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1. 发明申请

WO2012076150A1 RADIOTHERAPEUTIC APPARATUS 审中-公开
标题翻译：放射治疗仪
公开(公告)号：WO2012076150A1
公开(公告)日：2012-06-14
申请号：PCT/EP2011/006100
申请日：2011-12-06
申请人： ELEKTA AB (PUBL) , KONINKLIJKE PHILIPS ELECRONICS N.V. , KNOX, Christopher , BOURNE, Duncan , OVERWEG, Johan , RIETMA, Jan
发明人： KNOX, Christopher , BOURNE, Duncan , OVERWEG, Johan , RIETMA, Jan
IPC分类号： A61N5/10
CPC分类号： A61N5/1049 , A61B5/055 , A61B5/4836 , A61N5/1081 , A61N2005/1055
摘要： This application deals with practical problems relating to the delivery of power to a radiotherapeutic source that is being operated in conjunction with a magnetic imaging device. Given that the source needs to rotate around the patient, this power will usually be delivered by way of a slip ring arrangement that may create stray magnetic fields that degrade the image quality. We therefore provide a radiotherapeutic apparatus comprising a patient support, magnetic coils disposed around the patient support for creating a magnetic field therewithin, a radiation source producing a beam of radiation directed toward the patient support and mounted on a rotatable support thereby to rotate the radiation source around the patient support, a slip ring for conveying electrical power to the radiation source and located around the patient support, including at least one electrical interruption therein. This creates a slip ring in which there is no continuous circumferential path, and one in which the current is therefore forced to take a route via one side or the other. A corresponding treatment planning apparatus, and method of generating a treatment plan are also disclosed.
摘要翻译：该应用涉及与向磁性成像装置结合操作的放射治疗源的功率递送相关的实际问题。鉴于源需要围绕患者旋转，该功率通常将通过滑环布置递送，这可能产生降低图像质量的杂散磁场。因此，我们提供一种放射治疗装置，其包括患者支架，围绕患者支架设置的磁性线圈，用于在其中产生磁场;辐射源，产生朝向患者支架的辐射束，并安装在可旋转的支撑件上，从而使辐射源围绕患者支撑件，用于将电力传送到辐射源并位于患者支架周围的滑环，包括其中的至少一个电中断。这产生了一个滑环，其中没有连续的圆周路径，并且其中电流被迫经由一侧或另一侧进行路线的滑环。还公开了相应的治疗计划装置和产生治疗计划的方法。

2. 发明申请

WO2007066247A3 SYSTEM AND METHOD FOR MONITORING IN VIVO DRUG RELEASE USING OVERHAUSER-ENHANCED NMR 审中-公开
标题翻译：使用过氧化氢增强核磁共振监测血液药物释放的系统和方法
公开(公告)号：WO2007066247A3
公开(公告)日：2008-08-21
申请号：PCT/IB2006054273
申请日：2006-11-15
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , OVERWEG JOHAN
发明人： OVERWEG JOHAN
IPC分类号： A61K49/00 , A61K41/00 , A61K49/06 , A61K49/18
CPC分类号： A61K49/18 , A61K49/0002 , A61K49/20
摘要： Systems and methods for monitoring in vivo release of therapeutic and/or diagnostic agents, e.g., drugs, are provided. The disclosed systems and methods use a contrast agent and Overhauser-enhanced nuclear magnetic resonance (NMR) to monitor and/or measure the concentration and distribution of the contrast agent. Provided the contrast agent and the therapeutic/diagnostic agent have similar pharmaco-kinetics, the disclosed system/method may also be used to monitor and/or measure the concentration of such therapeutic/diagnostic agent (e.g., a drug), e.g., in the form of a volume-averaged signal and/or dynamic two-dimensional or three-dimensional images. In exemplary embodiments of the present disclosure, the therapeutic/diagnostic agent and the contrast agent are introduced to the body in an encapsulated form, e.g., within hollow nanoparticles.
摘要翻译：提供了用于监测体内释放治疗和/或诊断剂例如药物的系统和方法。所公开的系统和方法使用造影剂和Overhauser增强的核磁共振（NMR）来监测和/或测量造影剂的浓度和分布。如果造影剂和治疗/诊断剂具有相似的药物动力学，则所公开的系统/方法也可用于监测和/或测量此类治疗/诊断剂（例如药物）的浓度，例如在体积平均信号和/或动态二维或三维图像的形式。在本公开的示例性实施方案中，将治疗/诊断剂和造影剂以封装形式引入身体，例如在中空纳米颗粒内。

3. 发明申请

WO1994001983A1 WIGGLER WITH CONCENTRIC COIL ARRANGEMENT 审中-公开
标题翻译：与同心螺线圈组件的扭摆
公开(公告)号：WO1994001983A1
公开(公告)日：1994-01-20
申请号：PCT/EP1993001767
申请日：1993-07-07
申请人： SIEMENS AKTIENGESELLSCHAFT , OVERWEG, Johan
发明人： SIEMENS AKTIENGESELLSCHAFT
IPC分类号： H05H07/04
CPC分类号： H05H7/04
摘要： The invention relates to a wiggler with a longitudinal axis (1), a normal axis (2) intersecting and perpendicular to it and two coil arrangements arranged at a distance apart along the normal axis (2) and in substantially mirror image fashion in relation to a vertical central plane perpendicular to the main axis (2) and containing the longitudinal axis (1). Each coil arrangement has a plurality of coils (3, 4, 11). An inner coil (3) which is axially symmetrical in relation to the normal axis (2) is surrounded by an outer coil (4) which is axially symmetrical in relation to the normal axis (2). The inner coil (3) is preferably in the shape of a racetrack; the outer coil (4) may be circularly symmetrical. In addition, one coil (3, 4) of each coil arrangement may be associated with a balance coil (11) which can compensate the mechanical forces arising directly between corresponding coils (3, 4) of different coil arrangements. The wiggler is especially suitable for superconducting coils (3, 4, 11), particularly for the generation of a magnetic field of between 4 and 5 Tesla, and for use in synchrotron radiation sources.

4. 发明申请

WO2008084438A2 PET/MR SCANNERS FOR SIMULTANEOUS PET AND MR IMAGING 审中-公开
标题翻译： PET / MR扫描仪用于同时PET和MR成像
公开(公告)号：WO2008084438A2
公开(公告)日：2008-07-17
申请号：PCT/IB2008/050046
申请日：2008-01-08
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , U.S. PHILIPS CORPORATION , SCHULZ, Volkmar , SOLF, Torsten , OVERWEG, Johan , THON, Andreas
发明人： SCHULZ, Volkmar , SOLF, Torsten , OVERWEG, Johan , THON, Andreas
IPC分类号： A61B5/055 , G01R33/42 , G01T1/161
CPC分类号： A61B5/0035 , A61B6/037 , A61B6/4417 , A61B6/5247 , G01R33/481 , G01T1/1603
摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.
摘要翻译：在组合系统中，磁共振（MR）扫描器包括至少在从其获取MR数据的MR检查区域（12）中产生静态磁场（B0）的磁体（10,110）。辐射检测器（40,41,140）被配置为检测由正电子发射断层摄影（PET）检查区域（70）中的正电子 - 电子湮灭事件产生的伽马射线。辐射5检测器包括具有与静态磁场（B0）基本平行或反平行排列的电子加速度（ae）方向的电子倍增器元件（60,160）。在一些实施例中，磁体是具有设置在磁性10共振检查区域的相对侧上的第一和第二间隔开的磁极片（14,15）的开放磁体，并且辐射检测器包括第一和第二阵列（40,41）的辐射探测器，其布置有第一和第二间隔开的磁极片。

5. 发明申请

WO2007149824A3 MAGNETIC RESONANCE RECEIVE COIL ARRAY INTEGRATED INTO WALL OF SCANNER BORE 审中-公开
标题翻译：磁共振接收线圈阵列集成到扫描器的壁上
公开(公告)号：WO2007149824A3
公开(公告)日：2008-03-27
申请号：PCT/US2007071504
申请日：2007-06-19
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , OVERWEG JOHAN A , WIRTZ DANIEL
发明人： OVERWEG JOHAN A , WIRTZ DANIEL
IPC分类号： G01R33/341 , G01R33/3415
CPC分类号： G01R33/341 , G01R33/3415 , G01R33/3621 , G01R33/3642 , G01R33/3657
摘要： In a magnetic resonance scanner, a radio frequency transmit coil (30, 30') includes a plurality of parallel rods rungs (32, 32', 32' ') at least partially surrounding an examination region. The radio frequency transmit coil is configured to transmit radio frequency energy into the examination region at or near a magnetic resonance frequency. A plurality of magnetic resonance receive coils (40) are disposed with the radio frequency transmit coil. For decoupling, each magnetic resonance receive coil is positioned substantially centered on a proximate one rod or rung or proximate plurality of neighboring rods or rungs of the radio frequency transmit coil.
摘要翻译：在磁共振扫描器中，射频发射线圈（30,30'）包括至少部分地围绕检查区域的多个平行杆梯级（32,32'，32“）。射频发射线圈被配置为在磁谐振频率处或接近磁共振频率处将射频能量传送到检查区域。多个磁共振接收线圈（40）与射频发射线圈配置。为了解耦，每个磁共振接收线圈基本上定位在射频发射线圈的邻近的一个杆或梯级或邻近的多个相邻杆或梯级的中心。

6. 发明申请

WO2007149824A2 MAGNETIC RESONANCE RECEIVE COIL ARRAY INTEGRATED INTO WALL OF SCANNER BORE 审中-公开
标题翻译：磁共振接收线圈阵列集成到扫描器的壁上
公开(公告)号：WO2007149824A2
公开(公告)日：2007-12-27
申请号：PCT/US2007/071504
申请日：2007-06-19
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , OVERWEG, Johan, A. , WIRTZ, Daniel
发明人： OVERWEG, Johan, A. , WIRTZ, Daniel
CPC分类号： G01R33/341 , G01R33/3415 , G01R33/3621 , G01R33/3642 , G01R33/3657
摘要： In a magnetic resonance scanner, a radio frequency transmit coil (30, 30') includes a plurality of parallel rods rungs (32, 32', 32'') at least partially surrounding an examination region. The radio frequency transmit coil is configured to transmit radio frequency energy into the examination region at or near a magnetic resonance frequency. A plurality of magnetic resonance receive coils (40) are disposed with the radio frequency transmit coil. Each magnetic resonance receive coil is positioned substantially centered on a proximate one rod or rung or proximate plurality of neighboring rods or rungs of the radio frequency transmit coil.
摘要翻译：在磁共振扫描器中，射频发射线圈（30,30'）包括至少部分地围绕检查区域的多个平行杆梯级（32,32'，32“）。射频发射线圈被配置为在磁谐振频率处或接近磁共振频率处将射频能量传送到检查区域。多个磁共振接收线圈（40）与射频发射线圈配置。每个磁共振接收线圈基本上定位在射频发射线圈的邻近的一个杆或梯级或邻近的多个相邻杆或梯级的中心。

7. 发明申请

WO2007066247A2 SYSTEM AND METHOD FOR MONITORING IN VIVO DRUG RELEASE USING OVERHAUSER-ENHANCED NMR 审中-公开
标题翻译：使用过氧化物增强型核磁共振检测血液药物释放的系统和方法
公开(公告)号：WO2007066247A2
公开(公告)日：2007-06-14
申请号：PCT/IB2006/054273
申请日：2006-11-15
申请人： KONINKLIJKE PHILIPS ELECTRONICS, N.V. , U.S. PHILIPS CORPORATION , OVERWEG, Johan
发明人： OVERWEG, Johan
IPC分类号： A61K49/18
CPC分类号： A61K49/18 , A61K49/0002 , A61K49/20
摘要： Systems and methods for monitoring in vivo release of therapeutic and/or diagnostic agents, e.g., drugs, are provided. The disclosed systems and methods use a contrast agent and Overhauser-enhanced nuclear magnetic resonance (NMR) to monitor and/or measure the concentration and distribution of the contrast agent. Provided the contrast agent and the therapeutic/diagnostic agent have similar pharmaco-kinetics, the disclosed system/method may also be used to monitor and/or measure the concentration of such therapeutic/diagnostic agent (e.g., a drug), e.g., in the form of a volume-averaged signal and/or dynamic two-dimensional or three-dimensional images. In exemplary embodiments of the present disclosure, the therapeutic/diagnostic agent and the contrast agent are introduced to the body in an encapsulated form, e.g., within hollow nanoparticles.
摘要翻译：提供了用于监测体内释放治疗和/或诊断剂例如药物的系统和方法。所公开的系统和方法使用造影剂和Overhauser增强核磁共振（NMR）来监测和/或测量造影剂的浓度和分布。如果造影剂和治疗/诊断剂具有相似的药物动力学，则所公开的系统/方法也可用于监测和/或测量此类治疗/诊断剂（例如药物）的浓度，例如在体积平均信号和/或动态二维或三维图像的形式。在本公开的示例性实施方案中，将治疗/诊断剂和造影剂以封装形式引入身体，例如在中空纳米颗粒内。

8. 发明申请

WO2008084438A3 PET/MR SCANNERS FOR SIMULTANEOUS PET AND MR IMAGING 审中-公开
标题翻译：用于同时PET和MR成像的PET / MR扫描仪
公开(公告)号：WO2008084438A3
公开(公告)日：2008-11-06
申请号：PCT/IB2008050046
申请日：2008-01-08
申请人： KONINKL PHILIPS ELECTRONICS NV , PHILIPS CORP , SCHULZ VOLKMAR , SOLF TORSTEN , OVERWEG JOHAN , THON ANDREAS
发明人： SCHULZ VOLKMAR , SOLF TORSTEN , OVERWEG JOHAN , THON ANDREAS
IPC分类号： A61B5/055 , G01R33/42 , G01T1/161
CPC分类号： A61B5/0035 , A61B6/037 , A61B6/4417 , A61B6/5247 , G01R33/481 , G01T1/1603
摘要： In a combined system, a magnetic resonance (MR) scanner includes a magnet (10, 110) configured to generate a static magnetic field (B0) at least in a MR examination region (12) from which MR data are acquired. Radiation detectors (40, 41, 140) are configured to detect gamma rays generated by positron-electron annihilation events in a positron emission tomography (PET) examination region (70). The radiation 5 detectors include electron multiplier elements (60, 160) having a direction of electron acceleration (ae) arranged substantially parallel or anti-parallel with the static magnetic field (B0). In some embodiments, the magnet is an open magnet having first and second spaced apart magnet pole pieces (14, 15) disposed on opposite sides of a magnetic 10 resonance examination region, and the radiation detectors include first and second arrays (40, 41) of radiation detectors disposed with the first and second spaced apart magnet pole pieces.
摘要翻译：在组合系统中，磁共振（MR）扫描仪包括磁体（10,110），该磁体被配置为至少在MR检查区域（12）中产生静磁场（B0），MR检测区域（12）从其获取MR数据。辐射探测器（40,41,140）被配置为探测由正电子发射断层摄影（PET）检查区域（70）中的正电子 - 电子湮灭事件产生的伽马射线。辐射探测器包括具有与静态磁场（B 0）基本平行或反平行布置的电子加速度（ae）方向的电子倍增器元件（60,160）。在一些实施例中，磁体是具有设置在磁共振检查区域的相对侧上的第一和第二间隔开的磁极片（14,15）的开放磁体，并且辐射检测器包括第一和第二阵列（40,41）辐射检测器设置有第一和第二间隔开的磁极片。

9. 发明申请

WO2008122899A1 SPLIT GRADIENT COIL AND PET/MRI HYBRID SYSTEM USING THE SAME 审中-公开
标题翻译：分离梯度线圈和使用相同的PET / MRI混合系统
公开(公告)号：WO2008122899A1
公开(公告)日：2008-10-16
申请号：PCT/IB2008/050151
申请日：2008-01-16
申请人： KONINKLIJKE PHILIPS ELECTRONICS N.V. , OVERWEG, Johan, A. , SCHULZ, Volkmar , SOLF, Torsten, J. , DEMEESTER, Gordon, D. , MORICH, Michael, A.
发明人： OVERWEG, Johan, A. , SCHULZ, Volkmar , SOLF, Torsten, J. , DEMEESTER, Gordon, D. , MORICH, Michael, A.
IPC分类号： G01R33/385 , G01R33/421 , G01R33/48 , A61B5/055 , G01R33/3875
CPC分类号： G01R33/481 , A61B5/0035 , A61B5/055 , G01R33/385 , G01R33/3875 , G01R33/421 , G01R33/4215 , G01R33/4808
摘要： A generally cylindrical set of coil windings (10, 30, 80) includes primary coil windings (12, 32, 82) and shield coil windings (14, 34, 84) at a larger radial position than the primary coil windings, and an arcuate or annular central gap (16, 36, 86) that is free of coil windings, has an axial extent (W) of at least ten centimeters, and spans at least a 180° angular interval. Connecting conductors (24, 44, 94) disposed at each edge of the central gap electrically connect selected primary and secondary coil windings. In a scanner setting, a main magnet (62, 64) is disposed outside of the generally cylindrical set of coil windings. In a hybrid scanner setting, an annular ring of positron emission tomography (PET) detectors (66) is disposed in the central gap of the generally cylindrical set of coil windings.
摘要翻译：一般为圆柱形的线圈绕组（10,30,80）包括在比初级线圈绕组更大的径向位置处的初级线圈绕组（12,32,82）和屏蔽线圈绕组（14,34,84），以及弧形或没有线圈绕组的环形中心间隙（16,36,86）具有至少十厘米的轴向范围（W）并跨越至少180°的角度间隔。设置在中心间隙的每个边缘处的连接导体（24,44,94）电连接所选择的初级和次级线圈绕组。在扫描器设置中，主磁体（62,64）设置在大致圆柱形的线圈绕组的外侧。在混合扫描器设置中，正电子发射断层摄影（PET）检测器（66）的环形环设置在大致圆柱形的线圈绕组组的中心间隙中。

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