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1. 发明申请

WO2021243332A1 SYSTEM AND METHOD FOR DETECTING COUGHS FROM SENSOR DATA 审中-公开
公开(公告)号：WO2021243332A1
公开(公告)日：2021-12-02
申请号：PCT/US2021/035209
申请日：2021-06-01
申请人： LIFEQ B.V. , OLIVIER, Laurence, Richard
发明人： DELAUBENFELS, Tom , DU PREEZ, Franco , VILLET, Wikus, Theo
IPC分类号： A61B7/00 , A61B5/08 , A61M15/00
摘要： A method of detecting coughs using photoplethysmography sensor data is presented. In some embodiments, accelerometry sensor data may also be used in conjunction. A system is presented for the purpose of automatic cough detection, which may also incorporate auxiliary data relevant to the occurrence of coughs. Auxiliary data, may be used to improve cough detection and/or be for contextualization and categorization of detected coughs.

2. 发明申请

WO2018064579A1 DE-IDENTIFYING DISTRIBUTED BRIDGING NETWORK PLATFORM 审中-公开
标题翻译： DE -IDENTIFYING分布式桥接网络平台
公开(公告)号：WO2018064579A1
公开(公告)日：2018-04-05
申请号：PCT/US2017/054506
申请日：2017-09-29
申请人： OLIVIER, Laurence Richard , CONRADIE, Riaan , PAUL, Franc
发明人： OLIVIER, Laurence Richard , CONRADIE, Riaan , PAUL, Franc
IPC分类号： G06F9/44 , G06F15/16 , G06F15/173 , G06F17/30 , H04L29/06 , H04L29/08
摘要： Computer implemented systems and methods are presented comprising a platform coordinating data flows between data acquisition, data transformation and data delivery nodes, whilst protecting the identities of all entities whose data is being acquired, transformed and/or delivered. Metadata usage from different data transformation flows enables the platform to facilitate value distribution back to nodes and data subjects that contributed to output, enabling individual companies and/or data subjects subscribed to the platform to assess how and by whom their data is utilized in order to produce specific outputs, with the personal data of all entities being de-identified.
摘要翻译：提出了计算机实现的系统和方法，其包括协调数据采集，数据转换和数据传送节点之间的数据流的平台，同时保护其数据正在被采集，转换和/或传送的所有实体的身份。来自不同数据转换流程的元数据使用使得平台能够促进价值分布返回给有助于输出的节点和数据主体，使得订阅平台的各个公司和/或数据主体能够评估数据如何以及由谁利用以便产生具体的产出，所有实体的个人数据都被取消识别。

3. 发明申请

WO2017132236A1 SIMPLIFIED INSTANCES OF VIRTUAL PHYSIOLOGICAL SYSTEMS FOR INTERNET OF THINGS PROCESSING 审中-公开
标题翻译：虚拟生理系统在事物处理互联网中的简化实例
公开(公告)号：WO2017132236A1
公开(公告)日：2017-08-03
申请号：PCT/US2017/014897
申请日：2017-01-25
申请人： LIFEQ GLOBAL LIMITED , OLIVIER, Laurence, Richard , DU PREEZ, Franco, Bauer , CONRADIE, Riaan , UYS, Gerrida, Mathilda
发明人： OLIVIER, Laurence, Richard , DU PREEZ, Franco, Bauer , CONRADIE, Riaan , UYS, Gerrida, Mathilda
IPC分类号： A61B5/00
CPC分类号： A61B5/7278 , A61B5/02055 , A61B5/021 , A61B5/024 , A61B5/0816 , A61B5/14542 , G06F19/00 , G06F19/328 , G06Q40/08
摘要： The claimed invention presents methods for predicting the outcomes of physiological systems in real time using limited data input and computational resources. The claimed invention is comprised of simplified, or abstracted, physiological models, derived from detailed cloud- based computational systems biology models. Abstracted models are capable of utilizing limited data streams, typically obtained from non-invasive data acquisition devices, to accurately estimate, predict and display the outcomes of physiological systems in real time on the device, compared to detailed cloud-based estimations that are computationally demanding and can be used to continuously update abstracted models over time.
摘要翻译：本发明提出了使用有限的数据输入和计算资源实时预测生理系统的结果的方法。要求保护的发明包括从详细的基于云的计算系统生物学模型导出的简化或抽象的生理模型。抽象模型能够利用通常从非侵入式数据采集设备获得的有限数据流，以精确地估计，预测和显示设备上实时生理系统的结果，与详细的基于云计算的估计相比，计算要求高并且可以用来随时间不断更新抽象模型。

4. 发明申请

WO2022147271A1 HEALTH MONITORING AND MANAGEMENT SYSTEM USING ECTOPIC BEATS AS EARLY CARDIAC HEALTH MARKER 审中-公开
公开(公告)号：WO2022147271A1
公开(公告)日：2022-07-07
申请号：PCT/US2021/065709
申请日：2021-12-30
申请人： LIFEQ B.V. , OLIVIER, Laurence, Richard
发明人： DU PREEZ, Franco , VILLET, Wikus, Theo , DE WIT, Janina , KISTNER, Melissa , DELAUBENFELS, Tom , TERBLANCHE, Etienne
IPC分类号： A61B5/00 , A61B5/02 , A61B5/364 , G16H40/00 , G16H40/67
摘要： A method for health monitoring is provided including at least one non-invasive wearable device capable of collecting and storing data, and external monitoring devices that displays and analyses the data for accurate monitoring and anomaly detection. The wearable devices are configured to collect low-latency PPG-derived bio signals and can utilize multiple devices for accuracy and continuity. The system may further include a dashboard that analyzes the information as well as displaying basic information such as number of beds (in-use, available), staff-to-patient ratio, etc. The data can be collected and accessed remotely and may be utilized before, during, and/or after a patient is dispatched from a clinical setting.

5. 发明申请

WO2016111696A1 A PPG-BASED PHYSIOLOGICAL SENSING SYSTEM WITH A SPATIO-TEMPORAL SAMPLING APPROACH TOWARDS IDENTIFYING AND REMOVING MOTION ARTIFACTS FROM OPTICAL SIGNALS 审中-公开
标题翻译：基于PPG的生理感测系统，具有从光信号识别和移除运动人体的空间采样方法
公开(公告)号：WO2016111696A1
公开(公告)日：2016-07-14
申请号：PCT/US2015/010792
申请日：2015-01-09
申请人： LIFEQ GLOBAL LIMITED , OLIVIER, Laurence, Richard
发明人： OLIVIER, Laurence, Richard
IPC分类号： A61B5/0295
CPC分类号： A61B5/02416 , A61B5/0285 , A61B5/0295 , A61B5/0816 , A61B5/4866 , A61B5/7207
摘要： The invention pertains to fitness and/or sport performance by determination of physiological parameters, heart rate and breathing rate as indicators of physical exertion/intensity during exercise. In one embodiment, a PPG-based physiological sensing system employing spatiotemporal sampling towards identifying and removing motion artifacts received from a wearable optical sensing device in real-time and during various states of activity. The device capable of sensing and transmitting signals representative of physiological parameters to a remote electronic device. The device comprises an optical sensing unit with a light-emitting and light-detecting module for measuring blood volume changes caused by expansion and contraction of the small blood vessels in the skin and underlying tissue during the cardiac cycle. The spatial arrangement and temporal sampling configuration (sequence) allows for a common absorption point to be determined mathematically for each multi-channel sampling period, thereby obtaining an instantaneous optical measurement at different positions on the propagating pulse wave.
摘要翻译：本发明通过确定生理参数，心率和呼吸频率作为运动中体力消耗/强度的指标来适用于和/或运动性能。在一个实施例中，一种基于PPG的生理感测系统，其采用时空采样来实时识别和消除从可穿戴的光学感测装置实时和在各种活动状态期间接收到的运动伪影。该装置能够将表示生理参数的信号传感并传输到远程电子设备。该装置包括具有发光和光检测模块的光学感测单元，用于测量在心脏周期期间由皮肤和下面组织中的小血管的膨胀和收缩引起的血容量变化。空间布置和时间采样配置（序列）允许对于每个多通道采样周期以数学方式确定公共吸收点，从而在传播脉冲波的不同位置获得瞬时光学测量。

6. 发明申请

WO2016069082A1 BIOLOGICALLY INSPIRED MOTION COMPENSATION AND REAL-TIME PHYSIOLOGICAL LOAD ESTIMATION USING A DYNAMIC HEART RATE PREDICTION MODEL 审中-公开
标题翻译：使用动态心率预测模型进行生物识别运动补偿和实时生理负荷估计
公开(公告)号：WO2016069082A1
公开(公告)日：2016-05-06
申请号：PCT/US2015/043919
申请日：2015-08-06
申请人： LIFEQ GLOBAL LIMITED , OLIVIER, Laurence, Richard
发明人： OLIVIER, Laurence, Richard
IPC分类号： A61B5/024 , A61B5/0245
CPC分类号： A61B5/721 , A61B5/0002 , A61B5/0004 , A61B5/0022 , A61B5/0205 , A61B5/02416 , A61B5/02438 , A61B5/0245 , A61B5/0404 , A61B5/1118 , A61B5/4866 , A61B5/681 , A61B5/7207 , A61B5/7275 , A61B5/7278 , G06F19/00 , G16H50/50
摘要： The current invention pertains to a method whereby the accuracy of a heart rate prediction gathered from sensor data can be improved during periods when motion corrupts the signal. The model utilized can also be inverted to infer information on the physiological state of a subject, such as real-time energy utilization or physiological load. In addition, this method can also be used to segment the contribution of each energy system, namely the phosphagen system, anaerobic glycolysis and aerobic respiration, to the physiological load experienced by the user. At the core of this approach lies a model describing the dynamic adjustment of human heart rate under varying physiological demands.
摘要翻译：本发明涉及一种可以在运动破坏信号的周期期间改善从传感器数据收集的心率预测精度的方法。所使用的模型也可以被反转以推断关于受试者的生理状态的信息，例如实时能量利用或生理负荷。此外，该方法还可用于将每个能量系统（即磷酸盐系统，厌氧糖酵解和有氧呼吸）的贡献与用户所经历的生理负荷相分离。这种方法的核心是描述不同生理需求下人心率动态调整的模型。

7. 发明申请

WO2015134382A1 REAL-TIME AND CONTINUOUS DETERMINATION OF EXCESS POST-EXERCISE OXYGEN CONSUMPTION AND THE ESTIMATION OF BLOOD LACTATE 审中-公开
标题翻译：实时和连续测定过度运动后氧气消耗和血液泪液估算
公开(公告)号：WO2015134382A1
公开(公告)日：2015-09-11
申请号：PCT/US2015/018303
申请日：2015-03-02
申请人： GLOBAL NUTRITION & HEALTH, INC. , OLIVIER, Laurence, Richard
发明人： OLIVIER, Laurence, Richard
IPC分类号： A61B5/02 , A61B5/024 , A61B5/1455
CPC分类号： A61B5/14551 , A61B5/02416 , A61B5/02438 , A61B5/14546 , A61B5/222 , A61B5/4866 , A61B5/7278 , G06F19/00
摘要： The current invention pertains to an apparatus and method for the determination of excess post-exercise oxygen consumption (EPOC) and the estimation of blood lactate levels. While these exercise parameters are traditionally determined using indirect calorimetry and blood sampling, this invention provides a method for the determination of these parameters using heart rate data. A wearable photoplethysmography device for measuring heart rate is included as an exemplary embodiment, however, the method of the current inventions can also be used with heart rate data from any heart rate monitor. In an embodiment of the present invention a supply demand differential equation is used to continuously monitor EPOC in real-time. Furthermore, blood lactate levels can also be estimated as a function of EPOC. Importantly, the process of determining EPOC and blood lactate can be linked to a biomathematical model of human physiology to access additional parameters such as hormonal changes, body composition changes or other physiological fluctuations or transient physiological behavior.
摘要翻译：本发明涉及用于确定过量运动后氧耗（EPOC）和血乳酸水平的估计的装置和方法。尽管传统上使用间接量热法和血液取样来确定这些运动参数，但是本发明提供了使用心率数据来确定这些参数的方法。作为示例性实施例，包括用于测量心率的可穿戴式光体积测量装置，然而，本发明的方法也可以与来自任何心率监测器的心率数据一起使用。在本发明的一个实施例中，供应需求微分方程用于实时地连续监测EPOC。此外，血乳酸水平也可以作为EPOC的函数估计。重要的是，确定EPOC和血液乳酸盐的过程可以与人类生理学的生物化学模型相关联，以获得附加参数，如激素变化，身体组成变化或其他生理波动或暂时的生理行为。

8. 发明申请

WO2023092009A1 REMOTE HEALTH MONITORING SYSTEM 审中-公开
公开(公告)号：WO2023092009A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/080048
申请日：2022-11-17
申请人： LIFEQ B.V. , OLIVIER, Laurence, Richard
发明人： DU PREEZ, Franco , TERBLANCHE, Etienne
IPC分类号： A61B5/00
摘要： A health monitoring system is provided including at least one non-invasive wearable device capable of collecting and storing data, and external monitoring devices that displays and analyses the data for accurate monitoring and anomaly detection. The wearable devices are configured to collect low-latency PPG-derived bio-signals and can utilize multiple devices for accuracy and continuity. The system may further include a dashboard that analyzes the information as well as displaying basic information such as number of beds (in-use, available), staff-to-patient ratio, etc. The data can be collected and accessed remotely and may be utilized before, during, and/or after a patient is dispatched from a clinical setting.

9. 发明申请

WO2017117335A1 CARDIO-KINETIC CROSS-SPECTRAL DENSITY FOR ASSESSMENT OF SLEEP PHYSIOLOGY 审中-公开
标题翻译：心脏动力学交叉谱密度评估睡眠生理学
公开(公告)号：WO2017117335A1
公开(公告)日：2017-07-06
申请号：PCT/US2016/069085
申请日：2016-12-29
申请人： LIFEQ GLOBAL LIMITED , OLIVIER, Laurence, Richard
发明人： OLIVIER, Laurence, Richard
IPC分类号： A61B5/00 , A61B5/0205 , A61B5/05 , A61B5/08 , A61B5/024 , A61B34/10
CPC分类号： A61B5/4812 , A61B5/0006 , A61B5/0205 , A61B5/02416 , A61B5/0402 , A61B5/1102 , A61B5/4815 , A61B5/6802 , A61B5/7221 , A61B5/7278 , A61B5/742 , A61B2562/0219
摘要： The invention comprises methods and systems capable of processing simultaneously measured cardiac and motion signals, selecting from said signals the optimal cardiac and motion signal combination for cross spectral density calculations and, hereafter, itemizing the shared information in terms of the individual constituent frequencies and the effect exerted upon said frequencies by common underlying physiological states. The information is passed through a classifier, where said information is used to quantify the underlying physiological states, exemplified by but not limited to, sleep stage, quality and/or disorders that affect sleep stability. Inferences made by the methods described, for example, can be employed to aid home based sleep analysis and automated screening of patients with sleep disorders.
摘要翻译：本发明包括能够同时处理测量的心脏和运动信号的方法和系统，从所述信号中选择用于交叉谱密度计算的最佳心脏和运动信号组合，并且此后按照术语逐项列出共享信息通过共同的基础生理状态对各个组成频率和对所述频率施加的效应。信息通过分类器，其中所述信息用于量化潜在的生理状态，例如但不限于睡眠阶段，影响睡眠稳定性的质量和/或障碍。例如，通过所描述的方法进行的推断可用于帮助基于家庭的睡眠分析和自动筛选患有睡眠障碍的患者。

10. 发明申请

WO2017078759A1 NON-INVASIVE PHYSIOLOGICAL QUANTIFICATION OF STRESS LEVELS 审中-公开
标题翻译：应力水平的非侵入性生理量化
公开(公告)号：WO2017078759A1
公开(公告)日：2017-05-11
申请号：PCT/US2016/000105
申请日：2016-11-07
申请人： LIFEQ GLOBAL LIMITED , OLIVIER, Laurence, Richard , DU PREEZ, Franco, Bauer , HARE, Shannagh, Jane , FANFONI, Alida
发明人： OLIVIER, Laurence, Richard , DU PREEZ, Franco, Bauer , HARE, Shannagh, Jane , FANFONI, Alida
IPC分类号： A61B5/00
CPC分类号： A61B5/4884 , A61B5/02055 , A61B5/021 , A61B5/02416 , A61B5/0402 , A61B5/0476 , A61B5/053 , A61B5/0533 , A61B5/08 , A61B5/0816 , A61B5/11 , A61B5/14546 , A61B5/165 , A61B5/4035 , A61B5/4041 , A61B5/4227 , A61B5/6814 , A61B5/6823 , A61B5/6824 , A61B5/6826 , A61B5/6828 , A61B5/6831 , A61B5/6833 , A61B5/6861 , A61B5/7264 , A61B2560/0242 , A61B2562/0219 , A61B2562/0223 , G06F19/00
摘要： A data acquisition device includes measuring instruments to generate physiological and/or psychological data streams. Microprocessors within the acquisition device process the generated data streams into metrics, which feed into stress function algorithms. Algorithm processing may occur either on the device, or metrics may be communicated via wireless communication for external processing on mobile devices and/or cloud-based platforms. The calculated stress functions inform cloud-based computational systems biology-derived models describing the dynamics of hormones and neurotransmitters released in the body in response to stressful stimuli. Stress hormone levels are quantified using these models, and are used in combination to serve as biologically inspired metrics of acute and chronic stress an individual is experiencing.
摘要翻译：数据采集设备包括用于生成生理和/或心理数据流的测量仪器。采集设备中的微处理器将生成的数据流处理成度量值，并将其输入到压力函数算法中。算法处理可以发生在设备上，或者可以通过无线通信传达度量以用于移动设备和/或基于云的平台上的外部处理。计算的压力函数通知基于云的计算系统生物学派生模型，描述响应压力刺激时体内释放的激素和神经递质的动力学。使用这些模型对压力荷尔蒙水平进行量化，并将其结合起来用作个体正在经历的急性和慢性压力的生物学启发度量。

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