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1. 发明申请

WO2008014130A3 WIRELESS NON-INVASIVE ANALYTE MEASUREMENT DEVICE AND METHOD OF USE 审中-公开
标题翻译：无线非侵入式分析测量装置及其使用方法
公开(公告)号：WO2008014130A3
公开(公告)日：2008-03-27
申请号：PCT/US2007073460
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL
发明人： BURD JOHN F , WILLIAMS PAUL
IPC分类号： G06Q50/00
CPC分类号： G06Q50/22 , A61B5/0002 , A61B5/14532 , Y02A90/22
摘要： Systems and method for tracking measurements from a wireless measurement device are provided. A tracking server is in communication with wireless measurement devices deployed in the field and periodically receives usage reports from the measurement devices to ensure timely measurements by the user and to monitor usage of the measurement devices to ensure compliance. The wireless measurement device is configured to measure one or more analyte levels or concentrations, presence, and/or absence of one or more analytes of the user. The fact of the measurement and the results of the measurement are provided to the tracking server via a wireless communication network. The tracking server stores the information for historical tracking of measurement data usage data. The tracking server may send alerts to a predetermined list of people to notify them when the user is not using the measurement device or when the number of authorized uses needs to be replenished.
摘要翻译：提供了用于跟踪来自无线测量设备的测量的系统和方法。跟踪服务器与现场部署的无线测量设备进行通信，并周期性地接收来自测量设备的使用情况报告，以确保用户及时进行测量，并监测测量设备的使用情况，以确保合规性。无线测量装置被配置为测量一个或多个分析物水平或浓度，存在和/或不存在用户的一种或多种分析物。测量的事实和测量结果通过无线通信网络提供给跟踪服务器。跟踪服务器存储用于历史跟踪测量数据使用数据的信息。跟踪服务器可以向预先确定的人员列表发送警报，以在用户未使用测量设备时或当需要补充授权使用的数量时通知他们。

2. 发明申请

WO2008014131A2 APPARATUS AND METHOD OF USE FOR NON-INVASIVE ANALYTE MEASUREMENT DEVICE 审中-公开
标题翻译：用于无创分析测量装置的装置和方法
公开(公告)号：WO2008014131A2
公开(公告)日：2008-01-31
申请号：PCT/US2007073463
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL , SELL WILLIAM J
发明人： BURD JOHN F , WILLIAMS PAUL , SELL WILLIAM J
IPC分类号： A61B5/00 , G06F17/00 , G06Q99/00
CPC分类号： A61B5/14532 , A61B5/0002 , A61B5/6887
摘要： An apparatus and method of use for enabling a NAM device are provided. The NAM device is configured to authenticate its use each time a measurement is requested. The operation of the NAM device is governed by a refillable media card that tracks a predetermined number of authorized uses. The NAM device confirms that remaining authorized uses are available on the refillable media card. In addition to tracking the number of authorized uses of the NAM device, the media card may also store the results of the measurements for tracking by a tracking server. When the number of authorized uses on the media card is depleted, the media card may be refilled by completing a refill transaction over a wired or wireless communication network. Alternatively, the media card may be refilled at a kiosk station or a new media card may be obtained for use with the NAM device.
摘要翻译：提供了用于启用NAM设备的设备和方法。 NAM设备配置为在每次请求测量时验证其使用。 NAM设备的操作由跟踪预定数量的授权使用的可再填充媒体卡管理。 NAM设备确认剩余的授权使用可用于可填充媒体卡。除了追踪NAM设备的授权使用数量之外，媒体卡还可以存储测量结果以供跟踪服务器进行跟踪。当媒体卡上授权使用的数量被耗尽时，媒体卡可通过在有线或无线通信网络上完成再填充事务来重新填充。或者，媒体卡可以在自助终端站重新填充，或者可以获得新的媒体卡用于与NAM设备一起使用。

3. 发明申请

WO2008014134A2 NON-INVASIVE ANALYTE MEASUREMENT DEVICE FOR MEASURING TEARS AND OTHER OCULAR ELEMENTS USING ELECTROMAGNETIC RADIATION AND METHOD OF USING THE SAME 审中-公开
标题翻译：用于测量使用电磁辐射的眼镜和其他眼睛元件的非入侵分析仪测量装置及其使用方法
公开(公告)号：WO2008014134A2
公开(公告)日：2008-01-31
申请号：PCT/US2007073484
申请日：2007-07-13
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL
发明人： BURD JOHN F , WILLIAMS PAUL
IPC分类号： A61B5/00
CPC分类号： A61B5/6887 , A61B5/0002 , A61B5/14532 , A61B5/1455
摘要： A method of non-invasively measuring the presence, absence or concentration of one or more analytes in an ocular element of a subject, the subject including an eye with an ocular surface and a tear layer, includes exposing at least a portion of the tear layer and/or other ocular elements of the subject to electromagnetic radiation without contact with the ocular surface; detecting electromagnetic radiation reflected from the tear layer and/or other ocular elements without contact with the ocular surface; and determining a radiation signature of the reflected electromagnetic radiation to determine the presence, absence or concentration of the one or more analytes in the tear layer and/or other ocular elements of the subject.
摘要翻译：非侵入性地测量受试者的眼部元件中一种或多种分析物的存在，不存在或浓度的方法，所述受试者包括具有眼表面和泪液层的眼睛，包括将至少一部分泪液层和/或其他眼部元件与电磁辐射无关，而不与眼表面接触; 检测从眼泪层和/或其他眼部元件反射的电磁辐射而不与眼表面接触; 以及确定所述反射的电磁辐射的辐射特征，以确定所述受试者的泪液层和/或其它眼部元件中的一种或多种分析物的存在，不存在或集中。

4. 发明申请

WO2007140185A2 METHODS FOR NON-INVASIVE ANALYTE MEASUREMENT 审中-公开
标题翻译：非入侵分析测量方法
公开(公告)号：WO2007140185A2
公开(公告)日：2007-12-06
申请号：PCT/US2007069454
申请日：2007-05-22
申请人： OCULIR INC , BURD JOHN F , WILLIAMS PAUL , DAHLEN JEFFREY R , SELL WILLIAM J
发明人： BURD JOHN F , WILLIAMS PAUL , DAHLEN JEFFREY R , SELL WILLIAM J
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14546 , A61B5/7239
摘要： A method of non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject includes exposing at least a portion of a tissue of the subject to electromagnetic radiation; obtaining a measurement of electromagnetic radiation from the tissue; and determining the presence, absence, or concentration of one or more analytes by determining a radiation signature of the electromagnetic radiation; correlating the radiation signature of the electromagnetic radiation with at least one of concentration, presence, and absence of one or more analytes by utilizing a mathematic transformation such as a transformation based on a 1st or higher derivative of the measurement to determine the presence, absence, or concentration of one or more analytes in the subject.
摘要翻译：非侵入性测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括将受试者的组织的至少一部分暴露于电磁辐射; 获得来自组织的电磁辐射的测量; 以及通过确定所述电磁辐射的辐射特征来确定一种或多种分析物的存在，不存在或浓度; 通过利用诸如基于测量的第一或更高导数的变换的数学变换来将电磁辐射的辐射特征与浓度，存在和不存在一种或多种分析物的至少一种相关联，以确定存在，不存在，或浓度在受试者中的一种或多种分析物。

5. 发明申请

WO2008014132A3 COMBINATION ANALYTE MEASUREMENT DEVICE AND METHOD OF USE 审中-公开
标题翻译：组合分析仪测量装置及其使用方法
公开(公告)号：WO2008014132A3
公开(公告)日：2009-05-14
申请号：PCT/US2007073472
申请日：2007-07-13
申请人： JOHN F BURD , BURD JOHN F , WILLIAMS PAUL
发明人： BURD JOHN F , WILLIAMS PAUL
IPC分类号： A61B5/1455
CPC分类号： A61B5/6887 , A61B5/0002 , A61B5/14532 , A61B5/1455
摘要： A combination non-invasive analyte reading and sample analyte reading device for both non-invasively measuring the presence, absence, or concentration of one or more analytes in a tissue of a subject and measuring the presence, absence, or concentration of one or more analytes in a biological sample of a subject includes a device housing; one or more outputs carried by the device housing; one or more inputs carried by the device housing to control operation of the device; a non-invasive analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a tissue of a subject; and a sample analyte reader carried by the device housing and configured to measure the presence, absence, or concentration of one or more analytes in a biological sample of a subject.
摘要翻译：非侵入性分析物读数和样品分析物读取装置的组合，用于非侵入性地测量受试者组织中一种或多种分析物的存在，不存在或浓度，并测量一种或多种分析物的存在，不存在或浓度在受试者的生物样品中包括装置壳体; 由设备外壳承载的一个或多个输出; 由设备外壳承载的一个或多个输入以控制设备的操作; 一种非侵入式分析物读取器，由该装置壳体承载并被配置成测量受试者的组织中一种或多种分析物的存在，不存在或集中; 以及由所述装置容纳并被配置为测量受试者的生物样品中一种或多种分析物的存在，不存在或浓缩的样品分析物读取器。

6. 发明申请

WO2008014135A3 NON-INVASIVE ANALYTE MEASUREMENT GLASSES AND METHOD OF USE 审中-公开
标题翻译：无创分析测量眼镜和使用方法
公开(公告)号：WO2008014135A3
公开(公告)日：2008-12-04
申请号：PCT/US2007073487
申请日：2007-07-13
申请人： JOHN F BURD , BURD JOHN F , WILLIAMS PAUL
发明人： BURD JOHN F , WILLIAMS PAUL
IPC分类号： A61B5/1455
CPC分类号： A61B5/6887 , A61B5/0002 , A61B5/14532
摘要： A method of using a non-invasive analyte reading device to substantially continuously measure the presence, absence, or concentration of one or more analytes in a tissue of a subject includes wearing the non-invasive analyte reading device constantly or for at least the duration of the desired measurement period; and using the non-invasive analyte reading device to non-invasively measure the presence, absence, or concentration of one or more analytes in a tissue of a subject substantially continuously.
摘要翻译：使用非侵入式分析物读取装置基本连续地测量受试者组织中一种或多种分析物的存在，不存在或浓度的方法包括持续或至少持续期望的测量周期; 以及使用非侵入性分析物读取装置基本上连续地无创地测量受试者组织中一种或多种分析物的存在，不存在或浓度。

7. 发明申请

WO2012061835A9 APPARATUS AND METHOD FOR NON-INVASIVELY DETECTING DISEASES THAT AFFECT STRUCTURAL PROPERTIES IN BIOLOGICAL TISSUES 审中-公开
标题翻译：不利于生物组织结构特性影响的非侵入性检测疾病的装置和方法
公开(公告)号：WO2012061835A9
公开(公告)日：2012-06-28
申请号：PCT/US2011059653
申请日：2011-11-07
申请人： FREEDOM MEDITECH INC , RORABAUGH DALE A , DAVIS NEIL M , BRANCACCIO VINCENT F , WILLIAMS PAUL
发明人： RORABAUGH DALE A , DAVIS NEIL M , BRANCACCIO VINCENT F , WILLIAMS PAUL
IPC分类号： A61B5/1477 , A61B3/14
CPC分类号： A61B3/1173 , A61B5/0068 , A61B5/0071 , A61B5/14546 , A61B5/1455 , A61B5/4842 , G01N21/6486 , G01N21/65 , G01N2800/042
摘要： Apparatus and methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.
摘要翻译：用于生物组织的光谱分析的装置和方法，以将个体分类为糖尿病或非糖尿病，或确定个体中疾病或医学状况的概率，进展或水平。

8. 发明申请

WO2007034163A2 DECORATIVE INLAYS 审中-公开
公开(公告)号：WO2007034163A2
公开(公告)日：2007-03-29
申请号：PCT/GB2006003475
申请日：2006-09-20
申请人： WILLIAMS PAUL
发明人： WILLIAMS PAUL
IPC分类号： C04B41/45 , B44C1/26 , B44C5/04
CPC分类号： B44C1/26 , B44C3/10
摘要： A method of providing a decorative inlay in a substrate (10) comprising providing a channel or groove (12) in the substrate and filling the channel with a composite (14) comprising a crushed rock and/or crushed ceramic material, such as powdered slate, and a binding agent.

9. 发明申请

WO0025810A2 IMMUNOMODULATORY FACTORS FOR IMMUNOSUPPRESSANT AND ANTIALLERGIC TREATMENT 审中-公开
标题翻译：免疫抑制剂和抗感染治疗的免疫调节因子
公开(公告)号：WO0025810A2
公开(公告)日：2000-05-11
申请号：PCT/GB9903621
申请日：1999-11-02
申请人： UNIV NOTTINGHAM , PRITCHARD DAVID IDRIS , WILLIAMS PAUL
发明人： PRITCHARD DAVID IDRIS , WILLIAMS PAUL
IPC分类号： A61K35/56 , A61P11/06 , A61P33/00 , A61P37/02 , A61P37/06 , A61P37/08 , C07G99/00 , A61K39/00
CPC分类号： A61K35/62
摘要： An immunosuppressive agent, obtainable from the nematode Heligmosomoides polygyrus, characterised in that the agent has a molecular weight of less than 12 kDa, is resistant to proteinase K and is not bound to a polypeptide.
摘要翻译：一种可从线虫Heligmosomoides polygyrus获得的免疫抑制剂，其特征在于该试剂具有小于12kDa的分子量，对蛋白酶K具有抗性且不与多肽结合。

10. 发明申请

WO2012061836A3 IMPROVED ALGORITHM FOR DETECTION OF DIABETES 审中-公开
标题翻译：改进的糖尿病检测算法
公开(公告)号：WO2012061836A3
公开(公告)日：2012-08-16
申请号：PCT/US2011059654
申请日：2011-11-07
申请人： FREEDOM MEDITECH INC , IGNOTZ KEITH D , RORABAUGH DALE A , DAVIS NEIL M , BRANCACCIO VINCENT F , WILLIAMS PAUL , MISRACH CRAIG H
发明人： IGNOTZ KEITH D , RORABAUGH DALE A , DAVIS NEIL M , BRANCACCIO VINCENT F , WILLIAMS PAUL , MISRACH CRAIG H
IPC分类号： A61B5/1477 , A61B3/18 , A61B5/02
CPC分类号： A61B3/1173 , A61B5/0068 , A61B5/0071 , A61B5/14546 , A61B5/1455 , A61B5/4842 , G01N21/6486 , G01N21/65 , G01N2800/042
摘要： Methods for spectroscopic analysis of biological tissues to classify an individual as diabetic or non-diabetic, or to determine the probability, progression or level of a disease or medical condition in an individual.
摘要翻译：用于对生物组织进行光谱分析以将个体分类为糖尿病或非糖尿病，或确定个体中疾病或医学状况的可能性，进展或水平的方法。

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