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1. 发明申请

WO2012107857A1 MEDICAL IMAGING DEVICE FOR PROVIDING AN IMAGE REPRESENTATION SUPPORTING THE ACCURATE POSITIONING OF AN INVENTION DEVICE IN VESSEL INTERVENTION PROCEDURES 审中-公开
标题翻译：用于提供图像表示的医学成像装置，其支持本发明的精确定位装置在血管干预程序中
公开(公告)号：WO2012107857A1
公开(公告)日：2012-08-16
申请号：PCT/IB2012/050441
申请日：2012-01-31
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , FLORENT, Raoul , CATHIER, Pascal, Yves, François , NEMPONT, Olivier, Pierre
发明人： FLORENT, Raoul , CATHIER, Pascal, Yves, François , NEMPONT, Olivier, Pierre
IPC分类号： A61B6/12 , G06T7/00 , A61B19/00
CPC分类号： A61B5/0033 , A61B6/12 , A61B6/4441 , A61B6/481 , A61B6/487 , A61B6/488 , A61B6/504 , A61B6/5229 , A61B2017/00778 , A61B2090/364 , A61B2090/376 , G06T7/30 , G06T2207/10121 , G06T2207/20221 , G06T2207/30021 , G06T2207/30101
摘要： A medical imaging device and a method for providing an image representation supporting inaccurate positioning of an intervention device in a vessel intervention procedure is proposed. Therein, an anatomy representation (AR) of a vessel region of interest and at least one angiogram X-ray image (RA) and a live fluoroscopy X-ray image (LI) are acquired. The following steps are performed when a radio-opaque device is fixedly arranged within the vessel region of interest: (a) registering the anatomy representation to the at least one angiogram X-ray image in order to provide an anatomy-angiogram-registration (R1); (b) processing (DP) the at least one angiogram X-ray image and the at least one live fluoroscopy X-ray image in order to identify in each of the X-ray images the radio-opaque device; (c) registering (R2) the at least one angiogram X-ray image to the at least one live fluoroscopy X- ray image based on the identified radio-opaque device in order to provide an angiogram- fluoroscopy-registration; and (d) combining the anatomy-angiogram-registration and the angiogram-fluoroscopy-registration in order to provide an anatomy-fluoroscopy-registration (GTC; RALC). Finally, an image representation resulting from the anatomy-fluoroscopy- registration showing an overlay of live images with the anatomy representation may be output thereby helping a surgeon to accurately position for example a synthetic aortic valve within an aortic root of a heart.
摘要翻译：提出了一种医疗成像装置和用于在血管干预程序中提供支持干预装置的不准确定位的图像表示的方法。其中，获取血管区域的解剖学表示（AR）和至少一个血管造影X射线图像（RA）和活体荧光透视X射线图像（LI）。当无线电不透明设备固定地布置在感兴趣的血管区域内时，执行以下步骤：（a）将解剖学表现注册到至少一个血管造影X射线图像，以便提供解剖血管造影记录（R1 ）; （b）处理（DP）所述至少一个血管造影X射线图像和所述至少一个活体荧光透视X射线图像，以便在每个所述X射线图像中识别所述不透射线装置; （c）基于所识别的不透射线装置将至少一个血管造影X射线图像记录（R2）到所述至少一个活透视X射线图像，以便提供血管造影荧光透视注册; 和（d）结合解剖 - 血管造影照片和血管造影 - 荧光透视注册，以便提供解剖 - 透视注册（GTC; RALC）。最后，可以输出从解剖学 - 透视检查 - 对准显示由现场图像与解剖学表示的重叠的图像表示，从而帮助外科医生精确地将合成的主动脉瓣置于心脏的主动脉根部内。

2. 发明申请

WO1996011690A1 DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS 审中-公开
标题翻译： DIAZEPINO-INDOLES作为磷酸二酯酶IV抑制剂
公开(公告)号：WO1996011690A1
公开(公告)日：1996-04-25
申请号：PCT/FR1995001354
申请日：1995-10-13
申请人： INSTITUT DE RECHERCHE JOUVEINAL , PASCAL, Yves , MOODLEY, Indres , CALVET, Alain , JUNIEN, Jean-Louis , DAHL, Svein, G.
发明人： INSTITUT DE RECHERCHE JOUVEINAL
IPC分类号： A61K31/55
CPC分类号： C07D487/06 , A61K31/5517
摘要： The use of diazepino-indole derivatives of formula (I), wherein R is hydrogen, lower alkyl or lower alkoxy, and A is mono- to trisubstituted aryl or heteroaryl, and racemic forms, enantiomers and pharmaceutically acceptable salts thereof, containing novel products, for preparing drugs useful for treating disorders requiring therapy using phosphodiesterase IV inhibitors.
摘要翻译：使用式（I）的二氮杂 - 吲哚衍生物，其中R是氢，低级烷基或低级烷氧基，A是一至三取代的芳基或杂芳基，以及含有新产物的外消旋形式，对映异构体和药学上可接受的盐，用于制备用于治疗需要使用磷酸二酯酶IV抑制剂治疗的疾病的药物。

3. 发明申请

WO2012140553A1 EMBEDDED 3D MODELLING 审中-公开
标题翻译：嵌入式3D建模
公开(公告)号：WO2012140553A1
公开(公告)日：2012-10-18
申请号：PCT/IB2012/051700
申请日：2012-04-05
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , NEMPONT, Olivier, Pierre , FLORENT, Raoul , CATHIER, Pascal, Yves, François
发明人： NEMPONT, Olivier, Pierre , FLORENT, Raoul , CATHIER, Pascal, Yves, François
IPC分类号： G06T7/00 , A61B5/06 , G06T15/20
CPC分类号： A61B6/12 , A61B5/055 , A61B6/03 , A61B6/487 , A61B6/5235 , A61B2090/367 , G06T7/30 , G06T7/75 , G06T19/20 , G06T2207/10072 , G06T2207/10121 , G06T2207/30021 , G06T2207/30101 , G06T2210/41 , G06T2219/2004
摘要： The present invention relates to an image processing device for guidance support, a medical imaging system for providing guidance support, a method for guidance support, a method for operating an image processing device for guidance support, as well as a computer program element, and a computer readable medium. In order to provide enhanced and easily perceptible information about the actual situation, it is proposed to provide (110) 3D data (112) of a region of interest of an object, to provide (114) image data (116) of at least a part of the region of interest, wherein a device is located at least partly within the region of interest, to generate (118) a 3D model (120) of the device from the image data, and to provide (122) data for a model-updated 3D image (124) by embedding (126) the 3D model within the 3D data.
摘要翻译：本发明涉及一种用于引导支持的图像处理装置，用于提供引导支持的医学成像系统，用于引导支持的方法，用于引导支持的图像处理装置的操作方法以及计算机程序元素，以及计算机可读介质。为了提供关于实际情况的增强且容易感知的信息，提出了提供（110）对象感兴趣区域的3D数据（112），以提供（114）至少一个所述感兴趣区域的一部分，其中设备至少部分地位于所述感兴趣区域内，以从所述图像数据生成（118）所述设备的3D模型（120），并且为模型（122）提供（122）数据通过在3D数据内嵌入（126）3D模型来更新3D图像（124）。

4. 发明申请

WO2012117321A1 VISUALIZATION FOR NAVIGATION GUIDANCE 审中-公开
标题翻译：可视化导航指导
公开(公告)号：WO2012117321A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050855
申请日：2012-02-24
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , CATHIER, Pascal, Yves, François , FLORENT, Raoul
发明人： CATHIER, Pascal, Yves, François , FLORENT, Raoul
IPC分类号： G06T7/00 , G06T7/20 , A61B6/00
CPC分类号： G06T7/0012 , A61B6/032 , A61B6/12 , A61B6/4441 , A61B6/487 , A61B6/503 , A61B6/5247 , A61B6/5264 , A61B6/5288 , G06T7/246 , G06T7/30 , G06T2207/10072 , G06T2207/10121 , G06T2207/30021 , G06T2207/30048 , G06T2207/30101
摘要： The present invention relates to visualizing information of an object. In order to provide spatial information and in addition situation specific data to the user while ensuring an effective perceptibility, a method (110) is provided comprising the steps of: a) providing (112) pre-navigation data (114) of a region of interest of an object (22); wherein the pre-navigation data comprises spatial geometrical data (116) and a functional parameter surface (118) in correspondence to the spatial geometrical data; b) acquiring (120) live image data (122) of the region of interest; c) detecting (124) an element (126) in the live image data; d) determining (128) spatial relation (130) of the pre-navigation data and the live image data; e) determining (132) the position (134) of the detected element in the spatial geometrical data, which determining is based on the spatial relation, and computing (136) a predetermined related point of location (138) on the functional parameter surface; f) generating (140) a combination (142) of a simplified surface representation (144) of the region of interest, which simplified surface representation is based on a visualization of the functional parameter surface, and a marker (146) indicating the computed predetermined related point of location; and g) displaying (148) the combination as navigation guidance (150).
摘要翻译：本发明涉及可视化对象的信息。为了在确保有效的可感知性的同时向用户提供空间信息和附加情况特定数据，提供了一种方法（110），包括以下步骤：a）提供（112）前导数据（114）物体（22）的兴趣; 其中所述预导数据包括对应于所述空间几何数据的空间几何数据（116）和功能参数表面（118）; b）获取（120）感兴趣区域的实时图像数据（122）; c）在实况图像数据中检测（124）元素（126）; d）确定前导数据和实况图像数据的（128）空间关系（130）; e）确定（132）在空间几何数据中检测到的元素的位置（134），其基于空间关系进行确定，并且计算（136）功能参数表面上的预定相关位置点（138）; f）产生（140）所述感兴趣区域的简化表面表示（144）的组合（142），所述简化表面表示基于所述功能参数表面的可视化，以及指示所计算的预定相关点位置; 以及g）将所述组合显示（148）作为导航指导（150）。

5. 发明申请

WO2012117366A1 VISUALIZATION FOR NAVIGATION GUIDANCE 审中-公开
标题翻译：可视化导航指导
公开(公告)号：WO2012117366A1
公开(公告)日：2012-09-07
申请号：PCT/IB2012/050966
申请日：2012-03-01
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , KING'S COLLEGE LONDON , PHILIPS INTELLECTUAL PROPERTY & STANDARDS GMBH , MANZKE, Robert , ETYNGIER, Patrick , CATHIER, Pascal, Yves, François , VILLAIN, Nicolas, François , RASCHE, Volker , RHODE, Kawaldeep, Singh
发明人： MANZKE, Robert , ETYNGIER, Patrick , CATHIER, Pascal, Yves, François , VILLAIN, Nicolas, François , RASCHE, Volker , RHODE, Kawaldeep, Singh
IPC分类号： A61B6/00
CPC分类号： A61B5/066 , A61B6/032 , A61B6/12 , A61B6/488 , A61B6/503 , A61B6/5235 , A61B90/37 , A61B2034/2065 , A61B2090/364 , A61B2090/376
摘要： The present invention relates to visualizing information of an object. In order to provide spatial information and in addition situation specific data to the user while ensuring an effective perceptibility, a method (110) is provided comprising the steps of: a) providing (112) pre-navigation data (114) of a region of interest of an object (22); wherein the pre-navigation data comprises spatial geometrical data (116) and a functional parameter surface (118) in correspondence to the spatial geometrical data; b) acquiring (120) live image data (122) of the region of interest; c) detecting (124) an element (126) in the live image data; d) determining (128) spatial relation (130) of the pre-navigation data and the live image data; e) determining (132)the position (134) of the detected element in the spatial geometrical data, which determining is based on the spatial relation, and computing (136) a predetermined related point of location (138) on the functional parameter surface; f) generating (140) a combination (142) of a simplified surface representation (144) of the region of interest, which simplified surface representation is based on a visualization of the functional parameter surface, and a marker (146) indicating the computed predetermined related point of location; and g) displaying (148) the combination as navigation guidance (150).
摘要翻译：本发明涉及可视化对象的信息。为了在确保有效的可感知性的同时向用户提供空间信息和附加情况特定数据，提供了一种方法（110），包括以下步骤：a）提供（112）前导数据（114）物体（22）的兴趣; 其中所述预导数据包括对应于所述空间几何数据的空间几何数据（116）和功能参数表面（118）; b）获取（120）感兴趣区域的实时图像数据（122）; c）在实况图像数据中检测（124）元素（126）; d）确定前导数据和实况图像数据的（128）空间关系（130）; e）确定（132）在空间几何数据中检测到的元素的位置（134），其基于空间关系进行确定，并且计算（136）功能参数表面上的预定相关位置点（138）; f）产生（140）所述感兴趣区域的简化表面表示（144）的组合（142），所述简化表面表示基于所述功能参数表面的可视化，以及指示所计算的预定相关点位置; 以及g）将所述组合显示（148）作为导航指导（150）。

6. 发明申请

WO1994015917A1 ALPHA-METHYL-(R)-TRYPTOPHYL-ARYLCYCLOALKYLALKYLAMIDES AS LIGANDS FOR GASTRIN RECEPTORS 审中-公开
标题翻译：作为GASTRIN受体的配体的ALPHA-甲基 - （R） - 三氟乙烯基二甲基戊二酰胺
公开(公告)号：WO1994015917A1
公开(公告)日：1994-07-21
申请号：PCT/FR1994000033
申请日：1994-01-11
申请人： INSTITUT DE RECHERCHE JOUVEINAL (I.R.J.) , PASCAL, Yves , CALVET, Alain, Pierre , GROUHEL, Agnès , JUNIEN, Jean-Louis , PASCAUD, Xavier, Bernard, Louis , ROMAN, François, Joseph , WETTSTEIN, Joseph
发明人： INSTITUT DE RECHERCHE JOUVEINAL (I.R.J.)
IPC分类号： C07D209/20
CPC分类号： C07D401/12 , C07D209/20 , C07D403/12
摘要： An alpha -methyl-R-tryptophyl-arylcycloalkylalkylamide of formula (I), wherein (B) is methylene or ethylene, (C) is a valency bond or methylene, A is a valency bond or aminocarbonyl, p is 0, 1 or 2, R1 is a 1H-tetrazol-5-yl group, a carbonyl function -CO-R2 where R2 is hydroxyl, alkoxy or a cycloalkylamine, and * is the absolute configuration, according to Cahn, Ingold and Prelog, of the carbon atom adjacent thereto. It is useful as a drug for treating gastric and/or central nervous system disorders.
摘要翻译：式（I）的α-甲基-R-色氨酰 - 芳基环烷基烷基酰胺，其中（B）为亚甲基或亚乙基，（C）为价键或亚甲基，A为价键或氨基羰基，p为0,1或2 R1是1H-四唑-5-基，羰基官能团-CO-R2，其中R2是羟基，烷氧基或环烷基胺，*是绝对构型，根据Cahn，Ingold和Prelog，相邻的碳原子于此。它可用作治疗胃和/或中枢神经系统疾病的药物。

7. 发明申请

WO1997036905A1 DIAZEPINO-INDOLES AS PHOSPHODIESTERASE IV INHIBITORS 审中-公开
标题翻译： DIAZEPINO-INDOLES作为磷酸二酯酶IV抑制剂
公开(公告)号：WO1997036905A1
公开(公告)日：1997-10-09
申请号：PCT/FR1997000557
申请日：1997-03-27
申请人： INSTITUT DE RECHERCHE JOUVEINAL , PASCAL, Yves , JACOBELLI, Henry , CALVET, Alain , PAYNE, Adrian , DAHL, Svein, G.
发明人： INSTITUT DE RECHERCHE JOUVEINAL
IPC分类号： C07D487/06
CPC分类号： C07D487/06
摘要： Diazepino-indoles of formula (I), wherein A is mono- to trisubstituted aryl or heteroaryl, and B is an -OR1 or -NR2R3 group where R1, R2 and R3 are particularly hydrogen, and racemic forms, enantiomers and pharmaceutically acceptable salts thereof, as phosphodiesterase IV inhibitors, are disclosed.
摘要翻译：式（I）的二氮杂 - 吲哚，其中A是一至三取代的芳基或杂芳基，B是其中R 1，R 2和R 3特别是氢的-OR 1或-NR 2 R 3基团，外消旋形式，对映异构体和药学上可接受的盐，作为磷酸二酯酶IV抑制剂。

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