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1. 发明申请

WO2009112038A2 A MICROFLUIDIC SYSTEM AND A METHOD OF PERFORMING A TEST 审中-公开
标题翻译：微流控系统及其测试方法
公开(公告)号：WO2009112038A2
公开(公告)日：2009-09-17
申请号：PCT/DK2009/050058
申请日：2009-03-13
申请人： SCANDINAVIAN MICRO BIODEVICES ApS , BAU-MADSEN, Niels Kristian , JONSMANN, Jacques , OVERBY, Bent , BERENDSEN, Christianus
发明人： BAU-MADSEN, Niels Kristian , JONSMANN, Jacques , OVERBY, Bent , BERENDSEN, Christianus
IPC分类号： G01N33/49 , G01N33/86 , B01L3/00
CPC分类号： G01N33/4905 , B01L3/5027 , B01L2200/0684 , B01L2200/148 , B01L2300/0654 , B01L2300/0883 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , G01N33/5304 , G01N33/86
摘要： The invention relates to a microfluidic system comprising a microfluidic device having a first and a second opposite surfaces and an optical detector, the microfluidic device comprises a flow channel with a detection channel section having a length of at least about 1mm, the microfluidic device comprises at least one aperture section comprising at least a part of said detection channel section and a transparent window into said detection channel section, the optical detector is arranged to be in optical communication with said aperture section to determining at least one optical property of said aperture section as a function of time. The flow channel may have capillary dimensions and/or it may wholly or fully be arranged to drive a fluid flow by applying external forces. The optical detector may preferably be arranged to transmit light onto the aperture section and to detect a light transmission from the aperture section, wherein the light transmission from the aperture section being selected from light transmitted through the sample,reflectance scattering of light, transmittance scattering of light and any combinations thereof. The micro fluid device may be used to determine various properties of a sample fluid, for example it may be used to determine a samples coagulation properties and/or reactions of one or more components in a fluid sample as a function of time.
摘要翻译：本发明涉及一种微流体系统，其包括具有第一和第二相对表面的微流体装置和光学检测器，所述微流体装置包括具有至少约1mm长度的检测通道部分的流动通道，所述微流体装置包括至少一个孔径部分，其包括所述检测通道部分的至少一部分和在所述检测通道部分中的透明窗口，所述光学检测器布置成与所述孔部分光学连通，以将所述孔部分的至少一个光学特性确定为时间的功能。流动通道可以具有毛细管尺寸和/或其可以完全或完全地布置成通过施加外力来驱动流体流动。光检测器可以优选地被布置成将光透射到孔部分上并且检测从孔部分的光透射，其中来自孔部分的光透射选自透过样品的光，光的反射散射，透射散射光及其任何组合。微流体装置可以用于确定样品流体的各种性质，例如其可用于确定样品凝固性质和/或作为时间的函数的流体样品中的一种或多种组分的反应。

2. 发明申请

WO2006061026A2 A MICRO FLUIDIC DEVICE AND METHODS FOR PRODUCING A MICRO FLUIDIC DEVICE 审中-公开
标题翻译：一种用于生产微流体装置的微流体装置和方法
公开(公告)号：WO2006061026A2
公开(公告)日：2006-06-15
申请号：PCT/DK2005/050009
申请日：2005-12-07
申请人： SCANDINAVIAN MICRO BIODEVICES A/S , BAU-MADSEN, Niels Kristian , BARHOLM-HANSEN, Claus , JONSMANN, Jacques , OVERBY, Bent
发明人： BAU-MADSEN, Niels Kristian , BARHOLM-HANSEN, Claus , JONSMANN, Jacques , OVERBY, Bent
CPC分类号： B01L3/502746 , B81B2203/0323
摘要： The invention relates to a micro fluidic device comprising a flow channel with an interface between a cartridge base and a lid, as well as methods of producing it. The cartridge base comprises a channel shaped depression and the lid is bonded to said cartridge base to form the flow channel: The interface between the cartridge base and the lid, adjacent to and along with the flow channel comprises at least two, such as three or more capillary gap sections in the form of a gap between the Ii and the cartridge base, separated by a flow break section, which flow break section provides a barrier for a capillary flow of liquid along adjoining capillary gap sections . In one embodiment the surface of at least one of the cartridge base and the lid in the interface between the cartridge base and the lid in the flow break sections, adjacent to and along with the flow channel, is less hydrophilic than one or both of the surfaces of the c art ridge base and the lid in said capillary gap sections. In one embodiment the bonding material has at least partly penetrated into the flow channel.
摘要翻译：本发明涉及一种微流体装置，其包括具有在盒基座和盖子之间的界面的流动通道，以及其制造方法。墨盒底座包括通道形状的凹陷部分，并且盖子结合到所述墨盒底座以形成流动通道：墨盒底座和盖子之间的与流动通道相邻并与流动通道一起的界面包括至少两个，例如三个或更多的毛细孔隙部分以Ii和药筒基座之间的间隙的形式形成，由流动断裂部分分开，该流动断裂部分为沿着相邻的毛细管间隙部分的液体的毛细管流动提供了屏障。在一个实施例中，与底部和盖子之间的界面中的至少一个的位于流动断裂部分中的与流动通道相邻并与流动通道相邻的表面的表面的亲水性比其中一个或两个所述毛细孔隙部分中的c形脊底和盖的表面。在一个实施例中，接合材料至少部分地穿透到流动通道中。

3. 发明申请

WO2009112038A3 A MICROFLUIDIC SYSTEM AND A METHOD OF PERFORMING A TEST 审中-公开
标题翻译：微流控系统及其测试方法
公开(公告)号：WO2009112038A3
公开(公告)日：2009-12-17
申请号：PCT/DK2009050058
申请日：2009-03-13
申请人： SCANDINAVIAN MICRO BIODEVICES , BAU-MADSEN NIELS KRISTIAN , JONSMANN JACQUES , OVERBY BENT , BERENDSEN CHRISTIANUS
发明人： BAU-MADSEN NIELS KRISTIAN , JONSMANN JACQUES , OVERBY BENT , BERENDSEN CHRISTIANUS
IPC分类号： G01N33/49 , B01L3/00 , G01N33/86
CPC分类号： G01N33/4905 , B01L3/5027 , B01L2200/0684 , B01L2200/148 , B01L2300/0654 , B01L2300/0883 , B01L2300/18 , B01L2400/0406 , B01L2400/0487 , G01N33/5304 , G01N33/86
摘要： The invention relates to a microfluidic system comprising a microfluidic device (1) having a first and a second opposite surfaces, an optical detector (3a, 3b) a flow channel with a detection channel section having a length of at least about lmm, at least one aperture section (2) comprising at least a part of said detection channel section and a transparent window into said detection channel section. The optical detector (3a, 3b) is in optical communication with said aperture section (2) for determining at least one optical property of said aperture section as a function of time. The flow channel may have capillary dimensions and/or it may wholly or fully be arranged to drive a fluid flow by applying external forces. The optical detector (3a, 3b) is arranged to transmit light onto the aperture section (2) and to detect a light transmission from the aperture section. The microfluid device (1) may be used to determine various properties of a sample fluid, for example it may be used to determine a samples coagulation properties and/or reactions of one or more components in a blood sample as a function of time.
摘要翻译：本发明涉及一种微流体系统，其包括具有第一和第二相对表面的微流体装置（1），光学检测器（3a，3b），具有至少约1mm长度的检测通道部分的流动通道，至少一个孔径部分（2）包括所述检测通道部分的至少一部分和透明窗口进入所述检测通道部分。光学检测器（3a，3b）与所述孔径部分（2）光学连通，用于确定所述孔径部分的至少一个光学特性作为时间的函数。流动通道可以具有毛细管尺寸和/或其可以完全或完全地布置成通过施加外力来驱动流体流动。光检测器（3a，3b）被布置成将光传送到孔部（2）上并检测来自孔部的光透射。微流体装置（1）可以用于确定样品流体的各种性质，例如其可用于确定样品凝血性质和/或作为时间的函数的血液样品中的一种或多种组分的反应。

4. 发明申请

WO2006074665A3 A METHOD OF PRODUCING A MICROFLUIDIC DEVICE AND MICROFLUIDIC DEVICES 审中-公开
公开(公告)号：WO2006074665A3
公开(公告)日：2006-07-20
申请号：PCT/DK2006/050002
申请日：2006-01-11
申请人： INVERNESS MEDICAL SWITZERLAND GMBH , BARHOLM-HANSEN, Claus , JONSMANN, Jacques , BÆKMARK, Thomas, Rosleff , OVERBY, Bent , BERENDSEN, Christian , BOUAIDAT, Salim , BAU-MADSEN, Niels, Kristian
发明人： BARHOLM-HANSEN, Claus , JONSMANN, Jacques , BÆKMARK, Thomas, Rosleff , OVERBY, Bent , BERENDSEN, Christian , BOUAIDAT, Salim , BAU-MADSEN, Niels, Kristian
IPC分类号： B01L3/00 , B01J19/00 , B81B1/00
摘要： The present invention relates to a method of producing a microfluidic device with a flow path optionally comprising one or more chambers, e.g. reaction chambers. The method comprises the steps: (i) providing a base substrate with a first surface and a top substrate with a second surface, the substrates e.g. being of polymer material, (ii) hydrophilically treating at least one of the first and the second surfaces to provide a surface layer with a higher surface tension, such as about 60 mN/m or higher, than the surface tension prior to the hydrophilic treatment, (iii) partly or totally removing the surface layer with a higher surface tension in a selected pattern of the hydrophilically treated first and/or second surfaces, e.g. using laser, to thereby provide the selected pattern with a lower surface tension than prior to the partly or totally removal of the surface layer with a higher surface tension in said selected pattern of the hydrophilic treated first and/or second surfaces, and (iv) joining said base substrate and top substrate to each other to provide a flow path between said first and second surfaces. The selected pattern can be shaped with a variety of shapes to obtain the desired hydrophilic/hydrophobic character of the flow path, e.g. a micro- pattern in the form of one or more segments with at least one dimension less than 25 µm, a micro-dotted pattern, a pattern in the form of one or more straight or rounded lines e.g. extending totally or partly across the flow path. The invention also relates to a microfluidic device obtainable by the method.

5. 发明申请

WO2004088710A3 METHOD AND APPARATUS FOR GAS PLASMA TREATMENT WITH CONTROLLED EXTENT OF GAS PLASMA, AND USE THEREOF 审中-公开
标题翻译：气体等离子体等离子体处理气体等离子体处理方法及装置及其应用
公开(公告)号：WO2004088710A3
公开(公告)日：2005-12-08
申请号：PCT/DK2004000240
申请日：2004-04-02
申请人： NKT RES & INNOVATION AS , CHRISTENSEN SOEREN FLYGENRING , OVERBY BENT , CARLSEN RENE , PETERSEN STEEN GULDAGER , BERENDSEN CHRISTIANUS WILHELMU
发明人： CHRISTENSEN SOEREN FLYGENRING , OVERBY BENT , CARLSEN RENE , PETERSEN STEEN GULDAGER , BERENDSEN CHRISTIANUS WILHELMU
IPC分类号： H01J37/32
CPC分类号： H01J37/3244 , H01J37/32431 , H01J37/32568 , H01J37/32935
摘要： A method of controlling the extent of gas plasma, the method comprising: (A) providing a gas zone (110), said gas zone comprising a gas having a pressure; said gas comprising at least one gas component allowing generation of a plasma; (B) generating a plasma in said gas zone by supplying a potential difference between at least two electrodes (150); said at least two electrodes being configured to wholly or partly encompass said gas zone; and (C) controlling the extent of said generated plasma by controlling at least one of: said gas, said pressure, said potential difference, and said configuration of said at least two electrodes; a plasma treatment apparatus comprising at least one plasma measuring means (160) for measuring the extent of the plasma, and at least one controlling means (180, 191, 131) for controlling the extent of the plasma; and use of the method and apparatus in plasma treatment and/or plasma-assisted surface modification of electrodes and/or substrates.
摘要翻译：一种控制气体等离子体的程度的方法，所述方法包括：（A）提供气体区域（110），所述气体区域包括具有压力的气体; 所述气体包括允许产生等离子体的至少一种气体成分; （B）通过在至少两个电极（150）之间提供电位差来产生所述气体区域中的等离子体; 所述至少两个电极构造成完全或部分地包围所述气体区域; 以及（C）通过控制所述气体，所述压力，所述电位差和所述至少两个电极的所述构造中的至少一个来控制所述产生的等离子体的程度; 一种等离子体处理装置，包括用于测量等离子体的程度的至少一个等离子体测量装置（160）和用于控制等离子体的程度的至少一个控制装置（180,191,131）以及在电极和/或基板的等离子体处理和/或等离子体辅助表面改性中使用该方法和装置。

6. 发明申请

WO2004088710A2 METHOD AND APPARATUS FOR GAS PLASMA TREATMENT WITH CONTROLLED EXTENT OF GAS PLASMA, AND USE THEREOF 审中-公开
标题翻译：气体等离子体等离子体处理气体等离子体处理方法及装置及其应用
公开(公告)号：WO2004088710A2
公开(公告)日：2004-10-14
申请号：PCT/DK2004/000240
申请日：2004-04-02
申请人： NKT RESEARCH & INNOVATION A/S , CHRISTENSEN, Søren, Flygenring , OVERBY, Bent , CARLSEN, René , PETERSEN, Steen, Guldager , BERENDSEN, Christianus, Wilhelmus, Johannes
发明人： CHRISTENSEN, Søren, Flygenring , OVERBY, Bent , CARLSEN, René , PETERSEN, Steen, Guldager , BERENDSEN, Christianus, Wilhelmus, Johannes
IPC分类号： H01J37/32
CPC分类号： H01J37/3244 , H01J37/32431 , H01J37/32568 , H01J37/32935
摘要： A method of controlling the extent of gas plasma, the method comprising: (A) providing a gas zone (110), said gas zone comprising a gas having a pressure; said gas comprising at least one gas component allowing generation of a plasma; (B) generating a plasma in said gas zone by supplying a potential difference between at least two electrodes (150); said at least two electrodes being configured to wholly or partly encompass said gas zone; and (C) controlling the extent of said generated plasma by controlling at least one of: said gas, said pressure, said potential difference, and said configuration of said at least two electrodes; a plasma treatment apparatus comprising at least one plasma measuring means (160) for measuring the extent of the plasma, and at least one controlling means (180, 191, 131) for controlling the extent of the plasma; and use of the method and apparatus in plasma treatment and/or plasma-assisted surface modification of electrodes and/or substrates.
摘要翻译：一种控制气体等离子体的程度的方法，所述方法包括：（A）提供气体区域（110），所述气体区域包括具有压力的气体; 所述气体包括允许产生等离子体的至少一种气体成分; （B）通过在至少两个电极（150）之间提供电位差来产生所述气体区域中的等离子体; 所述至少两个电极构造成完全或部分地包围所述气体区域; 以及（C）通过控制所述气体，所述压力，所述电位差和所述至少两个电极的所述构造中的至少一个来控制所述产生的等离子体的程度; 一种等离子体处理装置，包括用于测量等离子体的程度的至少一个等离子体测量装置（160）和用于控制等离子体的程度的至少一个控制装置（180,191,131）以及在电极和/或基板的等离子体处理和/或等离子体辅助表面改性中使用该方法和装置。

7. 发明申请

WO2006061026A3 A MICRO FLUIDIC DEVICE AND METHODS FOR PRODUCING A MICRO FLUIDIC DEVICE 审中-公开
标题翻译：一种用于生产微流体装置的微流体装置和方法
公开(公告)号：WO2006061026A3
公开(公告)日：2007-05-24
申请号：PCT/DK2005050009
申请日：2005-12-07
申请人： INVERNESS MEDICAL SWITZERLAND , BAU-MADSEN NIELS KRISTIAN , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , OVERBY BENT
发明人： BAU-MADSEN NIELS KRISTIAN , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , OVERBY BENT
IPC分类号： B01L3/00
CPC分类号： B01L3/502746 , B81B2203/0323
摘要： The invention relates to a micro fluidic device comprising a flow channel with an interface between a cartridge base and a lid, as well as methods of producing it. The cartridge base comprises a channel shaped depression and the lid is bonded to said cartridge base to form the flow channel: The interface between the cartridge base and the lid, adjacent to and along with the flow channel comprises at least two, such as three or more capillary gap sections in the form of a gap between the Ii and the cartridge base, separated by a flow break section, which flow break section provides a barrier for a capillary flow of liquid along adjoining capillary gap sections. In one embodiment the surface of at least one of the cartridge base and the lid in the interface between the cartridge base and the lid in the flow break sections, adjacent to and along with the flow channel, is less hydrophilic than one or both of the surfaces of the cartridge base and the lid in said capillary gap sections. In one embodiment the bonding material has at least partly penetrated into the flow channel.
摘要翻译：本发明涉及一种微流体装置，其包括具有在盒基座和盖子之间的界面的流动通道，以及其制造方法。墨盒底座包括通道形凹陷部分，并且盖子结合到所述墨盒底座以形成流动通道：墨盒基座和盖子之间的与流动通道相邻并与流动通道一起的界面包括至少两个，例如三个或更多的毛细孔隙部分以Ii和药筒基座之间的间隙的形式形成，由流动断裂部分分开，该流动断裂部分为沿着相邻的毛细管间隙部分的液体的毛细管流动提供了屏障。在一个实施例中，与底部和盖子之间的界面中的至少一个的位于流动断裂部分中的与流动通道相邻并与流动通道相邻的表面的表面的亲水性比其中一个或两个所述毛细管间隙部分中的药筒基座和盖子的表面。在一个实施例中，接合材料至少部分地穿透到流动通道中。

8. 发明申请

WO2006074665A2 A METHOD OF PRODUCING A MICROFLUIDIC DEVICE AND MICROFLUIDIC DEVICES 审中-公开
标题翻译：一种制造微流体装置和微流体装置的方法
公开(公告)号：WO2006074665A2
公开(公告)日：2006-07-20
申请号：PCT/DK2006050002
申请日：2006-01-11
申请人： SCANDINAVIAN MICRO BIODEVICES , BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , BAEKMARK THOMAS ROSLEFF , OVERBY BENT , BERENDSEN CHRISTIAN , BOUAIDAT SALIM , BAU-MADSEN NIELS KRISTIAN
发明人： BARHOLM-HANSEN CLAUS , JONSMANN JACQUES , BAEKMARK THOMAS ROSLEFF , OVERBY BENT , BERENDSEN CHRISTIAN , BOUAIDAT SALIM , BAU-MADSEN NIELS KRISTIAN
CPC分类号： F16K99/0017 , B01L3/502738 , B01L3/502746 , B01L2200/12 , B01L2300/0816 , B01L2300/0887 , B01L2300/089 , B01L2300/165 , B01L2400/0406 , B01L2400/0688 , F16K99/0001 , F16K2099/0078
摘要： The present invention relates to a method of producing a microfluidic device with a flow path optionally comprising one or more chambers, e.g. reaction chambers. The method comprises the steps: (i) providing a base substrate with a first surface and a top substrate with a second surface, the substrates e.g. being of polymer material, (ii) hydrophilically treating at least one of the first and the second surfaces to provide a surface layer with a higher surface tension, such as about 60 mN/m or higher, than the surface tension prior to the hydrophilic treatment, (iii) partly or totally removing the surface layer with a higher surface tension in a selected pattern of the hydrophilically treated first and/or second surfaces, e.g. using laser, to thereby provide the selected pattern with a lower surface tension than prior to the partly or totally removal of the surface layer with a higher surface tension in said selected pattern of the hydrophilic treated first and/or second surfaces, and (iv) joining said base substrate and top substrate to each other to provide a flow path between said first and second surfaces. The selected pattern can be shaped with a variety of shapes to obtain the desired hydrophilic/hydrophobic character of the flow path, e.g. a micro- pattern in the form of one or more segments with at least one dimension less than 25 µm, a micro-dotted pattern, a pattern in the form of one or more straight or rounded lines e.g. extending totally or partly across the flow path. The invention also relates to a microfluidic device obtainable by the method.
摘要翻译：本发明涉及一种生产微流体装置的方法，该流体装置具有可选地包括一个或多个室的流路，例如，反应室。该方法包括以下步骤：（i）提供具有第一表面的基底基底和具有第二表面的顶部基底，作为聚合物材料，（ii）亲水处理第一和第二表面中的至少一个，以提供具有比亲水处理之前的表面张力更高的表面张力（例如约60mN / m或更高）的表面层，（iii）在亲水处理的第一和/或第二表面的选定图案中部分或完全地去除具有较高表面张力的表面层，例如使用激光，从而使得所选择的图案具有比在所述亲水处理的第一和/或第二表面的所述选择图案中具有更高表面张力部分地或完全去除表面层之前的较低表面张力，以及（iv）将所述基底基底和顶部基底彼此接合以提供所述第一和第二表面之间的流动路径。所选择的图案可以用各种形状成形，以获得所需的流动路径的亲水/疏水特征，例如，具有至少一个尺寸小于25μm的一个或多个片段形式的微图案，微点图案，一个或多个直线或圆形线形式的图案，例如，全部或部分穿过流路延伸。本发明还涉及通过该方法可获得的微流体装置。

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