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1. 发明申请

WO2008106174A1 ELECTRICAL STIMULATION DEVICE AND METHOD FOR THE TREATMENT OF NEUROLOGICAL DISORDERS 审中-公开
标题翻译：电刺激装置和治疗神经病的方法
公开(公告)号：WO2008106174A1
公开(公告)日：2008-09-04
申请号：PCT/US2008/002601
申请日：2008-02-27
申请人： ACCELERATED CARE PLUS CORP. , PALERMO, Francis, X. , CASTEL, Chris., J.
发明人： PALERMO, Francis, X. , CASTEL, Chris., J.
IPC分类号： A61N1/18
CPC分类号： A61N1/323 , A61N1/0452 , A61N1/0456 , A61N1/0476 , A61N1/0492 , A61N1/0526 , A61N1/0531 , A61N1/0548 , A61N1/20 , A61N1/36003 , A61N1/36025 , A61N1/36146
摘要： An electrical stimulation system and method for the treatment of neurological disorders is disclosed. In a preferred embodiment, the electrical stimulation system includes channels of electrodes (18a, 18b, 20a, 20b) positioned in electrical contact with tissue of a neuromuscular target body region of a patient to provide pattered neuromuscular stimulation to the patient's musculature. In addition, at least one electrode (118a, 118b, 120a 120b) from a channel is positioned in electrical contact with a tissue of the motor control region of the brain (135a, 135b, 135c). A series of patterned electrical pulses are then applied to the patient through the channels to provide peripheral neuromuscular stimulation, and a direct current is applied transcranially to the brain. Various exemplary embodiments of the invention are disclosed.
摘要翻译：公开了一种用于治疗神经障碍的电刺激系统和方法。在优选实施例中，电刺激系统包括定位成与患者的神经肌肉靶体区域的组织电接触的电极通道（18a，18b，20a，20b），以向患者的肌肉组织提供图案化的神经肌肉刺激。此外，来自通道的至少一个电极（118a，118b，120a，120b）定位成与脑（135a，135b，135c）的马达控制区域的组织电接触。然后通过通道将一系列图案化的电脉冲施加到患者以提供周围神经肌肉刺激，并且将直流电经常地施加到脑上。公开了本发明的各种示例性实施例。

2. 发明申请

WO2007081764A3 ELECTRICAL STIMULATION DEVICE AND METHOD FOR THE TREATMENT OF DYSPHAGIA 审中-公开
标题翻译：电刺激装置和用于治疗脱毛症的方法
公开(公告)号：WO2007081764A3
公开(公告)日：2007-12-21
申请号：PCT/US2007000211
申请日：2007-01-04
申请人： ACCELERATED CARE PLUS CORP , CASTEL CHRIS J , PALERMO FRANCIS X
发明人： CASTEL CHRIS J , PALERMO FRANCIS X
IPC分类号： A61N1/00
CPC分类号： A61N1/36014 , A61N1/0456 , A61N1/36007 , A61N1/3601
摘要： An electrical stimulation device (10) and method for the treatment of dysphagia is disclosed. In a preferred embodiment, the electrical stimulation device (10) includes one or more channels of electrodes (18a, 18b, 2Oa5 20b) each of which includes a first electrode (18a, 20a) positioned in electrical contact with tissue of a target region of a patient and a second electrode (18b, 20b) positioned in electrical contact with tissue of a posterior neck region or a posterior thoracic region of the patient. A series of electrical pulses are then applied to the patient through the one or more channels of electrodes (18a, 18b, 20a, 20b) in accordance with a procedure for treating dysphagia. The series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; a plurality of cycles of a triphasic overlapping pulse train pattern; a functional pulse train pattern; a low-frequency pulse train pattern; or a frequency-sequenced pulse burst train pattern. Various exemplary embodiments of the invention are disclosed.
摘要翻译：公开了用于治疗吞咽困难的电刺激装置（10）和方法。在一个优选实施例中，电刺激设备（10）包括一个或多个电极通道（18a，18b，20a，20b），每个电极通道包括与第一电极（18a，20a）患者和定位成与患者的后颈部区域或后胸部区域的组织电接触的第二电极（18b，20b）。然后根据治疗吞咽困难的程序通过一个或多个电极通道（18a，18b，20a，20b）向患者施加一系列电脉冲。该一系列电脉冲可以包括：双相顺序脉冲串模式的多个周期; 双相重叠脉冲串模式的多个周期; 三相顺序脉冲串模式的多个周期; 三相重叠脉冲串模式的多个周期; 功能脉冲串模式; 低频脉冲串模式; 或频率顺序脉冲串模式。公开了本发明的各种示例性实施例。

3. 发明申请

WO2010002517A1 ELECTRICAL STIMULATION METHOD FOR TREATMENT OF PERIPHERAL NEUROPATHY 审中-公开
标题翻译：用于治疗外周神经病变的电刺激方法
公开(公告)号：WO2010002517A1
公开(公告)日：2010-01-07
申请号：PCT/US2009/044928
申请日：2009-05-22
申请人： ACCELERATED CARE PLUS CORP. , CASTEL, J., Chris , PALERMO, Francis, X.
发明人： CASTEL, J., Chris , PALERMO, Francis, X.
IPC分类号： A61N1/00
CPC分类号： A61N1/36003 , A61K31/00 , A61K31/047 , A61K31/135 , A61K31/138 , A61K31/167 , A61K31/195 , A61K31/197 , A61K31/202 , A61K31/357 , A61K31/381 , A61K31/385 , A61K31/407 , A61K31/4164 , A61K31/4415 , A61K31/485 , A61K31/506 , A61K31/55 , A61K31/714 , A61K38/185 , A61N1/36021
摘要： An electrical stimulation method for the treatment of peripheral neuropathy is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device (10) that includes a plurality of channels of electrodes (18a, 18b, 20a, and 20b) each of which includes a first and second electrode positioned in electrical contact with tissue of a target region suffering from peripheral neuropathy. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion in the peripheral body regions are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for treating peripheral neuropathy. The patterned series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; and a plurality of cycles of a triphasic overlapping pulse train pattern.
摘要翻译：公开了一种治疗周围神经病变的电刺激方法。在优选实施例中，该方法使用电刺激装置（10），其包括多个电极通道（18a，18b，20a和20b），每个电极包括与第一和第二电极电连接的第一和第二电极目标区域患有周围神经病变。参与外展/内收，屈曲/伸展，仰卧/旋转，伸出/缩回和/或外周体区域中的/反转/反转的激动剂/拮抗剂肌肉通过根据电极的通道的电极的图案化系列的电脉冲被刺激治疗周围神经病的手术。图案化的一系列电脉冲可以包括：多个循环的双相顺序脉冲串模式; 双相重叠脉冲序列的多个周期; 三相序列脉冲串模式的多个周期; 以及三相重叠脉冲串模式的多个周期。

4. 发明申请

WO1995033516A1 ELECTRONIC NEUROMUSCULAR STIMULATION DEVICE 审中-公开
标题翻译：电子神经刺激装置
公开(公告)号：WO1995033516A1
公开(公告)日：1995-12-14
申请号：PCT/US1995006665
申请日：1995-05-31
申请人： PALERMO, Francis, X.
IPC分类号： A61N01/18
CPC分类号： A61N1/36021 , A61N1/0452 , A61N1/36003
摘要： An electronic neuromuscular stimulation device (10) that is operated by a computerized electronic control unit (20). The unit (20) includes at least two and preferably four output channels to which are connected a corresponding set of electrode output cables (12). Each cable has attached a positive electrode (12D) and a negative electrode (12E) that are attached to selected areas of a patient's anatomy. The unit (20) also includes controls, indicators, and circuitry that produce nerve stimulation pulses that are applied to the patient through the electrodes (12D, 12E). The nerve stimulation pulses consist of individual pulses that are arranged into pulse trains and pulse train patterns. The pulse train patterns, whose selection depends on the type of ailment being treated, includes sequential patterns, delayed overlapping patterns, triple-phase overlapping patterns, reciprocal pulse trains, and delayed sequenced "sprint interval" patterns. The overlapping patterns are particularly timed to take advantage of neurological enhancement.
摘要翻译：一种由计算机化电子控制单元（20）操作的电子神经肌肉刺激装置（10）。单元（20）包括至少两个并且优选地四个输出通道，其中连接有相应的一组电极输出电缆（12）。每个电缆已经附接到附接到患者解剖结构的选定区域的正电极（12D）和负电极（12E）。单元（20）还包括产生通过电极（12D，12E）施加到患者的神经刺激脉冲的控制，指示器和电路。神经刺激脉冲由布置成脉冲序列和脉冲序列模式的单个脉冲组成。脉冲序列模式的选择取决于被治疗的疾病的类型，包括顺序模式，延迟重叠模式，三相重叠模式，倒数脉冲序列和延迟排序的“冲刺间隔”模式。重叠模式特别适合利用神经功能的增强。

5. 发明申请

WO2009155436A1 ELECTRICAL STIMULATION METHOD FOR REDUCTION OF JOINT COMPRESSION 审中-公开
标题翻译：用于减少联合压缩的电刺激方法
公开(公告)号：WO2009155436A1
公开(公告)日：2009-12-23
申请号：PCT/US2009/047822
申请日：2009-06-18
申请人： ACCELERATED CARE PLUS CORP. , CASTEL, J., Cris , PALERMO, Francis, X.
发明人： CASTEL, J., Cris , PALERMO, Francis, X.
IPC分类号： A61N1/18
CPC分类号： A61N1/0452 , A61N1/36003 , A61N1/36014
摘要： An electrical stimulation method for the reduction of joint compression is disclosed. In a preferred embodiment, the method utilizes an electrical stimulation device that includes a plurality of channels of electrodes each of which includes at least a first and second electrode positioned in electrical contact with tissue of at least two muscles crossing a joint. Agonist/antagonist muscles involved in abduction/adduction, flexion/extension, supination/pronation, protraction/retraction, and/or eversion/inversion of body regions via joint movement are stimulated with a patterned series of electrical pulses through channels of electrodes in accordance with a procedure for reducing joint compression. The patterned series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; and a plurality of cycles of a triphasic overlapping pulse train pattern.
摘要翻译：公开了一种用于减少接头压缩的电刺激方法。在优选实施例中，该方法使用电刺激装置，其包括多个电极通道，每个通道包括至少第一和第二电极，其定位成与至少两个穿过关节的肌肉的组织电接触。根据电极的通道通过电脉冲的图案化系列来刺激参与外展/内收，屈曲/伸展，仰卧/旋前，伸展/缩回和/或通过关节运动的身体区域的外翻/反转的激动剂/拮抗剂肌肉减少关节压缩的程序。图案化的一系列电脉冲可以包括：多个循环的双相顺序脉冲串模式; 双相重叠脉冲序列的多个周期; 三相序列脉冲串模式的多个周期; 以及三相重叠脉冲串模式的多个周期。

6. 发明申请

WO2007081764A2 ELECTRICAL STIMULATION DEVICE AND METHOD FOR THE TREATMENT OF DYSPHAGIA 审中-公开
标题翻译：电刺激装置及其治疗方法
公开(公告)号：WO2007081764A2
公开(公告)日：2007-07-19
申请号：PCT/US2007/000211
申请日：2007-01-04
申请人： ACCELERATED CARE PLUS CORP. , CASTEL, Chris, J. , PALERMO, Francis, X.
发明人： CASTEL, Chris, J. , PALERMO, Francis, X.
IPC分类号： A61N1/00
CPC分类号： A61N1/36014 , A61N1/0456 , A61N1/36007 , A61N1/3601
摘要： An electrical stimulation device (10) and method for the treatment of dysphagia is disclosed. In a preferred embodiment, the electrical stimulation device (10) includes one or more channels of electrodes (18a, 18b, 2Oa5 20b) each of which includes a first electrode (18a, 20a) positioned in electrical contact with tissue of a target region of a patient and a second electrode (18b, 20b) positioned in electrical contact with tissue of a posterior neck region or a posterior thoracic region of the patient. A series of electrical pulses are then applied to the patient through the one or more channels of electrodes (18a, 18b, 20a, 20b) in accordance with a procedure for treating dysphagia. The series of electrical pulses may comprise: a plurality of cycles of a biphasic sequential pulse train pattern; a plurality of cycles of a biphasic overlapping pulse train pattern; a plurality of cycles of a triphasic sequential pulse train pattern; a plurality of cycles of a triphasic overlapping pulse train pattern; a functional pulse train pattern; a low-frequency pulse train pattern; or a frequency-sequenced pulse burst train pattern. Various exemplary embodiments of the invention are disclosed.
摘要翻译：公开了一种电刺激装置（10）和治疗吞咽困难的方法。在优选实施例中，电刺激装置（10）包括一个或多个通道的电极（18a，18b，20Aa，20b），每个通道包括与第一电极（18a，20a）电连接的第一电极患者和与患者的后颈部区域或后胸部区域的组织电接触的第二电极（18b，20b）。根据治疗吞咽困难的过程，通过电极的一个或多个通道（18a，18b，20a，20b）向病人施加一系列电脉冲。一系列电脉冲可以包括：多个循环的双相顺序脉冲串模式; 双相重叠脉冲序列的多个周期; 三相序列脉冲串模式的多个周期; 三相重叠脉冲序列的多个周期; 功能脉冲串模式; 低频脉冲串模式; 或频率序列脉冲串列表模式。公开了本发明的各种示例性实施例。

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