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1. 发明申请

WO2011112983A3 PSRP IS A PROTECTIVE ANTIGEN AGAINST PNEUMOCOCCAL INFECTION 审中-公开
标题翻译： PSRP是一种防止气管感染的保护性抗原
公开(公告)号：WO2011112983A3
公开(公告)日：2012-01-19
申请号：PCT/US2011028177
申请日：2011-03-11
申请人： UNIV TEXAS , ORIHUELA CARLOS
发明人： ORIHUELA CARLOS
IPC分类号： A61K39/395 , A61K38/16 , A61K38/17 , A61K48/00 , A61P11/00 , A61P31/04
CPC分类号： C07K16/1275 , A61K2039/505
摘要： Disclosed are method of inhibiting or preventing bacterial aggregation or biofilm formation that involve use of (a) an antibody or fragment thereof that binds to an epitope within an amino acid sequence selected from the group consisting of (i) an amino acid sequence that has at least 90% identity to SEQ ID NO: 1 (BR domain of PsrP), (ii) an amino acid sequence that has at least 90% identity to SEQ ID NO:2 (NR domain of SraP), and (iii) an amino acid sequence that has at least 90% identity to SEQ ID NO:3. These methods find particular application in the treatment or prevention of bacterial disease associated with bacterial aggregation, such as empyema and pneumococcal disease. Related kits, vaccines, and compositions are disclosed.
摘要翻译：公开了抑制或预防细菌聚集或生物膜形成的方法，其涉及使用（a）与选自以下的氨基酸序列中的表位结合的抗体或其片段：（i）具有与SEQ ID NO：1（PsrP的BR结构域）具有至少90％的同一性，（ii）与SEQ ID NO：2具有至少90％同一性（SraP的NR结构域）的氨基酸序列，和（iii）与SEQ ID NO：3具有至少90％同一性的酸序列。这些方法在治疗或预防与细菌聚集相关的细菌性疾病如脓胸和肺炎球菌病方面具有特殊应用。公开了相关试剂盒，疫苗和组合物。

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