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1. 发明申请

WO2011112983A3 PSRP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION 审中-公开
标题翻译： PSRP是一种防止气管感染的保护性抗原
公开(公告)号：WO2011112983A3
公开(公告)日：2012-01-19
申请号：PCT/US2011028177
申请日：2011-03-11
申请人： UNIV TEXAS , ORIHUELA CARLOS
发明人： ORIHUELA CARLOS
IPC分类号： A61K39/395 , A61K38/16 , A61K38/17 , A61K48/00 , A61P11/00 , A61P31/04
CPC分类号： C07K16/1275 , A61K2039/505
摘要： Disclosed are method of inhibiting or preventing bacterial aggregation or biofilm formation that involve use of (a) an antibody or fragment thereof that binds to an epitope within an amino acid sequence selected from the group consisting of (i) an amino acid sequence that has at least 90% identity to SEQ ID NO: 1 (BR domain of PsrP), (ii) an amino acid sequence that has at least 90% identity to SEQ ID NO:2 (NR domain of SraP), and (iii) an amino acid sequence that has at least 90% identity to SEQ ID NO:3. These methods find particular application in the treatment or prevention of bacterial disease associated with bacterial aggregation, such as empyema and pneumococcal disease. Related kits, vaccines, and compositions are disclosed.
摘要翻译：公开了抑制或预防细菌聚集或生物膜形成的方法，其涉及使用（a）与选自以下的氨基酸序列中的表位结合的抗体或其片段：（i）具有与SEQ ID NO：1（PsrP的BR结构域）具有至少90％的同一性，（ii）与SEQ ID NO：2具有至少90％同一性（SraP的NR结构域）的氨基酸序列，和（iii）与SEQ ID NO：3具有至少90％同一性的酸序列。这些方法在治疗或预防与细菌聚集相关的细菌性疾病如脓胸和肺炎球菌病方面具有特殊应用。公开了相关试剂盒，疫苗和组合物。

2. 发明申请

WO2009143483A3 PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION 审中-公开
标题翻译： PsrP是一种防治肺炎感染的保护性抗原
公开(公告)号：WO2009143483A3
公开(公告)日：2010-04-29
申请号：PCT/US2009045071
申请日：2009-05-22
申请人： UNIV TEXAS , ORIHUELA CARLOS J
发明人： ORIHUELA CARLOS J
IPC分类号： A61K38/16 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/04
CPC分类号： C07K16/1275 , A61K39/09
摘要： Disclosed are pharmaceutical compositions that include a PsrP polypeptide, a nucleic acid encoding a PsrP polypeptide, or an antibody or fragment thereof that binds to a PsrP polypeptide domain, and methods of inhibiting, modulating, treating, or preventing a bacterial infection, such as an infection due to Streptococcus pneumoniae, in a subject using these compositions.
摘要翻译：公开了包含PsrP多肽，编码PsrP多肽的核酸或其结合PsrP多肽结构域的抗体或其片段的药物组合物，以及抑制，调节，治疗或预防细菌感染的方法，例如在使用这些组合物的受试者中由于肺炎链球菌引起的感染。

3. 发明申请

WO2008039838A3 SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE 审中-公开
标题翻译：合成链球菌肺炎疫苗
公开(公告)号：WO2008039838A3
公开(公告)日：2008-05-15
申请号：PCT/US2007079527
申请日：2007-09-26
申请人： ST JUDE CHILDRENS RES HOSPITAL , EL KASMI KARIM C , JORDAN BRAD , KRIWACKI RICHARD , MANN BETH , ORIHUELA CARLOS J , TUOMANEN ELAINE
发明人： EL KASMI KARIM C , JORDAN BRAD , KRIWACKI RICHARD , MANN BETH , ORIHUELA CARLOS J , TUOMANEN ELAINE
IPC分类号： C07K14/315
CPC分类号： C07K14/3156 , A61K39/00
摘要： Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope. Compositions further include isolated nucleic acid molecules that encode the polypeptides of the invention, immunogenic compositions and vaccines comprising the disclosed polypeptides, and antibodies specific for these polypeptides.
摘要翻译：提供了预防和治疗肺炎球菌感染的组合物和方法。组合物包括新多肽，其包含对应于CbpA的R21或R22结构域的氨基酸序列或这些结构域之一的共有序列及其变体和片段，其中所述多肽以期望的构象，特别是环构象稳定。可以将本发明的多肽工程化以包含第一和第二半胱氨酸残基，从而导致形成使多肽稳定在所需构象的二硫键。或者，可修饰本发明的多肽以在存在于多肽内的第一和第二氨基酸残基之间产生合成连接，其中合成连接使多肽稳定在所需构象中。本发明的多肽可以进一步包含T细胞表位的氨基酸序列。组合物还包括编码本发明多肽的分离的核酸分子，包含所公开多肽的免疫原性组合物和疫苗以及对这些多肽特异的抗体。

4. 发明申请

WO2011112983A2 PSRP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION 审中-公开
标题翻译： PSRP是一种防止气管感染的保护性抗原
公开(公告)号：WO2011112983A2
公开(公告)日：2011-09-15
申请号：PCT/US2011/028177
申请日：2011-03-11
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , ORIHUELA, Carlos
发明人： ORIHUELA, Carlos
IPC分类号： A61K39/395 , A61K38/17 , A61K38/16 , A61K48/00 , A61P31/04 , A61P11/00
CPC分类号： C07K16/1275 , A61K2039/505
摘要： Disclosed are method of inhibiting or preventing bacterial aggregation or biofilm formation that involve use of (a) an antibody or fragment thereof that binds to an epitope within an amino acid sequence selected from the group consisting of (i) an amino acid sequence that has at least 90% identity to SEQ ID NO: 1 (BR domain of PsrP), (ii) an amino acid sequence that has at least 90% identity to SEQ ID NO:2 (NR domain of SraP), and (iii) an amino acid sequence that has at least 90% identity to SEQ ID NO:3. These methods find particular application in the treatment or prevention of bacterial disease associated with bacterial aggregation, such as empyema and pneumococcal disease. Related kits, vaccines, and compositions are disclosed.
摘要翻译：公开了抑制或预防细菌聚集或生物膜形成的方法，其涉及使用（a）与选自以下的氨基酸序列中的表位结合的抗体或其片段：（i）具有与SEQ ID NO：1（PsrP的BR结构域）具有至少90％的同一性，（ii）与SEQ ID NO：2具有至少90％同一性（SraP的NR结构域）的氨基酸序列，和（iii）与SEQ ID NO：3具有至少90％同一性的酸序列。这些方法在治疗或预防与细菌聚集相关的细菌性疾病如脓胸和肺炎球菌病方面具有特殊应用。公开了相关试剂盒，疫苗和组合物。

5. 发明申请

WO2009143483A9 PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION 审中-公开
公开(公告)号：WO2009143483A9
公开(公告)日：2009-11-26
申请号：PCT/US2009/045071
申请日：2009-05-22
申请人： THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , ORIHUELA, Carlos, J.
发明人： ORIHUELA, Carlos, J.
IPC分类号： A61K38/16 , A61P11/00 , A61P31/04 , A61K48/00 , A61K39/395
摘要： Disclosed are pharmaceutical compositions that include a PsrP polypeptide, a nucleic acid encoding a PsrP polypeptide, or an antibody or fragment thereof that binds to a PsrP polypeptide domain, and methods of inhibiting, modulating, treating, or preventing a bacterial infection, such as an infection due to Streptococcus pneumoniae , in a subject using these compositions.

6. 发明申请

WO2008039838A2 SYNTHETIC STREPTOCOCCUS PNEUMONIAE VACCINE 审中-公开
标题翻译：合成环孢菌素疫苗
公开(公告)号：WO2008039838A2
公开(公告)日：2008-04-03
申请号：PCT/US2007/079527
申请日：2007-09-26
申请人： ST. JUDE CHILDREN'S RESEARCH HOSPITAL , EL KASMI, Karim, C. , JORDAN, Brad , KRIWACKI, Richard , MANN, Beth , ORIHUELA, Carlos, J. , TUOMANEN, Elaine
发明人： EL KASMI, Karim, C. , JORDAN, Brad , KRIWACKI, Richard , MANN, Beth , ORIHUELA, Carlos, J. , TUOMANEN, Elaine
IPC分类号： C07K14/315
CPC分类号： C07K14/3156 , A61K39/00
摘要： Compositions and methods for preventing and treating pneumococcal infections are provided. Compositions include novel polypeptides comprising an amino acid sequence corresponding to the R2i or R22 domain of CbpA or a consensus sequence of one of these domains, and variants and fragments thereof, wherein the polypeptide is stabilized in a desired conformation, particularly a loop conformation. The polypeptides of the invention may be engineered to comprise a first and a second cysteine residue, thereby resulting in the formation of a disulfide bond that stabilizes the polypeptide in the desired conformation. Alternatively, a polypeptide of the invention may be modified to create a synthetic linkage between a first and second amino acid residue present within the polypeptide, wherein the synthetic linkage stabilizes the polypeptide in the desired conformation. The polypeptides of the invention may further comprise an amino acid sequence for a T cell epitope. Compositions further include isolated nucleic acid molecules that encode the polypeptides of the invention, immunogenic compositions and vaccines comprising the disclosed polypeptides, and antibodies specific for these polypeptides.
摘要翻译：提供了预防和治疗肺炎球菌感染的组合物和方法。组合物包括包含对应于CbpA的R2i或R22结构域的氨基酸序列或这些结构域之一的共有序列及其变体和片段的新型多肽，其中所述多肽被稳定为期望的构象，特别是环构象。本发明的多肽可被工程化以包含第一和第二半胱氨酸残基，从而导致二硫键的形成，从而将多肽稳定在所需构象。或者，可以修饰本发明的多肽以在多肽内存在的第一和第二氨基酸残基之间产生合成连接，其中所述合成连接使所述多肽以所需构象稳定。本发明的多肽还可以包含T细胞表位的氨基酸序列。组合物还包括编码本发明多肽的分离的核酸分子，包含所公开的多肽的免疫原性组合物和疫苗以及对这些多肽特异的抗体。

7. 发明申请

WO2009143483A2 PsrP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION 审中-公开
标题翻译： PsrP是一种防治肺炎感染的保护性抗原
公开(公告)号：WO2009143483A2
公开(公告)日：2009-11-26
申请号：PCT/US2009045071
申请日：2009-05-22
申请人： UNIV TEXAS , ORIHUELA CARLOS J
发明人： ORIHUELA CARLOS J
IPC分类号： A61K38/16 , A61K39/395 , A61K48/00 , A61P11/00 , A61P31/04
CPC分类号： C07K16/1275 , A61K39/09
摘要： Disclosed are pharmaceutical compositions that include a PsrP polypeptide, a nucleic acid encoding a PsrP polypeptide, or an antibody or fragment thereof that binds to a PsrP polypeptide domain, and methods of inhibiting, modulating, treating, or preventing a bacterial infection, such as an infection due to Streptococcus pneumoniae, in a subject using these compositions.
摘要翻译：公开了包含PsrP多肽，编码PsrP多肽的核酸或其结合PsrP多肽结构域的抗体或其片段的药物组合物，以及抑制，调节，治疗或预防细菌感染的方法，例如在使用这些组合物的受试者中由于肺炎链球菌引起的感染。

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