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1. 发明申请

WO2012047618A3 MESOTHELIOMA BIOMARKERS AND USES THEREOF 审中-公开
公开(公告)号：WO2012047618A3
公开(公告)日：2012-04-12
申请号：PCT/US2011/053377
申请日：2011-09-27
申请人： SOMALOGIC, INC. , OSTROFF, Rachel, M. , STEWART, Alex, A., E. , WILLIAMS, Stephen, Alaric , BRODY, Edward, N. , NIKRAD, Malti , RIEL-MEHAN, Michael
发明人： OSTROFF, Rachel, M. , STEWART, Alex, A., E. , WILLIAMS, Stephen, Alaric , BRODY, Edward, N. , NIKRAD, Malti , RIEL-MEHAN, Michael
IPC分类号： C12Q1/68 , G01N33/53
摘要： Biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically are disclosed.

2. 发明申请

WO2013102096A1 APTAMERS AND DIAGNOSTIC METHODS FOR DETECTING THE EGF RECEPTOR 审中-公开
标题翻译： APTAMERS和诊断EGF受体的诊断方法
公开(公告)号：WO2013102096A1
公开(公告)日：2013-07-04
申请号：PCT/US2012/072094
申请日：2012-12-28
申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , SOMALOGIC, INC. , BOCK, Chris , AYERS, Deborah , NIKRAD, Malti P. , GAWANDE, Bharat Nathu , BERTINO, Jennifer C.
发明人： BOCK, Chris , AYERS, Deborah , NIKRAD, Malti P. , GAWANDE, Bharat Nathu , BERTINO, Jennifer C. , SUN, Weimin , STROM, Charles M. , PARK, Noh Jin
IPC分类号： C12Q1/68
CPC分类号： G01N33/57492 , C07H21/04 , C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/3513 , C12N2310/3517 , C12N2320/10 , G01N2333/71 , G01N2800/52
摘要： The present invention provides aptamers that specifically bind to the EGF receptor in a sample, and diagnostic and analytical methods using those aptamers. In some embodiments, the aptamers include a 3' cap. In some embodiments, the 3' cap is an inverted deoxythymidine. In some embodiments the aptamers include a spacer and at least one moiety selected from the group consisting of binding pair member and a detectable label, wherein the spacer is attached to the 5'-end of the aptamer and the moiety is attached the 5' end of the spacer. In some embodiments the spacer is hexaethylene glycol. In some embodiments, the binding pair member biotin. In some embodiments the detectable label is a fluorophore.
摘要翻译：本发明提供了特异性结合样品中EGF受体的适体，以及使用这些适体的诊断和分析方法。在一些实施方案中，适体包括3'帽。在一些实施方案中，3'帽是反式脱氧胸苷。在一些实施方案中，适体包括间隔基和至少一个选自结合对成员和可检测标记的部分，其中间隔子连接到适体的5'末端，并且该部分连接5'末端的间隔物。在一些实施方案中，间隔物是六甘醇。在一些实施方案中，结合对成员生物素。在一些实施方案中，可检测标记是荧光团。

3. 发明申请

WO2012047618A2 MESOTHELIOMA BIOMARKERS AND USES THEREOF 审中-公开
标题翻译： MESOTHELIOMA生物标记及其用途
公开(公告)号：WO2012047618A2
公开(公告)日：2012-04-12
申请号：PCT/US2011053377
申请日：2011-09-27
申请人： SOMALOGIC INC , OSTROFF RACHEL M , STEWART ALEX A E , WILLIAMS STEPHEN ALARIC , BRODY EDWARD N , NIKRAD MALTI , RIEL-MEHAN MICHAEL
发明人： OSTROFF RACHEL M , STEWART ALEX A E , WILLIAMS STEPHEN ALARIC , BRODY EDWARD N , NIKRAD MALTI , RIEL-MEHAN MICHAEL
IPC分类号： C40B30/04 , C40B40/10
CPC分类号： C12Q1/6886 , C12Q2600/158 , G01N33/57407 , G01N2800/50
摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer generally and mesothelioma specifically. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer generally or mesothelioma specifically. In another aspect, methods are provided for diagnosing mesothelioma in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 1, wherein the individual is classified as having mesothelioma, or the likelihood of the individual having mesothelioma is determined, based on the at least one biomarker value. In a further aspect, methods are provided for diagnosing cancer generally in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 19, wherein the individual is classified as having cancer generally, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.
摘要翻译：本公开内容包括用于特异性检测和诊断癌症和间皮瘤的生物标志物，方法，装置，试剂，系统和试剂盒。在一个方面，本公开提供了可以单独使用或以各种组合使用以生物标志物来诊断癌症或特异性间皮瘤。在另一方面，提供了用于诊断个体间皮瘤的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表1中提供的生物标志物组的至少一种生物标志物的生物标记值，其中所述个体被分类为具有间皮瘤，或者所述个体具有间皮瘤的可能性基于所述至少一个生物标志物值被确定。在另一方面，提供了用于一般在个体中诊断癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于至少一种选自表中提供的生物标志物的生物标志物的生物标记值 19，其中，基于所述至少一种生物标记值，将所述个体一般分类为具有癌症或确定患有癌症的个体的可能性。

4. 发明申请

WO2011043840A1 CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：癌症生物标志物及其用途
公开(公告)号：WO2011043840A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/029878
申请日：2010-04-03
申请人： SOMALOGIC, INC. , GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , RIEL-MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
发明人： GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , RIEL-MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
IPC分类号： G01N33/53 , C12Q1/68 , G06F17/18 , G06F19/00
CPC分类号： G01N33/57449 , G06F19/24 , Y10T436/143333
摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 24, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.
摘要翻译：本公开内容包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。一方面，本公开提供可以单独使用或以各种组合使用以诊断癌症的生物标志物。在另一方面，提供了用于诊断个体癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一种对应于选自表24中提供的生物标志物组的生物标志物的生物标记值，其中基于所述至少一种生物标志物值将所述个体分类为具有癌症或确定患有癌症的个体的可能性。

5. 发明申请

WO2011031344A1 CANCER BIOMARKERS AND USES THEREOF 审中-公开
标题翻译：癌症生物标志物及其用途
公开(公告)号：WO2011031344A1
公开(公告)日：2011-03-17
申请号：PCT/US2010/026439
申请日：2010-03-05
申请人： SOMALOGIC, INC. , GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
发明人： GOLD, Larry , BRODY, Edward N. , OSTROFF, Rachel M. , ZICHI, Dominic , STEWART, Alex A.E. , MEHAN, Michael , MESSENBAUGH, Mark , SCHWARTZ, Randee S. , WALKER, Jeffery , WILLIAMS, Stephen Alaric , NIKRAD, Malti
IPC分类号： A61B5/00 , G01N33/48 , G01N33/574
CPC分类号： G01N33/57423
摘要： The present disclosure includes biomarkers, methods, devices, reagents, systems, and kits for the detection and diagnosis of cancer. In one aspect, the disclosure provides biomarkers that can be used alone or in various combinations to diagnose cancer. In another aspect, methods are provided for diagnosing cancer in an individual, where the methods include detecting, in a biological sample from an individual, at least one biomarker value corresponding to at least one biomarker selected from the group of biomarkers provided in Table 47, wherein the individual is classified as having cancer, or the likelihood of the individual having cancer is determined, based on the at least one biomarker value.
摘要翻译：本公开包括用于癌症的检测和诊断的生物标志物，方法，装置，试剂，系统和试剂盒。一方面，本公开提供可以单独使用或以各种组合使用以诊断癌症的生物标志物。在另一方面，提供了用于诊断个体癌症的方法，其中所述方法包括在来自个体的生物样品中检测至少一个对应于选自表47中提供的生物标志物组的生物标志物的生物标记值，其中所述个体基于所述至少一种生物标志物值被分类为具有癌症或确定个体患有癌症的可能性。

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