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1. 发明申请

WO2008030613A2 HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS 审中-公开
标题翻译：杂交细胞的杂交抑制剂TRNA
公开(公告)号：WO2008030613A2
公开(公告)日：2008-03-13
申请号：PCT/US2007/019655
申请日：2007-09-07
申请人： AMBRX, INC. , TIAN, Feng , NORMAN, Thea , CHU, Stephanie
发明人： TIAN, Feng , NORMAN, Thea , CHU, Stephanie
IPC分类号： C12P21/06 , C12N1/21
CPC分类号： C12P21/02 , C12N9/93 , C12N15/11
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O- tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
摘要翻译：本发明提供了用于产生翻译组分的组合物和方法，所述翻译组分增加了脊椎动物细胞中遗传编码的氨基酸的数量。这些成分包括正交tRNA，正交氨酰-tRNA合成酶，正交tRNA /合成酶和非天然氨基酸。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质和方法。本发明提供了具有翻译组分的脊椎动物细胞，例如用于脊椎动物蛋白质生物合成机器中的正交氨酰基-tRNA合成酶（O-RS）和正交tRNA（O-tRNA's）及其单个组分的成对以掺入非天然氨基酸在增长的多肽链中，在脊椎动物细胞中。

2. 发明申请

WO2007070659A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
公开(公告)号：WO2007070659A3
公开(公告)日：2007-06-21
申请号：PCT/US2006/047822
申请日：2006-12-13
申请人： AMBRX, INC. , MIAO, Zhenwei , LIU, Junjie , NORMAN, Thea
发明人： MIAO, Zhenwei , LIU, Junjie , NORMAN, Thea
IPC分类号： A61K38/00 , A61K38/16 , A61K38/19 , C07K7/00 , C07K14/00
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one aromatic amine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one alkylated amine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.

3. 发明申请

WO2004050684A3 METHODS FOR IMPROVING SECONDARY METABOLITE PRODUCTION IN FUNGI 审中-公开
公开(公告)号：WO2004050684A3
公开(公告)日：2004-06-17
申请号：PCT/US2003/038528
申请日：2003-12-03
申请人： MICROBIA, INC. , BUSBY, Robert , CALI, Brian, M. , HECHT, Peter , HOLTZMAN, Douglas , MADDEN, Kevin, T. , MAXON, Mary , MILNE, Todd, G. , NORMAN, Thea , ROYER, John, C. , SILVA, Jeffrey, C. , SUMMERS, Eric, F. , ZHANG, Lixin , MAYORGA, Maria , FEIBELMAN, Toby , DOTEN, Reed
发明人： BUSBY, Robert , CALI, Brian, M. , HECHT, Peter , HOLTZMAN, Douglas , MADDEN, Kevin, T. , MAXON, Mary , MILNE, Todd, G. , NORMAN, Thea , ROYER, John, C. , SILVA, Jeffrey, C. , SUMMERS, Eric, F. , ZHANG, Lixin , MAYORGA, Maria , FEIBELMAN, Toby , DOTEN, Reed
IPC分类号： C12N1/16
摘要： Methods for improving secondary metabolite production by modulating certain genes involved in secondary metabolite production, including genes encoding CreA, AreA, GanB, Gna3, FadA, Gna1, Gpa1, RfeH, An09, PacC, Lys14, LovU, Ste7, Pde2, Nc1, Vps34 and fungal homologs thereof.

4. 发明申请

WO2008030612A3 SITE SPECIFIC INCORPORATION OF NON-NATURAL AMINO ACIDS BY VERTEBRATE CELLS 审中-公开
标题翻译：非天然氨基酸的立体特异性结合纳米网状细胞
公开(公告)号：WO2008030612A3
公开(公告)日：2008-11-27
申请号：PCT/US2007019654
申请日：2007-09-07
申请人： AMBRX INC , TIAN FENG , NORMAN THEA , CHU STEPHANIE
发明人： TIAN FENG , NORMAN THEA , CHU STEPHANIE
IPC分类号： C12N5/02
CPC分类号： C12N9/93 , C12P21/02
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided.
摘要翻译：本发明提供了用于产生翻译组分的组合物和方法，所述翻译组分增加了脊椎动物细胞中遗传编码的氨基酸的数量。这些成分包括正交tRNA，正交氨酰-tRNA合成酶，正交tRNA /合成酶和非天然氨基酸。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质和方法。

5. 发明申请

WO2008030613A3 HYBRID SUPPRESSOR TRNA FOR VERTEBRATE CELLS 审中-公开
标题翻译：混合抑制剂TRNA用于VERTEBRATE细胞
公开(公告)号：WO2008030613A3
公开(公告)日：2008-11-20
申请号：PCT/US2007019655
申请日：2007-09-07
申请人： AMBRX INC , TIAN FENG , NORMAN THEA , CHU STEPHANIE
发明人： TIAN FENG , NORMAN THEA , CHU STEPHANIE
IPC分类号： C12N5/10 , C07H21/02 , C07H21/04 , C12N15/11
CPC分类号： C12P21/02 , C12N9/93 , C12N15/11
摘要： This invention provides compositions and methods for producing translational components that expand the number of genetically encoded amino acids in vertebrate cells. The components include orthogonal tRNA's, orthogonal aminoacyl-tRNA synthetases, orthogonal pairs of tRNA's/synthetases and unnatural amino acids. Proteins and methods of producing proteins with unnatural amino acids in vertebrate cells are also provided. The present invention provides vertebrate cells with translation components, e.g., pairs of orthogonal aminoacyl-tRNA synthetases (O-RSs) and orthogonal tRNA's (O- tRNA's) and individual components thereof, that are used in vertebrate protein biosynthetic machinery to incorporate an unnatural amino acid in a growing polypeptide chain, in a vertebrate cell.
摘要翻译：本发明提供用于生产翻译成分的组合物和方法，其扩展脊椎动物细胞中遗传编码氨基酸的数目。组分包括正交tRNA，正交氨酰-tRNA合成酶，tRNA /合成酶和非天然氨基酸的正交对。还提供了在脊椎动物细胞中产生具有非天然氨基酸的蛋白质的蛋白质和方法。本发明提供具有翻译成分的脊椎动物细胞，例如正交氨基-tRNA合成酶（O-RS）和正交tRNA（O-tRNA）及其各自成分的对，其用于脊椎动物蛋白质生物合成机制以掺入非天然氨基在生长的多肽链中，在脊椎动物细胞中。

6. 发明申请

WO2007022531A2 METHODS AND COMPOSITIONS FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS 审中-公开
标题翻译：用于治疗胃肠疾病的方法和组合物
公开(公告)号：WO2007022531A2
公开(公告)日：2007-02-22
申请号：PCT/US2006/032719
申请日：2006-08-21
申请人： MICROBIA, INC. , CURRIE, Mark, G. , MAHAJAN-MIKLOS, Shalina , FRETZEN, Angelika , SUN, Li Jing , KURTZ, Caroline , MILNE, G. Todd , NORMAN, Thea , ROBERTS, Shannon , SULLIVAN, E. Kelly
发明人： CURRIE, Mark, G. , MAHAJAN-MIKLOS, Shalina , FRETZEN, Angelika , SUN, Li Jing , KURTZ, Caroline , MILNE, G. Todd , NORMAN, Thea , ROBERTS, Shannon , SULLIVAN, E. Kelly
IPC分类号： C07K7/08
CPC分类号： C07K7/08 , C07K14/4705
摘要： The present invention features compositions and related methods for treating IBS and other gastrointestinal disorders and conditions (e.g., gastrointestinal motility disorders, functional gastrointestinal disorders, gastroesophageal reflux disease (GERD), duodenogastric reflux, Crohn's disease, ulcerative colitis, Inflammatory bowel disease, functional heartburn, dyspepsia (including functional dyspepsia or nonulcer dyspepsia), gastroparesis, chronic intestinal pseudo-obstruction (or colonic pseudo-obstruction), and disorders and conditions associated with constipation, e.g., constipation associated with use of opiate pain killers, post-surgical constipation (post-operative ileus), and constipation associated with neuropathic disorders as well as other conditions and disorders using peptides and other agents that activate the guanylate cyclase C (GC-C) receptor.
摘要翻译：本发明的特征在于用于治疗IBS和其他胃肠病症和病症（例如胃肠动力障碍，功能性胃肠病症，胃食管反流病（GERD），十二指肠胃逆流，克罗恩病，溃疡性结肠炎，炎症性肠病，功能性胃灼热，消化不良（包括功能性消化不良或非溃疡性消化不良），胃轻瘫，慢性肠假性梗阻（或结肠假性梗阻）以及与便秘相关的病症和状况，例如与使用阿片相关的便秘疼痛杀手，手术后便秘（手术后肠梗阻）和与神经病症相关的便秘以及使用肽和其他激活鸟苷酸环化酶C（GC-C）受体的试剂的其他病症和障碍。

7. 发明申请

WO2006069246A9 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：含有的组合物，涉及非天然氨基酸和多肽的方法和用途
公开(公告)号：WO2006069246A9
公开(公告)日：2006-08-31
申请号：PCT/US2005046618
申请日：2005-12-21
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
IPC分类号： C07K1/02
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一个非天然氨基酸的非天然氨基酸和多肽，以及制备此类非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可包括广泛范围的可能官能团，但通常具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，实现这种修饰的方法和纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步公开了使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

8. 发明申请

WO2010011735A3 MODIFIED BOVINE G-CSF POLYPEPTIDES AND THEIR USES 审中-公开
标题翻译：改性牛血清G-CSF多肽及其用途
公开(公告)号：WO2010011735A3
公开(公告)日：2010-04-15
申请号：PCT/US2009051388
申请日：2009-07-22
申请人： AMBRX INC , LILLY CO ELI , HAYS PUTNAM ANNA-MARIA A , KNUDSEN NICK , NORMAN THEA , KODER ALAN , KRAYNOV VADIM , HO LILLIAN , CANNING PETER C
发明人： HAYS PUTNAM ANNA-MARIA A , KNUDSEN NICK , NORMAN THEA , KODER ALAN , KRAYNOV VADIM , HO LILLIAN , CANNING PETER C
IPC分类号： A61K38/00
CPC分类号： C07K14/535
摘要： Modified bovine G-CSF polypeptides and uses thereof are provided.
摘要翻译：提供了改良的牛G-CSF多肽及其用途。

9. 发明申请

WO2010011735A2 MODIFIED BOVINE G-CSF POLYPEPTIDES AND THEIR USES 审中-公开
标题翻译：修饰牛G-CSF多肽及其应用
公开(公告)号：WO2010011735A2
公开(公告)日：2010-01-28
申请号：PCT/US2009/051388
申请日：2009-07-22
申请人： AMBRX, INC. , ELI LILLY AND COMPANY , HAYS PUTNAM, Anna-Maria, A. , KNUDSEN, Nick , NORMAN, Thea , KODER, Alan , KRAYNOV, Vadim , HO, Lillian , CANNING, Peter, C.
发明人： HAYS PUTNAM, Anna-Maria, A. , KNUDSEN, Nick , NORMAN, Thea , KODER, Alan , KRAYNOV, Vadim , HO, Lillian , CANNING, Peter, C.
IPC分类号： C07K14/535
CPC分类号： C07K14/535
摘要： Modified bovine G-CSF polypeptides and uses thereof are provided.
摘要翻译：提供了修饰的牛G-CSF多肽及其用途。

10. 发明申请

WO2006069246A3 COMPOSITIONS CONTAINING, METHODS INVOLVING, AND USES OF NON-NATURAL AMINO ACIDS AND POLYPEPTIDES 审中-公开
标题翻译：包含的组合物，涉及的方法和非天然氨基酸和多肽的使用
公开(公告)号：WO2006069246A3
公开(公告)日：2008-09-25
申请号：PCT/US2005046618
申请日：2005-12-21
申请人： AMBRX INC , MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
发明人： MIAO ZHENWEI , LIU JUNJIE , NORMAN THEA , DRIVER RUSSELL
IPC分类号： C07C22/00 , A61K38/00 , C07C227/00 , C07K2/00
CPC分类号： C07C225/10 , A61K31/198 , A61K38/17 , A61K47/08 , A61K47/10 , A61K47/34 , C07C229/36 , C07C237/32 , C07C251/28 , C07C251/54 , C07C251/60 , C07C251/86 , C07C323/63 , C07C2601/08 , C07D209/38 , C07D209/46 , C07D307/83 , C07D307/88 , C07D307/89 , C07D317/22 , C07D317/26 , C07D317/28 , C07D317/30 , C07D333/72 , C07K14/61 , C12P21/02 , G01N33/5008 , G01N33/68 , G01N33/6848 , G01N2500/00 , Y02P20/55
摘要： Disclosed herein are non-natural amino acids and polypeptides that include at least one non-natural amino acid, and methods for making such non-natural amino acids and polypeptides. The non-natural amino acids, by themselves or as a part of a polypeptide, can include a wide range of possible functionalities, but typical have at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Also disclosed herein are non-natural amino acid polypeptides that are further modified post-translationally, methods for effecting such modifications, and methods for purifying such polypeptides. Typically, the modified non-natural amino acid polypeptides include at least one oxime, carbonyl, dicarbonyl, and/or hydroxylamine group. Further disclosed are methods for using such non-natural amino acid polypeptides and modified non-natural amino acid polypeptides, including therapeutic, diagnostic, and other biotechnology uses.
摘要翻译：本文公开了包含至少一种非天然氨基酸的非天然氨基酸和多肽，以及制备这种非天然氨基酸和多肽的方法。非天然氨基酸本身或作为多肽的一部分可以包括广泛范围的可能的官能团，但是通常具有至少一个肟，羰基，二羰基和/或羟胺基团。本文还公开了在翻译后进一步修饰的非天然氨基酸多肽，用于实现这种修饰的方法，以及纯化这些多肽的方法。通常，修饰的非天然氨基酸多肽包括至少一个肟，羰基，二羰基和/或羟胺基团。进一步披露的是使用这种非天然氨基酸多肽和修饰的非天然氨基酸多肽的方法，包括治疗，诊断和其他生物技术用途。

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