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1. 发明申请

WO2008014135A2 NON-INVASIVE ANALYTE MEASUREMENT GLASSES AND METHOD OF USE 审中-公开
标题翻译：非入侵分析仪测量玻璃和使用方法
公开(公告)号：WO2008014135A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/073487
申请日：2007-07-13
申请人： OCULIR, INC. , BURD, John F. , WILLIAMS, Paul
发明人： BURD, John F. , WILLIAMS, Paul
IPC分类号： A61B5/00
CPC分类号： A61B5/6887 , A61B5/0002 , A61B5/14532
摘要： A method of using a non-invasive analyte reading device to substantially continuously measure the presence, absence, or concentration of one or more analytes in a tissue of a subject includes wearing the non-invasive analyte reading device constantly or for at least the duration of the desired measurement period; and using the non-invasive analyte reading device to non-invasively measure the presence, absence, or concentration of one or more analytes in a tissue of a subject substantially continuously.
摘要翻译：使用非侵入性分析物读取装置基本上连续地测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括不间断佩戴非侵入性分析物读取装置或至少持续期望的测量周期; 并且使用非侵入性分析物读取装置基本上连续不间断地测量受试者组织中一种或多种分析物的存在，不存在或浓度。

2. 发明申请

WO2008014130A3 WIRELESS NON-INVASIVE ANALYTE MEASUREMENT DEVICE AND METHOD OF USE 审中-公开
标题翻译：无线非侵入式分析测量装置及其使用方法
公开(公告)号：WO2008014130A3
公开(公告)日：2008-03-27
申请号：PCT/US2007073460
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL
发明人： BURD JOHN F , WILLIAMS PAUL
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , A61B5/0002 , A61B5/14532 , Y02A90/22
摘要： Systems and method for tracking measurements from a wireless measurement device are provided. A tracking server is in communication with wireless measurement devices deployed in the field and periodically receives usage reports from the measurement devices to ensure timely measurements by the user and to monitor usage of the measurement devices to ensure compliance. The wireless measurement device is configured to measure one or more analyte levels or concentrations, presence, and/or absence of one or more analytes of the user. The fact of the measurement and the results of the measurement are provided to the tracking server via a wireless communication network. The tracking server stores the information for historical tracking of measurement data usage data. The tracking server may send alerts to a predetermined list of people to notify them when the user is not using the measurement device or when the number of authorized uses needs to be replenished.
摘要翻译：提供了用于跟踪来自无线测量设备的测量的系统和方法。跟踪服务器与现场部署的无线测量设备进行通信，并周期性地接收来自测量设备的使用情况报告，以确保用户及时进行测量，并监测测量设备的使用情况，以确保合规性。无线测量装置被配置为测量一个或多个分析物水平或浓度，存在和/或不存在用户的一种或多种分析物。测量的事实和测量结果通过无线通信网络提供给跟踪服务器。跟踪服务器存储用于历史跟踪测量数据使用数据的信息。跟踪服务器可以向预先确定的人员列表发送警报，以在用户未使用测量设备时或当需要补充授权使用的数量时通知他们。

3. 发明申请

WO2008014131A3 APPARATUS AND METHOD OF USE FOR NON-INVASIVE ANALYTE MEASUREMENT DEVICE 审中-公开
公开(公告)号：WO2008014131A3
公开(公告)日：2008-01-31
申请号：PCT/US2007/073463
申请日：2007-07-13
申请人： OCULIR, INC. , BURD, John, F. , WILLIAMS, Paul , SELL, William, J.
发明人： BURD, John, F. , WILLIAMS, Paul , SELL, William, J.
IPC分类号： A61B5/00 , G06F17/00
摘要： An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.

4. 发明申请

WO2008014134A2 NON-INVASIVE ANALYTE MEASUREMENT DEVICE FOR MEASURING TEARS AND OTHER OCULAR ELEMENTS USING ELECTROMAGNETIC RADIATION AND METHOD OF USING THE SAME 审中-公开
标题翻译：用于测量使用电磁辐射的眼镜和其他眼睛元件的非入侵分析仪测量装置及其使用方法
公开(公告)号：WO2008014134A2
公开(公告)日：2008-01-31
申请号：PCT/US2007073484
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL
发明人： BURD JOHN F , WILLIAMS PAUL
IPC分类号： A61B5/00
CPC分类号： A61B5/6887 , A61B5/0002 , A61B5/14532 , A61B5/1455
摘要： A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and a tear layer, includes exposing at least a portion of the tear layer and/or other ocular elements of the subject to electromagnetic radiation without contact with the ocular surface; detecting electromagnetic radiation reflected from the tear layer and/or other ocular elements without contact with the ocular surface; and determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the tear layer and/or other ocular elements of the subject.
摘要翻译：非侵入性地测量受试者的眼部元件中一种或多种分析物的存在，不存在或浓度的方法，所述受试者包括具有眼表面和泪液层的眼睛，包括将至少一部分泪液层和/或其他眼部元件与电磁辐射无关，而不与眼表面接触; 检测从眼泪层和/或其他眼部元件反射的电磁辐射而不与眼表面接触; 以及确定所述反射的电磁辐射的辐射特征，以确定所述受试者的泪液层和/或其它眼部元件中的一种或多种分析物的存在，不存在或集中。

5. 发明申请

WO2007140185A2 METHODS FOR NON-INVASIVE ANALYTE MEASUREMENT 审中-公开
标题翻译：非入侵分析测量方法
公开(公告)号：WO2007140185A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069454
申请日：2007-05-22
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL , DAHLEN JEFFREY R , SELL WILLIAM J
发明人： BURD JOHN F , WILLIAMS PAUL , DAHLEN JEFFREY R , SELL WILLIAM J
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/7239
摘要： A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining a measurement of electromagnetic radiation from the tissue; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the electromagnetic radiation; correlating the radiation signature of the electromagnetic radiation with at least one of concentration, presence, and absence of one or more analytes by utilizing a mathematic transformation such as a transformation based on a 1st or higher derivative of the measurement to determine the presence, absence, or concentration of one or more analytes in the subject.
摘要翻译：非侵入性测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括将受试者的组织的至少一部分暴露于电磁辐射; 获得来自组织的电磁辐射的测量; 以及通过确定所述电磁辐射的辐射特征来确定一种或多种分析物的存在，不存在或浓度; 通过利用诸如基于测量的第一或更高导数的变换的数学变换来将电磁辐射的辐射特征与浓度，存在和不存在一种或多种分析物的至少一种相关联，以确定存在，不存在，或浓度在受试者中的一种或多种分析物。

6. 发明申请

WO2004099824A2 METHODS AND DEVICE FOR NON-INVASIVE ANALYTE MEASUREMENT 审中-公开
标题翻译：用于非入侵分析仪测量的方法和设备
公开(公告)号：WO2004099824A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/012893
申请日：2004-04-27
申请人： OCULIR, INC. , BURD, John, F. , SELL, William , FRADEN, Jacob , KRAMER, Charles, E. , KRANTZ, Gary , CHAPMAN, Bart
发明人： BURD, John, F. , SELL, William , FRADEN, Jacob , KRAMER, Charles, E. , KRANTZ, Gary , CHAPMAN, Bart
IPC分类号： G02B
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject's eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument. In another aspect of the invention, an instrument measures the level of mid-infrared radiation from the subject's body surface, such as the eye, and determines a specific analyte's concentration based on said analyte's distinctive mid-infrared radiation signature. A preferred aspect of the invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject's conjunctiva. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the preferred embodiment of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.
摘要翻译：本发明涉及用于检测受试者组织中分析物浓度水平的非侵入性方法和仪器。从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。在本发明的一个方面中，仪器用对象眼睛的中心红外范围的辐射使物体的身体表面泛滥，并且基于反射回仪器的中红外辐射来测量分析物浓度。在本发明的另一方面，仪器测量来自受试者的身体表面（例如眼睛）的中红外辐射的水平，并且基于所述分析物的独特的中红外辐射特征确定特定分析物的浓度。本发明的优选方面涉及通过测量来自受试者结膜的电磁辐射特征来检测受试者组织中分析物浓度水平的非侵入性方法和仪器。从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。在本发明的优选实施例的一个方面，仪器用中红外范围内的电磁辐射泛滥受试者的结膜，并且基于反射回仪器的中红外辐射来测量分析物浓度。

7. 发明申请

WO2008014132A2 COMBINATION ANALYTE MEASUREMENT DEVICE AND METHOD OF USE 审中-公开
标题翻译：组合分析仪测量装置及其使用方法
公开(公告)号：WO2008014132A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/073472
申请日：2007-07-13
申请人： OCULIR, INC. , BURD, John F. , WILLIAMS, Paul
发明人： BURD, John F. , WILLIAMS, Paul
IPC分类号： A61B5/00
CPC分类号： A61B5/6887 , A61B5/0002 , A61B5/14532 , A61B5/1455
摘要： A combination non-invasive analyte reading and sample analyte reading device for both non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject and measuring the presence, absence, or concentration of one or more analytes in a biological sample of a subject includes a device housing; one or more outputs carried by the device housing; one or more inputs carried by the device housing to control operation of the device; a non-invasive analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a tissue of a subject; and a sample analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a biological sample of a subject.
摘要翻译：非侵入性分析物读数和样品分析物读取装置的组合，用于非侵入性地测量受试者组织中一种或多种分析物的存在，不存在或浓度，并测量一种或多种分析物的存在，不存在或浓度在受试者的生物样品中包括装置壳体; 由设备外壳承载的一个或多个输出; 由设备外壳承载的一个或多个输入以控制设备的操作; 一种非侵入式分析物读取器，由该装置壳体承载并被配置成测量受试者的组织中一种或多种分析物的存在，不存在或集中; 以及由所述装置容纳并被配置为测量受试者的生物样品中一种或多种分析物的存在，不存在或浓缩的样品分析物读取器。

8. 发明申请

WO2008014131A2 APPARATUS AND METHOD OF USE FOR NON-INVASIVE ANALYTE MEASUREMENT DEVICE 审中-公开
标题翻译：用于无创分析测量装置的装置和方法
公开(公告)号：WO2008014131A2
公开(公告)日：2008-01-31
申请号：PCT/US2007073463
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL , SELL WILLIAM J
发明人： BURD JOHN F , WILLIAMS PAUL , SELL WILLIAM J
IPC分类号： A61B5/00 , G06F17/00 , G06Q99/00
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/6887
摘要： An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.
摘要翻译：提供了用于启用NAM设备的设备和方法。 NAM设备配置为在每次请求测量时验证其使用。 NAM设备的操作由跟踪预定数量的授权使用的可再填充媒体卡管理。 NAM设备确认剩余的授权使用可用于可填充媒体卡。除了追踪NAM设备的授权使用数量之外，媒体卡还可以存储测量结果以供跟踪服务器进行跟踪。当媒体卡上授权使用的数量被耗尽时，媒体卡可通过在有线或无线通信网络上完成再填充事务来重新填充。或者，媒体卡可以在自助终端站重新填充，或者可以获得新的媒体卡用于与NAM设备一起使用。

9. 发明申请

WO2008014130A2 WIRELESS NON-INVASIVE ANALYTE MEASUREMENT DEVICE AND METHOD OF USE 审中-公开
标题翻译：无线非入侵分析仪测量装置及其使用方法
公开(公告)号：WO2008014130A2
公开(公告)日：2008-01-31
申请号：PCT/US2007/073460
申请日：2007-07-13
申请人： OCULIR, INC. , BURD, John, F. , WILLIAMS, Paul
发明人： BURD, John, F. , WILLIAMS, Paul
IPC分类号： G06Q50/00 , G06Q10/00 , A61B5/00
CPC分类号： G06Q50/22 , A61B5/0002 , A61B5/14532 , Y02A90/22
摘要： Systems and method for tracking measurements from a wireless measurement device are provided. A tracking server is in communication with wireless measurement devices deployed in the field and periodically receives usage reports from the measurement devices to ensure timely measurements by the user and to monitor usage of the measurement devices to ensure compliance. The wireless measurement device is configured to measure one or more analyte levels or concentrations, presence, and/or absence of one or more analytes of the user. The fact of the measurement and the results of the measurement are provided to the tracking server via a wireless communication network. The tracking server stores the information for historical tracking of measurement data usage data. The tracking server may send alerts to a predetermined list of people to notify them when the user is not using the measurement device or when the number of authorized uses needs to be replenished.
摘要翻译：提供了用于跟踪来自无线测量装置的测量的系统和方法。跟踪服务器与现场部署的无线测量设备进行通信，并定期从测量设备接收使用报告，以确保用户及时进行测量并监控测量设备的使用情况以确保符合性。无线测量装置被配置为测量用户的一种或多种分析物的一种或多种分析物水平或浓度，存在和/或不存在。通过无线通信网络向跟踪服务器提供测量的事实和测量结果。跟踪服务器存储用于测量数据使用数据的历史跟踪的信息。跟踪服务器可以向预定的人员列表发送警报，以便在用户不使用测量设备时或当需要补充授权用途的数量时通知他们。

10. 发明申请

WO2004099824A3 METHODS AND DEVICE FOR NON-INVASIVE ANALYTE MEASUREMENT 审中-公开
标题翻译：用于非入侵分析测量的方法和设备
公开(公告)号：WO2004099824A3
公开(公告)日：2005-01-20
申请号：PCT/US2004012893
申请日：2004-04-27
申请人： OCULIR INC , BURD JOHN F , SELL WILLIAM , FRADEN JACOB , KRAMER CHARLES E , KRANTZ GARY , CHAPMAN BART
发明人： BURD JOHN F , SELL WILLIAM , FRADEN JACOB , KRAMER CHARLES E , KRANTZ GARY , CHAPMAN BART
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument(200) floods a body surface of the subject, such as the subject's eye (100), with radiation in the mid-infrared range (150) and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument (200).
摘要翻译：本发明涉及用于检测受试者组织中分析物浓度水平的非侵入性方法和仪器。从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。在本发明的一个方面中，仪器（200）使受试者的眼睛（100）的身体表面与中红外范围（150）中的辐射一起泛洪，并且测量基于中红外辐射的分析物浓度反射回仪器（200）。

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