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1. 发明申请

WO2004099824A2 METHODS AND DEVICE FOR NON-INVASIVE ANALYTE MEASUREMENT 审中-公开
标题翻译：用于非入侵分析仪测量的方法和设备
公开(公告)号：WO2004099824A2
公开(公告)日：2004-11-18
申请号：PCT/US2004/012893
申请日：2004-04-27
申请人： OCULIR, INC. , BURD, John, F. , SELL, William , FRADEN, Jacob , KRAMER, Charles, E. , KRANTZ, Gary , CHAPMAN, Bart
发明人： BURD, John, F. , SELL, William , FRADEN, Jacob , KRAMER, Charles, E. , KRANTZ, Gary , CHAPMAN, Bart
IPC分类号： G02B
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546
摘要： The present invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the invention, an instrument floods a body surface of the subject, such as the subject's eye, with radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument. In another aspect of the invention, an instrument measures the level of mid-infrared radiation from the subject's body surface, such as the eye, and determines a specific analyte's concentration based on said analyte's distinctive mid-infrared radiation signature. A preferred aspect of the invention is related to non-invasive methods and instruments to detect the level of analyte concentrations in the tissue of a subject by measuring electromagnetic radiation signatures from the subject's conjunctiva. The spectra of mid-infrared radiation emitted from a subject's body are altered corresponding to the concentration of various compounds within the radiating tissue. In one aspect of the preferred embodiment of the invention, an instrument floods the conjunctiva of the subject with electromagnetic radiation in the mid-infrared range and measures analyte concentrations based on mid-infrared radiation reflected back to the instrument.
摘要翻译：本发明涉及用于检测受试者组织中分析物浓度水平的非侵入性方法和仪器。从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。在本发明的一个方面中，仪器用对象眼睛的中心红外范围的辐射使物体的身体表面泛滥，并且基于反射回仪器的中红外辐射来测量分析物浓度。在本发明的另一方面，仪器测量来自受试者的身体表面（例如眼睛）的中红外辐射的水平，并且基于所述分析物的独特的中红外辐射特征确定特定分析物的浓度。本发明的优选方面涉及通过测量来自受试者结膜的电磁辐射特征来检测受试者组织中分析物浓度水平的非侵入性方法和仪器。从受试者身体发射的中红外辐射的光谱根据辐射组织内各种化合物的浓度而改变。在本发明的优选实施例的一个方面，仪器用中红外范围内的电磁辐射泛滥受试者的结膜，并且基于反射回仪器的中红外辐射来测量分析物浓度。

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