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1. 发明申请

WO2012066533A1 PROCESS FOR MANUFACTURING DIBROMONITROMETHANE 审中-公开
标题翻译：制备二溴喹啉酮的方法
公开(公告)号：WO2012066533A1
公开(公告)日：2012-05-24
申请号：PCT/IL2011/000871
申请日：2011-11-10
申请人： BROMINE COMPOUNDS LTD. , OREN, Jakob
发明人： OREN, Jakob
IPC分类号： C07C201/12 , C07C205/00 , C07C205/08
CPC分类号： C07C201/12 , C07C205/08
摘要： The present invention relates to a method of manufacturing dibromonitromethane by reacting bromopicrin with sodium bisulfite in a high yield, at ambient temperature, without employing caustic inorganic materials or organic solvents.
摘要翻译：本发明涉及一种通过溴环戊烯与亚硫酸氢钠在环境温度下以高收率反应而不使用苛性无机材料或有机溶剂来制备二溴硝基甲烷的方法。

2. 发明申请

WO2007057900A2 FLAME RETARDANT BROMOBENZYL SYSTEMS 审中-公开
标题翻译：阻燃剂BROMOBENZYL系统
公开(公告)号：WO2007057900A2
公开(公告)日：2007-05-24
申请号：PCT/IL2006/001327
申请日：2006-11-16
申请人： BROMINE COMPOUNDS LTD. , OREN, Jakob , YASSIN, Nasif , ZILBERMAN, Joseph , CANFI, Dorit , FRIM, Ron , BERUBEN, Dov
发明人： OREN, Jakob , YASSIN, Nasif , ZILBERMAN, Joseph , CANFI, Dorit , FRIM, Ron , BERUBEN, Dov
IPC分类号： C08K5/03
CPC分类号： C08K5/06 , C07C17/12 , C07C17/14 , C07C25/18 , C07C43/225 , C07C43/29 , C08K5/03 , C07C22/04
摘要： Polybrominated bisaryl compounds containing bromomethyl or bromomethylene groups are provided, as well as flameproof polymeric formulations comprising the compounds. The novel compounds exhibit a good thermal stability, and are particularly suitable for flame-retarding polystyrene thermoplastic foams. A process for making the polybrominated bisaryl compounds is also provided.
摘要翻译：提供了包含溴甲基或溴亚甲基的多溴二芳基化合物，以及包含该化合物的防火聚合物。新型化合物表现出良好的热稳定性，特别适用于阻燃聚苯乙烯热塑性泡沫塑料。还提供了制备多溴二芳基化合物的方法。

3. 发明申请

WO2008146277A1 CONTINUOUS PROCESS OF PREPARING BROMOPICRIN 审中-公开
标题翻译：连续制备BROMOPICRIN的方法
公开(公告)号：WO2008146277A1
公开(公告)日：2008-12-04
申请号：PCT/IL2008/000712
申请日：2008-05-26
申请人： BROMINE COMPOUNDS LTD. , OREN, Jakob , YASSIN, Nasif , FRIM, Ron
发明人： OREN, Jakob , YASSIN, Nasif , FRIM, Ron
IPC分类号： C07C201/12 , C07C205/08
CPC分类号： C07C201/12 , C07C205/08
摘要： A continuous process of preparing bromopicrin is disclosed. The process is effected by transferring a continuous flow of a first mixture and a continuous flow of a second mixture into a first reactor, the first mixture containing nitromethane and bromine and the second mixture containing an aqueous solution of an alkaline substance, to thereby obtain a reaction mixture which comprises bromopicrin in said first reactor; and collecting the bromopicrin from the reaction mixture. Highly pure bromopicrin obtained by this process is also disclosed.
摘要翻译：公开了制备溴氰菊酯的连续方法。该方法通过将第一混合物的连续流和第二混合物的连续流转移到第一反应器中，第一混合物含有硝基甲烷和溴，第二混合物含有碱性物质的水溶液，从而获得在所述第一反应器中包含溴化苦素的反应混合物; 并从反应混合物中收集溴氰菊酯。还公开了通过该方法获得的高纯度溴氰菊酯。

4. 发明申请

WO2006013554A1 NOVEL FLAME-RETARDANT POLYSTYRENES 审中-公开
标题翻译：新型阻燃聚苯乙烯
公开(公告)号：WO2006013554A1
公开(公告)日：2006-02-09
申请号：PCT/IL2005/000767
申请日：2005-07-19
申请人： BROMINE COMPOUNDS LTD. , KORNBERG, Nurit , OREN, Jakob , HINI, Smadar , PELED, Michael
发明人： KORNBERG, Nurit , OREN, Jakob , HINI, Smadar , PELED, Michael
IPC分类号： C08J9/00
CPC分类号： C08J9/0019 , C08J3/226 , C08J9/0038 , C08J2325/04 , C08J2425/00 , C08J2425/04 , C08K5/03 , C08L25/04
摘要： The present invention relates to a styrenic polymer composition comprising a flame-retardant effective amount of a compound of formula (I): (C 6 H (5-n) Y n )CH 2 X, wherein X is Cl or Br; Y is Cl or Br; and n is an integer between 1 and 5; or a mixture of two or more of said compounds of formula (I) or their homologues and derivatives or other Br-FRs.
摘要翻译：本发明涉及一种苯乙烯聚合物组合物，其包含阻燃有效量的式（I）化合物：（C 6 H 5 - （5-n） CH 2 X，其中X是Cl或Br; Y为Cl或Br; n为1〜5的整数。或两种或更多种所述式（I）化合物或其同系物和衍生物或其它Br-FR的混合物。

5. 发明申请

WO1998027047A1 PROCESS FOR THE PREPARATION OF 4,4'-OXYBISPHTHALIC DIANHYDRIDE 审中-公开
标题翻译：制备4,4'-二氧化二硅烷的方法
公开(公告)号：WO1998027047A1
公开(公告)日：1998-06-25
申请号：PCT/IL1997000415
申请日：1997-12-18
申请人： BROMINE COMPOUNDS LTD. , OREN, Jakob
发明人： BROMINE COMPOUNDS LTD.
IPC分类号： C07C51/567
CPC分类号： C07C63/68 , C07C51/56 , C07C51/567 , C07C65/24
摘要： A process for the preparation of 4,4'-oxybisphthalic dianhydride, comprises the steps of: (a) reacting a 4-halophthalic anhydride, wherein "halo-" is selected from the group consisting of bromo-, chloro-, and fluoro-, with an alkali metal hydroxide chosen from among aqueous KOH, aqueous NaOH, or a mixture thereof, to produce dipotassium- or disodium-4-halophthalate, or a mixture thereof; (b) drying said dipotassium- and/or disodium-4-halophthalate; and (c) reacting said dipotassium- and/or disodium-4-halophthalate with a 4-halophthalic anhydride, wherein "halo-" is selected from the group consisting of bromo-, chloro-, and fluoro-, in the presence of a suitable solvent and a phase transfer catalyst to give 4,4'-oxybisphthalic dianhydride.
摘要翻译：一种制备4,4'-氧邻苯二甲酸二酐的方法包括以下步骤：（a）使4-卤代邻苯二甲酸酐反应，其中“卤素”选自溴 - ，氯 - 和氟 - 与选自KOH水溶液，NaOH水溶液或其混合物的碱金属氢氧化物反应，生成2-卤代二钠或四钠盐，或其混合物; （b）干燥所述二钾和/或二卤代-4-邻苯二甲酸二钠; 和（c）使所述二卤代二钠和/或二钠邻苯二甲酸二钠与4-卤代邻苯二甲酸酐反应，其中“卤素”选自溴 - ，氯 - 和氟 - ，在合适的溶剂和相转移催化剂，得到4,4'-氧代双邻苯二甲酸二酐。

6. 发明申请

WO2007057900A3 FLAME RETARDANT BROMOBENZYL SYSTEMS 审中-公开
标题翻译：阻燃剂BROMOBENZYL系统
公开(公告)号：WO2007057900A3
公开(公告)日：2009-04-09
申请号：PCT/IL2006001327
申请日：2006-11-16
申请人： BROMINE COMPOUNDS LTD , OREN JAKOB , YASSIN NASIF , ZILBERMAN JOSEPH , CANFI DORIT , FRIM RON , BERUBEN DOV
发明人： OREN JAKOB , YASSIN NASIF , ZILBERMAN JOSEPH , CANFI DORIT , FRIM RON , BERUBEN DOV
IPC分类号： C08K5/03 , C08L25/06
CPC分类号： C08K5/06 , C07C17/12 , C07C17/14 , C07C25/18 , C07C43/225 , C07C43/29 , C08K5/03 , C07C22/04
摘要： Polybrominated bisaryl compounds containing bromomethyl or bromomethylene groups are provided, as well as flameproof polymeric formulations comprising the compounds. The novel compounds exhibit a good thermal stability, and are particularly suitable for flame-retarding polystyrene thermoplastic foams. A process for making the polybrominated bisaryl compounds is also provided.
摘要翻译：提供了包含溴甲基或溴亚甲基的多溴二芳基化合物，以及包含该化合物的防火聚合物。新型化合物表现出良好的热稳定性，特别适用于阻燃聚苯乙烯热塑性泡沫塑料。还提供了制备多溴二芳基化合物的方法。

7. 发明申请

WO2004046105A2 SYNTHESIS OF 3,5-DIHYDROXY-7-PYRROL-1-YL HEPTANOIC ACIDS 审中-公开
标题翻译： 3,5-二羟基-7-吡咯烷-1-基硫酸的合成
公开(公告)号：WO2004046105A2
公开(公告)日：2004-06-03
申请号：PCT/US2003/037026
申请日：2003-11-17
申请人： TEVA PHARMACEUTICAL INDUSTRIES LTD. , TEVA PHARMACEUTICALS USA, INC. , OREN, Jakob , DOLITZKY, Ben-Zion , HAREL, Zvi , PERLMAN, Nurit , LIDOR-HADAS, Ramy
发明人： OREN, Jakob , DOLITZKY, Ben-Zion , HAREL, Zvi , PERLMAN, Nurit , LIDOR-HADAS, Ramy
IPC分类号： C07D207/00
CPC分类号： C07D207/34 , C07C215/10 , C07D319/06 , C07D405/06 , C07F7/1892
摘要： Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihydroxy heptanoic acid esters undergo Paal Knorr reaction with 1,4-diketones to give valuable silylether-diprotected 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acid ester intermediates for preparing atorvastatin. The Paal Knorr reaction of ketal-proctected 7-amino-3 R , 5 R -dihydroxy heptanoic acid esters with 4-fluoro-α-(2-methyl-1-oxopropyl-γ-oxo-N,β-diphenylbenzenebutanamide occurs in high yield with few side products when it is conducted in a low boiling point ether.
摘要翻译：阿托伐他汀和相关的3,5-二羟基-7-吡咯-1-基庚酸可以通过从新颖但容易获得的原料氧化3,5-二羟基-7-吡咯-1-基庚醇前体制备。甲硅烷基醚保护的7-氨基-3,5-二羟基庚酸酯与1,4-二酮进行Paal Knorr反应，得到有价值的甲硅烷基醚 - 二保护的3,5-二羟基-7-吡咯-1-基庚酸酯中间体，用于制备阿托伐他汀。缩酮7-取代的7-氨基-3R，5R-二羟基庚酸酯与4-氟-α-（2-甲基-1-氧代丙基-γ-氧代-N，β-二苯基苯丁酰胺）的Paal Knorr反应以高产率与当它在低沸点乙醚中进行时很少的副产物。

8. 发明申请

WO2004046105A3 SYNTHESIS OF 3,5-DIHYDROXY-7-PYRROL-1-YL HEPTANOIC ACIDS 审中-公开
标题翻译： 3,5-二羟基-7-吡咯-1-基庚酸的合成
公开(公告)号：WO2004046105A3
公开(公告)日：2004-10-07
申请号：PCT/US0337026
申请日：2003-11-17
申请人： TEVA PHARMA , TEVA PHARMA , OREN JAKOB , DOLITZKY BEN-ZION , HAREL ZVI , PERLMAN NURIT , LIDOR-HADAS RAMY
发明人： OREN JAKOB , DOLITZKY BEN-ZION , HAREL ZVI , PERLMAN NURIT , LIDOR-HADAS RAMY
IPC分类号： C07D319/06 , C07D405/06 , C07F7/18 , C07C215/10
CPC分类号： C07D207/34 , C07C215/10 , C07D319/06 , C07D405/06 , C07F7/1892
摘要： Atorvastatin and related 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acids can be made by oxidation of a 3,5-dihydroxy-7-pyrrol-1-yl heptanol precursor from novel but readily accessible starting materials. Silylether-protected 7-amino-3,5-dihydroxy heptanoic acid esters undergo Paal Knorr reaction with 1,4-diketones to give valuable silylether-diprotected 3,5-dihydroxy-7-pyrrol-1-yl heptanoic acid ester intermediates for preparing atorvastatin. The Paal Knorr reaction of ketal-proctected 7-amino-3R, 5R-dihydroxy heptanoic acid esters with 4-fluoro-alpha-(2-methyl-1-oxopropyl-gamma-oxo-N,beta-diphenylbenzenebutanamide occurs in high yield with few side products when it is conducted in a low boiling point ether.
摘要翻译：阿托伐他汀和相关的3,5-二羟基-7-吡咯-1-基庚酸可以通过从新颖但容易获得的原料氧化3,5-二羟基-7-吡咯-1-基庚醇前体来制备。甲硅烷基醚保护的7-氨基-3,5-二羟基庚酸酯与1,4-二酮进行Paal Knorr反应，得到有价值的甲硅烷基醚 - 二保护的3,5-二羟基-7-吡咯-1-基庚酸酯中间体用于制备阿托伐他汀。经缩酮预处理的7-氨基-3R，5R-二羟基庚酸酯与4-氟-α-（2-甲基-1-氧代丙基-γ-氧代-N，β-二苯基苯丁酰胺）的Paal Knorr反应以高产率与当它在低沸点醚中进行时，产物很少。

9. 发明申请

WO1997026235A1 PROCESS FOR THE PREPARATION OF para-FLUOROPHENOL 审中-公开
标题翻译：制备对氟苯酚的方法
公开(公告)号：WO1997026235A1
公开(公告)日：1997-07-24
申请号：PCT/IL1997000019
申请日：1997-01-14
申请人： BROMINE COMPOUNDS LTD. , OREN, Jakob , ADDA, Michel
发明人： BROMINE COMPOUNDS LTD.
IPC分类号： C07C37/02
CPC分类号： C07C37/02 , C07C39/27
摘要： A process for the preparation of p-fluorophenol, which comprises hydrolyzing p-bromofluorobenzene with a mixture of NaOH and Na2CO3 in the presence of a copper catalyst.
摘要翻译：一种制备对氟苯酚的方法，其包括在铜催化剂存在下用NaOH和Na 2 CO 3的混合物水解对溴氟苯。

10. 发明申请

WO2007023496A3 PROCESS OF PREPARING BROMOPICRIN 审中-公开
标题翻译：制备BROMOPICRIN的方法
公开(公告)号：WO2007023496A3
公开(公告)日：2007-07-05
申请号：PCT/IL2006000978
申请日：2006-08-22
申请人： BROMINE COMPOUNDS LTD , OREN JAKOB , GOLAN LEAH , FRIM RON
发明人： OREN JAKOB , GOLAN LEAH , FRIM RON
IPC分类号： C07C205/00
CPC分类号： C07C201/12 , C07C205/08
摘要： Process of preparing high purity bromopicrin, and high purity bromopicrin produced therefrom. Providing a mixture of nitromethane and bromine, and preferably water, and absent of organic solvent. Adding an aqueous solution of an alkaline substance to the mixture, thereby providing a reaction mixture containing bromopicrin, the adding performed such that no excess of the alkaline substance occurs in the reaction mixture during the adding. Collecting the organic phase (containing the bromopicrin) from the reaction mixture. No need for subjecting the organic phase of the reaction mixture to distillation or extraction, for obtaining near quantitative yield of bromopicrin having purity of at least equal to or greater than 96 weight percent. Process parameters controlling selectivity of reaction forming bromopicrin are molar ratio of bromine and nitromethane in the mixture; reaction temperature while bromopicrin is formed; concentration of the alkaline substance in the aqueous solution; and reaction time.
摘要翻译：制备高纯度溴氰菊酯和由其制备的高纯度溴氰菊酯的方法。提供硝基甲烷和溴的混合物，优选水，并且不存在有机溶剂。向混合物中加入碱性物质的水溶液，由此提供含有溴氰菊酯的反应混合物，进行添加，使得在添加期间反应混合物中不会发生过量的碱性物质。从反应混合物中收集有机相（含溴氰菊酯）。不需要使反应混合物的有机相进行蒸馏或萃取，以获得纯度至少等于或大于96重量％的溴定额素的近定量产率。控制反应形成溴氰菊酯的选择性的工艺参数是混合物中溴和硝基甲烷的摩尔比; 反应温度，同时形成溴化铁; 碱性物质在水溶液中的浓度; 和反应时间。

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