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1. 发明申请

WO2018048882A9 POSITRON IMAGING TOMOGRAPHY IMAGING AGENT COMPOSITION AND METHOD FOR BACTERIAL INFECTION 审中-公开
公开(公告)号：WO2018048882A9
公开(公告)日：2018-03-15
申请号：PCT/US2017/050248
申请日：2017-09-06
申请人： THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK
发明人： TONGE, Peter , ZHANG, Zhuo , SMITH-JONES, Peter , LIU, Li , WANG, Hui
IPC分类号： A61K51/00 , C07B35/02 , C07B39/00 , C07C229/60
摘要： The present invention provides a composition comprising the compound having the structure: Formula or a salt of the compound; 4-amino-2- [ 19 F] -fluorobenzoic acid or a salt of 4-amino-2- [ 19 F] -fluorobenzoic acid; and at least one acceptable carrier.

2. 发明申请

WO2018034609A1 CONVERSION OF ALCOHOLS TO LINEAR AND BRANCHED FUNCTIONALIZED ALKANES 审中-公开
标题翻译：醇类转化为线性和分支功能化烷烃
公开(公告)号：WO2018034609A1
公开(公告)日：2018-02-22
申请号：PCT/SE2017/050826
申请日：2017-08-16
申请人： ORGANOFUEL SWEDEN AB
发明人： CORDOVA, Armando , AFEWERKI, Samson
IPC分类号： C07C29/34 , C07B31/00 , C07B33/00 , C07B35/02 , C07B35/04
摘要： Embodiments herein concerns the eco-friendly conversion of simple alcohols to linear or branched functionalized alkanes, by integrated catalysis. The alcohols are firstlyoxidized either chemically or enzymatically to the corresponding aldehydes or ketones, followed by aldol condensations using a catalyst to give the corresponding enals or enones. The enals or enones are subsequently and selectively hydrogenated using a recyclable heterogeneous metal catalyst, organocatalyst or an enzyme to provide linear or branched functionalized alkanes with an aldehyde, keto- or alcohol functionality. The process is also iterative and can be further extended by repeating the above integrated catalysis for producing long-chain functionalized alkanes from simple alcohols.
摘要翻译：这里的实施方式涉及通过整体催化将简单醇转化成线型或支化官能化烷烃的环保型转化。将醇以化学或酶的方式首先氧化成相应的醛或酮，然后使用催化剂进行醇醛缩合，得到相应的烯烃或烯酮。随后使用可再循环的多相金属催化剂，有机催化剂或酶选择氢化烯烃或烯酮以提供具有醛，酮或醇官能度的线性或支化官能化烷烃。该过程也是迭代的，并且可以通过重复上述用于从简单醇制备长链官能化烷烃的整体催化来进一步扩展。

3. 发明申请

WO2014125233A3 METHOD FOR SYNTHESISING 4-PIPERIDIN-4-YL-BENZENE-1,3-DIOL AND THE SALTS OF SAME AND NOVEL COMPOUND TERT-BUTYL 4-(2,4-DIHYDROXY-PHENYL)-4-HYDROXY-PIPERIDINE-1-CARBOXYLATE 审中-公开
标题翻译：合成4-哌啶-4-基苯-1,3-二醇及其盐和新化合物叔丁基4-（2,4-二羟基苯基）-4-羟基哌啶-1-羧酸酯的方法
公开(公告)号：WO2014125233A3
公开(公告)日：2014-10-09
申请号：PCT/FR2014050314
申请日：2014-02-14
申请人： GALDERMA RES & DEV
发明人： BOITEAU JEAN-GUY , MUSICKI BRANISLAV
IPC分类号： C07D211/22 , C07B35/02 , C07D211/52
CPC分类号： C07D211/52 , C07B35/02 , C07D211/22
摘要： The present invention relates to a method for synthesising 4-piperidin-4-yl-benzene-1,3-diol of the following formula (I): and the pharmaceutically acceptable salts thereof, as well as to tert-butyl 4-(2.4-dihydroxy-phenyl)-4-hydroxy-piperidine-1-carboxylate as a novel intermediate compound.
摘要翻译：本发明涉及合成下式（I）的4-哌啶-4-基 - 苯-1,3-二醇的方法：及其药学上可接受的盐，以及4-（2.4 苯基）-4-羟基 - 哌啶-1-甲酸叔丁酯作为新的中间体化合物。

4. 发明申请

WO2010074802A2 METHOD FOR EFFICIENT USE OF HYDROGEN IN AROMATICS PRODUCTION FROM HEAVY AROMATIC OIL 审中-公开
标题翻译：有效利用氢气重芳烃油生产芳烃的方法
公开(公告)号：WO2010074802A2
公开(公告)日：2010-07-01
申请号：PCT/US2009062022
申请日：2009-10-26
申请人： UOP LLC , FREY STANLEY J , THAKKAR VASANT P
发明人： FREY STANLEY J , THAKKAR VASANT P
IPC分类号： C07B31/00 , C07B35/02
CPC分类号： C10G65/12 , C07C15/04 , C07C15/06 , C07C15/08 , C10G67/02 , C10G2300/1044 , C10G2300/1096 , C10G2300/301 , C10G2400/04 , C10G2400/30
摘要： A method for efficient use of hydrogen in aromatics production from heavy aromatic oil. A hydrocarbonaceous stream comprising C9 + hydrocarbons and an essentially pure hydrogen stream are hydrotreated and hydrocracked to produce a hydrocracking zone effluent comprising aromatics. The hydrocracking zone effluent is fractionated to separately recover C4 and lighter hydrocarbons, hydrocarbons boiling between 180°F and 380°F, and diesel. The heavier hydrocarbons are combined with a low purity hydrogen-containing stream and heated, then dehydrogenated or transalkylated to form hydrogen, volatile compounds, and aromatics. The hydrogen and volatile components are separated from the aromatics and treated by pressure swing adsorption to provide an essentially pure hydrogen-containing stream, which is compressed and provided to the hydrotreating and hydrocracking steps. Liquid products are recovered from the aromatics-containing stream.
摘要翻译：一种有效利用重芳烃油生产芳烃的方法。将包含C 9+烃和基本上纯的氢气流的含烃料流加氢处理并加氢裂化以产生包含芳族化合物的加氢裂化区流出物。加氢裂化区流出物被分馏以分别回收C4和较轻的烃，在180°F和380°F之间沸腾的烃和柴油。较重的烃与低纯度含氢物流混合并加热，然后脱氢或烷基转移以形成氢，挥发性化合物和芳族化合物。将氢气和挥发性组分从芳烃中分离出来并通过变压吸附处理以提供基本上纯的含氢物流，将其压缩并提供给加氢处理和加氢裂化步骤。从含芳烃物流中回收液体产物。

5. 发明申请

WO2007007646A1 均一系不斉水素化反応用触媒审中-公开
标题翻译：均质不对称氢化催化剂
公开(公告)号：WO2007007646A1
公开(公告)日：2007-01-18
申请号：PCT/JP2006/313510
申请日：2006-07-06
申请人：高砂香料工業株式会社 , 清水英雄 , 五十嵐大輔 , 栗山亙 , 遊佐雪徳
发明人：清水英雄 , 五十嵐大輔 , 栗山亙 , 遊佐雪徳
IPC分类号： B01J31/24 , C07C29/145 , C07C31/125 , C07C33/22 , C07C35/08 , C07C35/18 , C07C45/62 , C07C49/403 , C07C67/303 , C07C69/24 , C07C69/612 , C07C231/12 , C07C233/05 , C07D209/08 , C07D307/46 , C07B35/02 , C07B53/00 , C07B61/00
CPC分类号： C07C29/145 , B01J31/2409 , B01J31/2452 , B01J31/2457 , B01J2231/643 , B01J2531/0266 , B01J2531/16 , C07B35/02 , C07B53/00 , C07B2200/07 , C07C29/175 , C07C41/26 , C07C45/62 , C07C67/303 , C07C231/12 , C07C2601/14 , C07C2601/16 , C07D209/08 , C07D307/46 , C07F9/5045 , C07F9/65517 , C07C49/403 , C07C69/612 , C07C69/24 , C07C233/47 , C07C43/196 , C07C31/125 , C07C33/18 , C07C33/22 , C07C35/08 , C07C35/18
摘要：　比較的容易に入手可能で、経済性及び作業性がよい、水素化反応、特に不斉水素化反応に有用な、不斉配位子を有する不斉銅錯体を含有する均一系水素化反応用触媒、特に均一系不斉水素化反応用触媒、及び該触媒を用いる収率及び光学純度がよい不飽和化合物の水素化物、特に光学活性化合物の製造方法の提供。
摘要翻译：公开了均相氢化催化剂，特别是含有具有手性配体的不对称铜络合物的均相不对称氢化催化剂。该催化剂可用于氢化反应，特别是对于不对称氢化反应。此外，该催化剂相对容易且经济地使用，同时具有良好的可加工性。还公开了不饱和化合物的氢化物的制造方法，特别是通过使用上述催化剂，以高收率制造光学纯度高的光学活性化合物的方法。

6. 发明申请

WO2005068403A3 METHOD FOR SELECTIVE REDUCTION OF AROMATIC COMPOUNDS 审中-公开
标题翻译：选择性还原芳香化合物的方法
公开(公告)号：WO2005068403A3
公开(公告)日：2005-09-01
申请号：PCT/US2004040243
申请日：2004-12-02
申请人： MALLINCKRODT INC , WANG PETER XIANQI , MOSER FRANK W
发明人： WANG PETER XIANQI , MOSER FRANK W
IPC分类号： C07B31/00 , C07B35/02 , C07B35/04 , C07C37/00 , C07C213/08 , C07C217/60 , C07C231/12 , C07C233/22 , C07C235/34
CPC分类号： C07B35/02 , C07B31/00 , C07C213/08 , C07C231/12 , C07C2601/10 , C07C2601/16 , C07C217/60 , C07C233/34
摘要： A method for the selective reduction of an aromatic compound. The present invention provides a method for preventing the reduction of at least one halogen substituted aromatic ring of an aromatic compound, while allowing the reduction of at least one functional group on the aromatic compound. In the present invention at least one hydroxyl group is placed on the at least one halogen substituted aromatic ring to be protected from reduction. The aromatic compound is then reacted with at least one alkali metal in at least one nitrogen containing base and at least one alcohol at a ratio of the alcohol to the nitrogen containing base at which the aromatic ring with the hydroxyl group is protected from reduction, while the desired functional group is reduced.
摘要翻译：一种选择性还原芳香族化合物的方法。本发明提供了一种方法，用于防止芳族化合物的至少一个卤素取代的芳族环的还原，同时使芳族化合物上的至少一个官能团还原。在本发明中，至少一个羟基置于至少一个卤素取代的芳族环上以防止还原。然后使芳族化合物与至少一种含氮碱和至少一种醇中的至少一种碱金属以醇与含氮碱的比例反应，其中具有羟基的芳环被保护免于还原，而所需的官能团减少。

7. 发明申请

WO2003097561A1 PROCESS FOR THE CATALYTIC HYDROGENATION OF A SUBSTANCE 审中-公开
标题翻译：一种物质的催化加氢方法
公开(公告)号：WO2003097561A1
公开(公告)日：2003-11-27
申请号：PCT/EP2003/005293
申请日：2003-05-20
申请人： HTE AKTIENGESELLSCHAFT , SCHUNK, Stephan, Andreas
发明人： SCHUNK, Stephan, Andreas
IPC分类号： C07B35/02
CPC分类号： C07B35/02 , C07C5/11 , C07C2523/46 , C07C2527/25 , C07C13/20
摘要： The present invention relates to a process for hydrogenating at least one organic substrate in at least two liquid phases which are at least partially immiscible with one another using a catalyst, wherein at one of the two or more liquid phases contains at least the following further components: (i) at least one surface-active substance and (ii) at least one salt which is at least partially soluble in at least one of the at least two liquid phases.
摘要翻译：本发明涉及使用催化剂使至少两个液相中的至少两个液相中的至少一个有机底物氢化的方法，其中两个或多个液相中的一个至少含有以下其它组分：（i）至少一种表面活性物质和（ii）至少部分可溶于至少两种液相中的至少一种的至少一种盐。

8. 发明申请

WO2003095084A3 HYDROGENATION IN SUPERCRITICAL C1-4 FLUORINATED HYDROCARBONS 审中-公开
公开(公告)号：WO2003095084A3
公开(公告)日：2003-11-20
申请号：PCT/GB2003/002067
申请日：2003-05-14
申请人： ADVANCED PHYTONICS LIMITED , ABBOTT, Andrew , ELTRINGHAM, Wayne , NICOLA, Mazin
发明人： ABBOTT, Andrew , ELTRINGHAM, Wayne , NICOLA, Mazin
IPC分类号： C07B35/02
摘要： A process for hydrogenating one or more functional groups in a compound, for example an alkene, involves contacting the compound with a hydrogen source in the presence of a reaction solvent and suitably in the presence of a catalyst, such as Wilkinson's catalyst. The reaction solvent may be a C 1 - 4 fluorinated hydrocarbon or a C 1 - 4 hydrofluorocarbon ether, with difluoromethane, tetrafluoroethane and heptafluoropropane being preferred solvents.

9. 发明申请

WO02055453A3 PROCESS FOR THE PREPARATION OF SATURATED ORGANIC COMPOUNDS 审中-公开
标题翻译：制备饱和有机化合物的方法
公开(公告)号：WO02055453A3
公开(公告)日：2002-12-19
申请号：PCT/EP0200210
申请日：2002-01-11
申请人： DEGUSSA
发明人： OSTGARD DANIEL , BERWEILER MONIKA , ROEDER STEFAN
IPC分类号： B01J25/02 , B01J35/08 , C07B35/02 , C07B61/00 , C07C5/10 , C07C13/16 , C07C29/17 , C07C29/19 , C07C29/20 , C07C31/20 , C07C33/035 , C07C211/09 , C07C209/50
CPC分类号： C07C29/17 , C07B35/02 , C07C5/10 , C07C29/172 , C07C2525/00 , C07C2525/02 , C07C33/035 , C07C31/207
摘要： Process for the preparation of completely or partly saturated organic compounds by catalytic hydrogenation of unsaturated organic compounds with hydrogen or hydrogen-containing gas mixtures in the presence of a shaped Raney catalyst as the hydrogenation catalyst, wherein the Raney catalyst is in the form of hollow bodies. Nickel, cobalt, copper, iron, platinum, palladium or ruthenium are preferably used as catalytically active constituents.
摘要翻译：在作为氢化催化剂的成型Raney催化剂存在下，通过用氢气或含氢气体混合物催化氢化不饱和有机化合物来制备完全或部分饱和的有机化合物的方法，其中阮内催化剂为中空体。镍，钴，铜，铁，铂，钯或钌优选用作催化活性成分。

10. 发明申请

WO02098925A2 COLLOID-CATALYSED GAS TRANSFER IN SUPERCRITICAL PHASES 审中-公开
标题翻译： KOLLOIDKATALYSIERTE输气管大约关键阶段
公开(公告)号：WO02098925A2
公开(公告)日：2002-12-12
申请号：PCT/EP0205719
申请日：2002-05-24
申请人： BASF AG , NIESSEN HEIKO G , WOELK KLAUS , EICHHORN ANDREAS , BARGON JOACHIM
发明人： NIESSEN HEIKO G , WOELK KLAUS , EICHHORN ANDREAS , BARGON JOACHIM
IPC分类号： C07B35/02 , C07B61/00 , C07C5/03 , C07C5/08 , C07C9/15 , C07C15/073 , C07C29/17 , C07C31/125 , C07C45/50 , C08F8/00
CPC分类号： C07B35/02 , C07C5/08 , C07C29/17 , Y02P20/544 , C07C31/125
摘要： The invention relates to a method for the transfer of hydrogen to chemical compounds, whereby the hydrogen transfer is carried out in supercritical or subcritical phases by using stabilised and dispersed metal particles. The invention further relates to the use of metal colloids embedded in, or stabilised by organic compounds as catalysts in a method for hydrogen transfer to chemical compounds in supercritical or subcritical phases for avoiding the formation of radical intermediates during the hydrogen transfer.
摘要翻译：本发明涉及用于氢转移，其中在超临界或亚临界相的氢转移使用稳定化并进行分散的金属粒子的化学化合物的方法。本发明还涉及通过稳定的有机化合物或到有机化合物中嵌入金属胶体如在用于氢转移到化学化合物在超临界或亚临界相的工艺催化剂的使用，以避免自由基中间体的氢转移过程中形成。

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