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1. 发明申请

WO2007078990A2 MODIFIED LYSINE-MIMETIC COMPOUNDS 审中-公开
标题翻译：改性赖氨酸 - 化合物
公开(公告)号：WO2007078990A2
公开(公告)日：2007-07-12
申请号：PCT/US2006048790
申请日：2006-12-21
申请人： ZEALAND PHARMA AS , WYETH CORP , LARSEN BJARNE DUE , PETERSEN JORGEN SOBERG , HAUGAN KETIL JORGEN , BUTERA JOHN A , HENNAN JAMES K , KERNS EDWARD H , PIATNITSKI EVGUENI LVOVICH
发明人： LARSEN BJARNE DUE , PETERSEN JORGEN SOBERG , HAUGAN KETIL JORGEN , BUTERA JOHN A , HENNAN JAMES K , KERNS EDWARD H , PIATNITSKI EVGUENI LVOVICH
IPC分类号： C07C233/81 , A61K31/4015 , A61K31/4166 , A61P9/00 , C07D207/16 , C07D207/50 , C07D233/02
CPC分类号： C07D207/16 , C07C233/31 , C07C233/61 , C07C233/83 , C07C237/20 , C07C237/24 , C07C237/30 , C07D233/02 , C07D403/04 , C07D403/06 , C07D405/04 , C07D407/12 , C07D413/04 , C07K5/06026
摘要： Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed.
摘要翻译：公开了具有有用的药理学活性如抗心律不齐活性和所需生物利用度性质的赖氨酸模拟物质。

2. 发明申请

WO0198324A8 PEPTIDE CONJUGATES MODIFIED N- AND/OR C-TERMINALLY BY SHORT CHARGED PEPTIDE CHAINS 审中-公开
标题翻译：通过短荷载链修饰N-和/或C-末端的肽结合
公开(公告)号：WO0198324A8
公开(公告)日：2002-03-21
申请号：PCT/US0119113
申请日：2001-06-15
申请人： ZEALAND PHARMACEUTICALS AS , LARSEN BJARNE DUE , PETERSEN JORGEN SOBERG , KAPUSTA DANIEL R , HARLOW KENNETH WILLIAM
发明人： LARSEN BJARNE DUE , PETERSEN JORGEN SOBERG , KAPUSTA DANIEL R , HARLOW KENNETH WILLIAM
IPC分类号： C12N15/09 , A61K38/00 , A61K38/04 , A61K38/16 , A61K38/33 , A61K47/48 , A61P1/18 , A61P3/12 , A61P3/14 , A61P7/10 , A61P9/04 , A61P9/12 , C07K1/00 , C07K7/04 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/575 , C07K14/665 , C07K16/18 , C07K16/44 , C07K17/00 , C07K19/00 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12P21/08
CPC分类号： C07K7/08 , A61K38/00 , A61K47/646 , C07K7/06
摘要： Disclosed are a variety of peptide conjugates represented by the following general formula (I): R1-Z-X-Z'-R2, wherein X represents a hexapeptide of the formula (II): A -A -A -A -A -A wherein A represents Arg, Lys, or His, A represents Tyr, Trp, or Phe, A represents Tyr, Asn, Trp or Phe, A represents Lys, Arg or His, A represents Phe, Tyr, Trp, Leu, Val or Ile, and A represents Arg, Lys, or His and wherein each amino acid residue in said hexapeptide may be in the L or D form; Z represents a charged peptide chain of from 4 to 20 amino acid residues having the D or L configuration or is missing; and Z' represents a charged peptide chain of from 4 to 20 amino acid residues having the D or L configuration or is missing, providing that not both of Z and Z' are missing; R1 represents H or an acyl group; R2 represents NR3R4 where each of R3 and R4 independently represents hydrogen, C(1-6)alkoxy, aryloxy, or a lower alkyl as defined herein; or R2 represents OH; the peptide conjugates of formula (I) being optionally further linked to a transport moiety; and salts, hydrates and solvates thereof, and C-terminally amidated or esterified derivatives thereof with suitable organic or inorganic acids, including methods or making and using such conjugates. Also provided are antibodies that specifically bind the peptide conjugates. The present invention has a wide spectrum of important applications including use in the treatment of disorders impacted by nociceptin and related opioid-like peptides.
摘要翻译：公开了由以下通式（I）表示的各种肽缀合物：R1-ZX-Z'-R2，其中X表示式（II）的六肽：A 1 -A 2 -A 3→-A 4 -A 5 -A -A 6其中A 1表示Arg，Lys或His，A 2表示Tyr，Trp或Phe，A 3表示Tyr，Asn ，Trp或Phe，A 4表示Lys，Arg或His，A 5表示Phe，Tyr，Trp，Leu，Val或Ile，A 6表示Arg，Lys或His，其中各氨基酸所述六肽中的残基可以是L或D形式; Z表示具有D或L构型或缺失的4至20个氨基酸残基的带电荷的肽链; 并且Z'表示具有D或L构型或缺失的4至20个氨基酸残基的带电荷的肽链，假定不存在Z和Z'两者; R1表示H或酰基; R 2表示NR 3 R 4，其中R 3和R 4各自独立地表示氢，C（1-6）烷氧基，芳氧基或如本文所定义的低级烷基; 或R 2表示OH; 式（I）的肽缀合物任选进一步连接至转运部分; 和其盐，水合物和溶剂化物，以及C末端酰胺化或酯化的衍生物与合适的有机或无机酸，包括方法或制备和使用这些共轭物。还提供了特异性结合肽缀合物的抗体。本发明具有广泛的重要应用，包括用于治疗受伤害感受肽和相关类阿片样肽类影响的障碍。

3. 发明申请

WO02077017A3 MEDICAL USES OF INTERCELLULAR COMMUNICATION FACILITATING COMPOUNDS 审中-公开
标题翻译：细胞间通讯促进化合物的医学用途
公开(公告)号：WO02077017A3
公开(公告)日：2003-10-09
申请号：PCT/US0205773
申请日：2002-02-22
申请人： ZEALAND PHARMA AS , LARSEN BJARNE DUE , PETERSEN JORGEN SOBERG , MEIER EDDIE , KJOLBYE ANNE LOUISE , JORGENSEN NIKLAS RYE , NIELSEN MORTEN SCHAK , HOLSTEIN-RATHLOU NIELS-HENRIK , MARTINS JAMES B
发明人： LARSEN BJARNE DUE , PETERSEN JORGEN SOBERG , MEIER EDDIE , KJOLBYE ANNE LOUISE , JORGENSEN NIKLAS RYE , NIELSEN MORTEN SCHAK , HOLSTEIN-RATHLOU NIELS-HENRIK , MARTINS JAMES B
IPC分类号： A61K38/00 , A61K31/00 , A61K31/05 , A61K31/198 , A61K31/485 , A61K31/53 , A61K38/04 , A61K38/08 , A61K38/11 , A61K38/12 , A61P1/00 , A61P1/02 , A61P1/04 , A61P1/14 , A61P3/00 , A61P3/10 , A61P7/00 , A61P7/02 , A61P9/04 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/04 , A61P13/10 , A61P13/12 , A61P15/04 , A61P15/08 , A61P15/10 , A61P17/00 , A61P17/02 , A61P19/00 , A61P19/02 , A61P19/04 , A61P19/10 , A61P25/00 , A61P25/04 , A61P25/22 , A61P25/24 , A61P25/28 , A61P27/00 , A61P27/02 , A61P27/12 , A61P27/16 , A61P29/00 , A61P35/00 , A61P37/06 , A61P43/00 , C07K20060101 , C07K5/00 , C07K5/023 , C07K5/06 , C07K5/062 , C07K5/072 , C07K5/08 , C07K5/083 , C07K5/087 , C07K5/10 , C07K5/103 , C07K5/107 , C07K5/12 , C07K7/00 , C07K7/06 , C07K7/54 , C07K7/64 , A61K31/195 , A61K31/4353 , C07C237/22
CPC分类号： C07K7/06 , A61K31/00 , A61K38/00 , C07K5/06026 , C07K5/06104 , C07K5/0806 , C07K5/0812 , C07K5/1008 , C07K5/1016 , C07K7/64
摘要： Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
摘要翻译：公开了包括具有改善的稳定性的抗心律失常肽的新型肽。进一步公开的是包括这些肽的组合物以及将组合物特别用作药物的方法。

4. 发明申请

WO2002077017A2 NEW MEDICAL USES OF INTERCELLULAR COMMUNICATION FACILITATING COMPOUNDS 审中-公开
标题翻译：细胞间通讯化合物的新医疗用途
公开(公告)号：WO2002077017A2
公开(公告)日：2002-10-03
申请号：PCT/US2002/005773
申请日：2002-02-22
申请人： ZEALAND PHARMACEUTICAL A/S , LARSEN, Bjarne, Due , PETERSEN, Jorgen, Soberg , MEIER, Eddie , KJOLBYE, Anne, Louise , JORGENSEN, Niklas, Rye , NIELSEN, Morten, Schak , HOLSTEIN-RATHLOU, Niels-Henrik , MARTINS, James, B.
发明人： LARSEN, Bjarne, Due , PETERSEN, Jorgen, Soberg , MEIER, Eddie , KJOLBYE, Anne, Louise , JORGENSEN, Niklas, Rye , NIELSEN, Morten, Schak , HOLSTEIN-RATHLOU, Niels-Henrik , MARTINS, James, B.
IPC分类号： C07K7/00
CPC分类号： C07K7/06 , A61K31/00 , A61K38/00 , C07K5/06026 , C07K5/06104 , C07K5/0806 , C07K5/0812 , C07K5/1008 , C07K5/1016 , C07K7/64
摘要： Disclosed are novel peptides including antiarrhythmic peptides that have improved stability. Further disclosed are compositions that include such peptides and methods of using the compositions particularly as medicaments.
摘要翻译：公开了包括具有改善的稳定性的抗心律不齐肽的新型肽。进一步公开的是包括这些肽的组合物以及将组合物特别用作药物的方法。

5. 发明申请

WO2007078990A3 MODIFIED LYSINE-MIMETIC COMPOUNDS 审中-公开
公开(公告)号：WO2007078990A3
公开(公告)日：2007-07-12
申请号：PCT/US2006/048790
申请日：2006-12-21
申请人： ZEALAND PHARMA A/S , WYETH , LARSEN, Bjarne, Due , PETERSEN, Jorgen, Soberg , HAUGAN, Ketil, Jorgen , BUTERA, John, A. , HENNAN, James, K. , KERNS, Edward, H. , PIATNITSKI, Evgueni, Lvovich
发明人： LARSEN, Bjarne, Due , PETERSEN, Jorgen, Soberg , HAUGAN, Ketil, Jorgen , BUTERA, John, A. , HENNAN, James, K. , KERNS, Edward, H. , PIATNITSKI, Evgueni, Lvovich
IPC分类号： C07C233/81 , C07D207/16 , C07D207/50 , C07D233/02 , A61K31/4015 , A61K31/4166 , A61P9/00
摘要： Lysine mimetic compounds having useful pharmacological activity such as antiarrhythmic activity and desirable bioavailability properties are disclosed.

6. 发明申请

WO2002079235A3 COMPOSITIONS AND METHODS FOR MODULATING GUANYLYL CYCLASE SIGNALING RECEPTOR (GC-C) ACTIVITY AND FOR TREATING MENIERE'S DISEASE 审中-公开
公开(公告)号：WO2002079235A3
公开(公告)日：2002-10-10
申请号：PCT/IB2002/002466
申请日：2002-03-29
申请人： UNIVERSITY OF COPENHAGEN , LARSEN, Bjarne, Due , NEVE, Soren , QVORTRUP, Klaus , PETERSEN, Jorgen, Soberg , MEIER, Eddi
发明人： LARSEN, Bjarne, Due , NEVE, Soren , QVORTRUP, Klaus , PETERSEN, Jorgen, Soberg , MEIER, Eddi
IPC分类号： C07K7/60
摘要： Disclosed are compositions and methods for modulating guanylyl cyclase signaling receptor (GC-C). Further disclosed are highly useful in vitro and in vivo screens for detecting compounds that modulate the GC-C receptor. The invention has a wide spectrum of useful applications including providing therapeutic compounds that can be employed to prevent and/or treat inner ear disorders and particularly Ménière's disease.

7. 发明申请

WO2002079235A2 COMPOSITIONS AND METHODS FOR MODULATING GUANYLYL CYCLASE SIGNALING RECEPTOR (GC-C) ACTIVITY AND FOR TREATING MENIERE'S DISEASE 审中-公开
标题翻译：用于调节人类循环信号受体（GC-C）活性和治疗男性疾病的组合物和方法
公开(公告)号：WO2002079235A2
公开(公告)日：2002-10-10
申请号：PCT/IB2002/002466
申请日：2002-03-29
申请人： ZEALAND PHARMA A/S , LARSEN, Bjarne, Due , NEVE, Soren , QVORTRUP, Klaus , PETERSEN, Jorgen, Soberg , MEIER, Eddi
发明人： LARSEN, Bjarne, Due , NEVE, Soren , QVORTRUP, Klaus , PETERSEN, Jorgen, Soberg , MEIER, Eddi
IPC分类号： C07K7/00
CPC分类号： C12N9/88
摘要： Disclosed are compositions and methods for modulating guanylyl cyclase signaling receptor (GC-C). Further disclosed are highly useful in vitro and in vivo screens for detecting compounds that modulate the GC-C receptor. The invention has a wide spectrum of useful applications including providing therapeutic compounds that can be employed to prevent and/or treat inner ear disorders and particularly Ménière's disease.
摘要翻译：公开了调节鸟苷酸环化酶信号受体（GC-C）的组合物和方法。进一步公开的是用于检测调节GC-C受体的化合物的体外和体内筛选。本发明具有广泛的有用应用，包括提供可用于预防和/或治疗内耳障碍，特别是梅内尔病的治疗化合物。

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