C07B2200/07 , C07C51/36 , C07C67/303 , C07C213/02 , C07C231/12 , C07F15/008 , C07F17/02 , C07C57/30 , C07C69/675 , C07C69/732 , C07C69/34 , C07C217/08 , C07C233/47
摘要： Ligands of the formula (I) secondary phosphine-Q-P(=O)HR 1 (I) in the form of mixtures of diastereomers or pure diastereomers, in which secondary phosphine is a secondary phosphine group with hydrocarbon radicals or heterohydrocarbon radicals as substituents; Q is a bivalent bisaryl or bisheteroaryl radical with an axial chiral centre to which the two phosphorus atoms are bonded in the ortho positions to the bisaryl or bisheteroaryl bridge bond, or Q is a bivalent ferrocenyl radical with a planar chiral centre or without a planar chiral centre, to which the phosphorus atom of the secondary phosphine is bonded directly or via a C 1 -C 4 -carbon chain to a cyclopentadienyl ring, the -P*(=O)HR 1 group is bonded either on the same cyclopentadienyl ring in ortho position to the bonded secondary phosphine or on the other cyclopentadienyl ring; P* is a chiral phosphorus atom, and R 1 is a hydrocarbon radical, a heterohydrocarbon radical or a ferrocenyl radical, where R 1 is a ferrocenyl radical with a planar chiral centre when Q is a ferrocenyl radical without a planar chiral centre. Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：式（I）以非对映异构体或纯非对映异构体的混合物形式的仲膦-PQ（= O）HR 1（I）的配体，其中次膦是具有烃基的仲膦基或杂烃基作为取代基; Q是具有轴向手性中心的二价双芳基或双杂芳基，其中两个磷原子与双芳基或双杂芳基桥键在邻位键合，或Q是具有平面手性中心或不具有平面手性的二价二茂铁基中心，仲膦的磷原子直接或通过C 1 -C 4 - 碳 - 链连接到环戊二烯基环上，-P *（= O）HR 1个基团键合在与键合的次膦或邻接的其它环戊二烯基的邻位相同的环戊二烯基环上; P *是手性磷原子，R 1是烃基，杂烃基或二茂铁基，其中R 1是具有平面手性中心的二茂铁基当Q是没有平面手性中心的二茂铁基时。这些配体的金属络合物是用于不对称加成反应，特别是氢化的均相催化剂。

3. 发明申请

WO2005056566A3 METHOD FOR PRODUCING ORTHOMETALATED AND ORTHOSUBSTITUTED AROMATIC COMPOUNDS 审中-公开
标题翻译：制备邻位和正位芳香族化合物的方法
公开(公告)号：WO2005056566A3
公开(公告)日：2005-12-01
申请号：PCT/EP2004053388
申请日：2004-12-10
申请人： SOLVIAS AG , PFALTZ ANDREAS , LOTZ MATTHIAS , SCHOENLEBER MARC , PUGIN BENOIT , KESSELGRUBER MARTIN , THOMMEN MARC
发明人： PFALTZ ANDREAS , LOTZ MATTHIAS , SCHOENLEBER MARC , PUGIN BENOIT , KESSELGRUBER MARTIN , THOMMEN MARC
IPC分类号： C07F9/48 , C07F9/6584 , C07F17/02
CPC分类号： C07F9/65848 , C07F17/02
摘要： The invention relates to compounds having a structural element of formula (I) in an aromatic hydrocarbon ring, wherein: M represents -Li, -MgX3, (C1-C18-Alkyl)3Sn-, -ZnX3 or -B(O-C1-C4-Alkyl)2; X1 and X2, independent of one another, represent O or N, and C-bound hydrocarbon radicals or heterohydrocarbon radicals are bound to the free bonds of the O and N atoms; group -C=C-, together with C atoms, forms a hydrocarbon aromatic compound and represents X3 Cl, Br or I. The inventive compounds are easily obtained by directly substituting the hydrogen in the ortho position to the P atom with metalation reagents. The metal atoms can then be substituted by a reactive electrophilic compound. The group -P(X1-)(X2-)----(BH3)0,1 can then be converted into a secondary phosphine group. The inventive method enables the production of monophosphines and diphosphines even on a large scale, which are valuable ligands for metal complexes serving as catalysts for, e.g. enantioselective hydrogenations.
摘要翻译：具有式（I）的结构元件的化合物中的芳香族烃环，其中M是Li，-MgX3，（C1-C18烷基）3Sn-，-ZnX3或-B（O-C1-C4-烷基）2， X1和X2独立地是O或N-均值和C连接的烃基或杂烃基结合到O和N原子的自由键，形成基团-C = C-的碳一起原子的烃基芳族化合物，和 X3代表Cl，Br或I，通过用金属化试剂将邻位的氢直接取代至P原子而容易地获得。金属原子可以被活性亲电子化合物取代。然后可以将-P（X1-）（X2-） - （BH3）0.1基团转化为仲膦基团。与单 - 和二膦也可以在更大的范围是对于金属配合物作为催化剂用于对映选择性氢化有价值的配体产生的，例如该过程。

4. 发明申请

WO2005056566A2 VERFAHREN ZUR HERSTELLUNG VON ORTHOMETALLIERTEN UND ORTHOSUBSTITUIERTEN AROMATISCHEN VERBINDUNGEN 审中-公开
标题翻译：用于生产orthometallised和邻取代的芳族CONNECTIONS
公开(公告)号：WO2005056566A2
公开(公告)日：2005-06-23
申请号：PCT/EP2004/053388
申请日：2004-12-10
申请人： SOLVIAS AG , PFALTZ, Andreas , LOTZ, Matthias , SCHÖNLEBER, Marc , PUGIN, Benoît , KESSELGRUBER, Martin , THOMMEN, Marc
发明人： PFALTZ, Andreas , LOTZ, Matthias , SCHÖNLEBER, Marc , PUGIN, Benoît , KESSELGRUBER, Martin , THOMMEN, Marc
IPC分类号： C07F9/48
CPC分类号： C07F9/65848 , C07F17/02
摘要： Verbindungen mit einem Strukturelement der Formel (I) in einem aromatischen Kohlenwasserstoffring, worin M für -Li, -MgX 3 , (C 1 -C 18 -Alkyl) 3 Sn-, -ZnX 3 oder -B(O-C 1 -C 4 -Alkyl) 2 steht, X 1 und X 2 unabhängig voneinander O oder N- bedeuten, und an die freien Bindungen der O- und N-Atome C-gebundene Kohlenwasserstoff- oder Heterokohlenwasserstoffreste gebunden sind, die Gruppe -C=C- zusammen mit C- Atomen einen Kohlenwasserstoffaromaten bildet, und X 3 Cl, Br oder I darstellt, werden in einfacher Weise durch direkte Substitution des Wasserstoffs in Orthostellung zum P-Atom mit Metallierungsreagenzien erhalten. Die Metallatome können dann durch reaktive elektrophile Verbindung substituiert werden. Die Gruppe -P(X 1 -)(X 2 -)----(BH 3 ) 0,1 kann dann in eine Sekundärphosphingruppe umgewandelt werden. Mit dem Verfahren können auch im grösseren Massstab Mono- und Diphosphine hergestellt werden, die wertvolle Liganden für Metallkomplexe als Katalysatoren für zum Beispiel enantioselektive Hydrierungen sind.
摘要翻译：具有式（I）的结构元件的化合物中的芳香族烃环，其中M是Li，-MgX3，（C1-C18烷基）3Sn-，-ZnX3或-B（O-C1-C4-烷基）2， X1和X2独立地是O或N-均值和C连接的烃基或杂烃基结合到O和N原子的自由键，形成基团-C = C-的碳一起原子的烃基芳族化合物，和 X3是Cl，Br或I，被以简单的方式通过在邻位金属化用试剂在P原子上的氢的直接取代而获得。所述金属原子可以然后通过反应性亲电子化合物所取代。基团-P（X 1 - ）（X 2 - ）----（BH 3）0.1然后可以转换成Sekundärphosphingruppe。与单 - 和二膦也可以在更大的范围是对于金属配合物作为催化剂用于对映选择性氢化有价值的配体产生的，例如该过程。

5. 发明申请

WO2010072746A1 CHIRAL LIGANDS 审中-公开
公开(公告)号：WO2010072746A1
公开(公告)日：2010-07-01
申请号：PCT/EP2009/067725
申请日：2009-12-22
申请人： SOLVIAS AG , PFALTZ, Andreas , SCHREMS, Marcus Georg , PUGIN, Benoît
发明人： PFALTZ, Andreas , SCHREMS, Marcus Georg , PUGIN, Benoît
IPC分类号： C07F9/653 , C07F15/00 , C07B53/00
CPC分类号： C07F9/653 , C07B53/00 , C07F15/0033
摘要： Chiral compounds of the formula (1 ), which are optically pure or highly optically enriched in which R 0 is C 1 -C 12 -alkyl which is unsubstituted or substituted by 1 to 2 C 1 -C 4 -alkoxy; cyclo- pentyl or cyclohexyl, which is unsubstituted or substituted by 1 to 3 C 1 -C 4 -alkyl or C 1 -C 4 -alkoxy; or benzyl, phenyl or naphtyl which is unsubstituted or substituted by 1 to 3 C 1 -C 4 -alkyl, C 1 -C 4 -alkoxy, C 1 -C 4 -fluoroalkyl or C 1 -C 4 -fluoroalkoxy, F or Cl, or R 0 is -C R 5 R 6 OH or -C R 5 R 6 OSi(C 1 -C 8 -alkyl) 3 wherein R 5 and R 6 are indedendently selected from the group consisting of H, unsubstituted C 1 - C 12 alkyl, substituted C 1 - C 12 alkyl, unsubstituted C 4 - C 8 cyclo alkyl, substituted C 4 - C 8 cyclo alkyl, unsubstituted aryl, substituted aryl or wherein R 5 and R 6 can form an unsubstituted 5-6 membered aliphatic carbocycle or a substituted 5-6 membered aliphatic carbocycle, each of R 1 and R' 1 independently is hydrogen or has the meaning of R 0 whereby R 1 , R' 1 and R 0 can be same or different, R 2 and R 3 are independently a C-bonded hydrocarbon radical or a heterohydrocarbon radical, and each of both R 4 is C 1 -C 6 -alkyl, cyclopentyl, cyclohexyl, phenyl, methylphenyl, methylbenzyl or benzyl, or both R 4 together form an aliphatic C 4 -C 6 carbocycle. Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reaction, particularly hydrogenations.
摘要翻译：式（1）的手性化合物，其是光学纯的或高度光学富集的，其中R 0是未被取代或被1至2个C 1 -C 4 - 烷氧基取代的C 1 -C 12 - 烷基; 未取代或被1至3个C 1 -C 4 - 烷基或C 1 -C 4 - 烷氧基取代的环戊基或环己基; 或未被取代或被1至3个C 1 -C 4 - 烷基，C 1 -C 4 - 烷氧基，C 1 -C 4 - 氟烷基或C 1 -C 4 - 氟烷氧基，F或Cl或R 10取代的苄基，苯基或萘基， OH或-C R5 R6 OSi（C1-C8-烷基）3，其中R5和R6独立地选自H，未取代的C1-C12烷基，取代的C1-C12烷基，未取代的C4-C8环烷基，取代的C4 -C 8环烷基，未取代的芳基，取代的芳基或其中R 5和R 6可以形成未取代的5-6元脂族碳环或取代的5-6元脂族碳环，R 1和R'1各自独立地是氢或具有 R 0，其中R 1，R'1和R 0可以相同或不同，R 2和R 3独立地是C键合的烃基或杂烃基，并且R 2各自为C 1 -C 6 - 烷基，环戊基，环己基，苯基，甲基苯基，甲基苄基或苄基，或两者一起形成脂族C 4 -C 6碳环。这些配体的金属络合物是用于不对称加成反应，特别是氢化的均相催化剂。

6. 发明申请

WO2010055162A1 ENANTIOSELECTIVE SYNTHESIS OF γ-AMINO-α,β-UNSATURATED CARBOXYLIC ACID DERIVATIVES 审中-公开
标题翻译： β-氨基-α，β-不饱和羧酸衍生物的选择性合成
公开(公告)号：WO2010055162A1
公开(公告)日：2010-05-20
申请号：PCT/EP2009/065241
申请日：2009-11-16
申请人： NOVARTIS AG , ACEMOGLU, Murat , PFALTZ, Andreas , SCHAERER, Claude
发明人： ACEMOGLU, Murat , PFALTZ, Andreas , SCHAERER, Claude
IPC分类号： C07C227/32 , C07C229/30 , C07C231/18 , C07C237/16 , C07C271/12 , C07C271/24 , C07D209/48 , C07F9/113
CPC分类号： C07C227/32 , C07B2200/07 , C07C229/30 , C07C231/18 , C07C237/16 , C07C271/12 , C07C271/24 , C07C2601/14 , C07D209/48 , C07F9/4015
摘要： Provided is an enantioselective, palladium-catalyzed method for the preparation of γ-amino-α,β-unsaturated carboxylic acid derivatives having the formulas II, III, IV and VIII.
摘要翻译：提供了用于制备具有式II，III，IV和VIII的α-氨基-α，β-不饱和羧酸衍生物的对映选择性钯催化方法。

7. 发明申请

WO2009065784A1 BIDENTATE CHIRAL LIGANDS FOR USE IN CATALYTIC ASYMMETRIC ADDITION REACTIONS 审中-公开
标题翻译：用于催化不对称添加反应的双歧杆菌配体
公开(公告)号：WO2009065784A1
公开(公告)日：2009-05-28
申请号：PCT/EP2008/065607
申请日：2008-11-14
申请人： SOLVIAS AG , PUGIN, Benoît , LOTZ, Matthias , LANDERT, Heidi , WYSS, Adrian , AARDOOM, Raphael , GSCHWEND, Björn , PFALTZ, Andreas , SPINDLER, Felix
发明人： PUGIN, Benoît , LOTZ, Matthias , LANDERT, Heidi , WYSS, Adrian , AARDOOM, Raphael , GSCHWEND, Björn , PFALTZ, Andreas , SPINDLER, Felix
IPC分类号： C07F9/46 , C07F9/50 , C07F9/655 , C07F9/6553 , B01J31/12 , C07B35/02 , C07B53/00 , C07C67/303 , C07C213/02 , C07C231/12 , C07C231/18 , C07F15/00 , C07F17/02
CPC分类号： C07F13/005 , B01J31/1875 , B01J31/2291 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/0238 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5004 , C07F9/5018 , C07F9/5022 , C07F9/5027 , C07F9/65515 , C07F9/65517 , C07F9/65522 , C07F9/655354 , C07F17/02 , C07C69/34 , C07C69/732 , C07C69/675 , C07C233/47
摘要： Compounds of the formula (I), in the form of mixtures comprising predominantly one diastereomer or in the form of pure diastereomers, Z 1 -Q-P*R 0 R 1 (I) in which Z 1 is a C-bonded, secondary phosphine group -P(R) 2 ; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals, or Z 1 is the -P*R 0 R 1 group; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C 1 -C 4 -alkylene skeleton, and in which base skeletons a secondary phosphine group Z 1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C 1 -C 4 -alkylene group, and in which base skeletons a P-chiral group -P*R 0 R 1 is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C 1 -C 4 -alkylene group to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; R 0 is methyl or hydroxyl, and R 0 is methyl when Z 1 is the -P*R 0 R 1 group; and R 1 is a C-bonded optically enriched or optically pure chiral, mono- or polycyclic, nonaromatic hydrocarbon or heterohydrocarbon radical which has 3 to 12 ring atoms and 1 to 4 rings and which has a stereogenic carbon atom at least in the α position to the P-C bond; Metal complexes of these ligands are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：主要为一种非对映体或纯非对映体形式的混合物形式的式（I）化合物，其中Z 1为C键，仲膦基-P（R）的Z1-QP * R0R1（I） 2; 其中R各自独立地为烃基或杂烃基，或Z1为-P * R0R1基团; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C1-C4-亚烷基骨架，其中，基骨架中的次膦基Z1直接键合或在环状基团骨架的情况下直接与碳原子或C 1 -C 4 - 亚烷基直接键合，并且其中的基础骨架中，P手性基团-P * R0R1直接键合到碳上或者在环状基骨架的情况下，直接连接到碳原子上，或者通过C1-C4-亚烷基与碳原子连接，使得磷原子通过1至7个任选被杂原子中断的碳链原子连接由O，S，N，Fe或Si组成; P *是手性磷原子; R 0是甲基或羟基，当Z 1是-P * R 0 R 1基团时，R 0是甲基; 并且R 1是C-键合的光学富集或光学纯的手性，单或多环，非芳族烃或杂烃基，其具有3至12个环原子和1至4个环，并且其具有立体碳原子至少在 PC债券; 这些配体的金属络合物是用于不对称加成反应的均相催化剂，特别是氢化。

8. 发明申请

WO2012171969A1 HYDROGENATION OF KETONES HAVING AT LEAST A CARBON-CARBON DOUBLE BOND IN THE γ, δ-POSITION 审中-公开
标题翻译：具有至少一个碳双重键的酮的加氢处理？，d-POSITION
公开(公告)号：WO2012171969A1
公开(公告)日：2012-12-20
申请号：PCT/EP2012/061226
申请日：2012-06-13
申请人： DSM IP ASSETS B.V. , MUELLER, Marc-André , PFALTZ, Andreas , MEDLOCK, Jonathan
发明人： MUELLER, Marc-André , PFALTZ, Andreas , MEDLOCK, Jonathan
IPC分类号： C07C45/62
CPC分类号： C07C45/62 , C07C29/143 , C07C45/61 , C07C49/04 , C07D311/72
摘要： The present invention relates in a first aspect to a process for hydrogenation of ketones having at least a carbon-carbon double bond in the y, 8 - position to the keto group by hydrogen in the presence of at least one chiral iridium complex of formula (I), where R1 represents a group of formula (II) or (III) or (IV). It has been shown that this process leads to a strong increase in preferential formation of a single isomer. The process is particu larly su itable for the hydrogenation of y, 8 - unsaturated ketones which can be used as flavours and fragrances or for the preparation of vitamin E and its derivatives or of flavours and fragrances.
摘要翻译：本发明在第一方面涉及在至少一种式（ⅩⅤ）的手性铱络合物存在下，在氢原子的至少8位上具有至少一个碳 - 碳双键的酮的氢化方法， I），其中R 1表示式（II）或（III）或（IV）的基团。已经表明，该方法导致单一异构体优先形成的强烈增加。该方法特别适用于可用作香料和香料的y，8-不饱和酮的氢化或用于制备维生素E及其衍生物或香料和香料的方法。

9. 发明申请

WO2009065783A1 BIDENTATE SECONDARY PHOSPHINE OXIDE CHIRAL LIGANDS FOR USE IN ASYMMETRIC ADDITION REACTIONS 审中-公开
标题翻译：用于非对称添加反应的二次磷酸二氢氧化锡配体
公开(公告)号：WO2009065783A1
公开(公告)日：2009-05-28
申请号：PCT/EP2008/065605
申请日：2008-11-14
申请人： SOLVIAS AG , PUGIN, Benoît , LANDERT, Heidi , GSCHWEND, Björn , PFALTZ, Andreas , SPINDLER, Felix
发明人： PUGIN, Benoît , LANDERT, Heidi , GSCHWEND, Björn , PFALTZ, Andreas , SPINDLER, Felix
IPC分类号： C07F9/46 , C07F9/50 , C07F9/655 , C07F9/6553 , B01J31/12 , C07F15/00 , C07B53/00 , C07C213/02 , C07C231/12 , C07C231/18 , C07C67/303
CPC分类号： C07F9/65517 , B01J31/2495 , B01J2231/643 , B01J2231/645 , B01J2531/822 , B01J2531/827 , C07B53/00 , C07B2200/07 , C07C67/303 , C07C67/31 , C07C213/02 , C07C231/12 , C07C231/18 , C07F9/46 , C07F9/5018 , C07F9/5022 , C07F9/655354 , C07C69/34 , C07C69/732 , C07C69/675 , C07C217/08 , C07C233/47
摘要： Compounds of the formula I, in the form of mixtures comprising predominantly one enantiomer or in the form of pure enantiomers, secondary phosphine-Q-P*(=O)HR 1 (I) in which secondary phosphine is a C-bonded, secondary phosphine group -P(R) 2 ; in which R is in each case independently hydrocarbon radicals or heterohydrocarbon radicals; Q is a bivalent, achiral, aromatic base skeleton, a bivalent, achiral ferrocene base skeleton, an optionally substituted bivalent cycloalkane or heterocycloalkane skeleton, or a C 1-C 4-alkylene skeleton, and in which base skeletons a secondary phosphine group is bonded directly to a carbon atom, or, in the case of cyclic base skeletons, directly to a carbon atom or via a C 1 -C 4 -alkylene group, and in which base skeletons a P-chiral group -P*(O)HR 1 is bonded to a carbon atom such that the phosphorus atoms are linked via 1 to 7 atoms of a carbon chain optionally interrupted by heteroatoms from the group of O, S, N, Fe or Si; P* is a chiral phosphorus atom; and R 1 is a hydrocarbon radical, a C-bonded heterohydrocarbon radical or a ferrocenyl radical, with the proviso that R 1 is an achiral ferrocenyl radical when Q is an achiral ferrocenyl base skeleton. Metal complexes of these ligands in a molarratio of ligand to metal of about 1.3:1 to 0.9:1are homogeneous catalysts for asymmetric addition reactions, particularly hydrogenations.
摘要翻译：主要为一种对映异构体或纯对映异构体形式的混合物形式的化合物，其中次膦是C键，仲膦基的仲膦-PQ *（= O）HR1（I） P（R）2; 其中R各自独立地为烃基或杂烃基; Q是二价，非手性，芳族碱基骨架，二价，非手性二茂铁碱骨架，任选取代的二价环烷烃或杂环烷骨架，或C 1 -C 4亚烷基骨架，其中基骨架与仲膦基键合直接与碳原子相连，或者在环状基骨架的情况下，直接连接到碳原子或经由C 1 -C 4亚烷基，并且其中的基础骨架中的P手性基团-P *（O）HR1为键合到碳原子，使得磷原子通过1至7个碳链连接，任选被来自O，S，N，Fe或Si基团的杂原子中断; P *是手性磷原子; 并且R 1是烃基，C键合的杂烃基或二茂铁基，条件是当Q是非手性二茂铁基时，R 1是非手性二茂铁基。这些配体在约1.3:1至0.9:1的配体与金属的摩尔比中的金属络合物是用于不对称加成反应的均相催化剂，特别是氢化。

10. 发明申请

WO2006066863A1 ASYMMETRIC HYDROGENATION OF ALKENNES USING CHIRAL IRIDIUM COMPLEXES 审中-公开
标题翻译：使用CHIRAL IRIDIUM复合物的不对称氢化亚烷基
公开(公告)号：WO2006066863A1
公开(公告)日：2006-06-29
申请号：PCT/EP2005/013694
申请日：2005-12-20
申请人： DSM IP ASSETS B.V. , BONRATH, Werner , MENGES, Frederik , NETSCHER, Thomas , PFALTZ, Andreas , WÜSTENBERG, Bettina
发明人： BONRATH, Werner , MENGES, Frederik , NETSCHER, Thomas , PFALTZ, Andreas , WÜSTENBERG, Bettina
IPC分类号： C07D311/72 , C07C49/04 , C07C29/17 , C07C67/303 , C07F15/00
CPC分类号： C07D311/72 , C07B53/00 , C07C29/172 , C07C45/30 , C07C45/62 , C07C67/303 , C07C47/02 , C07C49/04 , C07C69/24 , C07C31/125
摘要： The invention relates to the (stereoselective) hydrogenation of carbon-carbon double bonds in compounds having at least one such bond, e.g., isoprenoids, non-cyclic sesquiterpenes, tocomonoenols, tocodienols, tocotrienols or derivatives thereof, as well as to the (stereoselective) hydrogenation of parts/extracts of plant oils containing such tocotrienols or derivatives thereof, in the presence of a chiral Ir complex as the catalyst, whereby preferably one stereoisomer is manufactured in an excess.
摘要翻译：本发明涉及具有至少一个这种键的化合物中的碳 - 碳双键的（立体选择性）氢化，例如类异戊二烯，非环倍半萜烯，对羟基烯醇，苯环醇，生育三烯酚或其衍生物，以及（立体选择性）在手性Ir配合物作为催化剂的存在下氢化含有这种生育三烯酚或其衍生物的植物油的部分/提取物，由此优选制备过量的一种立体异构体。

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