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1. 发明申请

WO2012142493A2 ULTRASOUND TRANSDUCER PROBE AND METHODS 审中-公开
标题翻译：超声波传感器探头和方法
公开(公告)号：WO2012142493A2
公开(公告)日：2012-10-18
申请号：PCT/US2012/033632
申请日：2012-04-13
申请人： CORNELL UNIVERSITY , LEWIS JR., George K. , OLBRICHT, William L. , GELBER, Steven , LEWIS SR., George K.
发明人： LEWIS JR., George K. , OLBRICHT, William L. , GELBER, Steven , LEWIS SR., George K.
IPC分类号： A61B8/00 , G01N29/24
CPC分类号： A61B8/4494 , A61B5/4356 , A61B8/0866 , A61B8/4477 , A61B8/488 , A61B8/5223 , A61B8/54 , A61B8/56
摘要： There is set forth herein a uterine probe having one or more transducer for detecting a uterine parameter. The one or more parameter can be a fetal heart rate. The one or more parameter can be uterine contraction. In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a fetal heart rate (FHR). In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a uterine contraction. The one or more transducer can be of a common technology or can be of different technology. In one embodiment a uterine probe can include one or more transducer that is operative to be driven in different signaling configurations. A first signaling configuration can be a signaling configuration for detection of a fetal heart rate. A second signaling configuration can be a signaling configuration for detection of uterine contraction.
摘要翻译：这里提出了具有用于检测子宫参数的一个或多个换能器的子宫探针。一个或多个参数可以是胎儿心率。一个或多个参数可以是子宫收缩。在一个实施例中，子宫探针可以包括用于发射声波以检测胎儿心率（FHR）的换能器。在一个实施例中，子宫探针可以包括可操作地发射声波以用于检测子宫收缩的换能器。一个或多个传感器可以是通用技术或可以是不同的技术。在一个实施例中，子宫探针可以包括可操作地以不同的信令配置驱动的一个或多个换能器。第一信令配置可以是用于检测胎儿心率的信令配置。第二信号配置可以是用于检测子宫收缩的信号配置。

2. 发明申请

WO2011109735A2 ULTRASOUND-ASSISTED CONVECTION ENHANCED DELIVERY OF COMPOUNDS IN VIVO WITH A TRANSDUCER CANNULA ASSEMBLY 审中-公开
标题翻译：超声波辅助对流增强化学传感器中的化合物与传感器肛门组件
公开(公告)号：WO2011109735A2
公开(公告)日：2011-09-09
申请号：PCT/US2011/027238
申请日：2011-03-04
申请人： CORNELL UNIVERSITY , LEWIS, George K., Jr. , OLBRICHT, William L.
发明人： LEWIS, George K., Jr. , OLBRICHT, William L.
CPC分类号： A61M37/0092 , A61B8/0816 , A61M2210/0693 , Y10T29/42
摘要： A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.
摘要翻译：提供了一种化合物的对流增强输送（CED）方法和该方法使用的装置。超声换能器插管组件（TCA）装置的装置可以用于将化合物递送到身体中的目标，例如健康或患病状态下的细胞，组织或器官。超声TCA装置包括换能器套管组件（TCA）和超声系统，以增强靶中分子的渗透。超声系统可以是便携式和袖珍型。在超声波对比增强的输送系统中，将超声波包含在设备中提高了材料的分布体积四至六倍。由于靶点可以更集中，因此需要较少的化合物，从而降低对宿主和宿主细胞的有害影响的可能性。

3. 发明申请

WO2008100930A3 CONVECTION ENHANCED DELIVERY APPARATUS, METHOD AND APPLICATION 审中-公开
公开(公告)号：WO2008100930A3
公开(公告)日：2008-08-21
申请号：PCT/US2008/053716
申请日：2008-02-12
申请人： CORNELL UNIVERSITY , YALE UNIVERSITY , NEEVES, Keith, B. , OLBRICHT, William, L. , FOLEY, Conor , MATTHEWS, Russell, T. , SALTZMAN, W., Mark , SAWYER, Andrew
发明人： NEEVES, Keith, B. , OLBRICHT, William, L. , FOLEY, Conor , MATTHEWS, Russell, T. , SALTZMAN, W., Mark , SAWYER, Andrew
IPC分类号： A61K9/22
摘要： The Abstract, as currently written, exceeds the maximum number of allowable words, which is 150 words The text of the Abstract has been established to read as follows An embodiment of the invention is directed to a microfabπcated, silicon-based, Convection Enhanced Delivery (CED) device The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control devιce(s) or apparatus that supplies and/or delivers fluid (e g, a drug) to the microfabricated device The device may have multiple channels disposed side by side or in different surfaces of the device

4. 发明申请

WO2012142493A3 ULTRASOUND TRANSDUCER PROBE AND METHODS 审中-公开
标题翻译：超声波传感器探头和方法
公开(公告)号：WO2012142493A3
公开(公告)日：2013-01-17
申请号：PCT/US2012033632
申请日：2012-04-13
申请人： UNIV CORNELL , LEWIS JR GEORGE K , OLBRICHT WILLIAM L , GELBER STEVEN , LEWIS SR GEORGE K
发明人： LEWIS JR GEORGE K , OLBRICHT WILLIAM L , GELBER STEVEN , LEWIS SR GEORGE K
IPC分类号： A61B8/00 , G01N29/24
CPC分类号： A61B8/4494 , A61B5/4356 , A61B8/0866 , A61B8/4477 , A61B8/488 , A61B8/5223 , A61B8/54 , A61B8/56
摘要： There is set forth herein a uterine probe having one or more transducer for detecting a uterine parameter. The one or more parameter can be a fetal heart rate. The one or more parameter can be uterine contraction. In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a fetal heart rate (FHR). In one embodiment a uterine probe can include a transducer operative to emit sound waves for detection of a uterine contraction. The one or more transducer can be of a common technology or can be of different technology. In one embodiment a uterine probe can include one or more transducer that is operative to be driven in different signaling configurations. A first signaling configuration can be a signaling configuration for detection of a fetal heart rate. A second signaling configuration can be a signaling configuration for detection of uterine contraction.
摘要翻译：这里提出了具有用于检测子宫参数的一个或多个换能器的子宫探针。一个或多个参数可以是胎儿心率。一个或多个参数可以是子宫收缩。在一个实施例中，子宫探针可以包括用于发射声波以检测胎儿心率（FHR）的换能器。在一个实施例中，子宫探针可以包括可操作地发射声波以用于检测子宫收缩的换能器。一个或多个传感器可以是通用技术或可以是不同的技术。在一个实施例中，子宫探针可以包括可操作地以不同的信令配置驱动的一个或多个换能器。第一信令配置可以是用于检测胎儿心率的信令配置。第二信号配置可以是用于检测子宫收缩的信号配置。

5. 发明申请

WO2011109735A3 ULTRASOUND-ASSISTED CONVECTION ENHANCED DELIVERY OF COMPOUNDS IN VIVO WITH A TRANSDUCER CANNULA ASSEMBLY 审中-公开
标题翻译：超声波辅助对流增强化学传感器中的化合物与传感器肛门组件
公开(公告)号：WO2011109735A3
公开(公告)日：2012-01-05
申请号：PCT/US2011027238
申请日：2011-03-04
申请人： UNIV CORNELL , LEWIS GEORGE K JR , OLBRICHT WILLIAM L
发明人： LEWIS GEORGE K JR , OLBRICHT WILLIAM L
IPC分类号： A61B18/00 , A61B17/34 , A61M5/14 , A61M25/01 , A61N7/00
CPC分类号： A61M37/0092 , A61B8/0816 , A61M2210/0693 , Y10T29/42
摘要： A method for convection-enhanced delivery (CED) of compounds and an apparatus for use with the method are provided. The apparatus, an ultrasound transducer cannula assembly (TCA) apparatus, can be used for the delivery of a compound to a target in the body such as a cells, tissue or organ in a healthy or diseased state. The ultrasound TCA apparatus comprises a transducer cannula assembly (TCA) and an ultrasound system to enhance penetration of molecules in the target. The ultrasound system may be portable and pocket-sized. The inclusion of ultrasound in the apparatus improves the distribution volume of material four to six times over a convection-enhanced delivery system without ultrasound. Since the targeting can be more focused, less compound is needed, thus lowering the potential for harmful effects to the host and host cells.
摘要翻译：提供了一种化合物的对流增强输送（CED）方法和该方法使用的装置。超声换能器插管组件（TCA）装置的装置可以用于将化合物递送到身体中的目标，例如健康或患病状态下的细胞，组织或器官。超声TCA装置包括换能器套管组件（TCA）和超声系统，以增强靶中分子的渗透。超声系统可以是便携式和袖珍型。在超声波对比增强的输送系统中，将超声波包含在设备中提高了材料的分布体积四至六倍。由于靶点可以更集中，因此需要较少的化合物，从而降低对宿主和宿主细胞的有害影响的可能性。

6. 发明申请

WO2008100930A2 CONVECTION ENHANCED DELIVERY APPARATUS, METHOD AND APPLICATION 审中-公开
标题翻译：对流增强装置，方法和应用
公开(公告)号：WO2008100930A2
公开(公告)日：2008-08-21
申请号：PCT/US2008053716
申请日：2008-02-12
申请人： UNIV CORNELL , UNIV YALE , NEEVES KEITH B , OLBRICHT WILLIAM L , FOLEY CONOR , MATTHEWS RUSSELL T , SALTZMAN W MARK , SAWYER ANDREW
发明人： NEEVES KEITH B , OLBRICHT WILLIAM L , FOLEY CONOR , MATTHEWS RUSSELL T , SALTZMAN W MARK , SAWYER ANDREW
IPC分类号： C12M3/00
CPC分类号： A61K38/47 , A61M5/1408 , A61M37/00 , A61M37/0015 , A61M2037/0023 , A61M2037/003 , A61M2210/0693 , C12Y302/01 , C12Y302/01035
摘要： An embodiment of the invention is directed to a micro fabricated, silicon-based, Convection Enhanced Delivery (CED) device. The device comprises a silicon shank portion, at least one individual parylene channel disposed along at least a part of an entire length of the shank, wherein the channel has one or more dimensioned fluid exit ports disposed at one or more respective locations of the channel and a fluid (drug) input opening. The fluid input opening may be configured or adapted to be connected to a fluid reservoir and/or a pump and/or a meter and/or a valve or other suitable control device(s) or apparatus that supplies and/or delivers fluid (e.g., a drug) to the microfabricated device. The device may have multiple channels disposed side by side or in different surfaces of the device. The device may be rigid, or flexible, in which case a flexible device can be attached to a bio-degradable support scaffold that provides sufficient structural rigidity for insertion of the device into the target tissue. In certain "functionalized" embodiments of the invention, the CED device is equipped with integrated electrodes and/or a sensor (e.g., glutamate) to detect and convey selective parametric information. Another embodiment of the invention is directed to a CED method for drugs and/or other agents. The method may comprise the delivery of enzymes or other materials to modify tissue permeability and improve drug diffusion. Another embodiment of the invention is directed to a method for making a device for CED of drugs.
摘要翻译：本发明的实施例涉及一种微制造的基于硅的对流增强输送（CED）装置。所述装置包括硅柄部分，至少一个单独的聚对二甲苯通道沿着所述柄部的整个长度的至少一部分设置，其中所述通道具有设置在所述通道的一个或多个相应位置处的一个或多个尺寸尺寸的流体出口，流体（药物）输入口。流体输入开口可以被配置或适于连接到供给和/或输送流体的流体储存器和/或泵和/或流量计和/或阀或其它合适的控制装置或装置。，一种药物）到微细化装置。该装置可以具有并排设置在装置的不同表面中的多个通道。该装置可以是刚性的或柔性的，在这种情况下，柔性装置可以连接到生物可降解的支撑支架上，其提供足够的结构刚性以将装置插入到靶组织中。在本发明的某些“功能化”实施例中，CED装置配备有集成电极和/或传感器（例如谷氨酸盐）以检测和传送选择性参数信息。本发明的另一个实施方案涉及用于药物和/或其他试剂的CED方法。该方法可以包括递送酶或其它材料以改变组织渗透性并改善药物扩散。本发明的另一个实施方案涉及制备用于药物的CED的装置的方法。

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