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1. 发明申请

WO2010107392A1 CULTURE OF PLURIPOTENT AND MULTIPOTENT CELLS ON MICROCARRIERS 审中-公开
标题翻译：微生物培养和多细胞培养
公开(公告)号：WO2010107392A1
公开(公告)日：2010-09-23
申请号：PCT/SG2010/000091
申请日：2010-03-12
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , OH, Steve , CHEN, Allen , CHOO, Andre , REUVENY, Shaul
发明人： OH, Steve , CHEN, Allen , CHOO, Andre , REUVENY, Shaul
IPC分类号： C12N5/0735 , C12N5/074
CPC分类号： C12N5/0606 , C12N5/0696 , C12N2501/727 , C12N2531/00
摘要： A method is disclosed for culturing pluripotent or multipotent cells in vitro , the method comprising attaching pluripotent or multipotent cells to a plurality of microcarriers to form microcarrier-cell complexes, and culturing the microcarrier-cell complexes in suspension culture in the presence of a ROCK inhibitor.
摘要翻译：公开了用于在体外培养多能细胞或多能细胞的方法，所述方法包括将多能细胞或多能细胞连接到多个微载体上以形成微载体 - 细胞复合物，并在ROCK抑制剂存在下在悬浮培养物中培养微载体 - 细胞复合物。

2. 发明申请

WO2009116951A3 MICROCARRIERS FOR STEM CELL CULTURE 审中-公开
标题翻译：干细胞培养微生物
公开(公告)号：WO2009116951A3
公开(公告)日：2009-11-26
申请号：PCT/SG2009000088
申请日：2009-03-17
申请人： AGENCY SCIENCE TECH & RES , OH STEVE , LECINA MARTI , CHOO ANDRE , REUVENY SHAUL , ZWEIGERT ROBERT , CHEN ALLEN
发明人： OH STEVE , LECINA MARTI , CHOO ANDRE , REUVENY SHAUL , ZWEIGERT ROBERT , CHEN ALLEN
IPC分类号： C12N5/00 , C12N5/0735 , C12N5/0789
CPC分类号： C12N5/0606 , C12N5/0062 , C12N5/0075 , C12N5/0647
摘要： We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50µm and 400µm, such as about 200µm. It may have a cross sectional dimension of between 20µm and 30µm. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20µm and about 120µm, for example about 65 µm. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage. A method of propagating human embryonic stem cells (hESCs) in long term suspension culture using microcarriers coated in Matrigel or hyaluronic acid is also disclosed. We also disclose a method for differentiating stem cells.
摘要翻译：我们公开了包含其上涂覆有基质并具有正电荷的颗粒的颗粒，该颗粒的尺寸允许附着于其上的灵长类动物或人类干细胞的聚集。颗粒可以包括具有50μm至400μm之间的最长尺寸（例如约200μm）的基本上细长的圆柱形或棒状颗粒。它的横截面尺寸可以在20μm和30μm之间。颗粒可以包括大小为约20μm至约120μm，例如约65μm的基本致密或球形的颗粒。我们还公开了增加灵长类动物或人类干细胞的方法，该方法包括：提供连接到第一和第二相应颗粒上的第一和第二灵长类动物或人类干细胞，使第一灵长类动物或人类干细胞接触第二灵长类动物或人类干细胞细胞以形成细胞聚集体并培养所述聚集体以使所述灵长类动物或人类干细胞传播至少一个通道。还公开了使用包被在基质胶或透明质酸中的微载体在长期悬浮培养物中繁殖人胚胎干细胞（hESC）的方法。我们还公开了一种区分干细胞的方法。

3. 发明申请

WO2007112451A3 COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS 审中-公开
标题翻译：内酯与转铁蛋白和LACTOFERRIN受体结合剂之间的共价结合
公开(公告)号：WO2007112451A3
公开(公告)日：2008-11-20
申请号：PCT/US2007065399
申请日：2007-03-28
申请人： UNIV WASHINGTON , SASAKI TOMIKAZU , LAI HENRY C , SINGH NARENDRA P , OH STEVE J
发明人： SASAKI TOMIKAZU , LAI HENRY C , SINGH NARENDRA P , OH STEVE J
IPC分类号： C07K1/00
CPC分类号： C07K7/08 , A61K38/00 , A61K47/48246 , A61K47/48346 , A61K47/64 , A61K47/66 , B82Y5/00 , C07D493/18 , C07D493/20 , C07D519/00 , C07K7/06
摘要： The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
摘要翻译：本发明涉及内过氧化物与结合于转铁蛋白或乳铁蛋白受体上的分子腔的小肽和有机化合物之间的共价缀合物，以及包含这些缀合物的组合物用于治疗癌症，过度增殖性疾病，炎性疾病和感染的共价缀合物。

4. 发明申请

WO2009116951A2 MICROCARRIERS FOR STEM CELL CULTURE 审中-公开
标题翻译：微量培养基干细胞培养
公开(公告)号：WO2009116951A2
公开(公告)日：2009-09-24
申请号：PCT/SG2009/000088
申请日：2009-03-17
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , OH, Steve , LECINA, Marti , CHOO, Andre , REUVENY, Shaul , ZWEIGERT, Robert , CHEN, Allen
发明人： OH, Steve , LECINA, Marti , CHOO, Andre , REUVENY, Shaul , ZWEIGERT, Robert , CHEN, Allen
IPC分类号： C12N5/06 , C12N5/00
CPC分类号： C12N5/0606 , C12N5/0062 , C12N5/0075 , C12N5/0647
摘要： We disclose a particle comprising a matrix coated thereon and having a positive charge, the particle being of a size to allow aggregation of primate or human stem cells attached thereto. The particle may comprise a substantially elongate, cylindrical or rod shaped particle having a longest dimension of between 50μm and 400μm, such as about 200μm. It may have a cross sectional dimension of between 20μm and 30μm. The particle may comprise a substantially compact or spherical shaped particle having a size of between about 20μm and about 120μm, for example about 65 μm. We also disclose a method of propagating primate or human stem cells, the method comprising: providing first and second primate or human stem cells attached to first and second respective particles, allowing the first primate or human stem cell to contact the second primate or human stem cell to form an aggregate of cells and culturing the aggregate to propagate the primate or human stem cells for at least one passage. A method of propagating human embryonic stem cells (hESCs) in long term suspension culture using microcarriers coated in Matrigel or hyaluronic acid is also disclosed. We also disclose a method for differentiating stem cells.
摘要翻译：我们公开了一种颗粒，所述颗粒包含涂布于其上并具有正电荷的基质，所述颗粒具有允许与其连接的灵长类动物或人干细胞聚集的尺寸。颗粒可以包括具有最长尺寸在50μm和400μm之间，例如约200μm的基本上细长的圆柱形或棒形颗粒。它的横截面尺寸可能在20μm和30μm之间。颗粒可以包括尺寸在约20μm与约120μm之间，例如约65μm的基本上致密或球形的颗粒。我们还公开了增殖灵长类动物或人类干细胞的方法，该方法包括：提供附着于第一和第二相应颗粒的第一和第二灵长类动物或人类干细胞，使第一灵长类或人类干细胞接触第二灵长类或人类干细胞细胞以形成细胞聚集体并培养聚集体以繁殖灵长类动物或人类干细胞至少一次传代。还公开了使用涂覆在基质胶或透明质酸中的微载体在长期悬浮培养物中繁殖人胚胎干细胞（hESC）的方法。我们还公开了一种分化干细胞的方法。

5. 发明申请

WO2007112451A2 COVALENT CONJUGATES BETWEEN ENDOPEROXIDES AND TRANSFERRIN AND LACTOFERRIN RECEPTOR-BINDING AGENTS 审中-公开
标题翻译：内酯与转铁蛋白和LACTOFERRIN受体结合剂之间的共价结合
公开(公告)号：WO2007112451A2
公开(公告)日：2007-10-04
申请号：PCT/US2007/065399
申请日：2007-03-28
申请人： UNIVERSITY OF WASHINGTON , SASAKI, Tomikazu , LAI, Henry, C. , SINGH, Narendra, P. , OH, Steve, J.
发明人： SASAKI, Tomikazu , LAI, Henry, C. , SINGH, Narendra, P. , OH, Steve, J.
IPC分类号： A61K38/20 , A61K38/28 , A61K38/18 , C07D323/04
CPC分类号： C07K7/08 , A61K38/00 , A61K47/64 , A61K47/66 , B82Y5/00 , C07D493/18 , C07D493/20 , C07D519/00 , C07K7/06 , Y02A50/411
摘要： The invention relates to covalent conjugates between endoperoxides and small peptides and organic compounds that bind to molecular cavities on the transferrin or lactoferrin receptor, and the use of compositions comprising these conjugates to treat cancer, hyperproliferative disorders, inflammatory diseases, and infections.
摘要翻译：本发明涉及内过氧化物与结合于转铁蛋白或乳铁蛋白受体上的分子腔的小肽和有机化合物之间的共价缀合物，以及使用包含这些缀合物的组合物来治疗癌症，过度增殖性疾病，炎性疾病和感染。

6. 发明申请

WO2016176124A1 TRANSFORMABLE FOLDING ELECTRIC SCOOTER 审中-公开
标题翻译：可变形折叠电动玩具
公开(公告)号：WO2016176124A1
公开(公告)日：2016-11-03
申请号：PCT/US2016/029015
申请日：2016-04-22
申请人： OH, Steve
发明人： OH, Steve
IPC分类号： B62K11/00 , B62K3/00 , B62K15/00
CPC分类号： B62K15/006 , B62K3/002 , B62K15/008 , B62K21/16 , B62K2202/00 , B62K2204/00 , B62L1/02
摘要： A transformable folding electric scooter comprises a motor engine, a connecting frame, and a boarding plate. The connecting frame comprises a handle frame disposed upright and having a handle at a top portion thereof, a front frame extending forward from a lower portion of the handle frame and connected to the motor engine foldably at a first folding position provided on the motor engine, and a rear frame extending rearward from the lower portion of the handle frame. The boarding plate comprises a front plate portion connected to a lower portion of the rear frame fixedly, and a rear plate portion connected to the front plate portion foldably at a second folding position provided between the front plate portion and the rear plate portion of the connecting frame. The rear plate portion is folded upward with respect to the front plate portion at the second folding position.
摘要翻译：一种可变形的折叠式电动滑板车，包括电机发动机，连接架和登机板。连接框架包括直立设置的把手框架，在其顶部具有手柄，前框架从手柄框架的下部向前延伸并且在设置在电动发动机上的第一折叠位置可折叠地连接到电动发动机，以及从手柄框架的下部向后延伸的后框架。该登机板包括一固定地连接到该后框架的下部的前板部分，以及一后连接部分，该后板部分可折叠地连接到该前板部分，该第二折叠位置设置在该连接件的前板部分和后板部分之间帧。后板部分在第二折叠位置处相对于前板部分向上折叠。

7. 发明申请

WO2006089353A1 IMMORTALISED FEEDER CELLS 审中-公开
标题翻译：绝食饲料细胞
公开(公告)号：WO2006089353A1
公开(公告)日：2006-08-31
申请号：PCT/AU2006/000220
申请日：2006-02-23
申请人： AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH , IP ORGANISERS PTY LTD , CHOO, Andre, Boon, Hwa , OH, Steve, Kah, Weng
发明人： CHOO, Andre, Boon, Hwa , OH, Steve, Kah, Weng
IPC分类号： C12N5/10
CPC分类号： C12N15/86 , C12N5/0606 , C12N5/0652 , C12N2502/13 , C12N2510/04 , C12N2740/15043
摘要： The invention relates to an immortalized feeder cell line. The immortalized feeder cell line may be derived from an embryonic fibroblast, which may be a mouse embryonic fibroblast. A culture of an immortalized feeder cell line according to the invention in a suitable culture medium is also provided, as is a composition including an immortalized feeder cell line according to the invention in a suitable carrier or diluent and conditioned medium produced from growth of an immortalized feeder cell line according to the invention. The invention further provides a method of culturing a stem cell including use of a cell line or conditioned medium according to the invention and cells so produced.
摘要翻译：本发明涉及永生化饲养细胞系。永生化的饲养细胞系可以衍生自胚胎成纤维细胞，其可以是小鼠胚胎成纤维细胞。还提供了在合适的培养基中根据本发明的永生化饲养细胞系的培养物，以及包含根据本发明的永生化饲养细胞系在合适的载体或稀释剂中的组合物和由永生化饲养细胞系生长的条件培养基根据本发明的饲养细胞系。本发明还提供了培养干细胞的方法，所述干细胞包括使用根据本发明的细胞系或条件培养基以及如此制备的细胞。

8. 发明申请

WO2005082083A3 DETACHABLE MOTOR DRIVE FOR A BICYCLE 审中-公开
标题翻译：可拆卸的电机驱动自行车
公开(公告)号：WO2005082083A3
公开(公告)日：2006-04-27
申请号：PCT/US2005006263
申请日：2005-02-25
申请人： OH STEVE
发明人： OH STEVE
IPC分类号： B62K11/00
CPC分类号： B62M7/14
摘要： A motor drive (10) for a bicycle is provided. The motor drive includes a drive wheel (24) and a motor device (26) driving the drive wheel. The drive wheel contacts the ground and moves the bicycle by rotating friction between the drive wheel and the ground. The motor device includes a fixing portion (30) that attaches the motor device to the frame of the bicycle, and a driving portion (32) that holds the drive wheel and drives the drive wheel. The driving portion (32) is pivotable with respect to the fixing portion (30) between a parking state and a driving state. The drive wheel (24) is spaced from the ground in the parking state, and contacts the ground in the driving state.
摘要翻译：提供了一种用于自行车的马达驱动装置（10）。马达驱动器包括驱动轮（24）和驱动驱动轮的马达装置（26）。驱动轮接触地面并通过旋转驱动轮和地面之间的摩擦来移动自行车。马达装置包括将马达装置附接到自行车的框架的固定部分（30）和保持驱动轮并驱动驱动轮的驱动部分（32）。驱动部分（32）能够在停车状态和行驶状态之间相对于固定部分（30）枢转。驱动轮（24）在停车状态下与地面间隔开，并且在驾驶状态下与地面接触。

9. 发明申请

WO2005082083A2 DETACHABLE MOTOR DRIVE FOR A BICYCLE 审中-公开
标题翻译：可拆卸的电机驱动自行车
公开(公告)号：WO2005082083A2
公开(公告)日：2005-09-09
申请号：PCT/US2005/006263
申请日：2005-02-25
申请人： OH, Steve
发明人： OH, Steve
CPC分类号： B62M7/14
摘要： A motor drive (10) for a bicycle is provided. The motor drive includes a drive wheel (24) and a motor device (26) driving the drive wheel. The drive wheel contacts the ground and moves the bicycle by rotating friction between the drive wheel and the ground. The motor device includes a fixing portion (30) that attaches the motor device to the frame of the bicycle, and a driving portion (32) that holds the drive wheel and drives the drive wheel. The driving portion (32) is pivotable with respect to the fixing portion (30) between a parking state and a driving state. The drive wheel (24) is spaced from the ground in the parking state, and contacts the ground in the driving state.
摘要翻译：提供了一种用于自行车的马达驱动装置（10）。马达驱动器包括驱动轮（24）和驱动驱动轮的马达装置（26）。驱动轮接触地面并通过旋转驱动轮和地面之间的摩擦来移动自行车。马达装置包括将马达装置附接到自行车的框架的固定部分（30）和保持驱动轮并驱动驱动轮的驱动部分（32）。驱动部分（32）能够在停车状态和行驶状态之间相对于固定部分（30）枢转。驱动轮（24）在停车状态下与地面间隔开，并且在驾驶状态下与地面接触。

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